Science Quiz / Pathoma Chapter 2 pt1

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Can you name the Pathoma Chapter 2

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Stain for TB when granuloma present
What bind to CAMs
What cell is predominant in chronic inflammation
Nitroblue tetrazolium will turn blue in the presence of active:
Disease with defective NADPH Oxidase
Which leukotriene attracts and activates neutrophils
This cytokine continues acute inflammation, released by macrophages
Wall of fibrosis surrounding an area of acute inflammation
TH2 CD4 cytokine that causes class switching from IgM to IgA
Where is COX activity increased in the hypothalmus
DDx non caseating granuloma (Chemical exposure)
Cells present in chronic inflammation
DDx non caseating granuloma (Autoimmune)
In classical pathway, what does C1 bind to
Important bacteria that results in granulomatous infections in CGD
What cells are acted on by leukotrienes that constrict and result in increased cell permeability
What upregulates integrin?
'speed bumps' upregulated along endothelial surface during Rolling step
Where are P-selectins released from
Mediates vasodilation, increased vascular permeability, and Pain
What type of heart failure is associated with hypovolemia
What induces E selectin
What is released by phospohlipase A2
What TLR binds to LPS
Two methods of cytotoxic killing by CD8 Tcells
Innate immunity provides what type of inflammation
Apoptosis and conversion to pus of neutrophils that happens within 24hrs of inflammation
What induces P-Selectins
Mediates fever, pain, vasodilation and increased vascular permeability
What provides the second signal in CD4 activation
C5a, IL-8, LTB4, and Kallikein are all
Key cell that defines granulma
Disease with autosomal recessive protein trafficking defect
Two cytokines involved in the healing phase, antiinflammatory
DDx non caseating granuloma (animal)
What complement product is an opsonin for phagocytosis
TH2 CD4 cytokine that causes class switching from IgM to IgE
Increased risk of pyogenic infections, neutropenia, giant granules in leukocytes
Where in the body do about 50% of nuetrophils live
What increases the body temperature set point
Naive B cells express what on surface
What provides the second signal that activates B cells
Enzyme that converts O2 to O2rad
Enzyme that converts H2O2 to HOCl
Macrophage with abundant pink cytoplasm
What mediates diapedesis (neutrophil traffic inbetween endothelial cells)
What category of bacteria cause infections in Chronic Granulomatous Disease
Mediates vasocontstriction, bronchospasm, and increased permeability
Enzyme that converts O2rad to H2O2
What cell is predominant in acute inflammation
CD4 T cells can only recognize antigen present in the context of what MHC
Present on surface of macropahages and dendritic cells which recognize PAMP
What is the end product of 5-lipooxygenase pathwaye
What do TH1 CD4 cells secrete that convert macrophages to epitheliod histocytes
Most effective mechanism in cellular killing is?
What is on the surface of leukocytes which binds to selectins
Stellate shaped granuloma is caused by what?
Activates Mast cells (immune)
Inactive proinflammatory protein produced in liver
First phase of acute inflmmation
DDx non caseating granuloma (systemic disease)
This phase begins 2-3 days into the acute inflammatory period
What complement product makes a hole in target cell
cell present in second phase of acute inflmmation
Disease with defective integrin CD18 subunit
TH1 CD4 cytokine that activates macrophages
Formation of granuloma is mediated by which T cells
TH1 CD4 cytokine that activates CD8 tcells and TCGF
what complement product attracts neutrophils
How do bradykinin and PGE2 cause pain
Albinism, peripheral neuropathy
Nitroblue tetrazolium test normal, increased in Candida infections, mostly asymptomatic. Defect in what enzyme
In which vascular structure does increased permeability occur as a result or prostoglandins
What type of heart failure is associated with sepsis
Defect in tubules that prevent transport along tubules
Opsonins that enhance phagocytosis
Key mediator in swelling
What is upregulated after binding of TLR which activates immune response genes
Activates Mast cells (mechanical)
CD8 T cells can only recognize antigen present in the context of what MHC
TH2 CD4 cytokine that inhibits TH1 phenotype
What provides the second signal that activates CD8 cells
What complement products trigger mast cell degranulation
Process of neutrophils going to periphery of vasculature
What activates alternative pathway
Make Von Willebrand factor and P-Selectin
Activated by subendothelial or tissue collagen, plays an important role in DIC
Lack of pus, delayed separation of umbilical cord, increased circulating neutrophils, recurrent bacterial infections
Test to screen for CGD
What small molecule plays a key role in oxygen dependent killing
Activates Mast cells (antigenic)
What tissue characteristic is hallmark of acute inflammation
What is the key product of the cyclooxygenase pathway
TH1 CD4 cytokine that causes class switching from IgM to IgG
What binds to mannose on microorganisms to activate 3d complement pathway
Stain for fungus when granuloma present
In which vascular structure does vasodilation occur as a result or prostoglandins
What does a B cell become after antigen binding to IgM or IgD
What do macrophages secrete that induce TH1 subtype of CD4 cells
What upregulates adhesion molecules (ICAM and VCAM)
Prostoglandin that mediates fever and pain
Third phase of acute inflmmation
What product of mast cells allows for progression and maintenance of immune response

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