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Science Quiz / Pharmacokinetics

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Can you name the Pharmacokinetics?

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questionhint
is physical transport useful for large or small molecules?
does dehydration cause increased or decreased volume of distribution
most drugs given orally are absorbed in the _____
active transport is from high to low concentration, T or F
acidic drugs are primarily in nonionized form in _____ environment
biotransformation occurs primarily in what organ?
factor that influences blood levels of a drug: ____ of absorption
lipophilic drugs are absorbed best _____
the random movement of drug molecules
facilitated diffusion is from high to low concentration, T or F
amount of drug that actually reaches the bloodstream
altered form of a drugusually inactive
pH where drug molecules are half ionized and half non-ionized
some drugs bind to large _____ in the bloodstream
factor that influences blood levels of a drug: _____ of drug absorbed
does physical transport require energy?
cell eating
endothelial cells in the brain are coated with ___ cells
putting drugs in oil slows absorption, this is a ____
lipophilic molecules dissolve in ____
hydrophilic drug given SQ or IM is absorbed quickly or slowly?
a protein molecule in or on the cell that binds specific drugs to produce an effect, they will then determine which tissue will respond to the drug
questionhint
factor that influences blood levels of a drug: rate and ____ of excretion
a special 'carrier molecule' in the cell membrane HELPS move certain drug molecules across the membranecarrier helps, does not move molecule actively
If a molecule changes to primarily hydrophilic form, it may not be able to leave the cell; what is this called?
does ascites cause increased or decreased volume of distribution
tablets, granules, or powders cannot be absorbed until they _______ into smaller particles
passive diffusion is from high to low concentration, T or F
sustained-release tablets dissolve fast or slow?
Cat livers have increased or decreased ability to biotransform drugs
does active transport require energy?
the time, after certain number of doses, where the peak and trough concentrations remain the same
what type of drugs move into the bloodstream by moving between capillary endothelial cells
drug that occupies the receptor sand produces no cellular effectite
molecules having a net positive or negative charge are ____
drug concentrations decrease by half at repeatable time intervals, this time is what?
T or F: drug molecules can change from ionized to non-ionized or vice versa as they move to different compartments
factor that influences blood levels of a drug: drug _____ or breakdown
the movement of blood from the blood stream into tissues is _____
measure of the acidity or alkalinity of the drugs environment
does facilitated diffusion require energy?
lipophilic drug given SQ or IM is absorbed quickly or slowly?
what removes foreign substances and toxins from the blood?
are solids or liquids more rapidly absorbed?
questionhint
what type of drugs pass through the cell membranes?
What makes it hard for drug molecules to get through to the brain?
drug molecules are surrounded by part of the cell membrane and taken within the cell
if more than one drug starts to compete for binding sites on protein does the amount of free drug increase or decrease?
endothelial cells in the brain have ____ junctions
hydrophilic molecules dissolve in ____
the dose of highly protein-bound drugs should be _____ if diseases are present that cause low plasma protein levels
steady state= __ x half life
drugs that combine with other ions or compounds to produce an effect
drug that occupies a receptor site producing a cellular effect
drugs move most rapidly and in greater concentrations to compartments with good ____ perfusion
body's ability to change the original drug into a form that can be eliminated
T or F: different compartments of the body have different pHs
a special 'carrier molecule' in the cell membrane moves the drug across the membrane
if a drug is highly protein bound, is there more or less drug free to exert a therapeutic effect?
most abundant protein in the blood
does passive diffusion require energy?
factor that influences blood levels of a drug: _____ of drug in body
low plasma protein= more or less of drug free?
cell drinking
alkaline drugs are primarily in nonionized form in _____ environment
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