Science Quiz / USMLE Tumor Suppressor Genes

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Can you name the USMLE Tumor Suppressor Genes?

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Condition and Gene ProductTumor Suppressor Gene
Colorectal Cancer (FAP)
Pancreatic Cancer
Wilms Tumor (nephroblastoma)
Neurofibromatosis Type 1 - Ras GTPase Activating Protein
Breast, Prostate, and Endometrial Cancers
Reninoblastoma and Osteosarcoma - inhibits E2F blocking G1-->S phase
Melanoma, Pancreatic Cancer - p16, blocks G1 --> S phase
Neurofibromatosis Type 2 - Merlin (schwannomin) protein
Condition and Gene ProductTumor Suppressor Gene
von Hippel-Lindau Disease, RCC
MEN 1
Breast and Ovarian Cancer - DNA Repair Protein
Male Breast Cancer
Many human cancers and Li-Fraumeni Syndrome
Tuberous Sclerosis - Hamartin Protein
Colon Cancer
Tuberous Sclerosis - Tuberin Protein

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