Science Quiz / Chemotherapy Pharmocology

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Can you name the Chemotherapy Pharmocology

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inhibitor of xanthine oxidase; used to treat gout
inhibits viral DNA polymerase; acts as a DNA chain temrinator due to missing C 2' and 3'
mimics GMP; acts by feedback inhibition of PRPP amidotransferase, adenylsuccinate synthase, and IMP deydrogenase; effective against lymphocytic leukemia
incorporates itself into DNA inhibiting transcription and translation; effective against myeloid leukemia
Glutamine analog; blocks amine transfer reactions; too toxic for clinical use
incorporated into DNA and inhibits DNA polymerase; effective against leukemia and lymphomas, not solid tumors
inhibitors of retroviral-encoded reverse transcriptases
Demethylating agents; binds to dinucleotide methyl transferase resulting in its degradation
incorporated into DNA and inhibits DNA polymerase; blocks ribonucleotide reductase (RR); effective against leukemia, lymphoma, and solid tumors
inhibits dTMP synthase(TS) by covalently bonding to the active site; blocks conversion of dUMP into dTMP
blocks dihydrofolate reductase (DHFR); results in no purine synthesis and no dTMP
inhibitor of ribonucleotide reductase (RR);results in no dNTPs; only affects DNA

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Created Jan 15, 2014ReportNominate

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