Science Quiz / Hermel MidBlock 3 Lectures

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Can you name the Hermel MidBlock 3 Lectures?

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DNA alkylating agent used to prevent and reverse organ graft rejection. Toxicity is hemorrhagic cystitis and bone marrow toxicity.
Degranulation inhibitor that inhibits the release of LT, TNF, IL-4, IL-5 and other cytokines.
In Graft vs. Leukemia effect, patients surviving acute GVHD have reduced tumor __________
Inhibits mTOR and used in prevention of renal transplant rejection.
Lymphocyte trafficking inhibitor that targets alpha4 integrin and prevents lymphocyte entry into the brain or gut.
Skin blistering disease where autoantibodies are directed against epidermal antigens.
Purine antagonist that treats RA and acute graft rejection. Contraindication is pancreatitis. Toxicity is myelosuppression.
Drug: Uses G-CSF for bone marrow recovery after stem cell transplantation.
Rare disorder characterized by recurrent episodes of painless angioedema without urticaria or pruritis
Graft between members of two different species
Type II hypersensitivity in blood via complement and FcR+ phagocytes and causes DIRECT CYTOTOXICITY.
Used in diagnosing autoimmune hemolytic anemia.
Bacteria characteristic of AIDS
Type of SCID where there are defects in proteins involved in VDJ rearrangement or T cell signal transduction
MAb used as an immunosuppressant in organ transplantation.Binds to IL2R (CD25)
Likelihood of developing certain autoimmune diseases in persons who inherit particular HLA alleles than in persons who lack these alleles.
Bronchodilator used as intervention for allergies.
Detects antibodies to HIV. Cannot be used alone to diagnose HIV.
Drug: Uses GM-CSF for recovery of bone marrow after stem cell transplantation.
Antibody deficiency disease where there is a total lack of Ig, mature B cells, and germinal centers in the lymph nodes or spleen. Patients lack tonsils and adenoids.
Allergy Intervention that keeps skin wet
Disease: makes antibodies to acetylcholine receptors. The consequence is progressive muscle weakness. This can be treated with cyclophosphamide.
Antibody deficiency disease where there are normal B cell numbers but poor antibody response to TD or TI antigens.
Disease that induces continuous synthesis and release of thyroid hormones. It is a Type II hypersensitivity in endocrine cells.
Condition where damage to the eye causes the release of proteins never previously encountered by the immune system.
Drug that inhibits transcription of many inflammatory mediator genes. Side effect includes Cushing's syndrome
Graft from an individual to the same individual
Th2 mediated inflammation of the airways. Type IV hypersensitivity. Chronic inflammation from Eosinophils leads to airway remodeling.
Number of new HIV infections a day in 2008.
Drug: Uses IL-11 to treat thrombocytopenia
Phagocyte function deficiency: Defect in Lysosomal fusion
Disease from gluten allergy. HLA-DQ presents the modified peptide of gluten. Type IV hypersensitivity.
Dominant genetic factor affecting susceptibility to autoimmune diseases.
Disease that has a diagnostic butterfly rash. Most common in females. Rash is caused by deposition of immune complexes in the skin. Type III hypersensitivity.
This treatment extends lifespan of HIV+ women.
Parasite characteristic of AIDS
Inflammatory disease characterized by joint destruction. Can be treated with Methotrexate as the Gold Standard.
Heterozygosity of HLA, being null for chemokine receptor CCR5, and circumcision are __________ factors for AIDS
Type III hypersensitivity done experimentally. It is induced in skin by subcutaneous injection of the antigen.
Women tend to be more susceptible to autoimmune diseases except for this disease.
Binds to CD33 on Leukemic cell. First FDA approved immunoconjugate.
Targets CD20 and treats RA, CLL, and B cell lymphoma
Fungi characteristic of AIDS
Targets Her2/Neu and treats breast cancer
Virus characteristic of AIDS
Soluble CTLA-Ig fusion molecule and a competitive inhibitor of CD28. Prevents T cell activation of APCs.Used to treat RA.
Immunoconjugate that is not an antibody. Used to treat T cell lymphoma and Chronic lymphocytic leukemia (CLL)

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