Science Quiz / Pharmacokinetics

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Can you name the Pharmacokinetics?

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questionhint
hydrophilic drug given SQ or IM is absorbed quickly or slowly?
the dose of highly protein-bound drugs should be _____ if diseases are present that cause low plasma protein levels
if more than one drug starts to compete for binding sites on protein does the amount of free drug increase or decrease?
some drugs bind to large _____ in the bloodstream
what removes foreign substances and toxins from the blood?
does dehydration cause increased or decreased volume of distribution
what type of drugs move into the bloodstream by moving between capillary endothelial cells
the movement of blood from the blood stream into tissues is _____
steady state= __ x half life
hydrophilic molecules dissolve in ____
pH where drug molecules are half ionized and half non-ionized
low plasma protein= more or less of drug free?
cell drinking
alkaline drugs are primarily in nonionized form in _____ environment
lipophilic drugs are absorbed best _____
acidic drugs are primarily in nonionized form in _____ environment
endothelial cells in the brain have ____ junctions
What makes it hard for drug molecules to get through to the brain?
most abundant protein in the blood
passive diffusion is from high to low concentration, T or F
facilitated diffusion is from high to low concentration, T or F
putting drugs in oil slows absorption, this is a ____
questionhint
body's ability to change the original drug into a form that can be eliminated
a protein molecule in or on the cell that binds specific drugs to produce an effect, they will then determine which tissue will respond to the drug
tablets, granules, or powders cannot be absorbed until they _______ into smaller particles
measure of the acidity or alkalinity of the drugs environment
drug that occupies a receptor site producing a cellular effect
active transport is from high to low concentration, T or F
is physical transport useful for large or small molecules?
endothelial cells in the brain are coated with ___ cells
T or F: drug molecules can change from ionized to non-ionized or vice versa as they move to different compartments
drug molecules are surrounded by part of the cell membrane and taken within the cell
does active transport require energy?
drug concentrations decrease by half at repeatable time intervals, this time is what?
sustained-release tablets dissolve fast or slow?
altered form of a drugusually inactive
T or F: different compartments of the body have different pHs
drugs that combine with other ions or compounds to produce an effect
are solids or liquids more rapidly absorbed?
the time, after certain number of doses, where the peak and trough concentrations remain the same
Cat livers have increased or decreased ability to biotransform drugs
factor that influences blood levels of a drug: _____ of drug in body
most drugs given orally are absorbed in the _____
what type of drugs pass through the cell membranes?
questionhint
does passive diffusion require energy?
If a molecule changes to primarily hydrophilic form, it may not be able to leave the cell; what is this called?
cell eating
factor that influences blood levels of a drug: drug _____ or breakdown
biotransformation occurs primarily in what organ?
the random movement of drug molecules
does ascites cause increased or decreased volume of distribution
lipophilic molecules dissolve in ____
a special 'carrier molecule' in the cell membrane moves the drug across the membrane
does physical transport require energy?
if a drug is highly protein bound, is there more or less drug free to exert a therapeutic effect?
amount of drug that actually reaches the bloodstream
factor that influences blood levels of a drug: _____ of drug absorbed
drugs move most rapidly and in greater concentrations to compartments with good ____ perfusion
does facilitated diffusion require energy?
factor that influences blood levels of a drug: rate and ____ of excretion
drug that occupies the receptor sand produces no cellular effectite
factor that influences blood levels of a drug: ____ of absorption
a special 'carrier molecule' in the cell membrane HELPS move certain drug molecules across the membranecarrier helps, does not move molecule actively
lipophilic drug given SQ or IM is absorbed quickly or slowly?
molecules having a net positive or negative charge are ____

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