Science Quiz / BU Therapeutics3 Final 2011-01

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Can you name the answers to these Therapeutics questions?

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Amantadine/Rimantadine are specific for influenza
Y/N Aminoglycosides can be used monotherapy for CNS infections.
A common side effect of using interferon is (think endorphin suppression)
HIV patients should get primary prophylaxis for Pneumocystis jiroveci if their CD4 counts are less than
Oropharyngeal candidiasis is often treated with ___ suspension
Tenofovir(Tdf) + Emtricitabine(FTC) =
Which azole requires renal adjustment?
What should PO telaprevir be taken with
Primary prophylaxis of toxoplasmosis is indicated when CD4 is less than
Most CMV drugs cause nephrotoxicity, but cidofovir also causes this anti-immune effect
Telbivudine can cause this neurologic problem
An AIDS pateint should be considered at great risk for opportunistic infection once CD4 counts are below
Before starting maraviroc therapy, a patient must have a
T/F Maraviroc has its dose halved with inhibitors and doubled with inducers of CYP3A4
Famciclovir, a prodrug of penciclovir, inhibits
The IV form of acyclovir is strongly associated with this adverse effect
An AIDS patient should be treated for tuberculosis if their PPD has an induration of over ___mm
Foscarnet chelates divalent cations and leads to imbalances in
Primary indication for valganciclovir
Which '-cyclovir' antiviral needs an induction dose
Which antifungal has a ceiling dose which should not be exceeded?
Which NRTI requires screening for HLA-B*5701
Treatment of choice for diabetes in CF?
T/F Pyrazinamide is cidal vs dormant/semidormant TB?
What is the preferred drug for chemoprophylaxis of H. influenzae CNS infections?
Voriconazole brand name
Telbivudine is great for hep-b because it can almost cure in some cases, but it can elevate
When changing regimens, any NNRTIs should be discontinued ___ days before the rest of the regimen to account for the long t1/2
The big adverse effect with ganciclovir is
If a patient cannot take Bactrim SS/DS for prophylaxis of PCP, the recommended agent is
Special dose of IV gent for CF (mg/kg)?
HIV patient presents with a unilateral focal lesion on frontal lobe - likely cause
Telaprevir is metaoblized by this hepatic enzyme
T/F Prophylactic doses for MAC cannot be split
Which TB drug requires periodic tests for visual acuity?
A common pharmacy board question: What is a severe side effect of Indinavir(IDV)
Most common adverse event with CF inhaled therapies
Cidofovir therapy requires pre-infusion hydration with NS and a 2g dose of ___ before and after the infusion
Which common UTI symptom is absent in pediatric patient presentation?
T/F The preferred secondary prophylaxis of toxoplasmosis is: Pyrimethamine 25-50mg PO daily + Sulfadiazine 500-1000 mg QID + Leucovorin 10-25 mg PO daily
Itraconazole oral solution should be taken ____ food
Which NRTI is specifically indicated for treatment of Hepatitis B
Maraviroc(Selzentry) inhibits
What's the D.O.C. for coverage of Listeria in an elderly meningitis patient?
One clinical manifestation fairly unique to MAC infections is
Minimum duration of treatment for prostatitis (days)?
T/F If a hep-b patient fails therapy on emtricitabine you should try lamivudine
Enfuvirtide has an increased risk of
Reverse Transcriptase Inhibitors usually have to be phosphorylated 3x to be active. Which one only needs 2x
Ganciclovir dosing needs to be adjusted for ___ function
Which UTI drug maintains therapeutics urine concentrations 48-72 hours after a single dose?
Acyclovir and Valacyclovir inhibit
Altered taste perception is a stand-out side effect of
The major (potentially fatal) side effect of ribavirin is
Atazanavir(ATV) doesn't cause
Primary prophylaxis of MAC is with (drug)
Which NRTI can cause Fanconi's syndrome?
T/F Resistance testing of an antiretroviral regimen should be done during a 'drug holiday'
The most common infecting agent in complications with CF patients?
Endocarditis doseof daptomycin (Xmg/kgqYh)?
Enfuvirtide (T-20/Fuzeon) is availabile in what dosage form
Pegylated interferon is dosed __ time(s) weekly
What is the long-term therapy of choice for cryptococcal meningitis?
This class of HIV drugs is associated with the 'metabolic syndrome' effects
Cidofovir is contraindicated in CrCl less than
Which has less drug interactions, telaprevir or boceprevir
Ritonavir(RTV) is associated with isolated elevation of

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