Science Quiz / Pathoma Chapter 2 pt1

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Can you name the Pathoma Chapter 2

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What cells are acted on by leukotrienes that constrict and result in increased cell permeability
Naive B cells express what on surface
What complement product is an opsonin for phagocytosis
what complement product attracts neutrophils
TH1 CD4 cytokine that activates CD8 tcells and TCGF
What provides the second signal in CD4 activation
What do macrophages secrete that induce TH1 subtype of CD4 cells
Prostoglandin that mediates fever and pain
What upregulates adhesion molecules (ICAM and VCAM)
In which vascular structure does increased permeability occur as a result or prostoglandins
What is the end product of 5-lipooxygenase pathwaye
Macrophage with abundant pink cytoplasm
Albinism, peripheral neuropathy
Mediates fever, pain, vasodilation and increased vascular permeability
Opsonins that enhance phagocytosis
Key mediator in swelling
What do TH1 CD4 cells secrete that convert macrophages to epitheliod histocytes
What category of bacteria cause infections in Chronic Granulomatous Disease
TH2 CD4 cytokine that causes class switching from IgM to IgE
How do bradykinin and PGE2 cause pain
What does a B cell become after antigen binding to IgM or IgD
Formation of granuloma is mediated by which T cells
Disease with autosomal recessive protein trafficking defect
'speed bumps' upregulated along endothelial surface during Rolling step
Cells present in chronic inflammation
What activates alternative pathway
What increases the body temperature set point
Make Von Willebrand factor and P-Selectin
Test to screen for CGD
Inactive proinflammatory protein produced in liver
Two methods of cytotoxic killing by CD8 Tcells
What complement product makes a hole in target cell
In which vascular structure does vasodilation occur as a result or prostoglandins
C5a, IL-8, LTB4, and Kallikein are all
Enzyme that converts O2 to O2rad
Process of neutrophils going to periphery of vasculature
TH2 CD4 cytokine that causes class switching from IgM to IgA
Present on surface of macropahages and dendritic cells which recognize PAMP
Where are P-selectins released from
What small molecule plays a key role in oxygen dependent killing
What mediates diapedesis (neutrophil traffic inbetween endothelial cells)
What induces P-Selectins
Activates Mast cells (immune)
DDx non caseating granuloma (systemic disease)
Activates Mast cells (antigenic)
Wall of fibrosis surrounding an area of acute inflammation
Lack of pus, delayed separation of umbilical cord, increased circulating neutrophils, recurrent bacterial infections
TH2 CD4 cytokine that inhibits TH1 phenotype
Disease with defective integrin CD18 subunit
Mediates vasocontstriction, bronchospasm, and increased permeability
Important bacteria that results in granulomatous infections in CGD
What provides the second signal that activates B cells
What is on the surface of leukocytes which binds to selectins
TH1 CD4 cytokine that causes class switching from IgM to IgG
What binds to mannose on microorganisms to activate 3d complement pathway
Nitroblue tetrazolium test normal, increased in Candida infections, mostly asymptomatic. Defect in what enzyme
What is released by phospohlipase A2
DDx non caseating granuloma (Chemical exposure)
What complement products trigger mast cell degranulation
This cytokine continues acute inflammation, released by macrophages
Two cytokines involved in the healing phase, antiinflammatory
What TLR binds to LPS
Innate immunity provides what type of inflammation
Enzyme that converts H2O2 to HOCl
What product of mast cells allows for progression and maintenance of immune response
cell present in second phase of acute inflmmation
TH1 CD4 cytokine that activates macrophages
Apoptosis and conversion to pus of neutrophils that happens within 24hrs of inflammation
Defect in tubules that prevent transport along tubules
Nitroblue tetrazolium will turn blue in the presence of active:
Most effective mechanism in cellular killing is?
What upregulates integrin?
What cell is predominant in acute inflammation
Stellate shaped granuloma is caused by what?
Stain for fungus when granuloma present
Where in the body do about 50% of nuetrophils live
Disease with defective NADPH Oxidase
What cell is predominant in chronic inflammation
What tissue characteristic is hallmark of acute inflammation
What is upregulated after binding of TLR which activates immune response genes
DDx non caseating granuloma (Autoimmune)
What induces E selectin
This phase begins 2-3 days into the acute inflammatory period
DDx non caseating granuloma (animal)
Third phase of acute inflmmation
Increased risk of pyogenic infections, neutropenia, giant granules in leukocytes
What type of heart failure is associated with sepsis
Where is COX activity increased in the hypothalmus
What type of heart failure is associated with hypovolemia
What provides the second signal that activates CD8 cells
Enzyme that converts O2rad to H2O2
CD4 T cells can only recognize antigen present in the context of what MHC
What bind to CAMs
Key cell that defines granulma
Activated by subendothelial or tissue collagen, plays an important role in DIC
CD8 T cells can only recognize antigen present in the context of what MHC
What is the key product of the cyclooxygenase pathway
In classical pathway, what does C1 bind to
Which leukotriene attracts and activates neutrophils
Stain for TB when granuloma present
Activates Mast cells (mechanical)
Mediates vasodilation, increased vascular permeability, and Pain
First phase of acute inflmmation

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