Science Quiz / Cholesterol

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Can you name the Cholesterol?

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Degradation of dietary triglycerides in small intestine
Delivers hepatic cholesterol to peripheral tissues. Formed by HL modification of IDL in liver and peripheral tissue
Catalyzes esterification of 2/3 of plasma cholesterol
Degradation of TGs remaining in IDL
Dyslipidemia with defective ApoE
Delivers hepatic TGs to peripheral tissue. Secreted by liver
Degradation of TGs stored in adipocytes
Presents with creamy layer in supernatant
Apolipoprotein that is lipoprotein lipase cofactor; catalyzes cleavage
Dyslipidemia with absent or defective LDL receptors
Mediates transfer of cholesterol esters to other lipoprotein particles
Apolipoprotein that mediates chylomicron secretion into lymphatics
Mediates reverse cholesterol transport from periphery to liver
Apolipoprotein that activates LCAT
Enzyme that catalyzes Nascent HDL --> Mature HDL
HintAnswer
Presents with acute pancreatitis
Taken up by target cells via receptor-mediated endocytosis
Dyslipidemia with lipoprotein lipase or apolipoprotein C-II deficiency
Delivers dietary TGs to peripheral tissues; delivers cholesterol to liver in form of remnants (most depleted of their TGs). Secreted by intestinal epithelial cells
Dyslipidemia with hepatic overproduction of VLDL
Needed to maintain cell membrane integrity and synthesize bile acids, steroids, and vitamin D
Presents with premature atherosclerosis, tuberoeruptive xanthomas, xanthoma striatum palmare
Presents with accelerated atherosclerosis, tendon xanthomas, corneal arcus
Only apolipoprotein on LDL
Apolipoprotein that binds LDL receptor
Formed in degradation of VLDL. Delivers TGs and cholesterol to liver
Apolipoprotein that mediates remnant uptake
Degradation of TGs circulating in chylomicrons and VLDLs; found on vascular endothelial surface
Acts as repository for apo C & E (needed for chylomicron and VLDL metabolism). Secreted from both liver and intestine
Vitamin used in tx of abetalipoproteinemia?

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