Science Quiz / Gugliucci Lectures

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Can you name the Gugliucci Lectures ?

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Most important of the plasminogen activators
A protease that cleaves fibrinogen into fibrin. Other functions include activation of endothelium to generate tPA, NO, PGI2, and PDGF mediators.
Ratio of the patient's PT to the mean PT for a group of normal patients
Activated by heparin and inactivates thrombin, Xa, and IXa
Inhibits clotting by proteolytic cleavage of factor Va and VIIIa
Name a granule released by platelets
A disease where patients are photosensitive and the most common type of error in heme synthesis.
A or B: N-acetyl glucosamine
Deficiency in this receptor results in Glanzmann thrombastenia
Released by endothelial cells as anti-coagulant.
Accumulation of ALA and porphobillinogen in the urine and no photosensitization characterizes this disease caused by errors in heme synthesis.
20X Bilirubin levels that goes to lipid membranes and accumulate in basal ganglia result into this neurological disorder in neonates.
Fetal blood gets in touch with the mother's blood when this detaches.
A presence of this protein means the person is Rh+
Degranulates, changes shape, and puts out 3 receptors when activated.
Treatment monitored with PT
Treatment monitored with APTT
A or B: Galactose
Where coagulation factors are synthesized
A fetus synthesizes heme in this organ
Exposed when the vessel has a lesion. GPIb binds to this.
Reduced heme in a linear chain and is green in color
RBC synthesis takes how many days
Used to cover the baby's Rh+ RBC
Deficiency in GPIb results into this syndrome
Bilirubin is conjugated with glucuronic acid in this organ
Neonatal jaundice has low activity of this hepatic enzyme, which reaches adult level in 4 weeks.
A clinical sign characterized by yellow skin, sclera, and mucosa. Bilirubin is 3X above normal.
Unconjugated bilirubin is transported through the blood with this protein
Intrinsic or Extrinsic: Most physiologically relevant in driving coagulation after vascular damage.
Process that breaks down the clot and has enzymatic activity of plasmin to break down fibrin and interfere with its polymerization
Coagulation cascade includes 1) tissue factor 2) phospholipid complex expression 3) thrombin activation and 4)__________
Endothelial injury, abnormal blood flow, and hypercoagulability make up________________ triad
A,B,O are alleles of the same gene on a single locus on this chromosome
O allele codes for the inactive form of this enzyme
Where does heme synthesis occur?
Takes up RBC after 120 days

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