Pharmacokinetics

Can you name the Pharmacokinetics?

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questionhint
T or F: different compartments of the body have different pHs
sustained-release tablets dissolve fast or slow?
endothelial cells in the brain are coated with ___ cells
passive diffusion is from high to low concentration, T or F
drugs move most rapidly and in greater concentrations to compartments with good ____ perfusion
does facilitated diffusion require energy?
what removes foreign substances and toxins from the blood?
biotransformation occurs primarily in what organ?
body's ability to change the original drug into a form that can be eliminated
T or F: drug molecules can change from ionized to non-ionized or vice versa as they move to different compartments
facilitated diffusion is from high to low concentration, T or F
what type of drugs pass through the cell membranes?
if a drug is highly protein bound, is there more or less drug free to exert a therapeutic effect?
does physical transport require energy?
a special 'carrier molecule' in the cell membrane moves the drug across the membrane
most abundant protein in the blood
Cat livers have increased or decreased ability to biotransform drugs
the movement of blood from the blood stream into tissues is _____
If a molecule changes to primarily hydrophilic form, it may not be able to leave the cell; what is this called?
altered form of a drugusually inactive
What makes it hard for drug molecules to get through to the brain?
hydrophilic molecules dissolve in ____
questionhint
tablets, granules, or powders cannot be absorbed until they _______ into smaller particles
most drugs given orally are absorbed in the _____
if more than one drug starts to compete for binding sites on protein does the amount of free drug increase or decrease?
drug that occupies the receptor sand produces no cellular effectite
a special 'carrier molecule' in the cell membrane HELPS move certain drug molecules across the membranecarrier helps, does not move molecule actively
are solids or liquids more rapidly absorbed?
the time, after certain number of doses, where the peak and trough concentrations remain the same
measure of the acidity or alkalinity of the drugs environment
does passive diffusion require energy?
drug concentrations decrease by half at repeatable time intervals, this time is what?
lipophilic drug given SQ or IM is absorbed quickly or slowly?
factor that influences blood levels of a drug: rate and ____ of excretion
hydrophilic drug given SQ or IM is absorbed quickly or slowly?
the dose of highly protein-bound drugs should be _____ if diseases are present that cause low plasma protein levels
is physical transport useful for large or small molecules?
factor that influences blood levels of a drug: _____ of drug in body
lipophilic drugs are absorbed best _____
factor that influences blood levels of a drug: drug _____ or breakdown
does active transport require energy?
alkaline drugs are primarily in nonionized form in _____ environment
pH where drug molecules are half ionized and half non-ionized
acidic drugs are primarily in nonionized form in _____ environment
questionhint
does dehydration cause increased or decreased volume of distribution
drugs that combine with other ions or compounds to produce an effect
drug molecules are surrounded by part of the cell membrane and taken within the cell
a protein molecule in or on the cell that binds specific drugs to produce an effect, they will then determine which tissue will respond to the drug
drug that occupies a receptor site producing a cellular effect
cell eating
endothelial cells in the brain have ____ junctions
cell drinking
active transport is from high to low concentration, T or F
the random movement of drug molecules
molecules having a net positive or negative charge are ____
factor that influences blood levels of a drug: ____ of absorption
putting drugs in oil slows absorption, this is a ____
does ascites cause increased or decreased volume of distribution
factor that influences blood levels of a drug: _____ of drug absorbed
low plasma protein= more or less of drug free?
steady state= __ x half life
what type of drugs move into the bloodstream by moving between capillary endothelial cells
amount of drug that actually reaches the bloodstream
some drugs bind to large _____ in the bloodstream
lipophilic molecules dissolve in ____

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