Science Quiz / Hermel MidBlock 3 Lectures

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Can you name the Hermel MidBlock 3 Lectures?

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Degranulation inhibitor that inhibits the release of LT, TNF, IL-4, IL-5 and other cytokines.
Rare disorder characterized by recurrent episodes of painless angioedema without urticaria or pruritis
Skin blistering disease where autoantibodies are directed against epidermal antigens.
Disease that has a diagnostic butterfly rash. Most common in females. Rash is caused by deposition of immune complexes in the skin. Type III hypersensitivity.
This treatment extends lifespan of HIV+ women.
Fungi characteristic of AIDS
Soluble CTLA-Ig fusion molecule and a competitive inhibitor of CD28. Prevents T cell activation of APCs.Used to treat RA.
In Graft vs. Leukemia effect, patients surviving acute GVHD have reduced tumor __________
Disease: makes antibodies to acetylcholine receptors. The consequence is progressive muscle weakness. This can be treated with cyclophosphamide.
Th2 mediated inflammation of the airways. Type IV hypersensitivity. Chronic inflammation from Eosinophils leads to airway remodeling.
Type III hypersensitivity done experimentally. It is induced in skin by subcutaneous injection of the antigen.
Inflammatory disease characterized by joint destruction. Can be treated with Methotrexate as the Gold Standard.
Lymphocyte trafficking inhibitor that targets alpha4 integrin and prevents lymphocyte entry into the brain or gut.
Type II hypersensitivity in blood via complement and FcR+ phagocytes and causes DIRECT CYTOTOXICITY.
Parasite characteristic of AIDS
Targets CD20 and treats RA, CLL, and B cell lymphoma
Binds to CD33 on Leukemic cell. First FDA approved immunoconjugate.
Targets Her2/Neu and treats breast cancer
MAb used as an immunosuppressant in organ transplantation.Binds to IL2R (CD25)
Used in diagnosing autoimmune hemolytic anemia.
Disease from gluten allergy. HLA-DQ presents the modified peptide of gluten. Type IV hypersensitivity.
Drug: Uses G-CSF for bone marrow recovery after stem cell transplantation.
Phagocyte function deficiency: Defect in Lysosomal fusion
Drug that inhibits transcription of many inflammatory mediator genes. Side effect includes Cushing's syndrome
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Allergy Intervention that keeps skin wet
Antibody deficiency disease where there are normal B cell numbers but poor antibody response to TD or TI antigens.
Heterozygosity of HLA, being null for chemokine receptor CCR5, and circumcision are __________ factors for AIDS
DNA alkylating agent used to prevent and reverse organ graft rejection. Toxicity is hemorrhagic cystitis and bone marrow toxicity.
Bronchodilator used as intervention for allergies.
Likelihood of developing certain autoimmune diseases in persons who inherit particular HLA alleles than in persons who lack these alleles.
Condition where damage to the eye causes the release of proteins never previously encountered by the immune system.
Graft from an individual to the same individual
Inhibits mTOR and used in prevention of renal transplant rejection.
Virus characteristic of AIDS
Graft between members of two different species
Number of new HIV infections a day in 2008.
Drug: Uses GM-CSF for recovery of bone marrow after stem cell transplantation.
Drug: Uses IL-11 to treat thrombocytopenia
Detects antibodies to HIV. Cannot be used alone to diagnose HIV.
Purine antagonist that treats RA and acute graft rejection. Contraindication is pancreatitis. Toxicity is myelosuppression.
Women tend to be more susceptible to autoimmune diseases except for this disease.
Type of SCID where there are defects in proteins involved in VDJ rearrangement or T cell signal transduction
Immunoconjugate that is not an antibody. Used to treat T cell lymphoma and Chronic lymphocytic leukemia (CLL)
Dominant genetic factor affecting susceptibility to autoimmune diseases.
Antibody deficiency disease where there is a total lack of Ig, mature B cells, and germinal centers in the lymph nodes or spleen. Patients lack tonsils and adenoids.
Bacteria characteristic of AIDS
Disease that induces continuous synthesis and release of thyroid hormones. It is a Type II hypersensitivity in endocrine cells.

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