Science Quiz / Viral Hepatitis Hermel

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Can you name the Viral Hepatitis Hermel ?

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Hepatitis ___: Spread via fecal-oral route; HEV hepatitis is a zoonotic disease, as animal (esp. pigs) and shellfish reservoirs are known. Unlike HAV, poorly spread person-person.
YF Prevention: _____ attenuated vaccine; highly recommended for travelers in endemic regions!
Havrix® and Vaqta® are killed ____ virus vaccines for hepatitis A.
Hepatitis ___: hepatotropic virus belonging to the Hepadnaviridae DNA virus.
Factors with the highest evidence of risk for development of hepatocellular carcinoma (HCC) or cirrhosis include
Pts who are anti-HBeAg negative/HBeAg+ have _____ prognoses.
Other YF symptoms include: massive GI tract ______(“black vomit”), fever and chills, severe headache, back pain, myalgia, nausea, prostration, coagulopathy.
Immune globulin is _____% effective in preventing disease when administered before exposure or early in the incubation period.
Hepatitis ___: Defective virus-like particle: not infectious unless co-infecting a cell with HBV
Presence of HBeAg increases risk of HCC _____x.
Name a risk factor for HBV infection in the US.
Hepatitis ___: Nonenveloped, ssRNA virus; genus Hepeviridae.
Hepatitis ____: Non-enveloped RNA virus. member Picornaviridae. Spread by fecal-oral route.
Yellow fever is ______-borne in tropical Americas and sub-Saharan Africa
Hepatitis ___: Major cause of “non-A, non-B” hepatitis in Mexico, Middle East , India, China
Other viruses causing hepatitis
Infectious Hepatitis spread by fecal-oral route
Newborns have a ___% chance of getting Chronic HBV infection
____ is a marker for active HBV viral replication and high infectivity. Not all pts have this.
Name a symptom of viral hepatitis
Yellow fever virus replicates in _____ cells and causes mid-zonal necrotizing hepatitis. About 15% of pts are jaundiced. Early jaundice (d3) and high fever indicate a poor prognosi
Hepatis __: Coinfection with Chronic HBV results in Superinfection. higher risk (90%) of developing chronic HDV infection, with severe, chronic liver disease (cirrhosis).
_______ HBV infection = HBsAg+ for 6 mos OR HBsAg+ AND IgM anti-HBcAg(-)
Hepatitis ___: Coinfection with Hepatitis B causes severe acute disease. Low risk (5%) of chronic infection.
HBV vaccine: _____ subunit vaccines available (Recombivax-HB and Engerix-B). The incidence of acute HBV infection in the US has declined as much as 80% between 1987 and 2004, attri
Hepatitis ___: Complication is relapsing hepatitis that may occur weeks to months after apparent recovery.
HCV: Only ___% of symptomatic patients will have jaundice.
Hepatitis____: Six genotypes are known, with multiple sub-genotypes. Most common in the US: 1 > 2, 3.
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_____ fever: Enveloped, ssRNA virus, member of the Flaviviridae.
____ protein HBx is a viral transcription factor, activating signal transduction pathways. HBx also targets and disrupts cell cycle regulation, DNA repair, apoptosis, oncogenes and
______ cellular immune responses seem to lie at the root of chronic HBV (and HCV) infections.
anti-HBsAg (ID persons who have been infected or _____)
Liver TPX has been used successfully for both _______HBV infection, and end-stage disease.
Hepatitis ___: Enveloped, ssRNA virus belonging to the Flaviviridae (Genus Hepaciviridae).
Hepatitis ___: Course is acute and self-limited, similar to that of HAV. Chronic infection occurs only in immunosuppressed persons. Mortality rate
anti-HBcAg (ID acute or _____ infections); anti-HBeAg (ID carriers or convalescence)
_______ hepatitis (massive hepatic necrosis) leading to ~100 deaths/yr, mainly in pts >50 with pre-existing liver disease
Hepatitis ____: Routes of infection are similar to HBV (see next slide), but sexual transmission is inefficient.
Chronic HBV infection leads to constant inflammation and _______ (= constant cell division)
Clinical illness is mild, but _____ causes chronic illness in 50-75% of pts. About 20% of pts progress to cirrhosis after two decades.
Hepatitis ___: No chronic infection
Hepatitis ___: Enveloped, often pleiotropic virus with a circular ds DNA genome, with both strands being incomplete.
Yellow fever is Transmitted by Aedes spp. mosquitoes from monkeys to humans in sylvatic (wild animals) or____ settings
Extrahepatic sequelae: Immune complex disease, caused by immune complex formation of viral particles and antibodies, seen in ~___% of pts
Serum hepatitis spread by parenteral (IVDA, transfusion), perinatal or sexual contact
HCV RNA detection by polymerase chain reaction (PCR) remains the most sensitive and specific method of diagnosing ______ HCV infection.
Several HCV proteins (esp. NS3/4A), a serine protease and RNA helicase) down-regulate immune responses, especially cellular anti-viral signaling, and ______ activity.
Name a risk factor for Chronic HCV infection
HBV DNA integrates into ______ cell chromosomes, which can lead to chromosomal aberrations, and can also activate telomerase.
Hepatitis ___: During acute infection, clinical illness occurs in only 20-30% of pts; 1% of these develop fulminant illness.
HBV is not _______; host immune responses are the principle determinant of hepatocellular injury.
Hepatitis ___: High risk are injecting drug use, HIV+ status, and Hemophiliacs prior to 1987
Hepatitis ____: Uses a reverse transcriptase in its replication cycle.
Hepatitis ___: Increases severity of HBV hepatitis. Spread is similar to HBV.
NS3 is a ______ protease, helicase, and adenosine triphosphatase with complex activities. NS3 and its cofactor NS4A are responsible for the cleavage of the HCV polyprotein.

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