Science Quiz / Rate-Limiting Metabolic Enzymes

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Can you name the rate limiting enzymes for important metabolic processes?

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ProcessRate-Limiting Enzyme+/-
GluconeogenesisStimulated by ATP; Inhibited by AMP, fructose 2,6 bisphosphate
De Novo Pyrimidine Synthesis
GlycogenolysisStimulated by AMP, epinephrine, glucagon; inhibited by insulin, ATP
Ketogenesis
Hexose MonoPhosphate Shunt/ Pentose PhosphateStimulated by NADP+, Inhibited by NADPH
Fatty Acid SynthesisStimulated by Insulin, citrate; inhibited by glucagon, palmitoyl-CoA
De Novo Purine SynthesisInhibited by AMP, GMP, IMP
ProcessRate-Limiting Enzyme+/-
Fatty Acid OxidationInhibited by malonyl-CoA
TCA CycleStimulated by ADP; Inhibited by ATP, NADH
Cholesterol Synthesisstimulated by insulin, thyroxine (T4); inhibited by glucagon, cholesterol
Urea CycleStimulated by N-acetylglutamate
Glycogen SynthesisStimulated by glucose, insulin; inhibited by epinephrine, glucagon
GlycolysisStimulated by AMP, Fructose 2,6 bisphosphate, and insulin(indirectly); inhibited by ATP, citrate, glucagon (indirectly)

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