Entertainment Quiz / Pathoma Chapter 2 pt2

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Can you name the Pathoma Chapter 2 pt2

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Small vegetation on both sides of mitral valve
Drug that induces SLE (Antiarrythmic)
Which Anti-ANA has prognostic value and predics renal damage
Mutatated protein in X linked agammaglobulinemia
IPEX syndrome is caused by mutations in what?
Endothelium, smooth muscle, fibroblast growth factor
Deposit type III collagen during granulation
Are drug induced SLE pts ANA+
Antigen-antibody complex (Type III) deposition on multiple tissue
Child with two very swollen eylids
What must be avoided in XLG babies
Antibodies are to what in limited scleroderma
What does a keloid have excess of
What is a hypertrophic scar made up of predominantly
What deficiency disposes an individual to SLE
Growth factor in angiogenesis, skeletal development
How long after birth do XLG babies present with symptoms
Antibodies are to what in diffuse scleroderma
What are the specific Anti-ribonucleoproteins, Anti-
Libman-Sacks endocarditis, Arthritis
Selection type in thymus that checks binding to self antigen
Initial phase of repair
Features of SLE, Systemic sclerosis, polymyositis, autoimmune
Etiology in SCID (enzyme)
Provide nutrients during granulation
Tissue that is quiescent but can reenter cell cycle
T in CREST
Tyrosine phosphatase that has mutations associated with autoimmune disorders
Where are the stem cells for the skin
Lack of thymus, lack of parathyroids, abnormalities in heart, great vessels, face
What disease is highly associated with IgA deficiency
What type of selection is the checkpoint between double positive and single positive cells, also called MHC restriction
Contract would during granulation
tightness of skin, loss of wrinkles on fingers
Where are the stem cells for the bowels
CREST symptoms are for what subtype of scleroderma
What is the cardiovascular complication for late SLE
Most common cause of death in diffuse scleroderma involves what organ
African american females, CNS psychosis, renal damage
Receptor editing in B cells is facilitated by which gene
Drug that induces SLE (Smooth muscle relaxant)
Autoimmune lymphoproliferative syndrome is cause by a defect in what pathway
Which HLA subtype is associated with ankylosing spondylitis
Thrombocytopenia, eczema, reccurent infections
What would be seen on biopsy that is diagnostic of Sjogrens
What can anti SSA,SSB cause in children
Tx of DiGeorge pt
What is the marker for hematopoietic stem cells
What are Sjogrens pts at a higher risk for late in the disease
Most common and most sever renal injury for SLE pts
Drug that induces SLE (TB Tx)
E in CREST
Most commonly involved organ system in diffuse scleroderma
What percent of people with early complement deficiency develop lupus
Complete lack of Ig's
What element is necessar for collagenase to remove type III collagen
ANA with serum antibodies against U1 ribonucleoprotein
Developmental failure of 3d and 4th pouches
What type of collagen makes up cartilage
Which antibody produces a false positive test for syphillis
Disease with mutated CD40L or CD40, no class switching
What type of hypersensitivity is Sjogren's
Polyendocrine syndrome is caused by a mutation in what protein
Deficiency in C5-C9, increased risk for infections with ?
What type of collagen is in the basement membrane
What is the 5 year survival for SLE
Antibodies against host nuclear material
What part of the thymus does positive selection occur
Sudden onset of acute renal failure and hypertension, diffuse scleroderma
Hereditary angioedema of skin, periorbital membranes, and mucosal surfaces
What is present in the serum of pts with Sjogrens
S in CREST
R in CREST
What cytokine is necessary for survival of Tregs
Epithelial and fibroblast growth factor
In scar formation, type III collagen is replaced by what type of collagen
Second most common cause of death in diffuse scleroderma involves what organ
Growth factor in angiogenesis
C in CREST
What is increased in Scleroderma that is a potent vasocontrictor
Autoantibodies present in Sjogrens syndrome, Anti-
Etiology in SCID (cell surface)
Cell surface marker for monocyte lineage (macrophages)
Binding of antigen by CD4 cell without second signal leads to what
Fibroblast growth factor, inhibits inflammation
What is necessary for crosslinking of glycine and lysine by lysyl oxidase
Lymphocytic destruction of salivary and lacrimal glands
Of dry eyes/mouth, ANA/ASSA/ASSB, and biopsy, how many need to be positive for Dx of Sjogrens
Hardening of tissue, deposition of collagen, systemic
What type of collagen makes up vasculature, granulation tissue, embryonic tissue
immunodysregulation polyendocrinopathy enteropathy X-linked
What is the stem cell of the lung
Which ANA are specific for lupus
Is APA syndrome more commonly primary or secondary to SLE?
What does the biopsy exclude as causes for destruction of salivary gland
Most common Ig deficiency
Cells that present single positive cells with many self antigens
CD4+ CD25+(IL2r) FoxP3+
APA plus hypercoaguble state is called
Inheritance pattern for Wiskott-aldrich syndrome
What type of cells suppress Tcells by competitive binding of CTLA4 to CD28
Anemia, thromboytopenia, and leukopenia are due to what type of hypersensitivity in SLE
What part of the thymus does negative selection occur
Disease with low IgG due to defects in B or T cells
Do drug induced SLE pts get renal damage commonly?
Infections in CVID and X linked agammaglobulinemia pts
What is necessary for hydroxylation of glycine and lysine
Defective cell mediated and humoral immunities
Oral or nasopharyngeal ulcers, discoid rash, arthritis, peripheral vasospasm

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