Science Quiz / BU Therapeutics3 Final 2011-01

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QUIZ: Can you name the answers to these Therapeutics questions?

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QuestionAnswer
Primary indication for valganciclovir
Cidofovir is contraindicated in CrCl less than
Which antifungal has a ceiling dose which should not be exceeded?
Itraconazole oral solution should be taken ____ food
Which NRTI requires screening for HLA-B*5701
Telbivudine can cause this neurologic problem
Atazanavir(ATV) doesn't cause
HIV patient presents with a unilateral focal lesion on frontal lobe - likely cause
Most common adverse event with CF inhaled therapies
The most common infecting agent in complications with CF patients?
Most CMV drugs cause nephrotoxicity, but cidofovir also causes this anti-immune effect
Which NRTI can cause Fanconi's syndrome?
Which NRTI is specifically indicated for treatment of Hepatitis B
Acyclovir and Valacyclovir inhibit
The IV form of acyclovir is strongly associated with this adverse effect
HIV patients should get primary prophylaxis for Pneumocystis jiroveci if their CD4 counts are less than
Before starting maraviroc therapy, a patient must have a
Which TB drug requires periodic tests for visual acuity?
Ganciclovir dosing needs to be adjusted for ___ function
Reverse Transcriptase Inhibitors usually have to be phosphorylated 3x to be active. Which one only needs 2x
An AIDS patient should be treated for tuberculosis if their PPD has an induration of over ___mm
Primary prophylaxis of MAC is with (drug)
What is the preferred drug for chemoprophylaxis of H. influenzae CNS infections?
QuestionAnswer
Famciclovir, a prodrug of penciclovir, inhibits
When changing regimens, any NNRTIs should be discontinued ___ days before the rest of the regimen to account for the long t1/2
What is the long-term therapy of choice for cryptococcal meningitis?
Which UTI drug maintains therapeutics urine concentrations 48-72 hours after a single dose?
This class of HIV drugs is associated with the 'metabolic syndrome' effects
T/F Resistance testing of an antiretroviral regimen should be done during a 'drug holiday'
Oropharyngeal candidiasis is often treated with ___ suspension
Altered taste perception is a stand-out side effect of
Enfuvirtide (T-20/Fuzeon) is availabile in what dosage form
If a patient cannot take Bactrim SS/DS for prophylaxis of PCP, the recommended agent is
Treatment of choice for diabetes in CF?
Which common UTI symptom is absent in pediatric patient presentation?
Pegylated interferon is dosed __ time(s) weekly
Cidofovir therapy requires pre-infusion hydration with NS and a 2g dose of ___ before and after the infusion
Tenofovir(Tdf) + Emtricitabine(FTC) =
Which azole requires renal adjustment?
An AIDS pateint should be considered at great risk for opportunistic infection once CD4 counts are below
T/F Pyrazinamide is cidal vs dormant/semidormant TB?
Amantadine/Rimantadine are specific for influenza
A common pharmacy board question: What is a severe side effect of Indinavir(IDV)
Telbivudine is great for hep-b because it can almost cure in some cases, but it can elevate
T/F Prophylactic doses for MAC cannot be split
Primary prophylaxis of toxoplasmosis is indicated when CD4 is less than
QuestionAnswer
T/F If a hep-b patient fails therapy on emtricitabine you should try lamivudine
Foscarnet chelates divalent cations and leads to imbalances in
Which '-cyclovir' antiviral needs an induction dose
Telaprevir is metaoblized by this hepatic enzyme
T/F The preferred secondary prophylaxis of toxoplasmosis is: Pyrimethamine 25-50mg PO daily + Sulfadiazine 500-1000 mg QID + Leucovorin 10-25 mg PO daily
T/F Maraviroc has its dose halved with inhibitors and doubled with inducers of CYP3A4
The big adverse effect with ganciclovir is
Y/N Aminoglycosides can be used monotherapy for CNS infections.
Endocarditis doseof daptomycin (Xmg/kgqYh)?
Ritonavir(RTV) is associated with isolated elevation of
One clinical manifestation fairly unique to MAC infections is
Voriconazole brand name
The major (potentially fatal) side effect of ribavirin is
A common side effect of using interferon is (think endorphin suppression)
Maraviroc(Selzentry) inhibits
Special dose of IV gent for CF (mg/kg)?
Enfuvirtide has an increased risk of
Minimum duration of treatment for prostatitis (days)?
What's the D.O.C. for coverage of Listeria in an elderly meningitis patient?
Which has less drug interactions, telaprevir or boceprevir
What should PO telaprevir be taken with

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