Science Quiz / BU Therapeutics3 Final 2011-01

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Can you name the answers to these Therapeutics questions?

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QuestionAnswer
Reverse Transcriptase Inhibitors usually have to be phosphorylated 3x to be active. Which one only needs 2x
Tenofovir(Tdf) + Emtricitabine(FTC) =
Atazanavir(ATV) doesn't cause
Acyclovir and Valacyclovir inhibit
Primary prophylaxis of toxoplasmosis is indicated when CD4 is less than
Which NRTI requires screening for HLA-B*5701
What is the long-term therapy of choice for cryptococcal meningitis?
Enfuvirtide has an increased risk of
The IV form of acyclovir is strongly associated with this adverse effect
T/F Resistance testing of an antiretroviral regimen should be done during a 'drug holiday'
An AIDS pateint should be considered at great risk for opportunistic infection once CD4 counts are below
Which NRTI can cause Fanconi's syndrome?
Most CMV drugs cause nephrotoxicity, but cidofovir also causes this anti-immune effect
What should PO telaprevir be taken with
Y/N Aminoglycosides can be used monotherapy for CNS infections.
Special dose of IV gent for CF (mg/kg)?
Telbivudine is great for hep-b because it can almost cure in some cases, but it can elevate
Treatment of choice for diabetes in CF?
Pegylated interferon is dosed __ time(s) weekly
Telaprevir is metaoblized by this hepatic enzyme
Before starting maraviroc therapy, a patient must have a
Oropharyngeal candidiasis is often treated with ___ suspension
T/F The preferred secondary prophylaxis of toxoplasmosis is: Pyrimethamine 25-50mg PO daily + Sulfadiazine 500-1000 mg QID + Leucovorin 10-25 mg PO daily
QuestionAnswer
What is the preferred drug for chemoprophylaxis of H. influenzae CNS infections?
Cidofovir is contraindicated in CrCl less than
Voriconazole brand name
Which antifungal has a ceiling dose which should not be exceeded?
The most common infecting agent in complications with CF patients?
Most common adverse event with CF inhaled therapies
Altered taste perception is a stand-out side effect of
T/F Pyrazinamide is cidal vs dormant/semidormant TB?
This class of HIV drugs is associated with the 'metabolic syndrome' effects
Famciclovir, a prodrug of penciclovir, inhibits
Maraviroc(Selzentry) inhibits
What's the D.O.C. for coverage of Listeria in an elderly meningitis patient?
Which '-cyclovir' antiviral needs an induction dose
Foscarnet chelates divalent cations and leads to imbalances in
Ritonavir(RTV) is associated with isolated elevation of
Endocarditis doseof daptomycin (Xmg/kgqYh)?
Ganciclovir dosing needs to be adjusted for ___ function
T/F If a hep-b patient fails therapy on emtricitabine you should try lamivudine
A common pharmacy board question: What is a severe side effect of Indinavir(IDV)
HIV patient presents with a unilateral focal lesion on frontal lobe - likely cause
The big adverse effect with ganciclovir is
Which azole requires renal adjustment?
If a patient cannot take Bactrim SS/DS for prophylaxis of PCP, the recommended agent is
QuestionAnswer
Telbivudine can cause this neurologic problem
A common side effect of using interferon is (think endorphin suppression)
T/F Maraviroc has its dose halved with inhibitors and doubled with inducers of CYP3A4
Which UTI drug maintains therapeutics urine concentrations 48-72 hours after a single dose?
Which common UTI symptom is absent in pediatric patient presentation?
Itraconazole oral solution should be taken ____ food
Which TB drug requires periodic tests for visual acuity?
Amantadine/Rimantadine are specific for influenza
One clinical manifestation fairly unique to MAC infections is
Minimum duration of treatment for prostatitis (days)?
Which NRTI is specifically indicated for treatment of Hepatitis B
Which has less drug interactions, telaprevir or boceprevir
Primary prophylaxis of MAC is with (drug)
Primary indication for valganciclovir
The major (potentially fatal) side effect of ribavirin is
When changing regimens, any NNRTIs should be discontinued ___ days before the rest of the regimen to account for the long t1/2
Enfuvirtide (T-20/Fuzeon) is availabile in what dosage form
HIV patients should get primary prophylaxis for Pneumocystis jiroveci if their CD4 counts are less than
An AIDS patient should be treated for tuberculosis if their PPD has an induration of over ___mm
T/F Prophylactic doses for MAC cannot be split
Cidofovir therapy requires pre-infusion hydration with NS and a 2g dose of ___ before and after the infusion

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Created Dec 7, 2011ReportFavoriteNominate
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