Science Quiz / Pathoma Chapter 2 pt1

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Can you name the Pathoma Chapter 2

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TH2 CD4 cytokine that causes class switching from IgM to IgE
What TLR binds to LPS
How do bradykinin and PGE2 cause pain
Where in the body do about 50% of nuetrophils live
Activates Mast cells (immune)
What is the key product of the cyclooxygenase pathway
What cells are acted on by leukotrienes that constrict and result in increased cell permeability
Mediates vasodilation, increased vascular permeability, and Pain
What upregulates adhesion molecules (ICAM and VCAM)
Nitroblue tetrazolium test normal, increased in Candida infections, mostly asymptomatic. Defect in what enzyme
DDx non caseating granuloma (Chemical exposure)
'speed bumps' upregulated along endothelial surface during Rolling step
Where are P-selectins released from
What binds to mannose on microorganisms to activate 3d complement pathway
cell present in second phase of acute inflmmation
What provides the second signal that activates CD8 cells
First phase of acute inflmmation
Disease with defective NADPH Oxidase
Present on surface of macropahages and dendritic cells which recognize PAMP
What complement product makes a hole in target cell
What tissue characteristic is hallmark of acute inflammation
Important bacteria that results in granulomatous infections in CGD
What bind to CAMs
In which vascular structure does vasodilation occur as a result or prostoglandins
Activates Mast cells (antigenic)
What induces E selectin
What type of heart failure is associated with hypovolemia
Increased risk of pyogenic infections, neutropenia, giant granules in leukocytes
Wall of fibrosis surrounding an area of acute inflammation
DDx non caseating granuloma (systemic disease)
Apoptosis and conversion to pus of neutrophils that happens within 24hrs of inflammation
In which vascular structure does increased permeability occur as a result or prostoglandins
What does a B cell become after antigen binding to IgM or IgD
Lack of pus, delayed separation of umbilical cord, increased circulating neutrophils, recurrent bacterial infections
Key cell that defines granulma
What product of mast cells allows for progression and maintenance of immune response
This phase begins 2-3 days into the acute inflammatory period
CD4 T cells can only recognize antigen present in the context of what MHC
Two cytokines involved in the healing phase, antiinflammatory
Formation of granuloma is mediated by which T cells
Enzyme that converts H2O2 to HOCl
Disease with defective integrin CD18 subunit
What complement products trigger mast cell degranulation
Where is COX activity increased in the hypothalmus
What is upregulated after binding of TLR which activates immune response genes
Process of neutrophils going to periphery of vasculature
Stain for fungus when granuloma present
TH1 CD4 cytokine that causes class switching from IgM to IgG
CD8 T cells can only recognize antigen present in the context of what MHC
Cells present in chronic inflammation
What increases the body temperature set point
Which leukotriene attracts and activates neutrophils
Opsonins that enhance phagocytosis
DDx non caseating granuloma (animal)
What is the end product of 5-lipooxygenase pathwaye
Two methods of cytotoxic killing by CD8 Tcells
What provides the second signal that activates B cells
Activated by subendothelial or tissue collagen, plays an important role in DIC
Third phase of acute inflmmation
Macrophage with abundant pink cytoplasm
What do macrophages secrete that induce TH1 subtype of CD4 cells
TH2 CD4 cytokine that causes class switching from IgM to IgA
TH1 CD4 cytokine that activates macrophages
What activates alternative pathway
What type of heart failure is associated with sepsis
Stain for TB when granuloma present
This cytokine continues acute inflammation, released by macrophages
Mediates vasocontstriction, bronchospasm, and increased permeability
In classical pathway, what does C1 bind to
What cell is predominant in acute inflammation
What is on the surface of leukocytes which binds to selectins
What upregulates integrin?
Inactive proinflammatory protein produced in liver
Defect in tubules that prevent transport along tubules
What is released by phospohlipase A2
Disease with autosomal recessive protein trafficking defect
What induces P-Selectins
Most effective mechanism in cellular killing is?
What category of bacteria cause infections in Chronic Granulomatous Disease
Naive B cells express what on surface
TH2 CD4 cytokine that inhibits TH1 phenotype
What mediates diapedesis (neutrophil traffic inbetween endothelial cells)
What cell is predominant in chronic inflammation
what complement product attracts neutrophils
Make Von Willebrand factor and P-Selectin
C5a, IL-8, LTB4, and Kallikein are all
Innate immunity provides what type of inflammation
Activates Mast cells (mechanical)
Prostoglandin that mediates fever and pain
What small molecule plays a key role in oxygen dependent killing
Albinism, peripheral neuropathy
TH1 CD4 cytokine that activates CD8 tcells and TCGF
Stellate shaped granuloma is caused by what?
What complement product is an opsonin for phagocytosis
Key mediator in swelling
What provides the second signal in CD4 activation
Mediates fever, pain, vasodilation and increased vascular permeability
What do TH1 CD4 cells secrete that convert macrophages to epitheliod histocytes
Enzyme that converts O2rad to H2O2
Test to screen for CGD
Nitroblue tetrazolium will turn blue in the presence of active:
DDx non caseating granuloma (Autoimmune)
Enzyme that converts O2 to O2rad

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Created May 15, 2014ReportFavoriteNominate

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