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Monoclonal antibody against HER-2
Small molecule inhibitor of BRAF + melanoma
Selective estrogen receptor modulators
Proteasome inhibitors, insude arrest at G2-M phase and apoptosis
Monoclonal antibody against CD20
Tyrosine kinase inhibitor of BCR-ABL & c-kit
Monoclonal antibody against EGFR
ERGF tyrosine kinase inhibitor
Monoclonal antibody against VEGF
Inhibits ribonucleotide reductase
Inhibit topoisomerase I and prevent DNA unwinding and replication
Inhibit topoisomerase II
Cross-link DNA (testicular, bladder, ovary, lung carcinomas)
Bind B-tubulin and inhibit polymerization into microtubules
Hyperstabilize polymerized microtubules in M phase
Nitrogen mustard
Cross-links DNA (CML, myeloablation)
Folic acid analog
Pyrimidine analog bioactivated to 5-FdUMP
Pyrimidine analog --> inhibition of DNA polymerase
Purine analog (hairy cell leukemia)
Purine (thiol) analog; activated by HGPRT
Glycoprotein IIb/IIIa inhibitors
Phosphodiesterase inhibitors; vasodilators
ADP receptor inhibitors
Thrombolytics
Direct factor Xa inhibitors
Interferes with g-carboxylation of vitamin-K dep clotting factors
Direct thrombin inhibitors
Low-molecular-weight heparins
Lowers activity of thrombin and factor Xa
Recombinant uricase that catalyzes metabolism of uric acid to allantoin; prevents and treats tumor lysis syndrome
Adverse: Ototoxicity and neprotoxicity
Adverse: Peripheral neuropathy
Adverse: pulmonary fibrosis
Adverse: Cardiotoxicity
Adverse: Hemorrhagic cystitis
Adverse: peripheral neuropathy, herpes zoster reactivation
Adverse: Increased risk of progressive multifocal leukoencephalopathy
Adverse: hemorrhage, blood clots, impaired wound healing
Cross-link tumors in CNS (cross BBB)
Adverse: hepatotoxicity, mucositis, pulmonary fibrosis
Adverse: palmar-plantar erythrodysesthesia (hand-foot syndrome)
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