Science Quiz / Viral Infections of the GI Tract

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Can you name the Viral Infections of the GI Tract ?

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Non-enveloped ssRNa virus. Acid resistant. Have a 'cup-like' indentations on virion surface.
Outbreaks or epidemic gastroenteritis, which occurs either in semi-closed communities (families, institutions, ships, vacation spots) or as a result of classic food-borne or water-
Treatment: Oral rehydration. In cases of severe dehydration, IV solutions can be used.
Symptoms: “stomach flu”; sudden onset of diarrhea (more common in adults) and/or vomiting, abdominal cramps, nausea, anorexia, malaise, prostration, low-grade fever, myalgia, h
Sporadic gastroenteritis in infants, which is most frequently caused by _____
Rotavirus: Children can have from 10-20 bowel movements/day, and as a consequence, develop severe ______.
Virus activates of parasympathetic nerves of the gut, increasing peristalsis and secretion of fluids and solutes.
Norovirus pathogenesis: Infected persons can shed virus even during asymptomatic infection, or after ____ infection resolves.
Worldwide the most common cause of viral GI infections, esp. in developing countries (>110 million cases, with >500-600,000 deaths per year). Accounts for one third of hospitalizat
New epidemic strains arise as antigenic ____ occurs in the viral capsid protein.
Norovirus transmission includes fecal-oral route, direct contact with contaminated surfaces, and ______ transmission from vomiting.
In the pathology of enteric viruses and infection of intestinal epithelium, Leukocytes, blood or mucus are mostly undetectable in _____
Incubation period 1-3 days; illness lasts 4-5 days with low-grade fever, watery, bloodless diarrhea and vomiting, anorexia, abdominal cramps.
Spread by fecal-oral route or via aerosols; shellfish-, food- or water-borne outbreaks described, especially in institutional settings (restaurants, nursing homes, schools and crui
Rotavirus diarrhea is thus multifactorial, with malabsorption and _____ components.
Populations at risk for norovirus include restaurant patrons, children in developing and industrialized nations, and travelers to developing nations and ____ ship passengers.
Sporadic acute gastroenteritis of _____, which is most likely caused by caliciviruses, rotaviruses, astroviruses, or adenoviruses.
Vaccine: Live attenuated oral vaccines (Rotateq and Rotarix) are safe and 85-100% effective.
____, a rotavirus-encoded protein, is a viral enterotoxin that induces secretion by triggering a phospholipase C-dependent calcium signaling pathway.
In general, enterotoxigenic bacteria and viruses affect the ____ bowel, causing watery (NOT inflammatory) diarrhea and periumbilical pain.
Mainly affects infants, but adults appear to be susceptible as well. Virtually all children in the US are infected by age 4.
The most common cause of outbreaks of non-bacterial gastroenteritis worldwide, and a common cause of sporadic gastroenteritis.
Invasive bacteria act primarily in the colon (Shigella and Campylobacter) or lower ileum (Salmonella). The stool in these diseases may contain ____ and leukocytes.
Loss of villus tissue leads to intestinal malabsorption with ______ diarrhea resulting from the transit of mono- and disaccharides and carbohydrates in the intestinal lumen.
Acute diarrheal disease kills up to 5-10 million children/year (>10-20,000/day). Viral infections make up ~___ % of that number.
Members of the Reoviridae family
The majority of cases of viral gastroenteritis include
Non-enveloped, segmented ds RNA virus. Virion possesses an RNA-dependent RNA polymerase

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