Science Quiz / Hermel MidBlock 3 Lectures

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Targets Her2/Neu and treats breast cancer
Drug: Uses IL-11 to treat thrombocytopenia
Disease that has a diagnostic butterfly rash. Most common in females. Rash is caused by deposition of immune complexes in the skin. Type III hypersensitivity.
Drug that inhibits transcription of many inflammatory mediator genes. Side effect includes Cushing's syndrome
Rare disorder characterized by recurrent episodes of painless angioedema without urticaria or pruritis
Fungi characteristic of AIDS
Antibody deficiency disease where there are normal B cell numbers but poor antibody response to TD or TI antigens.
Type II hypersensitivity in blood via complement and FcR+ phagocytes and causes DIRECT CYTOTOXICITY.
In Graft vs. Leukemia effect, patients surviving acute GVHD have reduced tumor __________
Heterozygosity of HLA, being null for chemokine receptor CCR5, and circumcision are __________ factors for AIDS
Condition where damage to the eye causes the release of proteins never previously encountered by the immune system.
Allergy Intervention that keeps skin wet
Degranulation inhibitor that inhibits the release of LT, TNF, IL-4, IL-5 and other cytokines.
Bacteria characteristic of AIDS
Targets CD20 and treats RA, CLL, and B cell lymphoma
Drug: Uses GM-CSF for recovery of bone marrow after stem cell transplantation.
Disease: makes antibodies to acetylcholine receptors. The consequence is progressive muscle weakness. This can be treated with cyclophosphamide.
Graft between members of two different species
Used in diagnosing autoimmune hemolytic anemia.
Antibody deficiency disease where there is a total lack of Ig, mature B cells, and germinal centers in the lymph nodes or spleen. Patients lack tonsils and adenoids.
Skin blistering disease where autoantibodies are directed against epidermal antigens.
Type III hypersensitivity done experimentally. It is induced in skin by subcutaneous injection of the antigen.
Women tend to be more susceptible to autoimmune diseases except for this disease.
Parasite characteristic of AIDS
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Phagocyte function deficiency: Defect in Lysosomal fusion
Soluble CTLA-Ig fusion molecule and a competitive inhibitor of CD28. Prevents T cell activation of APCs.Used to treat RA.
Dominant genetic factor affecting susceptibility to autoimmune diseases.
DNA alkylating agent used to prevent and reverse organ graft rejection. Toxicity is hemorrhagic cystitis and bone marrow toxicity.
Inhibits mTOR and used in prevention of renal transplant rejection.
Inflammatory disease characterized by joint destruction. Can be treated with Methotrexate as the Gold Standard.
Bronchodilator used as intervention for allergies.
Detects antibodies to HIV. Cannot be used alone to diagnose HIV.
Disease that induces continuous synthesis and release of thyroid hormones. It is a Type II hypersensitivity in endocrine cells.
Graft from an individual to the same individual
Immunoconjugate that is not an antibody. Used to treat T cell lymphoma and Chronic lymphocytic leukemia (CLL)
Lymphocyte trafficking inhibitor that targets alpha4 integrin and prevents lymphocyte entry into the brain or gut.
This treatment extends lifespan of HIV+ women.
Type of SCID where there are defects in proteins involved in VDJ rearrangement or T cell signal transduction
Drug: Uses G-CSF for bone marrow recovery after stem cell transplantation.
Purine antagonist that treats RA and acute graft rejection. Contraindication is pancreatitis. Toxicity is myelosuppression.
Disease from gluten allergy. HLA-DQ presents the modified peptide of gluten. Type IV hypersensitivity.
Virus characteristic of AIDS
Likelihood of developing certain autoimmune diseases in persons who inherit particular HLA alleles than in persons who lack these alleles.
MAb used as an immunosuppressant in organ transplantation.Binds to IL2R (CD25)
Th2 mediated inflammation of the airways. Type IV hypersensitivity. Chronic inflammation from Eosinophils leads to airway remodeling.
Number of new HIV infections a day in 2008.
Binds to CD33 on Leukemic cell. First FDA approved immunoconjugate.
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Created Nov 18, 2010ReportNominate

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