Science Quiz / Pharmacokinetics

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Can you name the Pharmacokinetics?

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cell drinking
factor that influences blood levels of a drug: rate and ____ of excretion
amount of drug that actually reaches the bloodstream
the time, after certain number of doses, where the peak and trough concentrations remain the same
altered form of a drugusually inactive
a special 'carrier molecule' in the cell membrane HELPS move certain drug molecules across the membranecarrier helps, does not move molecule actively
putting drugs in oil slows absorption, this is a ____
factor that influences blood levels of a drug: _____ of drug in body
if more than one drug starts to compete for binding sites on protein does the amount of free drug increase or decrease?
does active transport require energy?
is physical transport useful for large or small molecules?
T or F: drug molecules can change from ionized to non-ionized or vice versa as they move to different compartments
the movement of blood from the blood stream into tissues is _____
drug concentrations decrease by half at repeatable time intervals, this time is what?
does dehydration cause increased or decreased volume of distribution
drug molecules are surrounded by part of the cell membrane and taken within the cell
the random movement of drug molecules
a special 'carrier molecule' in the cell membrane moves the drug across the membrane
Cat livers have increased or decreased ability to biotransform drugs
does ascites cause increased or decreased volume of distribution
most drugs given orally are absorbed in the _____
drug that occupies the receptor sand produces no cellular effectite
questionhint
lipophilic drugs are absorbed best _____
alkaline drugs are primarily in nonionized form in _____ environment
some drugs bind to large _____ in the bloodstream
tablets, granules, or powders cannot be absorbed until they _______ into smaller particles
lipophilic molecules dissolve in ____
cell eating
does passive diffusion require energy?
T or F: different compartments of the body have different pHs
pH where drug molecules are half ionized and half non-ionized
facilitated diffusion is from high to low concentration, T or F
the dose of highly protein-bound drugs should be _____ if diseases are present that cause low plasma protein levels
does physical transport require energy?
molecules having a net positive or negative charge are ____
hydrophilic drug given SQ or IM is absorbed quickly or slowly?
what type of drugs pass through the cell membranes?
endothelial cells in the brain have ____ junctions
endothelial cells in the brain are coated with ___ cells
lipophilic drug given SQ or IM is absorbed quickly or slowly?
measure of the acidity or alkalinity of the drugs environment
sustained-release tablets dissolve fast or slow?
body's ability to change the original drug into a form that can be eliminated
steady state= __ x half life
questionhint
factor that influences blood levels of a drug: _____ of drug absorbed
biotransformation occurs primarily in what organ?
passive diffusion is from high to low concentration, T or F
factor that influences blood levels of a drug: ____ of absorption
active transport is from high to low concentration, T or F
what type of drugs move into the bloodstream by moving between capillary endothelial cells
What makes it hard for drug molecules to get through to the brain?
most abundant protein in the blood
drugs move most rapidly and in greater concentrations to compartments with good ____ perfusion
acidic drugs are primarily in nonionized form in _____ environment
If a molecule changes to primarily hydrophilic form, it may not be able to leave the cell; what is this called?
drug that occupies a receptor site producing a cellular effect
are solids or liquids more rapidly absorbed?
if a drug is highly protein bound, is there more or less drug free to exert a therapeutic effect?
hydrophilic molecules dissolve in ____
drugs that combine with other ions or compounds to produce an effect
factor that influences blood levels of a drug: drug _____ or breakdown
low plasma protein= more or less of drug free?
what removes foreign substances and toxins from the blood?
does facilitated diffusion require energy?
a protein molecule in or on the cell that binds specific drugs to produce an effect, they will then determine which tissue will respond to the drug

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