History Quiz / Vasculitis

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Can you name the Vasculitis

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Smokers under 40, reynauds, gangrene of fingers
ESR greater than 100
Most common vasculitis in children
63yo with Hx of hyperlipid, wt loss, bloody nasal discharge, non blanching non tender rash, high CRP, PR3 ANCA positive
fibrinoid necrosis with No granulomas
older than 50, headache, female, scandanavian, temporal arteries
organ infarcts, peripheral neuropathy
proliferation of intima, leg pain, jaw pain (S/M/or L)
what in cells do c-anca bind to
Focal vaculitis with transmural fibrinoid necrosis
Fibrinoid necrosis, granuloma, EOSINOPHELIA
neutorphils, inflammation from inside out(S/M/or L)
affects medium to small muscular arteries
Orbital pseudotumor, necrotizing scleritis
Tx for MPA, CS
outside in, macrophages, hyperplasia of intima, NO FIBRINOID NECROSIS (S/M/or L)
Alveolar hemmorhagge, NCGN
Associated with polymylagia rheumatica
disease with anti-endothelial cell AB
What is measured as a proxy for IL6
30% of cases associated with Hep B
Dx of HSP
Northern european, middle age, purpura, pauci immune (S/M/or L)
Three ANCA associated vasculitis
Tx of Kawasaki disease
Bilateral conjunctivitis, strawberry tounge, rash, desquamation of digist
Small to medium vessels, ANCA negative, aneurysms
Young adult with stomach pain, melena, hypertension, HBsAg positive
Tx in GPA
57yo, DMII, Hep B, Peripheral neuropathy, negative ANCA, hematochezia
Anti endothelial, anti smooth muscle cell antibodies
Fibrinoid necrosis, upper respiratory granuloma
Tx of HSP
what in cells do p-anca bind to
Nasal polyps, asthma, allergy, NCGN
String of pearls appearance on imaging
Children under 5, coranary artery, self limiting
Children, palpable purpura, NO ANCA, abdominal pain
Tx for Polyarteritis nodosa
What do you do to confirm P or C Anca
hyperplastic intima, asymptomatic, unequal BP, claudiation
Most common acquired heart disease of children
Corkscrew collaterals on imaging or ultrasound
Tx of Giant cell arteritis
'pulseless disease', under than 50, female
fibrinoid necrosis (S/M/or L)
Dx of takayasu
CD20 AB used in GPA
Saddle nose, NCGN
Hilighter pink colored vessel wall
Constitutional symptoms of vasculitis are caused by which cytokine?
Involves aorta, renal arteries, great vessels
Marked fibrosis between intima and media on histo
70yo, HX of GCA, off steroids, low BP in R arm, what would cause dissection after high dose steroids
Palpable purpura on buttocks and legs, upper respiratory tract infection
granulomatous inflammation, patchy, segmented, fragmentation of internal elastic membrane
'skip lesions', focal lesions, aneurysm (S/M/or L)
Tx of takayasu's arteritis
palpable purpura (S/M/or L)
renal, coronary, hepatic, testicular arteries, lung SPARED

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