Science Quiz / Heme/onc Drugs

Random Science Quiz

QUIZ: Can you pick the Heme/onc Drugs

Quiz not verified by Sporcle

Challenge
Share
Tweet
Embed
Score 0/67 Timer 20:00
HintDrugOther info
Anticholinergic; motion sickness induced nausea
SNRI antidepressants used to treat neuropathic pain; AEs: cardiac conduction abnormalities and HTN
BCR-ABL inhibitors; Ph+ CML; drug interactions with CYP3a4; hepatotoxic and GI toxic (dose limiting)
relieves constipation associated with opioids; stool softener
histone deacetylator inhibitors (HDAL); opens up DNA for normal xscription; indicated in CTCL and PTCL; VEs thrombotic events, QT prolongation, GI
HER-2 MAB; cardiotoxicity
pyrimidine analogue; inhibits DNA polymerase or thymidylate synthase
bypasses methotrexate MOA to provide folate; complexes with FdUMP to potentiate TS inihibition
local anesthetic with weak benefit; patch; AE: skin irriation
Topo I inhibitors; severe diarrhea; indicated in colon cancer, ovarian and SCLC
strong opiod used to treat severe pain
Neurokinin-1 receptor antagnoists; inhibits substance P; acute and delayed CINV
JAK 1/2 inhibitors; myelofibrosis, skin rash/acne
Direct thrombin inhibitor; indicated in PC coronary intervention
Cox-3 inhibitor; little anti-inflammatory effects; hepatotoxic, blocks fever; max daily dose 4gs (adult)
Cannabinoid pill
anti-tumor antibiotic causing pulmonary fibrosis indicated in testicular cancer and hodgkins; produces free radicals
Personalized therapy using conditioned T-cells; prostate cancer
used to prevent cardiotoxicity with anthracyclines; decreases free radical formation
hedgehog pathway inhibitor; prevents SMOH receptor from being expressed on membrane; causes muscle spasms, nausea, vomiting and alopecia; treats BCC
CD30 MAB
purine analogs; inhibit purine synthesis; immunosuppression (t-helper cells)
partial opiod agonist; increased doses cause QTc prolongation (IV/xderm/subling)
HintDrugOther info
used to alleviate prolonged diarrhea from camptothecans
Degrades asparagine; allergic reactions, pancreatitis, decreased fibrinogen; leukemia/lymphoma
Treats hemorrhagic cystitis associated with nitrogen mustards; MOA: blocks acrolein
topo II inhibitors causing cardiotoxicity, extravasation injury, etc
alkylating agents;highly lipophilic agents used to treat CNS tumors, melanoma, and lymphoma
topo II inhibitor causing mucositis and hypotension; sometimes used for AML
PI3K kinase inhibitors
Strong opioid with many routes of administration (IV/IM/xderm/xmucosal)
used to treat AML with t(15;17); RAR problem; can cause mass maturation syndrome --> fever, dyspnea, pleural effusion
alkylating agent causing hemorrhagic cystitis, and neurotoxicity
proteasome inhibitors; inhibits NF-kB --> stops transcription; multiple myeloma and mantel cell lymphoma t(11; 15)
IL-6 blockers
promote microtubule assembly and block disassembley; mucositis, hypersensitivity, cumulative peripheral neuropathy
Abnormal analgesic; for moderate-severe pain; Mu receptor binding and SNRI effects; AE's nausea, constipation, HA
mitotic inhibitor; prevents assembly of tubulin dimers into microtubules (blocks anaphase)
factor Xa inihbitor; AE's: bleeding, fever, nausea
alkylating agent causing nephrotoxicity, N/V, neurotoxicity, and hypersensitivity
used to alleviate acute diarrhea from camptothecins
PO opiod analgesic to relieve mild-severe pain
antimetabolite; inhibits DHFR; VE's: nephrotoxic, mucositis, hepatotoxic, neurotoxic, dermatitis
hypomethylating agent used to treat MDS and AML
class of drugs; topoisomerase II inhibitors; cardiotoxic, extravasation injury, red/orange urine
anticonvulsant used to treat neuropathic pain; binds Ca++ channels
HintDrugOther info
MTOR inhibiors; AE: hyperglycemia/hyperlipidemia
reverses Mu binding in GI only
Strong opioid; used for opiate detox due to NMDA inhibition
low molecular weight heparin (affecting Xa only); no effect on PTT or PT
antitumor antibiotic causing myelosuppression; indicated for childhood tumors, rhabdomyocarcoma
immunomodulator highly teratogenic; increased VTE, peripheral neuropathy, myelosuppression; indicated in Multiple myeloma
indicated for CML blast crisis and sickle cell anemia; inhibits ribonucleotide reductase
inhibits protein synthesis of BCR-ABL; indicated for CML w/ T3151 mutation; hyperglycemia, hemorrhage
BTK inhibits (brutons tyrosine kinase); mantle cell, CLL
topo II inhibitor without the side effect profile; causes blue-green urine
BRAF inihbitor used to treat melanoma; skin rash/acne
indicated in VTE treatment, can cause necrosis, processed by CYP2c9, delaryed onset, increases PT
oral alkylating agent; used for leukemia/xplant and decreases seizure threshold
CD20 MAB
COX-2 inhibitor; AE: peripheral edema, MI, Nephrotoxic
Non-vitamin K warfarin reversal agent
VEGF inhibitors; bleeding, VTE, HTN
effects reversible by protamine sulfate
COX inhibitors; platelet inhibitors; GI insult; Renal Insult
CTLA-4 blockers; prevents cells from being turned off; overactive immune system; metastatic melanoma
directly inhibits methotrexate like drugs

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.