Science Quiz / USMLE Tumor Suppressor Genes

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Can you name the USMLE Tumor Suppressor Genes?

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Condition and Gene ProductTumor Suppressor Gene
Wilms Tumor (nephroblastoma)
Melanoma, Pancreatic Cancer - p16, blocks G1 --> S phase
Pancreatic Cancer
Tuberous Sclerosis - Tuberin Protein
Neurofibromatosis Type 1 - Ras GTPase Activating Protein
Breast, Prostate, and Endometrial Cancers
Colorectal Cancer (FAP)
Neurofibromatosis Type 2 - Merlin (schwannomin) protein
Condition and Gene ProductTumor Suppressor Gene
MEN 1
Many human cancers and Li-Fraumeni Syndrome
Tuberous Sclerosis - Hamartin Protein
Reninoblastoma and Osteosarcoma - inhibits E2F blocking G1-->S phase
Breast and Ovarian Cancer - DNA Repair Protein
von Hippel-Lindau Disease, RCC
Colon Cancer
Male Breast Cancer

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