Science Quiz / Heme/onc Drugs

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Can you pick the Heme/onc Drugs

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HintDrugOther info
anti-tumor antibiotic causing pulmonary fibrosis indicated in testicular cancer and hodgkins; produces free radicals
directly inhibits methotrexate like drugs
reverses Mu binding in GI only
hypomethylating agent used to treat MDS and AML
Cannabinoid pill
used to alleviate prolonged diarrhea from camptothecans
strong opiod used to treat severe pain
Non-vitamin K warfarin reversal agent
used to prevent cardiotoxicity with anthracyclines; decreases free radical formation
Cox-3 inhibitor; little anti-inflammatory effects; hepatotoxic, blocks fever; max daily dose 4gs (adult)
Abnormal analgesic; for moderate-severe pain; Mu receptor binding and SNRI effects; AE's nausea, constipation, HA
effects reversible by protamine sulfate
used to alleviate acute diarrhea from camptothecins
local anesthetic with weak benefit; patch; AE: skin irriation
histone deacetylator inhibitors (HDAL); opens up DNA for normal xscription; indicated in CTCL and PTCL; VEs thrombotic events, QT prolongation, GI
BCR-ABL inhibitors; Ph+ CML; drug interactions with CYP3a4; hepatotoxic and GI toxic (dose limiting)
relieves constipation associated with opioids; stool softener
JAK 1/2 inhibitors; myelofibrosis, skin rash/acne
topo II inhibitor without the side effect profile; causes blue-green urine
mitotic inhibitor; prevents assembly of tubulin dimers into microtubules (blocks anaphase)
anticonvulsant used to treat neuropathic pain; binds Ca++ channels
COX-2 inhibitor; AE: peripheral edema, MI, Nephrotoxic
COX inhibitors; platelet inhibitors; GI insult; Renal Insult
HintDrugOther info
used to treat AML with t(15;17); RAR problem; can cause mass maturation syndrome --> fever, dyspnea, pleural effusion
PO opiod analgesic to relieve mild-severe pain
class of drugs; topoisomerase II inhibitors; cardiotoxic, extravasation injury, red/orange urine
alkylating agents;highly lipophilic agents used to treat CNS tumors, melanoma, and lymphoma
immunomodulator highly teratogenic; increased VTE, peripheral neuropathy, myelosuppression; indicated in Multiple myeloma
alkylating agent causing hemorrhagic cystitis, and neurotoxicity
CD30 MAB
VEGF inhibitors; bleeding, VTE, HTN
pyrimidine analogue; inhibits DNA polymerase or thymidylate synthase
proteasome inhibitors; inhibits NF-kB --> stops transcription; multiple myeloma and mantel cell lymphoma t(11; 15)
bypasses methotrexate MOA to provide folate; complexes with FdUMP to potentiate TS inihibition
Personalized therapy using conditioned T-cells; prostate cancer
Degrades asparagine; allergic reactions, pancreatitis, decreased fibrinogen; leukemia/lymphoma
CD20 MAB
Direct thrombin inhibitor; indicated in PC coronary intervention
alkylating agent causing nephrotoxicity, N/V, neurotoxicity, and hypersensitivity
antimetabolite; inhibits DHFR; VE's: nephrotoxic, mucositis, hepatotoxic, neurotoxic, dermatitis
HER-2 MAB; cardiotoxicity
IL-6 blockers
indicated for CML blast crisis and sickle cell anemia; inhibits ribonucleotide reductase
MTOR inhibiors; AE: hyperglycemia/hyperlipidemia
purine analogs; inhibit purine synthesis; immunosuppression (t-helper cells)
PI3K kinase inhibitors
HintDrugOther info
topo II inhibitors causing cardiotoxicity, extravasation injury, etc
partial opiod agonist; increased doses cause QTc prolongation (IV/xderm/subling)
Topo I inhibitors; severe diarrhea; indicated in colon cancer, ovarian and SCLC
indicated in VTE treatment, can cause necrosis, processed by CYP2c9, delaryed onset, increases PT
low molecular weight heparin (affecting Xa only); no effect on PTT or PT
inhibits protein synthesis of BCR-ABL; indicated for CML w/ T3151 mutation; hyperglycemia, hemorrhage
Anticholinergic; motion sickness induced nausea
Treats hemorrhagic cystitis associated with nitrogen mustards; MOA: blocks acrolein
BRAF inihbitor used to treat melanoma; skin rash/acne
BTK inhibits (brutons tyrosine kinase); mantle cell, CLL
Strong opioid with many routes of administration (IV/IM/xderm/xmucosal)
SNRI antidepressants used to treat neuropathic pain; AEs: cardiac conduction abnormalities and HTN
antitumor antibiotic causing myelosuppression; indicated for childhood tumors, rhabdomyocarcoma
promote microtubule assembly and block disassembley; mucositis, hypersensitivity, cumulative peripheral neuropathy
factor Xa inihbitor; AE's: bleeding, fever, nausea
oral alkylating agent; used for leukemia/xplant and decreases seizure threshold
Strong opioid; used for opiate detox due to NMDA inhibition
Neurokinin-1 receptor antagnoists; inhibits substance P; acute and delayed CINV
CTLA-4 blockers; prevents cells from being turned off; overactive immune system; metastatic melanoma
hedgehog pathway inhibitor; prevents SMOH receptor from being expressed on membrane; causes muscle spasms, nausea, vomiting and alopecia; treats BCC
topo II inhibitor causing mucositis and hypotension; sometimes used for AML

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