Entertainment Quiz / Pathoma Chapter 2 pt2

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Can you name the Pathoma Chapter 2 pt2

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Drug that induces SLE (TB Tx)
Lymphocytic destruction of salivary and lacrimal glands
Mutatated protein in X linked agammaglobulinemia
What type of collagen makes up vasculature, granulation tissue, embryonic tissue
Polyendocrine syndrome is caused by a mutation in what protein
Second most common cause of death in diffuse scleroderma involves what organ
Which HLA subtype is associated with ankylosing spondylitis
Thrombocytopenia, eczema, reccurent infections
Binding of antigen by CD4 cell without second signal leads to what
What is present in the serum of pts with Sjogrens
What is increased in Scleroderma that is a potent vasocontrictor
What would be seen on biopsy that is diagnostic of Sjogrens
What can anti SSA,SSB cause in children
Child with two very swollen eylids
Is APA syndrome more commonly primary or secondary to SLE?
CREST symptoms are for what subtype of scleroderma
ANA with serum antibodies against U1 ribonucleoprotein
Hardening of tissue, deposition of collagen, systemic
Lack of thymus, lack of parathyroids, abnormalities in heart, great vessels, face
CD4+ CD25+(IL2r) FoxP3+
What type of collagen makes up cartilage
What must be avoided in XLG babies
Hereditary angioedema of skin, periorbital membranes, and mucosal surfaces
What is the marker for hematopoietic stem cells
What type of cells suppress Tcells by competitive binding of CTLA4 to CD28
What is the stem cell of the lung
What element is necessar for collagenase to remove type III collagen
In scar formation, type III collagen is replaced by what type of collagen
What is necessary for crosslinking of glycine and lysine by lysyl oxidase
Libman-Sacks endocarditis, Arthritis
What disease is highly associated with IgA deficiency
Initial phase of repair
How long after birth do XLG babies present with symptoms
E in CREST
What type of hypersensitivity is Sjogren's
Cells that present single positive cells with many self antigens
S in CREST
Most common Ig deficiency
APA plus hypercoaguble state is called
Growth factor in angiogenesis, skeletal development
What part of the thymus does positive selection occur
Growth factor in angiogenesis
Endothelium, smooth muscle, fibroblast growth factor
Most common cause of death in diffuse scleroderma involves what organ
What cytokine is necessary for survival of Tregs
Provide nutrients during granulation
tightness of skin, loss of wrinkles on fingers
Receptor editing in B cells is facilitated by which gene
Tyrosine phosphatase that has mutations associated with autoimmune disorders
Epithelial and fibroblast growth factor
Which ANA are specific for lupus
Small vegetation on both sides of mitral valve
Drug that induces SLE (Antiarrythmic)
immunodysregulation polyendocrinopathy enteropathy X-linked
Tx of DiGeorge pt
What deficiency disposes an individual to SLE
What type of collagen is in the basement membrane
T in CREST
Antibodies are to what in diffuse scleroderma
Of dry eyes/mouth, ANA/ASSA/ASSB, and biopsy, how many need to be positive for Dx of Sjogrens
Infections in CVID and X linked agammaglobulinemia pts
Which Anti-ANA has prognostic value and predics renal damage
Features of SLE, Systemic sclerosis, polymyositis, autoimmune
Where are the stem cells for the bowels
What does a keloid have excess of
What is necessary for hydroxylation of glycine and lysine
What are the specific Anti-ribonucleoproteins, Anti-
Tissue that is quiescent but can reenter cell cycle
Drug that induces SLE (Smooth muscle relaxant)
Complete lack of Ig's
Which antibody produces a false positive test for syphillis
Where are the stem cells for the skin
What are Sjogrens pts at a higher risk for late in the disease
Cell surface marker for monocyte lineage (macrophages)
Contract would during granulation
Disease with low IgG due to defects in B or T cells
Defective cell mediated and humoral immunities
Antibodies against host nuclear material
Are drug induced SLE pts ANA+
R in CREST
Deposit type III collagen during granulation
What type of selection is the checkpoint between double positive and single positive cells, also called MHC restriction
Autoantibodies present in Sjogrens syndrome, Anti-
What part of the thymus does negative selection occur
C in CREST
Most commonly involved organ system in diffuse scleroderma
IPEX syndrome is caused by mutations in what?
African american females, CNS psychosis, renal damage
Etiology in SCID (cell surface)
Do drug induced SLE pts get renal damage commonly?
Developmental failure of 3d and 4th pouches
What percent of people with early complement deficiency develop lupus
What is a hypertrophic scar made up of predominantly
Etiology in SCID (enzyme)
What does the biopsy exclude as causes for destruction of salivary gland
Antigen-antibody complex (Type III) deposition on multiple tissue
What is the 5 year survival for SLE
Sudden onset of acute renal failure and hypertension, diffuse scleroderma
Inheritance pattern for Wiskott-aldrich syndrome
Autoimmune lymphoproliferative syndrome is cause by a defect in what pathway
Deficiency in C5-C9, increased risk for infections with ?
Anemia, thromboytopenia, and leukopenia are due to what type of hypersensitivity in SLE
Oral or nasopharyngeal ulcers, discoid rash, arthritis, peripheral vasospasm
Antibodies are to what in limited scleroderma
Selection type in thymus that checks binding to self antigen
What is the cardiovascular complication for late SLE
Most common and most sever renal injury for SLE pts
Disease with mutated CD40L or CD40, no class switching
Fibroblast growth factor, inhibits inflammation

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