History Quiz / Vasculitis

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QUIZ: Can you name the Vasculitis

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Tx in GPA
affects medium to small muscular arteries
what in cells do c-anca bind to
String of pearls appearance on imaging
Most common vasculitis in children
Nasal polyps, asthma, allergy, NCGN
Three ANCA associated vasculitis
70yo, HX of GCA, off steroids, low BP in R arm, what would cause dissection after high dose steroids
Associated with polymylagia rheumatica
Children under 5, coranary artery, self limiting
'skip lesions', focal lesions, aneurysm (S/M/or L)
renal, coronary, hepatic, testicular arteries, lung SPARED
disease with anti-endothelial cell AB
granulomatous inflammation, patchy, segmented, fragmentation of internal elastic membrane
Involves aorta, renal arteries, great vessels
Tx of Kawasaki disease
Northern european, middle age, purpura, pauci immune (S/M/or L)
Tx for MPA, CS
Saddle nose, NCGN
Tx of HSP
Anti endothelial, anti smooth muscle cell antibodies
Smokers under 40, reynauds, gangrene of fingers
Tx of takayasu's arteritis
Most common acquired heart disease of children
what in cells do p-anca bind to
What is measured as a proxy for IL6
older than 50, headache, female, scandanavian, temporal arteries
'pulseless disease', under than 50, female
C-ANCA, PR3
Fibrinoid necrosis, upper respiratory granuloma
Orbital pseudotumor, necrotizing scleritis
63yo with Hx of hyperlipid, wt loss, bloody nasal discharge, non blanching non tender rash, high CRP, PR3 ANCA positive
Alveolar hemmorhagge, NCGN
Fibrinoid necrosis, granuloma, EOSINOPHELIA
57yo, DMII, Hep B, Peripheral neuropathy, negative ANCA, hematochezia
proliferation of intima, leg pain, jaw pain (S/M/or L)
fibrinoid necrosis (S/M/or L)
Focal vaculitis with transmural fibrinoid necrosis
What do you do to confirm P or C Anca
Palpable purpura on buttocks and legs, upper respiratory tract infection
Tx of Giant cell arteritis
CD20 AB used in GPA
30% of cases associated with Hep B
Tx for Polyarteritis nodosa
ESR greater than 100
Young adult with stomach pain, melena, hypertension, HBsAg positive
palpable purpura (S/M/or L)
Small to medium vessels, ANCA negative, aneurysms
organ infarcts, peripheral neuropathy
Marked fibrosis between intima and media on histo
Children, palpable purpura, NO ANCA, abdominal pain
outside in, macrophages, hyperplasia of intima, NO FIBRINOID NECROSIS (S/M/or L)
P-ANCA/ MPO
fibrinoid necrosis with No granulomas
Bilateral conjunctivitis, strawberry tounge, rash, desquamation of digist
Dx of HSP
Hilighter pink colored vessel wall
hyperplastic intima, asymptomatic, unequal BP, claudiation
Constitutional symptoms of vasculitis are caused by which cytokine?
neutorphils, inflammation from inside out(S/M/or L)
Corkscrew collaterals on imaging or ultrasound
Dx of takayasu

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