Science Quiz / Side Effects of EBSE drugs

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Can you name the EBSE drugs?

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antiviral AIDS: Bone marrow suppression (reverse with G-CSF and EPO), peripheral neuropathy****, rash****. Examples of -- neVIRapine, efaVIRenz, delaVIRidine.
anti-epileptic: ( stablizied VG Na channels) Diplopia, ataxia, agranulocytosis, aplastic anemia, liver tox, teratogenesis, induction of p-450, stevens johnson, SIADH ( bc potentiat
tx crohns or UC, Malaise, nausea, sulfonamide tox, reversible oliogospermia
abx: GI upset, superinfections, rash, HA, dizziness. CI in pregnant women/children because caritlage damage. Tendonitis/rupture
give example of low potency antipsychotic drug ( D antagonist antihistamin/serotonin/cholinergic also) extrapyramidal system effects (EPS -- acute dystonia -> akinesia -> akathisia
immunosuppressive: purine analogue:--Bone marrow suppression. Metabolite mercaptopurine ( 6MP) is metabolzied by xanthine oxidase... don't give allopurinol.
beta blocker that causes Dyslipidemia
abx: Hepatotoxic, increases p-450, orange fluids
Nausea, cramps, steatorrhea. Used for acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors.
Myelosuppression, hemorrhagic cystitis (remember the chemo tox man),
abx: Prolonged QT interval (especially erythromycin), GI discomfort, acute cholestatic hepatitis, eosinophilia, skin rashes.
ulcers, Reye's syndrome
tx hypercholesterol: Hepatotoxicity (increased LFT), rhabomyolysis
Countless SAFe Moms Take Really good Care -- Clarithromycin (embryotoxic), Sulfonamides (kernicterus), aminoglycosides (cartilage damage), fluoroquinolones (cartilage damage), metr
anti pyretic/ pain releif- Hepatic necrosis. Metabolite depletes glutathione,
antiviral : leukopenia, neutropenia, thrombocytopenia, renal toxitity
anti malarial - Retinopathy, G6PD deficiency hemolysis ( MoA binds to parasite heme product leading to toxic build up and autodestruction of infected RBC)
pain blocker: Addiction, respiratory depression, miosis, additive CNS depression,
transplant drug :Nephrotoxic, peripheral neuropathy, HTN, pleural effusion, hyperglycemia
Foscarnet SE
Cushings, immunosuppression, *cataracts*, acne, osteoperosis, hypertension, peptic ulcers, hyperglycemia
antacid ,, diarrhea
Bone marrow suppression, upset GI. Used for melanoma, CML, sickel cell.
chemo drug: toxicity that can be rescued with leucovorin (abbrv)
antiepileptic: Nystagmus, dplopia, ataxia, sedation, hirsuitism, megalobalstic anemia,(teratogen: MR and craniofacial abnl) , SLE-like syndrome, induction p-450, gingival hyperplas
Myelosuppression, hypersensitivity.
Convulsions, coma, cardiotoxicity. Also respiratory depression, hyperpyrexia. Confusion and hallucinations in elderly due to anticholinergic side effects.
PDE5 inh, aka reddys fav drug: HA, flushing, dyspepsia, risk of life-threatening hypotension with nitrates (Hot and sweaty, then HA, Heartburn, Hypotension). Impaired blue/green co
abx: neurotoxiticy (prevent with B6), hepatotoxicity, lupus
antifungal: teratogenic, carcinogenic, confusion, HA, increase p-450 and warfarin metabolism ( MoA binds to tubulin , inh mitosis…alters keratin, for dermatophite infx)
abx: Disulfiram-like reaction wit halcohol, HA, metallic taste
parkinson drug: Arrhythmias from peripheral conversion to D. long term use leads to dyskinesia with akinesia between doses. carbidopa is a peripheral decaboxylase inhibitor that li
tx bipolar: ( enhance GABA, block VG Na channel) GI distress, rare but fatal hepatotoxicity, tremor, weight gain, CI in pregnancy
bipolar tx: Ebsetin's anomaly and malformation of great vessels, tremor, sedation, dema, heart blcok. hypothyroidism, polyuria (ADH antagnoist that causes nephrogenic DI). Excreted
antidepresant: GI distress, sexual dysfunction. ___ syndrome with any drug that increases __ (like MAO inhibitors)-- hyperthermia, myoclonyus, CV collapse, flushing, diarrhea, seiz
abx:GI distress, discoloration of teeth, inhibition of bone growth in children, photosensitivtiy, CI in pregnancy
anti HTN, anti edema: ( abbrev) Hypokalemic metabolic alkalosis, hyponatremia ( hyperGLUC) , hyperGlycemia, hyperLipidemia, hyperUricemia, hyperCalcemia.. Sulfa allergy.
p450 inducers or inhibitors Chronic CARBs, Greasy Worts, barbed-wire Phences, all rifAMP up ….. Chronic alcohol, carbamazepine, griseofulvin, st. john's wort, barbiturates, pheny
abx: pseudomembranous colitis, fever, diarrhea
antidepressant:( inh Serotonin reuptake, used for insomina and as antidepressan) .**Priapism** sedation, nausea, posutral hypotension.
anti- osteoporosis: corrosive esophagitis (except zoledronate), nausea, diarrhea , osteonecrosis of jaw
antiHTN : Impotence, asthma exacerbation, bradycardia, AV block, CHF, sedation, sleep alterations, may mask signs of hypoglycemia.
abx: hypersensitivity, interstitial nephritis
anticoagulant...teratogen, can lead to thrombosis
Bleeding -- treat with aminocaproic acid
abx: Nephrotoxicity, ototoxicity (especially with loop diuretics), teratogen
abx: optic neuropathy (red/green colorblindness)
abx: hypersensitivity, ampicillin rash, pseudomembranous colitis
tx hyperthyroid: Agranulocytosis, aplastic anemia, hepatotoxitiy, skin rash. Methimazole is the same except also a possible teratogen and no hepatotoxicity.
antiviral : Hemolytic anemia, severe teratogen ( for hep c and RSV, purine prodrug)
chemo: Nephro/acoustic nerve . Prevent nephrotoxicity with amifostine.
anti HTN and anti CHF- (abbrv) Hyperkalemia. Cough, angioedema, taste changes, hypotension, fetal renal damage, rash, increased renin, lower AGII.
antidepressant: Increase in BP, stimulant effects, sedation, nausea
anxiolytic: ( bind specific receptor on CABA) Dependence, additive CNS depression w/alcohol, less risk of respiratory depression and coma than barbiturates.
abx: megaloblastic anemia, leukopenia, granulocytopenia (alleviate with leucovorin)
abx: Anemia, aplastic anemia, gray baby syndrome (infants lack UDP-glucuronyl transferase).
order of Atypical antipsychotic that cause most___ to least ….Crazy old queens politely reach zen with antipsychotics (clozapine, olanzapine, quetiapine, paliperidone, risperidon
Rx incr HDL: Red, flushed face, decreased by aspirin. Hyperglycemia, hyperuricemia
Neutropenia ( blocks ADP receptors, thus preventing GIIb/IIIa from being expressed and fibrinogen from binding. Used in PCI.
Inhibits p-450, antiandrogenic effects, decrease creatinine excretion
antifungal: GI upset, flushing
diuretic : Ototoxicity, hypokalemia, dehydration, allergy (sulfa), nephritis, gout (OH DANG!)
SE of interferons
abx: hypersensitivity, vitamin K deficiency. Can cause cross-hypersensitivity with peniccilin. Increases nephrotoxicity of aminoglycosides. Disulfiram-like reaction with ethanol.
antiviral AIDS: Hyperglycemia, GI intolerance, lipodystrophy
diabetes drug: N/V, pancreatitis
Nausea, HA, flushing, hypotension, AP. (PDE3 inhibitor. More cAMP in platelets inhibits response to ADP
antiinflammatory- Renal damage, fluid retention, aplastic anemia, GI distress, ulcers
azheimer drug ( AchE Inhibitor) : Nausea, dizziness, insomnia
antifungal: Hormone synthesis (gynecomastia), liver dysfunction (inhibits p-450, especially ketoconazole), fever, chills
diabetes drug : ( abbrev)Weight gain, edema, heart failure, hepatotoxicity
Rarely increases LFTs (mechanism is prevents cholesterol absorption in intestine )
anxiolytic ( stimulate 5HT1a receptor) : DOESN’T interacti with alcohol
DUMBBELSS -- diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of muscle and CNS, lacrimation, sweating, salivation
anti HTN : SLE-like syndrome, compensatory tachycardia (CI in angina/CAD), fluid retention, nausea, HA, angina
Last resort in tachyarrhythmias (class 1C), proarrhythmic, especially post-MI (contraindicated). Prolongs refractory period in AV node.
alzheimers drug: (NMDA receptor antagonist) dizziness, confusion, hallucinations
Antacid, causes constipation
diabetes drug: Lactic acidosis -- CI in renal failure
abx: GI distress, skin rash, seizures at high plasma levels.
Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter
antiviral AIDS: Bone marrow suppression (reverse with G-CSF and EPO), peripheral neuropathy,** lactic acidosis**, megloblastic anemia (ZDV). Examples of - tenofovir, emtricitabine,
tx congested nose: HTN, CNS stimulation/anxiety with pseudoephedrine.
antibiotic: fever, UTI, pruritic rash, stvens-Johnson, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria.
tx CHF: ECG -- increased PR, decreased QT, T wave inversion, arrhythmia, hyperkalemia. Worsened by renal failure, hypokalemia (less competition for binding on Na/K ATPase), quinidi
H2 blocker: Ataxia, dizziness, slurred speech
tx angina: Reflex tachycardia, hypotension, HA,
atypical antipsychotic : agranulocytosis
K sparing diureticL Hyperkalemia (can lead to arrhythmias), aldosterone antagonist (gynecomastia).
antidepresant : (alpha-2 antagonist, increases NE as antidepressant)sedation, increased appeitite, ***weight gain***, dry mouth
anti arrythmic: pulmonary fibrosis, hepatotoxicity, hypothyroidism/hyperthyroidism ( think the name iodine hidden in drug). Check PFT, LFT, TFTs.
abx: red man syndrome (prevent with pretreatment with antihistamines and slow infusion rate), does NOT have many problems (actually does cause nephrotoxicity, ototoxicity, thrombop
anti HTN and anti angina : cardiac depression, AV block, peripheral edema, flushing, dizziness, constipation
anti migraine: (5HT 1b/1D agonist) Coronary vasospasm (CI in patients with CAD or prinzmetal's angina)
abx: hypersensitivity, hemolysis with G6PD deficiency, nephrotoxicity, photosensitivtiy, kernicterus in infants, displace warfarin from albumin
abx: hypersensitivity, hemolytic anemia
antiviral: tx CMV retinitis, Nephrotoxicity (so give with probenecid)
transplant drug: Nephrotoxic, preventable with mannitol diuresis
TB drug: hyperuricemia, hepatotoxicity
HA / constipation (used for anti nausea, anti 5-HT3a)
tx kidney failure and brain swelling ( osmotic diuresis) Pulmonary edema, dehydration, CI in anuria and CHF
antifungal: abnormal LFT, visual disturbances
anticoag that can cause thrombocytopenia + clotting…...platelet factor IV, stimulating antibodies that activate and clear platelets. 5-14 days after starting.
atypical antipsychotic :Prolongs QT interval
diabetes drug: 2nd gen (glyburide, glimepiride, glipizide) -- hypoglycemia, weight gain, siADH.
Myositis, hepatotoxicity, cholesterol gallstones (activate LPL to decr TG)
incr risk of endometrial carcinoma because it's a partial agonist,
antifungal: Fever/chills, hypotension, nephrotoxicity, arhythmias, anemia, IV phlebitis.
antidepresant: ( incr NE, D, unknown MoA) no sexual SE! stimulant effect ( tachy, insomnia) HA, seizure if bulemic ***used for smoking cessation**
antiepileptic: steven-johnson rash
tx arrhythmia: HA, tinnitus, thrombocytopenia, torsades de pointes from increased QT interval.
antacids all can cause
Decreased creatinine excretion
transplant drug: Hyperlipidemia, thrombocytopenia, leukopenia. Notice it's not nephrotoxic!!!
chemo: Peripheral neuropathy ,bone (myelosuppresion
Diarrhea. CI in women of childbearing potential (abortifacient).
Tx endometriosis, fibrocystic breast disease, and hereditary angioedema( synthetic androgen) Weight gain, edema, acne, hirsutism, less HDL.
diabetic and post-surgery gastroparesis.: ( D2 antagonist that increases tone/contractility) Parkinsonian effects, drug interaction with digoxin and diabetic agents
antidepressant: ( incr NE , D , 5HT) Hypertensive crisis with tyramine ingestion (wine and cheese, tyramine gets converted to NE inside nerve terminals)
Immonosuppressant - monoclonal ab on cd3, SE Cytokine release syndrome (binds CD3 on T cells).
MAO-B inhibitor that can enhance adverse effects of L-dopa
MAGIC RACKS -- macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, seldane
tx: glaucoma, mountain sickness ( CA ( carbonic anhydrase inhibitor) ( Hyperchloremic metabolic acidosis, neruopathy, NH3 toxicity, sulfa allergy
anxiolytic ( bind GABA A receptor) : Dependence, additive CNS depression w/alcohol, inducer of p-450.
tx hypothyroid tachycardia, heat intolerance, tremors, arrhythmias
breast cancer drug SE Cardiotoxicity

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