Science Quiz / Viral Hepatitis Hermel

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Can you name the Viral Hepatitis Hermel ?

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Yellow fever virus replicates in _____ cells and causes mid-zonal necrotizing hepatitis. About 15% of pts are jaundiced. Early jaundice (d3) and high fever indicate a poor prognosi
YF Prevention: _____ attenuated vaccine; highly recommended for travelers in endemic regions!
Pts who are anti-HBeAg negative/HBeAg+ have _____ prognoses.
Hepatitis ___: No chronic infection
____ protein HBx is a viral transcription factor, activating signal transduction pathways. HBx also targets and disrupts cell cycle regulation, DNA repair, apoptosis, oncogenes and
HCV RNA detection by polymerase chain reaction (PCR) remains the most sensitive and specific method of diagnosing ______ HCV infection.
_______ hepatitis (massive hepatic necrosis) leading to ~100 deaths/yr, mainly in pts >50 with pre-existing liver disease
Hepatitis ___: Increases severity of HBV hepatitis. Spread is similar to HBV.
Hepatitis ____: Non-enveloped RNA virus. member Picornaviridae. Spread by fecal-oral route.
Hepatitis ___: Spread via fecal-oral route; HEV hepatitis is a zoonotic disease, as animal (esp. pigs) and shellfish reservoirs are known. Unlike HAV, poorly spread person-person.
HBV vaccine: _____ subunit vaccines available (Recombivax-HB and Engerix-B). The incidence of acute HBV infection in the US has declined as much as 80% between 1987 and 2004, attri
Hepatitis ___: During acute infection, clinical illness occurs in only 20-30% of pts; 1% of these develop fulminant illness.
Name a symptom of viral hepatitis
anti-HBcAg (ID acute or _____ infections); anti-HBeAg (ID carriers or convalescence)
____ is a marker for active HBV viral replication and high infectivity. Not all pts have this.
Infectious Hepatitis spread by fecal-oral route
______ cellular immune responses seem to lie at the root of chronic HBV (and HCV) infections.
Presence of HBeAg increases risk of HCC _____x.
Hepatitis ___: Course is acute and self-limited, similar to that of HAV. Chronic infection occurs only in immunosuppressed persons. Mortality rate
Hepatitis ___: High risk are injecting drug use, HIV+ status, and Hemophiliacs prior to 1987
Name a risk factor for Chronic HCV infection
_____ fever: Enveloped, ssRNA virus, member of the Flaviviridae.
Other YF symptoms include: massive GI tract ______(“black vomit”), fever and chills, severe headache, back pain, myalgia, nausea, prostration, coagulopathy.
Hepatitis ___: Nonenveloped, ssRNA virus; genus Hepeviridae.
Name a risk factor for HBV infection in the US.
Hepatitis ___: Major cause of “non-A, non-B” hepatitis in Mexico, Middle East , India, China
HBV is not _______; host immune responses are the principle determinant of hepatocellular injury.
Hepatis __: Coinfection with Chronic HBV results in Superinfection. higher risk (90%) of developing chronic HDV infection, with severe, chronic liver disease (cirrhosis).
xxx
Other viruses causing hepatitis
Hepatitis ___: Enveloped, ssRNA virus belonging to the Flaviviridae (Genus Hepaciviridae).
Hepatitis ____: Routes of infection are similar to HBV (see next slide), but sexual transmission is inefficient.
Hepatitis ___: Defective virus-like particle: not infectious unless co-infecting a cell with HBV
Hepatitis ___: hepatotropic virus belonging to the Hepadnaviridae DNA virus.
Serum hepatitis spread by parenteral (IVDA, transfusion), perinatal or sexual contact
Immune globulin is _____% effective in preventing disease when administered before exposure or early in the incubation period.
Factors with the highest evidence of risk for development of hepatocellular carcinoma (HCC) or cirrhosis include
HBV DNA integrates into ______ cell chromosomes, which can lead to chromosomal aberrations, and can also activate telomerase.
Yellow fever is ______-borne in tropical Americas and sub-Saharan Africa
Chronic HBV infection leads to constant inflammation and _______ (= constant cell division)
Extrahepatic sequelae: Immune complex disease, caused by immune complex formation of viral particles and antibodies, seen in ~___% of pts
Several HCV proteins (esp. NS3/4A), a serine protease and RNA helicase) down-regulate immune responses, especially cellular anti-viral signaling, and ______ activity.
HCV: Only ___% of symptomatic patients will have jaundice.
Hepatitis____: Six genotypes are known, with multiple sub-genotypes. Most common in the US: 1 > 2, 3.
Hepatitis ___: Complication is relapsing hepatitis that may occur weeks to months after apparent recovery.
Havrix® and Vaqta® are killed ____ virus vaccines for hepatitis A.
Hepatitis ____: Uses a reverse transcriptase in its replication cycle.
Liver TPX has been used successfully for both _______HBV infection, and end-stage disease.
NS3 is a ______ protease, helicase, and adenosine triphosphatase with complex activities. NS3 and its cofactor NS4A are responsible for the cleavage of the HCV polyprotein.
_______ HBV infection = HBsAg+ for 6 mos OR HBsAg+ AND IgM anti-HBcAg(-)
Hepatitis ___: Coinfection with Hepatitis B causes severe acute disease. Low risk (5%) of chronic infection.
Hepatitis ___: Enveloped, often pleiotropic virus with a circular ds DNA genome, with both strands being incomplete.
Yellow fever is Transmitted by Aedes spp. mosquitoes from monkeys to humans in sylvatic (wild animals) or____ settings
anti-HBsAg (ID persons who have been infected or _____)
Newborns have a ___% chance of getting Chronic HBV infection
Clinical illness is mild, but _____ causes chronic illness in 50-75% of pts. About 20% of pts progress to cirrhosis after two decades.

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Created Feb 2, 2012ReportNominate
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