Entertainment Quiz / Pathoma Chapter 2 pt2

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Can you name the Pathoma Chapter 2 pt2

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Do drug induced SLE pts get renal damage commonly?
What are Sjogrens pts at a higher risk for late in the disease
C in CREST
Hardening of tissue, deposition of collagen, systemic
What type of collagen is in the basement membrane
Libman-Sacks endocarditis, Arthritis
What disease is highly associated with IgA deficiency
Mutatated protein in X linked agammaglobulinemia
ANA with serum antibodies against U1 ribonucleoprotein
Second most common cause of death in diffuse scleroderma involves what organ
Most common Ig deficiency
tightness of skin, loss of wrinkles on fingers
Initial phase of repair
What is the marker for hematopoietic stem cells
What does the biopsy exclude as causes for destruction of salivary gland
What does a keloid have excess of
APA plus hypercoaguble state is called
African american females, CNS psychosis, renal damage
Tyrosine phosphatase that has mutations associated with autoimmune disorders
What part of the thymus does positive selection occur
Disease with mutated CD40L or CD40, no class switching
Drug that induces SLE (Smooth muscle relaxant)
CD4+ CD25+(IL2r) FoxP3+
CREST symptoms are for what subtype of scleroderma
Features of SLE, Systemic sclerosis, polymyositis, autoimmune
Endothelium, smooth muscle, fibroblast growth factor
Developmental failure of 3d and 4th pouches
Which ANA are specific for lupus
Binding of antigen by CD4 cell without second signal leads to what
What is present in the serum of pts with Sjogrens
What type of collagen makes up vasculature, granulation tissue, embryonic tissue
IPEX syndrome is caused by mutations in what?
immunodysregulation polyendocrinopathy enteropathy X-linked
Antibodies against host nuclear material
Drug that induces SLE (Antiarrythmic)
Defective cell mediated and humoral immunities
Is APA syndrome more commonly primary or secondary to SLE?
What type of cells suppress Tcells by competitive binding of CTLA4 to CD28
S in CREST
Most common and most sever renal injury for SLE pts
Selection type in thymus that checks binding to self antigen
What would be seen on biopsy that is diagnostic of Sjogrens
Tx of DiGeorge pt
Fibroblast growth factor, inhibits inflammation
What deficiency disposes an individual to SLE
What is a hypertrophic scar made up of predominantly
Growth factor in angiogenesis, skeletal development
Growth factor in angiogenesis
Autoantibodies present in Sjogrens syndrome, Anti-
R in CREST
What type of selection is the checkpoint between double positive and single positive cells, also called MHC restriction
What type of collagen makes up cartilage
Inheritance pattern for Wiskott-aldrich syndrome
Of dry eyes/mouth, ANA/ASSA/ASSB, and biopsy, how many need to be positive for Dx of Sjogrens
Sudden onset of acute renal failure and hypertension, diffuse scleroderma
Which HLA subtype is associated with ankylosing spondylitis
Cell surface marker for monocyte lineage (macrophages)
Which antibody produces a false positive test for syphillis
What element is necessar for collagenase to remove type III collagen
Where are the stem cells for the bowels
Complete lack of Ig's
What is the 5 year survival for SLE
What is necessary for hydroxylation of glycine and lysine
Epithelial and fibroblast growth factor
Antigen-antibody complex (Type III) deposition on multiple tissue
Which Anti-ANA has prognostic value and predics renal damage
Tissue that is quiescent but can reenter cell cycle
Autoimmune lymphoproliferative syndrome is cause by a defect in what pathway
Deficiency in C5-C9, increased risk for infections with ?
Infections in CVID and X linked agammaglobulinemia pts
What is increased in Scleroderma that is a potent vasocontrictor
What part of the thymus does negative selection occur
Lack of thymus, lack of parathyroids, abnormalities in heart, great vessels, face
Drug that induces SLE (TB Tx)
What type of hypersensitivity is Sjogren's
Hereditary angioedema of skin, periorbital membranes, and mucosal surfaces
Cells that present single positive cells with many self antigens
T in CREST
Child with two very swollen eylids
What can anti SSA,SSB cause in children
Disease with low IgG due to defects in B or T cells
Contract would during granulation
Most common cause of death in diffuse scleroderma involves what organ
Lymphocytic destruction of salivary and lacrimal glands
Antibodies are to what in limited scleroderma
What percent of people with early complement deficiency develop lupus
Most commonly involved organ system in diffuse scleroderma
Polyendocrine syndrome is caused by a mutation in what protein
What are the specific Anti-ribonucleoproteins, Anti-
E in CREST
What must be avoided in XLG babies
Etiology in SCID (cell surface)
What cytokine is necessary for survival of Tregs
Provide nutrients during granulation
Etiology in SCID (enzyme)
Thrombocytopenia, eczema, reccurent infections
Oral or nasopharyngeal ulcers, discoid rash, arthritis, peripheral vasospasm
What is the stem cell of the lung
Small vegetation on both sides of mitral valve
In scar formation, type III collagen is replaced by what type of collagen
How long after birth do XLG babies present with symptoms
Receptor editing in B cells is facilitated by which gene
Are drug induced SLE pts ANA+
Antibodies are to what in diffuse scleroderma
Anemia, thromboytopenia, and leukopenia are due to what type of hypersensitivity in SLE
Where are the stem cells for the skin
What is necessary for crosslinking of glycine and lysine by lysyl oxidase
What is the cardiovascular complication for late SLE
Deposit type III collagen during granulation

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