History Quiz / Vasculitis

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Can you name the Vasculitis

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Tx of takayasu's arteritis
Tx of Giant cell arteritis
63yo with Hx of hyperlipid, wt loss, bloody nasal discharge, non blanching non tender rash, high CRP, PR3 ANCA positive
older than 50, headache, female, scandanavian, temporal arteries
palpable purpura (S/M/or L)
what in cells do p-anca bind to
Fibrinoid necrosis, granuloma, EOSINOPHELIA
Small to medium vessels, ANCA negative, aneurysms
P-ANCA/ MPO
Tx for MPA, CS
Smokers under 40, reynauds, gangrene of fingers
Children under 5, coranary artery, self limiting
organ infarcts, peripheral neuropathy
Dx of takayasu
Associated with polymylagia rheumatica
Dx of HSP
Hilighter pink colored vessel wall
Tx for Polyarteritis nodosa
Young adult with stomach pain, melena, hypertension, HBsAg positive
granulomatous inflammation, patchy, segmented, fragmentation of internal elastic membrane
Tx of HSP
affects medium to small muscular arteries
Northern european, middle age, purpura, pauci immune (S/M/or L)
fibrinoid necrosis (S/M/or L)
Orbital pseudotumor, necrotizing scleritis
renal, coronary, hepatic, testicular arteries, lung SPARED
Involves aorta, renal arteries, great vessels
ESR greater than 100
hyperplastic intima, asymptomatic, unequal BP, claudiation
Anti endothelial, anti smooth muscle cell antibodies
Three ANCA associated vasculitis
Bilateral conjunctivitis, strawberry tounge, rash, desquamation of digist
proliferation of intima, leg pain, jaw pain (S/M/or L)
Saddle nose, NCGN
Most common vasculitis in children
Nasal polyps, asthma, allergy, NCGN
Marked fibrosis between intima and media on histo
Tx in GPA
70yo, HX of GCA, off steroids, low BP in R arm, what would cause dissection after high dose steroids
outside in, macrophages, hyperplasia of intima, NO FIBRINOID NECROSIS (S/M/or L)
30% of cases associated with Hep B
Alveolar hemmorhagge, NCGN
What do you do to confirm P or C Anca
neutorphils, inflammation from inside out(S/M/or L)
CD20 AB used in GPA
disease with anti-endothelial cell AB
Corkscrew collaterals on imaging or ultrasound
'pulseless disease', under than 50, female
what in cells do c-anca bind to
'skip lesions', focal lesions, aneurysm (S/M/or L)
Children, palpable purpura, NO ANCA, abdominal pain
Tx of Kawasaki disease
Palpable purpura on buttocks and legs, upper respiratory tract infection
Constitutional symptoms of vasculitis are caused by which cytokine?
fibrinoid necrosis with No granulomas
Fibrinoid necrosis, upper respiratory granuloma
What is measured as a proxy for IL6
57yo, DMII, Hep B, Peripheral neuropathy, negative ANCA, hematochezia
String of pearls appearance on imaging
Focal vaculitis with transmural fibrinoid necrosis
C-ANCA, PR3
Most common acquired heart disease of children

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