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Heme/onc Drugs Stats
Can you pick the Heme/onc Drugs
By
rmmorganjr
20m
67 Questions
6 Plays
6 Plays
6 Plays
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Score
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Hint
Drug
% Correct
effects reversible by protamine sulfate
unfractionated heparin
50%
COX inhibitors; platelet inhibitors; GI insult; Renal Insult
NSAIDs
50%
strong opiod used to treat severe pain
Morphine
50%
Strong opioid; used for opiate detox due to NMDA inhibition
methadone
50%
alkylating agent causing nephrotoxicity, N/
V, neurotoxicity, and hypersensitivity
Cisplatin
50%
oral alkylating agent; used for leukemia/
xplant and decreases seizure threshold
busulfan
50%
anti-
tumor antibiotic causing pulmonary fibrosis indicated in testicular cancer and hodgkins; produces free radicals
Bleomycin
50%
CD20 MAB
rituximab
50%
VEGF inhibitors; bleeding, VTE, HTN
Bevacizumab
50%
Anticholinergic; motion sickness induced nausea
scopolamine
50%
low molecular weight heparin (affecting Xa only); no effect on PTT or PT
Enoxaparin
33.3%
indicated in VTE treatment, can cause necrosis, processed by CYP2c9, delaryed onset, increases PT
Warfarin
33.3%
Cox-
3 inhibitor; little anti-
inflammatory effects; hepatotoxic, blocks fever; max daily dose 4gs (adult)
Acetaminophen
33.3%
anticonvulsant used to treat neuropathic pain; binds Ca++ channels
Gabapentin
33.3%
Treats hemorrhagic cystitis associated with nitrogen mustards; MOA: blocks acrolein
MESNA
33.3%
alkylating agent causing hemorrhagic cystitis, and neurotoxicity
Cyclophosphamide
33.3%
antimetabolite; inhibits DHFR; VE's: nephrotoxic, mucositis, hepatotoxic, neurotoxic, dermatitis
Methotrexate
33.3%
used to treat AML with t(15;17); RAR problem; can cause mass maturation syndrome -
-
> fever, dyspnea, pleural effusion
ATRA
33.3%
Neurokinin-
1 receptor antagnoists; inhibits substance P; acute and delayed CINV
Aprepitant
33.3%
factor Xa inihbitor; AE's: bleeding, fever, nausea
Fondaparinux
16.7%
COX-
2 inhibitor; AE: peripheral edema, MI, Nephrotoxic
celecoxib
16.7%
Abnormal analgesic; for moderate-
severe pain; Mu receptor binding and SNRI effects; AE's nausea, constipation, HA
tramadol
16.7%
PO opiod analgesic to relieve mild-
severe pain
codine
16.7%
Strong opioid with many routes of administration (IV/
IM/
xderm/
xmucosal)
fentanyl
16.7%
local anesthetic with weak benefit; patch; AE: skin irriation
lidocaine
16.7%
alkylating agents;highly lipophilic agents used to treat CNS tumors, melanoma, and lymphoma
Carmustine
16.7%
class of drugs; topoisomerase II inhibitors; cardiotoxic, extravasation injury, red/
orange urine
anthracyclines
16.7%
topo II inhibitors causing cardiotoxicity, extravasation injury, etc
daunorubicin
16.7%
topo II inhibitor causing mucositis and hypotension; sometimes used for AML
etoposide
16.7%
Topo I inhibitors; severe diarrhea; indicated in colon cancer, ovarian and SCLC
irinotecan
16.7%
used to alleviate acute diarrhea from camptothecins
atropine
16.7%
used to alleviate prolonged diarrhea from camptothecans
loperamide
16.7%
directly inhibits methotrexate like drugs
glucarpidase
16.7%
bypasses methotrexate MOA to provide folate; complexes with FdUMP to potentiate TS inihibition
leucovorin
16.7%
Hint
Drug
% Correct
pyrimidine analogue; inhibits DNA polymerase or thymidylate synthase
ara-c
16.7%
purine analogs; inhibit purine synthesis; immunosuppression (t-
helper cells)
6-mercaptopurine
16.7%
mitotic inhibitor; prevents assembly of tubulin dimers into microtubules (blocks anaphase)
vinblastine
16.7%
antitumor antibiotic causing myelosuppression; indicated for childhood tumors, rhabdomyocarcoma
dactinomycin
16.7%
hedgehog pathway inhibitor; prevents SMOH receptor from being expressed on membrane; causes muscle spasms, nausea, vomiting and alopecia; treats BCC
Vismodegib
16.7%
indicated for CML blast crisis and sickle cell anemia; inhibits ribonucleotide reductase
hydroxyurea
16.7%
Degrades asparagine; allergic reactions, pancreatitis, decreased fibrinogen; leukemia/
lymphoma
asparaginase
16.7%
HER-
2 MAB; cardiotoxicity
traztuzumab
16.7%
BCR-
ABL inhibitors; Ph+ CML; drug interactions with CYP3a4; hepatotoxic and GI toxic (dose limiting)
imatinib
16.7%
CTLA-
4 blockers; prevents cells from being turned off; overactive immune system; metastatic melanoma
Ipilimumab
16.7%
IL-
6 blockers
Siltuximab
16.7%
Personalized therapy using conditioned T-
cells; prostate cancer
Sipuleucel-t
16.7%
Non-
vitamin K warfarin reversal agent
Kcentra
0%
Direct thrombin inhibitor; indicated in PC coronary intervention
argatroban
0%
reverses Mu binding in GI only
Methylnaltrexone
0%
relieves constipation associated with opioids; stool softener
polyethylene glycol
0%
partial opiod agonist; increased doses cause QTc prolongation (IV/
xderm/
subling)
buprenorphine
0%
SNRI antidepressants used to treat neuropathic pain; AEs: cardiac conduction abnormalities and HTN
Venlafaxine
0%
used to prevent cardiotoxicity with anthracyclines; decreases free radical formation
dexrazoxane
0%
topo II inhibitor without the side effect profile; causes blue-
green urine
mitoxantrone
0%
promote microtubule assembly and block disassembley; mucositis, hypersensitivity, cumulative peripheral neuropathy
paclitaxel
0%
proteasome inhibitors; inhibits NF-
kB -
-
> stops transcription; multiple myeloma and mantel cell lymphoma t(11; 15)
Bortezomib
0%
immunomodulator highly teratogenic; increased VTE, peripheral neuropathy, myelosuppression; indicated in Multiple myeloma
thalidomide
0%
histone deacetylator inhibitors (HDAL); opens up DNA for normal xscription; indicated in CTCL and PTCL; VEs thrombotic events, QT prolongation, GI
vorinostat
0%
hypomethylating agent used to treat MDS and AML
azacitidine
0%
inhibits protein synthesis of BCR-
ABL; indicated for CML w/
T3151 mutation; hyperglycemia, hemorrhage
omacetaxine mepesuccinate
0%
CD30 MAB
brentuximab vedotin
0%
BRAF inihbitor used to treat melanoma; skin rash/
acne
vemurafenib
0%
JAK 1/
2 inhibitors; myelofibrosis, skin rash/
acne
ruxolitinib
0%
BTK inhibits (brutons tyrosine kinase); mantle cell, CLL
Ibrutinib
0%
PI3K kinase inhibitors
Idelalisib
0%
MTOR inhibiors; AE: hyperglycemia/
hyperlipidemia
Temsirolimus
0%
Cannabinoid pill
Dronabinol
0%
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Chemotherapy Pharmocology
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Jan 15, 2014
Heme/onc Drugs
6
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Sep 2, 2014
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