Science Quiz / Neoplasia III-IV

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Can you name the Neoplasia III-IV Fun ?

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Gram negative bacteria that causes peptic ulcer and implicated in gastric adenocarcinoma and gastric lymphoma.
Transcription factor involved in TGF-beta signaling.
Kill tumor cells through the secretion of TNF and reactive oxygen species.
Fos, Jun, and Myc are types of what?
Phosphotase that loses tumor suppression with haploinsufficiency
Signaling molecule encoded on Philadelphia Chromosome
Approved cytokines for treatment of cancer
Controls the G1-S transition. It is inactivated by Rb.
DNA repair protein. Mutations in this gene leads to hereditary breast cancer or ovarian cancer.
Type of Cancer immunotherapy where cytokines, IFN-alpha, IL-2, GM-CSF, IL-12 or bacterial adjuvants are used.
Tyrosine Kinase (non-receptor)
CDK inhibitor and causes cell cycle arrest
GTP-binding protein that is constitutively activated if there is a mutation in codon 12, 13, and 61. It is on when bound to GTP and inactivated when bound to GDP
Viral oncoprotein associated with KSHV
Viral oncoprotein associated with Epstein-Barr virus and Burkitt's Lymphoma
Type of Cancer immunotherapy where peptide based vaccines, DNA vaccines, or tumor cells that are modified to boost immune response are used.
Degrades p53
Type of Smad mutated in 50% of pancreatic cancer.
GTPase that hydrolyzes GTP to GDP
Causes DNA repair
Catalyzes the replacement of GDP with GTP bound to Ras
Type of Cancer immunotherapy where the effector cell is isolated from the host, exposed to IL-2, and directly infused back to the host to enhance antigen presentation.
Inactivated by E7 and prevents E2F from binding to promoters of proto-oncogenes such as c-myc.
Signaling molecule in B-cell lymphoma. Shares homology domains where Bad/Bax are pro-cell death.
Allows for stabilization of Beta-catenin, nuclear import, and acts as an activator for transcription.
Viral oncoprotein associated with adult T cell leukemia (HTLV-1)
Recognize tumor cells with low MHC I Expression
Major tumor suppressor that guards the genome integrity. Mutations in this gene are found in 50% of all human cancers.
Type of Cancer immunotherapy where administration of exogenous antibodies and complements for B-lymphomas are used.
Inhibitor of cyclin-dependent kinase
Major APC presenting TAA to T cells. Central in the initiation of tumor-specific immune response.

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