Science Quiz / Pathoma Chapter 2 pt1

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Can you name the Pathoma Chapter 2

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What provides the second signal in CD4 activation
DDx non caseating granuloma (animal)
C5a, IL-8, LTB4, and Kallikein are all
Disease with defective NADPH Oxidase
What is released by phospohlipase A2
Mediates fever, pain, vasodilation and increased vascular permeability
Innate immunity provides what type of inflammation
Enzyme that converts O2rad to H2O2
Nitroblue tetrazolium will turn blue in the presence of active:
What upregulates integrin?
Macrophage with abundant pink cytoplasm
In which vascular structure does vasodilation occur as a result or prostoglandins
Most effective mechanism in cellular killing is?
What bind to CAMs
What activates alternative pathway
In which vascular structure does increased permeability occur as a result or prostoglandins
Inactive proinflammatory protein produced in liver
Activates Mast cells (antigenic)
DDx non caseating granuloma (systemic disease)
Stellate shaped granuloma is caused by what?
Two cytokines involved in the healing phase, antiinflammatory
Apoptosis and conversion to pus of neutrophils that happens within 24hrs of inflammation
Prostoglandin that mediates fever and pain
Activated by subendothelial or tissue collagen, plays an important role in DIC
What mediates diapedesis (neutrophil traffic inbetween endothelial cells)
TH2 CD4 cytokine that causes class switching from IgM to IgE
Enzyme that converts O2 to O2rad
What upregulates adhesion molecules (ICAM and VCAM)
Formation of granuloma is mediated by which T cells
In classical pathway, what does C1 bind to
TH2 CD4 cytokine that inhibits TH1 phenotype
Where is COX activity increased in the hypothalmus
Albinism, peripheral neuropathy
What cell is predominant in acute inflammation
This phase begins 2-3 days into the acute inflammatory period
What category of bacteria cause infections in Chronic Granulomatous Disease
Stain for TB when granuloma present
Opsonins that enhance phagocytosis
Key mediator in swelling
What do TH1 CD4 cells secrete that convert macrophages to epitheliod histocytes
Third phase of acute inflmmation
What tissue characteristic is hallmark of acute inflammation
Present on surface of macropahages and dendritic cells which recognize PAMP
Lack of pus, delayed separation of umbilical cord, increased circulating neutrophils, recurrent bacterial infections
'speed bumps' upregulated along endothelial surface during Rolling step
Key cell that defines granulma
What provides the second signal that activates B cells
Make Von Willebrand factor and P-Selectin
Mediates vasocontstriction, bronchospasm, and increased permeability
What is the key product of the cyclooxygenase pathway
TH2 CD4 cytokine that causes class switching from IgM to IgA
What complement product is an opsonin for phagocytosis
 
TH1 CD4 cytokine that activates macrophages
cell present in second phase of acute inflmmation
What cells are acted on by leukotrienes that constrict and result in increased cell permeability
Mediates vasodilation, increased vascular permeability, and Pain
Test to screen for CGD
What increases the body temperature set point
What TLR binds to LPS
Cells present in chronic inflammation
CD8 T cells can only recognize antigen present in the context of what MHC
What does a B cell become after antigen binding to IgM or IgD
what complement product attracts neutrophils
What is on the surface of leukocytes which binds to selectins
What induces P-Selectins
Activates Mast cells (immune)
What do macrophages secrete that induce TH1 subtype of CD4 cells
Defect in tubules that prevent transport along tubules
Wall of fibrosis surrounding an area of acute inflammation
First phase of acute inflmmation
Disease with autosomal recessive protein trafficking defect
Naive B cells express what on surface
What product of mast cells allows for progression and maintenance of immune response
What type of heart failure is associated with sepsis
CD4 T cells can only recognize antigen present in the context of what MHC
What provides the second signal that activates CD8 cells
Increased risk of pyogenic infections, neutropenia, giant granules in leukocytes
How do bradykinin and PGE2 cause pain
Important bacteria that results in granulomatous infections in CGD
TH1 CD4 cytokine that causes class switching from IgM to IgG
What type of heart failure is associated with hypovolemia
This cytokine continues acute inflammation, released by macrophages
Which leukotriene attracts and activates neutrophils
Where are P-selectins released from
DDx non caseating granuloma (Autoimmune)
Enzyme that converts H2O2 to HOCl
Stain for fungus when granuloma present
Disease with defective integrin CD18 subunit
Activates Mast cells (mechanical)
Process of neutrophils going to periphery of vasculature
TH1 CD4 cytokine that activates CD8 tcells and TCGF
Nitroblue tetrazolium test normal, increased in Candida infections, mostly asymptomatic. Defect in what enzyme
What cell is predominant in chronic inflammation
What is the end product of 5-lipooxygenase pathwaye
DDx non caseating granuloma (Chemical exposure)
Two methods of cytotoxic killing by CD8 Tcells
Where in the body do about 50% of nuetrophils live
What complement product makes a hole in target cell
What is upregulated after binding of TLR which activates immune response genes
What small molecule plays a key role in oxygen dependent killing
What complement products trigger mast cell degranulation
What induces E selectin
What binds to mannose on microorganisms to activate 3d complement pathway

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