Science Quiz / Phase 2 Drugs List - Mechanism of Action

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Class / Mechanism of ActionDrug Name
Antacid / Gastric acid neutralisation
Antacid + alginate / Gastric acid neutralisation and increasing viscosity of stomach contents
H2-receptor antagonist / Blockade of gastric H2 histamine receptors
H2-receptor antagonist / Blockade of gastric H2 histamine receptors
PPI / Blockade of parietal cell proton transporters
PPI / Blockade of parietal cell proton transporters
Pancreatic Enzymes / Restoration of pancreatic enzymes
Bulk laxative / Water retention in intestinal lumen to soften & bulk stools
Bulk laxative / Water retention in intestinal lumen to soften & bulk stools
Osmotic laxative / Water retention in intestinal lumen to soften & bulk stools
Osmotic laxative / Water retention in intestinal lumen to soften & bulk stools
Osmotic laxative / Water retention in intestinal lumen to soften & bulk stools
Faecal softener / Stimulates water & electrolyte secretion into intestinal lumen; lower surface tension, allowing water and fat to enter stool
Faecal softener / Stimulates water & electrolyte secretion into intestinal lumen; lower surface tension, allowing water and fat to enter stool
Stimulant purgative / Increase intestinal motility
Stimulant purgative / Increase intestinal motility
Opioid anti-motility agent / Agonist for μ-opioid receptors in myenteric plexus. Blocks intestinal muscarinic receptors
Opioid anti-motility agent / Agonist for μ-opioid receptors in myenteric plexus. Blocks intestinal muscarinic receptors
Carbonic anhydrase inhibitor / Prevent renal reabsorption of bicarbonate
Loop diuretic / Inhibits Na+/K+/2Cl- transporter in loop of Henle
Thiazide / Inhibits Na+/Cl- co-transporter in early distal tubule
Thiazide / Inhibits Na+/Cl- co-transporter in early distal tubule
Thiazide / Inhibits Na+/Cl- co-transporter in early distal tubule
Thiazide / Inhibits Na+/Cl- co-transporter in early distal tubule
Potassium sparing diuretic / Mineralocorticoid receptor blockade
Potassium sparing diuretic / Mineralocorticoid receptor blockade
Potassium sparing diuretic / Blockade of sodium reabsorption via ENaC channel
Osmotic diuretic / Increases osmolarity of glomerular filtrate
ACEi / Inhibits conversion of AG1 to AG2. Blocks vasoconstriction
ACEi / Inhibits conversion of AG1 to AG2. Blocks Vasoconstriction
ARB / Blockade of cell signalling induced by angiotensin II
ARB / Blockade of cell signalling induced by angiotensin II
Beta blockers / Blockade of beta-adrenergic receptors on cardiomyocytes, reducing inotropy & chronotropy
Cardioselective Beta-1 blockers / Blockade of beta-adrenergic receptors on cardiomyocytes, reducing inotropy & chronotropy
Beta 1 and 2 adrenergic receptor antagonist (beta blockers) / Blockade of beta-adrenergic receptors on cardiomyocytes, reducing inotropy & chronotropy
Neprilysin inhibitors / Inhibition of natriuretic peptide breakdown
Alpha-adrenergic blocker / Vasodilator (Smooth muscle relaxant), decreases total peripheral resistance
CCB / Blockade of L-type calcium channels, promoting vasodilation
CCB / Blockade of L-type calcium channels, promoting vasodilation
CCB / Blockade of L-type calcium channels, promoting vasodilation
Nitrate vasodilator / Release of nitric oxide – relaxation of vascular smooth muscle
Nitrate vasodilator / Release of nitric oxide – relaxation of vascular smooth muscle
Alpha and Beta Sympathomimetic / Stimulation of cardiac inotropy and chronotropy
Alpha Sympathomimetic / Stimulation of cardiac inotropy and chronotropy
Beta Sympathomimetic / Stimulation of cardiac inotropy and chronotropy
Antiplatelet / Inhibition of thromboxane A2 production
Antiplatelet / Blockade of platelet ADP receptors
Anticoagulant / Inhibition of clotting factor synthesis
Anticoagulant / Direct inhibition of thrombin
Anticoagulants / Inhibition of Factor Xa in Coagulation cascade
Anticoagulants / Inhibition of Factor Xa in Coagulation cascade
Anticoagulants / Inhibition of Factor Xa in Coagulation cascade
Anticoagulants - Heparins / Inactivation of Thrombin and Factor Xa - Complexing Antithrombin III
Anticoagulants - Heparins / Inactivation of Thrombin and Factor Xa - Complexing Antithrombin III
Anticoagulants - Heparins / Inactivation of Thrombin and Factor Xa - Complexing Antithrombin III
Anticoagulant / Enhances action of antithrombin III
Thrombolytic / Activation of Plasminogen for proteolytic breakdown of thrombus fibrin
Thrombolytic / Activation of Plasminogen for proteolytic breakdown of thrombus fibrin
Thrombolytic / Activation of Plasminogen for proteolytic breakdown of thrombus fibrin
HMG-CoA Reductase Inhibitor (statin) / Inhibition of mavelonate metabolism in cholesterol synthesis pathway
HMG-CoA Reductase Inhibitor (statin) / Inhibition of mavelonate metabolism in cholesterol synthesis pathway
Sodium Channel blockers / Class Ia Anti-arrythmic Voltage Sensitive Na channel blockade
Sodium Channel blockers / Class Ia Anti-arrythmic Voltage Sensitive Na channel blockade
Sodium Channel blockers / Class Ib Anti-arrythmic Voltage Sensitive Na channel blockade
Sodium Channel blockers / Class Ic Anti-arrythmic Voltage Sensitive Na channel blockade
Sodium Channel blockers / Class Ic Anti-arrythmic Voltage Sensitive Na channel blockade
Beta Blockers / Class II Anti-arrythmic Beta blocker
Potassium Channel Blockers / Class III Anti-arrythmic Potassium channel blocker
Potassium Channel Blockers / Class III Anti-arrythmic Potassium channel blocker
Potassium Channel Blockers / Class III Anti-arrythmic Potassium channel blocker with some Beta blocker activity
Calcium Channel Blockers / Class IV Anti-arrythmic Cardiac Calcium channel blockade
Calcium Channel Blockers / Class IV Anti-arrythmic Cardiac Calcium channel blockade
Cardiac Glycosides / Reduces conductivity of the AV node
Adenosine / Activates adenosine receptor - causes hyperpolarisation. Slows conduction through AV node
Anti-cholinergic (for emergency bradycardia treatment) / Blockade of cardiac muscarinic receptors
Magnesium / Unclear - possible alteration of Na, K, Ca ion balance
SABA / Stimulation of airway smooth muscle relaxation
SABA / Stimulation of airway smooth muscle relaxation
LABA / Stimulation of airway smooth muscle relaxation
LABA / Stimulation of airway smooth muscle relaxation
Short-acting Anti-cholinergic / Blockade of cholinergic activity in airway smooth muscle leading to muscle relaxation
Long-acting Anti-cholinergic / Blockade of cholinergic activity in airway smooth muscle leading to muscle relaxation
Methylxanthine / Inhibition of phosphodiesterase, increasing cellular cAMP
Methylxanthine / Inhibition of phosphodiesterase, increasing cellular cAMP
Glucocorticoid / Activation of glucocorticoid receptors in immune cells, reducing airway inflammation
Glucocorticoid / Activation of glucocorticoid receptors in immune cells, reducing airway inflammation
Glucocorticoid / Activation of glucocorticoid receptors in immune cells, reducing airway inflammation
Glucocorticoid / Activation of glucocorticoid receptors in immune cells, reducing airway inflammation
Leukotriene receptor antagonist / Blockade of proinflammatory leukotriene signalling
Leukotriene receptor antagonist / Blockade of proinflammatory leukotriene signalling
Mucolytic / Synthetic DNAse 1 - breakdown of extracellular DNA to reduce sputum viscosity
Dopaminergic / Dopamine precursor
Dopaminergic / Dopamine receptor agonist (synthetic)
Dopaminergic / Dopamine receptor agonist (synthetic)
Class / Mechanism of ActionDrug Name
Dopaminergic / Dopamine receptor agonist (synthetic)
Dopa-decarboxylase inhibitor / Stops breakdown of Levadopa in the periphery by inhibiting dopa-decarboxylase
Dopa-decarboxylase inhibitor / Stops breakdown of Levadopa in the periphery by inhibiting dopa-decarboxylase
MAOI-B / Stops breakdown of DA in CNS by inhibition of MAOIB
MAOI-B / Stops breakdown of DA in CNS by inhibition of MAOIB
COMT Inhibitor / Stops breakdown of DA in CNS by inhibition of COMT
COMT Inhibitor / Stops breakdown of DA in CNS by inhibition of COMT
Anticholinergic / Muscarinic receptor antagonist
Anticholinergic / Muscarinic receptor antagonist
Anticholinergic / Muscarinic receptor antagonist
Dopamine-depleting / Blocks VMAT, preventing uptake of DA into vesicles
SSRI / Inhibits serotonin (5HT) reuptake pump
SSRI / Inhibits serotonin (5HT) reuptake pump
SSRI / Inhibition of 5HT reuptake pump in synaptic cleft
MAOI-A / Stops breakdown of monoamines in CNS. Reversible inhibitor of monoamine oxidase A (RIMA)
TCA / SRI, NRI, H1 antagonist, M1 antagonist, Adrenergic antagonist
TCA / SRI, NRI, H1 antagonist, M1 antagonist, Adrenergic antagonist
TCA / Inhibition of NA and 5HT reuptake pump in synaptic cleft - H1, M1 and Adrenergic antagonist
Atypical Antidepressant / 5HT1a partial agonist
Atypical Antidepressant / SNRI
Atypical Antidepressant / NRI
Atypical Antidepressant / NDRI
Atypical Antidepressant / Melatonin agonist
Atypical Antidepressant / α2-Adrenergic antagonist
1st Generation Antipsychotic / Selective dopamine (D2) receptor antagonist
1st Generation Antipsychotic / Selective dopamine (D2) receptor antagonist
2nd Generation Antipsychotic / Serotonin (5HT2A) and dopamine (D2) antagonist
2nd Generation Antipsychotic / Serotonin (5HT2A) and dopamine (D2) antagonist
2nd Generation Antipsychotic / Selective D2 and 5HT receptor blocker
2nd Generation Antipsychotic / Serotonin (5HT2A) and dopamine (D2) antagonist
2nd Generation Antipsychotic / Serotonin (5HT7) and dopamine (D2) antagonist
Mood Stabiliser / Unclear - possible neuronal Ca channel blockade
Anticholinesterase / Reversible Inhibitor of acetylcholinesterase
Anticholinesterase / Reversible Inhibitor of acetylcholinesterase
Anticholinesterase / Reversible Inhibitor of acetylcholinesterase
Glutamate (NMDA) receptor antagonist / VD blocker of NMDA receptors (NMDA NAM)
Non-Benzodiazepine Hypnotic / Enhances GABA binding to GABA-A receptors
Anti-epilepsy drug (AED) / Sodium channel blocker
Anti-epilepsy drug (AED) / Sodium channel blocker
Anti-epilepsy drug (AED) / Sodium channel blocker
Anti-epilepsy drug (AED) / Calcium channel blocker (T-type)
Benzodiazepine (BDZ ) / GABA PAM (γ-subunit)
Benzodiazepine (BDZ ) / GABA PAM (γ-subunit)
Benzodiazepine (BDZ ) / GABA PAM (γ-subunit)
Muscle relaxants/sedatives/anxiolytic-hypnotic / GABA PAM (γ-subunit)
Benzodiazepine (BDZ ) / BDZ antagonist
Barbiturate (Barb) / GABA PAM (β-subunit)
Barbiturate (Barb) / GABA PAM (β-subunit)
Barbiturate (Barb) / GABA PAM (β-subunit)
Weak analgesic/ antipyretic / Non-selective COX inhibitor (CNS)
NSAID / Non-selective COX inhibitor
NSAID / Non-selective COX inhibitor
NSAID / Non-selective COX inhibitor
NSAID / Selective COX-2 inhibitor
NSAID / Selective COX-2 inhibitor
Weak opioid analgesic / Opioid receptor agonist
Weak opioid analgesic / Opioid receptor agonist
Strong opioid analgesic / Opioid receptor agonist
Strong opioid analgesic / Opioid receptor agonist
Strong Opioid / Stimulation of analgesic opioid receptors
Strong Opioid / Stimulation of analgesic opioid receptors
Mixed/Partial agonist opioid analgesics (also used in management of opioid addiction) / Opioid receptor agonist (μ)/antagonist (κ)
Partial/Mixed agonist opioid analgesic / Modulation of analgesic opioid receptors (Mu and kappa)
Opioid receptor antagonist / Opioid receptor antagonist
Opioid receptor antagonist / Opioid receptor antagonist
Drug used in management of opioid addiction / Opioid receptor agonist
Drug used to treat neuropathic pain / Inhibits VDCC, Increases GABA transmission
Drug used to treat neuropathic pain / Inhibits VDCC
Drug used to treat neuropathic pain / TCA
Inhaled Analgesics / Unclear
General anaesthetic / MoA Unclear
General anaesthetic / MoA Unclear
General anaesthetic / MoA Unclear
General anaesthetic / NMDA (glutamate) receptor antagonist
Local anaesthetic / Voltage-gated sodium channel blocker
Local anaesthetic / Voltage-gated sodium channel blocker
Local anaesthetic / Voltage-gated sodium channel blocker
Neuromuscular blockers / Competitive antagonist at AChR (Non-depolarising)
Neuromuscular blocker / Competitive antagonist at AChR
Neuromuscular blocker / Initially depolarisation and desensitization of AChR
Drugs used for reversing NMB block / Oligosaccharide that forms a complex with NMB removing them from NMJ
Neuromuscular blocker (also used to reverse NMB) / Peripheral inhibitor of acetylcholinesterase
Muscle relaxants/sedatives/anxiolytic-hypnotic / GABA PAM (γ-subunit)
Muscle relaxants/sedatives/anxiolytic-hypnotic / α2-adrenergic receptor agonist
Muscle relaxants/sedatives/anxiolytic-hypnotic / Opioid receptor agonist
Muscle relaxants/sedatives/anxiolytic-hypnotic / Opioid receptor agonist
Muscle relaxants/sedatives/anxiolytic-hypnotic / Opioid receptor agonist
H1 receptor antagonist anti-emetic / H1 receptor blocker
D2 receptor antagonist anti-emetic / D2 receptor blocker in chemoreceptor trigger zone
Penicillin / Bactericidal – cell lysis by blocking cell wall synthesis
Penicillin / Bactericidal – cell lysis by blocking cell wall synthesis
Penicillins / Beta-lactam - Inhibition of bacterial cell wall synthesis
Penicillin / Bactericidal – cell lysis by blocking cell wall synthesis
Penicillins / Beta-lactam - Inhibition of bacterial cell wall synthesis
Class / Mechanism of ActionDrug Name
Carbapenem / Bactericidal – cell lysis by blocking cell wall synthesis
Cephalosporin / Bactericidal – cell lysis by blocking cell wall synthesis
Antifolate antibiotic / Inhibition of dihydrofolate reductase
Fluoroquinolone / Bacteriostatic – inhibition of bacterial DNA coiling
Macrolide / Inhibition of bacterial protein synthesis
Macrolide / Inhibition of bacterial protein synthesis
Tetracycline / Bacteriostatic – inhibition of bacterial protein synthesis
Nitrofuran / Bacterial DNA interference
Aminoglycoside / Inhibition of bacterial protein synthesis
Glycopeptide / Inhibition of cell wall synthesis in Gram(+)
Nitroimidazole / Bacteriostatic – inhibition of bacterial DNA synthesis
Anti-TB drugs / Inhibition of mycobacterial cell wall synthesis
Anti-TB drugs / Inhibition of mycobacterial cell wall synthesis
Anti-TB drugs / Inhibition of mycobacterial RNA synthesis
Anti-TB drugs / Unclear
Therapeutic Cytokines / Activation of antiviral intracellular and immune responses
Antimicrobial/antiviral / Inhibits viral DNA synthesis
DNA polymerase inhibitors / Virus replication blocker
Neuraminidase inhibitor / Prevention of viral budding and infectivity
Nucleoside analogue / Disrupts viral RNA synthesis
Nucleoside reverse transcriptase inhibitor / Blockade of viral reverse transcriptase
Non-nucleoside reverse transcriptase inhibitor / Blockade of viral reverse transcriptase
Viral protease inhibitor / Blockade of viral proteas required for virus assmebly
Integrase inhibitor / Dirupts integration of HIV genome into host chromosomes
Viral protease inhibitor / Blockade of viral proteas required for virus assmebly
Chemokine receptor antagonist / Blockade of HIV binding to co-factor for cell entry
Triazole anti-fungal agent / Disruption of fungal membrane function
Blood glucose-reducing hormone / Stimulation of glucose uptake by cells
Oral Biguanide / Increases insulin sensitivity, inhibits hepatic gluconeogenesis
Sulphonylureas / Stimulates pancreatic insulin secretion
Thiazolidinediones / Increases insulin sensitivity in muscle and adipose tissue
Glucagon-like peptide 1 receptor (GLP-1) agonist / Incretin analogue - improves glucose control
Dipeptidyl peptidase 4 (DPP-4) inhibitor / Reduces inactivation of incretins
Lipase inhibitor / Inhibition of GI uptake of dietary fat
Thyroid hormone / Activation of thyroid hormone receptors
Thyroid hormone / Activation of thyroid hormone receptors
Anti-proliferative agent / Reduces lymphocyte proliferation
Anti-proliferative agent / Reduces lymphocyte proliferation
Cytokine modulators / TNF-alpha blockade
Cytokine modulators / TNF-alpha blockade
Monoclonal antibodies / Bind and block proinflammatory function of TNF-alpha
Aminosalicylate / MoA Unclear
Aminosalicylate / MoA Unclear
COCP / Mimics ovulation, reduces LH and FSH
POCP / Mimics ovulation, reduces LH and FSH, endometrial changes
POCP (Emergency) / Mimics ovulation, reduces LH and FSH, endometrial changes
Contraceptive implant / Mimics ovulation, reduces LH and FSH
HRT / Restores decreased hormone level and function
HRT / Restores decreased hormone level and function
HRT / Restores decreased hormone level and function
Induction of labour / Prostaglandin E2 - stimulates cervical ripening
Drugs used to augment labour / Drives myometrial contraction
Antiprogestogen/ Prostaglandin for medical termination / Steroidal antiprogestogen in combination with synthetic prostaglandin
Antifibrinolytic / Inhibits fibrin clot breakdown by plasmin
NSAID (for dysmenorrhoea) / Inhibition of Prostaglandin synthesis
Alpha-1 blocker / Smooth muscle relaxant acting on bladder neck
Urinary anti-spasmodic, anticholinergic (urinary incontinence) / Blockade of muscarinic receptors leading to reduction of bladder detrusor activity
Beta-3 agonist / Stimulation of Beta-3 adrenergic receptors, leading to detrusor smooth muscle relaxation
Anti-androgens / Inhibition of synthesis of Dihydrotestosterone
Antihistamine / H1 receptor blockade
Glucocorticoids / Intracellular transcription factor interactions, gene expression
Calcineurin inhibitor / Inhibition of T cell signalling
Calcineurin inhibitor / Inhibition of T cell signalling
Classical alkylating agents / DNA crosslinking
Taxanes / Inhibition of microtubule assembly in mitotic spindle
Taxanes / Inhibition of microtubule assembly in mitotic spindle
Vinca alkaloids / Inhibition of microtubule assembly in mitotic spindle
Vinca alkaloids / Inhibition of microtubule assembly in mitotic spindle
Antifolate / Inhibition of dihydrofolate reductase and DNA synthesis
Antipyrimidines / Inhibition of DNA and RNA synthesis
Antipyrimidines / Inhibition of DNA and RNA synthesis
Antipurines / Inhibition of DNA and RNA synthesis
Antipurines / Inhibition of DNA and RNA synthesis
Anthracycline Abx / DNA intercalation, Inhibition of DNA and RNA synthesis
Antineoplastic Monoclonal Antibodies / Targeting of cells overexpressing HER2 for tumour reduction and destruction
Antineoplastic Monoclonal Antibodies / Targeted destruction of CD20+ B cells
Antineoplastic monoclonal Antibodies / Stimulation of anti-tumour responses via blocking PD-1
Immunomodulator / Stimulation of T-cell response
SERM / Inhibition of Oestrogen receptor function and cell proliferation in breast
LHRH receptor agonist / Synthetic analogue of LHRH, activates LHRH receptor leading to sustained reduction in testosterone
Drug management of hypercalcaemia / Inhibition of release of calcium from bone
Drug management of hypercalcaemia and Osteoporosis / Inhibition of release of calcium from bone
Bisphosphonates / Inhibits osteoclast function and bone resorption
Drug management of hypocalcaemia / Restoration of calcium levels and retention
Drug management of hypocalcaemia and Osteoporosis / Restoration of calcium levels and retention
Drug management of osteoporosis / Inhibition of release of calcium from bone, inhibition of osteoclast activity
Drug management of vitamin D deficiency / Restoration of vitamin D levels
Drug management of vitamin D deficiency / Restoration of vitamin D levels
Drug management of osteoporosis / Inhibition of release of calcium from bone, inhibition of osteoclast activity
Drug management of osteoporosis / Inhibition of release of calcium from bone, inhibition of osteoclast activity
Oral Iron Compound / Iron Provision
Water soluble vitamin / Supports nucleic acid synthesis
Parenteral Water soluble vitamin / Enzyme co-factor
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Created Mar 3, 2020ReportNominate
Tags:Action, class, Drug, mechanism, phase

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