Science Quiz / Side Effects of EBSE drugs

Random Science Quiz

QUIZ: Can you name the EBSE drugs?

Quiz not verified by Sporcle

Forced Order
Also try: Pop Quiz: Physics
Challenge
Share
Tweet
Embed
Score 0/128 Timer 20:00
SEDruginfo
tx crohns or UC, Malaise, nausea, sulfonamide tox, reversible oliogospermia
diabetes drug: 2nd gen (glyburide, glimepiride, glipizide) -- hypoglycemia, weight gain, siADH.
Cushings, immunosuppression, *cataracts*, acne, osteoperosis, hypertension, peptic ulcers, hyperglycemia
Myelosuppression, hypersensitivity.
antidepresant : (alpha-2 antagonist, increases NE as antidepressant)sedation, increased appeitite, ***weight gain***, dry mouth
tx arrhythmia: HA, tinnitus, thrombocytopenia, torsades de pointes from increased QT interval.
diabetes drug: Lactic acidosis -- CI in renal failure
antiviral: tx CMV retinitis, Nephrotoxicity (so give with probenecid)
antiviral : Hemolytic anemia, severe teratogen ( for hep c and RSV, purine prodrug)
tx angina: Reflex tachycardia, hypotension, HA,
abx: GI upset, superinfections, rash, HA, dizziness. CI in pregnant women/children because caritlage damage. Tendonitis/rupture
tx bipolar: ( enhance GABA, block VG Na channel) GI distress, rare but fatal hepatotoxicity, tremor, weight gain, CI in pregnancy
abx: neurotoxiticy (prevent with B6), hepatotoxicity, lupus
antiviral AIDS: Hyperglycemia, GI intolerance, lipodystrophy
transplant drug: Nephrotoxic, preventable with mannitol diuresis
antiepileptic: Nystagmus, dplopia, ataxia, sedation, hirsuitism, megalobalstic anemia,(teratogen: MR and craniofacial abnl) , SLE-like syndrome, induction p-450, gingival hyperplas
antidepressant: Increase in BP, stimulant effects, sedation, nausea
anti HTN : SLE-like syndrome, compensatory tachycardia (CI in angina/CAD), fluid retention, nausea, HA, angina
tx hyperthyroid: Agranulocytosis, aplastic anemia, hepatotoxitiy, skin rash. Methimazole is the same except also a possible teratogen and no hepatotoxicity.
SE of interferons
chemo drug: toxicity that can be rescued with leucovorin (abbrv)
beta blocker that causes Dyslipidemia
anxiolytic ( bind GABA A receptor) : Dependence, additive CNS depression w/alcohol, inducer of p-450.
parkinson drug: Arrhythmias from peripheral conversion to D. long term use leads to dyskinesia with akinesia between doses. carbidopa is a peripheral decaboxylase inhibitor that li
Antacid, causes constipation
antidepresant: GI distress, sexual dysfunction. ___ syndrome with any drug that increases __ (like MAO inhibitors)-- hyperthermia, myoclonyus, CV collapse, flushing, diarrhea, seiz
anti pyretic/ pain releif- Hepatic necrosis. Metabolite depletes glutathione,
antifungal: abnormal LFT, visual disturbances
H2 blocker: Ataxia, dizziness, slurred speech
anti- osteoporosis: corrosive esophagitis (except zoledronate), nausea, diarrhea , osteonecrosis of jaw
antiepileptic: steven-johnson rash
Immonosuppressant - monoclonal ab on cd3, SE Cytokine release syndrome (binds CD3 on T cells).
K sparing diureticL Hyperkalemia (can lead to arrhythmias), aldosterone antagonist (gynecomastia).
pain blocker: Addiction, respiratory depression, miosis, additive CNS depression,
Myositis, hepatotoxicity, cholesterol gallstones (activate LPL to decr TG)
Decreased creatinine excretion
abx: hypersensitivity, hemolysis with G6PD deficiency, nephrotoxicity, photosensitivtiy, kernicterus in infants, displace warfarin from albumin
anticoagulant...teratogen, can lead to thrombosis
diuretic : Ototoxicity, hypokalemia, dehydration, allergy (sulfa), nephritis, gout (OH DANG!)
antidepressant: ( incr NE , D , 5HT) Hypertensive crisis with tyramine ingestion (wine and cheese, tyramine gets converted to NE inside nerve terminals)
Bone marrow suppression, upset GI. Used for melanoma, CML, sickel cell.
TB drug: hyperuricemia, hepatotoxicity
abx: GI distress, skin rash, seizures at high plasma levels.
SEDruginfo
antiinflammatory- Renal damage, fluid retention, aplastic anemia, GI distress, ulcers
anti migraine: (5HT 1b/1D agonist) Coronary vasospasm (CI in patients with CAD or prinzmetal's angina)
antacid ,, diarrhea
abx: Anemia, aplastic anemia, gray baby syndrome (infants lack UDP-glucuronyl transferase).
ulcers, Reye's syndrome
antifungal: GI upset, flushing
abx: hypersensitivity, vitamin K deficiency. Can cause cross-hypersensitivity with peniccilin. Increases nephrotoxicity of aminoglycosides. Disulfiram-like reaction with ethanol.
HA / constipation (used for anti nausea, anti 5-HT3a)
 
DUMBBELSS -- diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of muscle and CNS, lacrimation, sweating, salivation
diabetic and post-surgery gastroparesis.: ( D2 antagonist that increases tone/contractility) Parkinsonian effects, drug interaction with digoxin and diabetic agents
abx: Hepatotoxic, increases p-450, orange fluids
give example of low potency antipsychotic drug ( D antagonist antihistamin/serotonin/cholinergic also) extrapyramidal system effects (EPS -- acute dystonia -> akinesia -> akathisia
abx: pseudomembranous colitis, fever, diarrhea
diabetes drug : ( abbrev)Weight gain, edema, heart failure, hepatotoxicity
Convulsions, coma, cardiotoxicity. Also respiratory depression, hyperpyrexia. Confusion and hallucinations in elderly due to anticholinergic side effects.
abx:GI distress, discoloration of teeth, inhibition of bone growth in children, photosensitivtiy, CI in pregnancy
MAGIC RACKS -- macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, seldane
antiviral AIDS: Bone marrow suppression (reverse with G-CSF and EPO), peripheral neuropathy,** lactic acidosis**, megloblastic anemia (ZDV). Examples of - tenofovir, emtricitabine,
abx: optic neuropathy (red/green colorblindness)
Bleeding -- treat with aminocaproic acid
tx congested nose: HTN, CNS stimulation/anxiety with pseudoephedrine.
abx: Nephrotoxicity, ototoxicity (especially with loop diuretics), teratogen
abx: red man syndrome (prevent with pretreatment with antihistamines and slow infusion rate), does NOT have many problems (actually does cause nephrotoxicity, ototoxicity, thrombop
antifungal: Hormone synthesis (gynecomastia), liver dysfunction (inhibits p-450, especially ketoconazole), fever, chills
transplant drug: Hyperlipidemia, thrombocytopenia, leukopenia. Notice it's not nephrotoxic!!!
anti malarial - Retinopathy, G6PD deficiency hemolysis ( MoA binds to parasite heme product leading to toxic build up and autodestruction of infected RBC)
Myelosuppression, hemorrhagic cystitis (remember the chemo tox man),
diabetes drug: N/V, pancreatitis
antibiotic: fever, UTI, pruritic rash, stvens-Johnson, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria.
Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter
anti arrythmic: pulmonary fibrosis, hepatotoxicity, hypothyroidism/hyperthyroidism ( think the name iodine hidden in drug). Check PFT, LFT, TFTs.
Countless SAFe Moms Take Really good Care -- Clarithromycin (embryotoxic), Sulfonamides (kernicterus), aminoglycosides (cartilage damage), fluoroquinolones (cartilage damage), metr
anti HTN and anti angina : cardiac depression, AV block, peripheral edema, flushing, dizziness, constipation
antifungal: Fever/chills, hypotension, nephrotoxicity, arhythmias, anemia, IV phlebitis.
antacids all can cause
Inhibits p-450, antiandrogenic effects, decrease creatinine excretion
alzheimers drug: (NMDA receptor antagonist) dizziness, confusion, hallucinations
MAO-B inhibitor that can enhance adverse effects of L-dopa
tx: glaucoma, mountain sickness ( CA ( carbonic anhydrase inhibitor) ( Hyperchloremic metabolic acidosis, neruopathy, NH3 toxicity, sulfa allergy
atypical antipsychotic : agranulocytosis
chemo: Nephro/acoustic nerve . Prevent nephrotoxicity with amifostine.
Nausea, cramps, steatorrhea. Used for acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors.
SEDruginfo
antiviral : leukopenia, neutropenia, thrombocytopenia, renal toxitity
anti HTN and anti CHF- (abbrv) Hyperkalemia. Cough, angioedema, taste changes, hypotension, fetal renal damage, rash, increased renin, lower AGII.
abx: Prolonged QT interval (especially erythromycin), GI discomfort, acute cholestatic hepatitis, eosinophilia, skin rashes.
order of Atypical antipsychotic that cause most___ to least ….Crazy old queens politely reach zen with antipsychotics (clozapine, olanzapine, quetiapine, paliperidone, risperidon
anxiolytic ( stimulate 5HT1a receptor) : DOESN’T interacti with alcohol
abx: hypersensitivity, interstitial nephritis
tx hypothyroid tachycardia, heat intolerance, tremors, arrhythmias
antifungal: teratogenic, carcinogenic, confusion, HA, increase p-450 and warfarin metabolism ( MoA binds to tubulin , inh mitosis…alters keratin, for dermatophite infx)
hypoglycemia
transplant drug :Nephrotoxic, peripheral neuropathy, HTN, pleural effusion, hyperglycemia
chemo: Peripheral neuropathy ,bone (myelosuppresion
antiviral AIDS: Bone marrow suppression (reverse with G-CSF and EPO), peripheral neuropathy****, rash****. Examples of -- neVIRapine, efaVIRenz, delaVIRidine.
anticoag that can cause thrombocytopenia + clotting…...platelet factor IV, stimulating antibodies that activate and clear platelets. 5-14 days after starting.
Rx incr HDL: Red, flushed face, decreased by aspirin. Hyperglycemia, hyperuricemia
tx CHF: ECG -- increased PR, decreased QT, T wave inversion, arrhythmia, hyperkalemia. Worsened by renal failure, hypokalemia (less competition for binding on Na/K ATPase), quinidi
abx: hypersensitivity, ampicillin rash, pseudomembranous colitis
antidepressant:( inh Serotonin reuptake, used for insomina and as antidepressan) .**Priapism** sedation, nausea, posutral hypotension.
tx hypercholesterol: Hepatotoxicity (increased LFT), rhabomyolysis
anti HTN, anti edema: ( abbrev) Hypokalemic metabolic alkalosis, hyponatremia ( hyperGLUC) , hyperGlycemia, hyperLipidemia, hyperUricemia, hyperCalcemia.. Sulfa allergy.
abx: megaloblastic anemia, leukopenia, granulocytopenia (alleviate with leucovorin)
incr risk of endometrial carcinoma because it's a partial agonist,
tx kidney failure and brain swelling ( osmotic diuresis) Pulmonary edema, dehydration, CI in anuria and CHF
bipolar tx: Ebsetin's anomaly and malformation of great vessels, tremor, sedation, dema, heart blcok. hypothyroidism, polyuria (ADH antagnoist that causes nephrogenic DI). Excreted
Last resort in tachyarrhythmias (class 1C), proarrhythmic, especially post-MI (contraindicated). Prolongs refractory period in AV node.
antidepresant: ( incr NE, D, unknown MoA) no sexual SE! stimulant effect ( tachy, insomnia) HA, seizure if bulemic ***used for smoking cessation**
Diarrhea. CI in women of childbearing potential (abortifacient).
immunosuppressive: purine analogue:--Bone marrow suppression. Metabolite mercaptopurine ( 6MP) is metabolzied by xanthine oxidase... don't give allopurinol.
Nausea, HA, flushing, hypotension, AP. (PDE3 inhibitor. More cAMP in platelets inhibits response to ADP
abx: Disulfiram-like reaction wit halcohol, HA, metallic taste
anti-epileptic: ( stablizied VG Na channels) Diplopia, ataxia, agranulocytosis, aplastic anemia, liver tox, teratogenesis, induction of p-450, stevens johnson, SIADH ( bc potentiat
Rarely increases LFTs (mechanism is prevents cholesterol absorption in intestine )
PDE5 inh, aka reddys fav drug: HA, flushing, dyspepsia, risk of life-threatening hypotension with nitrates (Hot and sweaty, then HA, Heartburn, Hypotension). Impaired blue/green co
Tx endometriosis, fibrocystic breast disease, and hereditary angioedema( synthetic androgen) Weight gain, edema, acne, hirsutism, less HDL.
Neutropenia ( blocks ADP receptors, thus preventing GIIb/IIIa from being expressed and fibrinogen from binding. Used in PCI.
atypical antipsychotic :Prolongs QT interval
breast cancer drug SE Cardiotoxicity
antiHTN : Impotence, asthma exacerbation, bradycardia, AV block, CHF, sedation, sleep alterations, may mask signs of hypoglycemia.
anxiolytic: ( bind specific receptor on CABA) Dependence, additive CNS depression w/alcohol, less risk of respiratory depression and coma than barbiturates.
Foscarnet SE
p450 inducers or inhibitors Chronic CARBs, Greasy Worts, barbed-wire Phences, all rifAMP up ….. Chronic alcohol, carbamazepine, griseofulvin, st. john's wort, barbiturates, pheny
abx: hypersensitivity, hemolytic anemia
azheimer drug ( AchE Inhibitor) : Nausea, dizziness, insomnia

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.