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Cancer Therapies
Can you name the Cancer Therapies?
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Class of Drug
Example
What it Does
Alkylating Agents
Chemically damages DNA by reacting with electrophilic sites in DNA eg N7 of guanine
Anti-Metabolites
Inhibits DNA synthesis- eg. inhibiting thymidylate synthase (5FU)/dihydrofolate reductase (methotrexate)
Anti-Tumour Antibiotics
Doxorubicin is a topoisomerase-II inhibitor. Others bind to DNA
Anti-Mitotics
Blocks mitosis by binding tubulin and dissolving it or the taxanes by stabilising microtubules in metaphase.
Molecularly Targeted: treating CML
Targest philadelphia chromosome bcr-abl fusion protein tyrosine kinase- blocks it as it's normally constitutively active
Molecularly Targeted: treating melanomas
Target mutant version of RAF, part of the Ras cascade- would be constitutively active.
Hormone-Dependent Cancers:Oestrogen-dependent breast cancer
Antagonises oestrogen receptors
Testosterone-dependent prostate cancer
Downregulate GnRH receptors
Antibodies (Breast cancer)
Binds to HER2- growth factor
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