Science Quiz / Pharmacokinetics

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Can you name the Pharmacokinetics?

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questionhint
measure of the acidity or alkalinity of the drugs environment
what type of drugs move into the bloodstream by moving between capillary endothelial cells
cell drinking
hydrophilic molecules dissolve in ____
lipophilic molecules dissolve in ____
biotransformation occurs primarily in what organ?
factor that influences blood levels of a drug: _____ of drug in body
what type of drugs pass through the cell membranes?
are solids or liquids more rapidly absorbed?
a special 'carrier molecule' in the cell membrane HELPS move certain drug molecules across the membranecarrier helps, does not move molecule actively
does ascites cause increased or decreased volume of distribution
some drugs bind to large _____ in the bloodstream
endothelial cells in the brain have ____ junctions
body's ability to change the original drug into a form that can be eliminated
hydrophilic drug given SQ or IM is absorbed quickly or slowly?
factor that influences blood levels of a drug: rate and ____ of excretion
pH where drug molecules are half ionized and half non-ionized
steady state= __ x half life
amount of drug that actually reaches the bloodstream
T or F: drug molecules can change from ionized to non-ionized or vice versa as they move to different compartments
passive diffusion is from high to low concentration, T or F
putting drugs in oil slows absorption, this is a ____
questionhint
factor that influences blood levels of a drug: drug _____ or breakdown
if a drug is highly protein bound, is there more or less drug free to exert a therapeutic effect?
T or F: different compartments of the body have different pHs
lipophilic drug given SQ or IM is absorbed quickly or slowly?
does physical transport require energy?
drugs that combine with other ions or compounds to produce an effect
Cat livers have increased or decreased ability to biotransform drugs
altered form of a drugusually inactive
drug molecules are surrounded by part of the cell membrane and taken within the cell
molecules having a net positive or negative charge are ____
does passive diffusion require energy?
lipophilic drugs are absorbed best _____
alkaline drugs are primarily in nonionized form in _____ environment
what removes foreign substances and toxins from the blood?
cell eating
does facilitated diffusion require energy?
most abundant protein in the blood
the dose of highly protein-bound drugs should be _____ if diseases are present that cause low plasma protein levels
acidic drugs are primarily in nonionized form in _____ environment
tablets, granules, or powders cannot be absorbed until they _______ into smaller particles
most drugs given orally are absorbed in the _____
the random movement of drug molecules
questionhint
is physical transport useful for large or small molecules?
sustained-release tablets dissolve fast or slow?
What makes it hard for drug molecules to get through to the brain?
if more than one drug starts to compete for binding sites on protein does the amount of free drug increase or decrease?
active transport is from high to low concentration, T or F
factor that influences blood levels of a drug: _____ of drug absorbed
drug that occupies a receptor site producing a cellular effect
the movement of blood from the blood stream into tissues is _____
a protein molecule in or on the cell that binds specific drugs to produce an effect, they will then determine which tissue will respond to the drug
does active transport require energy?
factor that influences blood levels of a drug: ____ of absorption
does dehydration cause increased or decreased volume of distribution
drug that occupies the receptor sand produces no cellular effectite
If a molecule changes to primarily hydrophilic form, it may not be able to leave the cell; what is this called?
low plasma protein= more or less of drug free?
facilitated diffusion is from high to low concentration, T or F
the time, after certain number of doses, where the peak and trough concentrations remain the same
drugs move most rapidly and in greater concentrations to compartments with good ____ perfusion
drug concentrations decrease by half at repeatable time intervals, this time is what?
endothelial cells in the brain are coated with ___ cells
a special 'carrier molecule' in the cell membrane moves the drug across the membrane

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Created Feb 8, 2011ReportNominate

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