Science Quiz / Cholesterol

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Can you name the Cholesterol?

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HintAnswer
Apolipoprotein that mediates chylomicron secretion into lymphatics
Degradation of TGs stored in adipocytes
Vitamin used in tx of abetalipoproteinemia?
Degradation of dietary triglycerides in small intestine
Presents with acute pancreatitis
Delivers dietary TGs to peripheral tissues; delivers cholesterol to liver in form of remnants (most depleted of their TGs). Secreted by intestinal epithelial cells
Dyslipidemia with defective ApoE
Apolipoprotein that mediates remnant uptake
Apolipoprotein that is lipoprotein lipase cofactor; catalyzes cleavage
Delivers hepatic TGs to peripheral tissue. Secreted by liver
Acts as repository for apo C & E (needed for chylomicron and VLDL metabolism). Secreted from both liver and intestine
Dyslipidemia with absent or defective LDL receptors
Degradation of TGs circulating in chylomicrons and VLDLs; found on vascular endothelial surface
Presents with creamy layer in supernatant
Dyslipidemia with lipoprotein lipase or apolipoprotein C-II deficiency
HintAnswer
Catalyzes esterification of 2/3 of plasma cholesterol
Taken up by target cells via receptor-mediated endocytosis
Delivers hepatic cholesterol to peripheral tissues. Formed by HL modification of IDL in liver and peripheral tissue
Enzyme that catalyzes Nascent HDL --> Mature HDL
Apolipoprotein that activates LCAT
Formed in degradation of VLDL. Delivers TGs and cholesterol to liver
Mediates transfer of cholesterol esters to other lipoprotein particles
Mediates reverse cholesterol transport from periphery to liver
Apolipoprotein that binds LDL receptor
Degradation of TGs remaining in IDL
Dyslipidemia with hepatic overproduction of VLDL
Presents with accelerated atherosclerosis, tendon xanthomas, corneal arcus
Needed to maintain cell membrane integrity and synthesize bile acids, steroids, and vitamin D
Only apolipoprotein on LDL
Presents with premature atherosclerosis, tuberoeruptive xanthomas, xanthoma striatum palmare

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