Science Quiz / Neoplasia III-IV

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CDK inhibitor and causes cell cycle arrest
Type of Cancer immunotherapy where cytokines, IFN-alpha, IL-2, GM-CSF, IL-12 or bacterial adjuvants are used.
Causes DNA repair
Type of Cancer immunotherapy where the effector cell is isolated from the host, exposed to IL-2, and directly infused back to the host to enhance antigen presentation.
GTPase that hydrolyzes GTP to GDP
Major tumor suppressor that guards the genome integrity. Mutations in this gene are found in 50% of all human cancers.
Tyrosine Kinase (non-receptor)
Phosphotase that loses tumor suppression with haploinsufficiency
Inactivated by E7 and prevents E2F from binding to promoters of proto-oncogenes such as c-myc.
Viral oncoprotein associated with Epstein-Barr virus and Burkitt's Lymphoma
Signaling molecule encoded on Philadelphia Chromosome
Fos, Jun, and Myc are types of what?
Type of Cancer immunotherapy where peptide based vaccines, DNA vaccines, or tumor cells that are modified to boost immune response are used.
Catalyzes the replacement of GDP with GTP bound to Ras
Controls the G1-S transition. It is inactivated by Rb.
Allows for stabilization of Beta-catenin, nuclear import, and acts as an activator for transcription.
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GTP-binding protein that is constitutively activated if there is a mutation in codon 12, 13, and 61. It is on when bound to GTP and inactivated when bound to GDP
Kill tumor cells through the secretion of TNF and reactive oxygen species.
Viral oncoprotein associated with adult T cell leukemia (HTLV-1)
Recognize tumor cells with low MHC I Expression
Gram negative bacteria that causes peptic ulcer and implicated in gastric adenocarcinoma and gastric lymphoma.
Major APC presenting TAA to T cells. Central in the initiation of tumor-specific immune response.
Type of Smad mutated in 50% of pancreatic cancer.
Signaling molecule in B-cell lymphoma. Shares homology domains where Bad/Bax are pro-cell death.
Viral oncoprotein associated with KSHV
Type of Cancer immunotherapy where administration of exogenous antibodies and complements for B-lymphomas are used.
Transcription factor involved in TGF-beta signaling.
DNA repair protein. Mutations in this gene leads to hereditary breast cancer or ovarian cancer.
Degrades p53
Inhibitor of cyclin-dependent kinase
Approved cytokines for treatment of cancer
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Created Nov 1, 2010ReportNominate

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