Science Quiz / Pharmacokinetics

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Can you name the Pharmacokinetics?

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questionhint
factor that influences blood levels of a drug: ____ of absorption
pH where drug molecules are half ionized and half non-ionized
drugs that combine with other ions or compounds to produce an effect
drugs move most rapidly and in greater concentrations to compartments with good ____ perfusion
endothelial cells in the brain are coated with ___ cells
steady state= __ x half life
most abundant protein in the blood
lipophilic molecules dissolve in ____
does ascites cause increased or decreased volume of distribution
if more than one drug starts to compete for binding sites on protein does the amount of free drug increase or decrease?
alkaline drugs are primarily in nonionized form in _____ environment
a special 'carrier molecule' in the cell membrane moves the drug across the membrane
is physical transport useful for large or small molecules?
are solids or liquids more rapidly absorbed?
endothelial cells in the brain have ____ junctions
tablets, granules, or powders cannot be absorbed until they _______ into smaller particles
sustained-release tablets dissolve fast or slow?
drug that occupies a receptor site producing a cellular effect
cell eating
factor that influences blood levels of a drug: _____ of drug in body
T or F: different compartments of the body have different pHs
factor that influences blood levels of a drug: rate and ____ of excretion
questionhint
factor that influences blood levels of a drug: drug _____ or breakdown
lipophilic drug given SQ or IM is absorbed quickly or slowly?
does passive diffusion require energy?
amount of drug that actually reaches the bloodstream
lipophilic drugs are absorbed best _____
drug molecules are surrounded by part of the cell membrane and taken within the cell
does active transport require energy?
If a molecule changes to primarily hydrophilic form, it may not be able to leave the cell; what is this called?
body's ability to change the original drug into a form that can be eliminated
a special 'carrier molecule' in the cell membrane HELPS move certain drug molecules across the membranecarrier helps, does not move molecule actively
does facilitated diffusion require energy?
the dose of highly protein-bound drugs should be _____ if diseases are present that cause low plasma protein levels
hydrophilic drug given SQ or IM is absorbed quickly or slowly?
drug that occupies the receptor sand produces no cellular effectite
What makes it hard for drug molecules to get through to the brain?
the movement of blood from the blood stream into tissues is _____
measure of the acidity or alkalinity of the drugs environment
active transport is from high to low concentration, T or F
the time, after certain number of doses, where the peak and trough concentrations remain the same
Cat livers have increased or decreased ability to biotransform drugs
drug concentrations decrease by half at repeatable time intervals, this time is what?
low plasma protein= more or less of drug free?
questionhint
does physical transport require energy?
factor that influences blood levels of a drug: _____ of drug absorbed
altered form of a drugusually inactive
what removes foreign substances and toxins from the blood?
most drugs given orally are absorbed in the _____
a protein molecule in or on the cell that binds specific drugs to produce an effect, they will then determine which tissue will respond to the drug
if a drug is highly protein bound, is there more or less drug free to exert a therapeutic effect?
facilitated diffusion is from high to low concentration, T or F
some drugs bind to large _____ in the bloodstream
does dehydration cause increased or decreased volume of distribution
biotransformation occurs primarily in what organ?
putting drugs in oil slows absorption, this is a ____
cell drinking
the random movement of drug molecules
T or F: drug molecules can change from ionized to non-ionized or vice versa as they move to different compartments
passive diffusion is from high to low concentration, T or F
acidic drugs are primarily in nonionized form in _____ environment
hydrophilic molecules dissolve in ____
what type of drugs move into the bloodstream by moving between capillary endothelial cells
molecules having a net positive or negative charge are ____
what type of drugs pass through the cell membranes?

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Created Feb 8, 2011ReportNominate

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