Science Quiz / Cholesterol

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Can you name the Cholesterol?

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Mediates transfer of cholesterol esters to other lipoprotein particles
Apolipoprotein that activates LCAT
Delivers hepatic TGs to peripheral tissue. Secreted by liver
Degradation of TGs circulating in chylomicrons and VLDLs; found on vascular endothelial surface
Presents with accelerated atherosclerosis, tendon xanthomas, corneal arcus
Apolipoprotein that binds LDL receptor
Enzyme that catalyzes Nascent HDL --> Mature HDL
Needed to maintain cell membrane integrity and synthesize bile acids, steroids, and vitamin D
Presents with premature atherosclerosis, tuberoeruptive xanthomas, xanthoma striatum palmare
Dyslipidemia with hepatic overproduction of VLDL
Acts as repository for apo C & E (needed for chylomicron and VLDL metabolism). Secreted from both liver and intestine
Catalyzes esterification of 2/3 of plasma cholesterol
Dyslipidemia with absent or defective LDL receptors
Apolipoprotein that is lipoprotein lipase cofactor; catalyzes cleavage
Mediates reverse cholesterol transport from periphery to liver
Only apolipoprotein on LDL
Degradation of dietary triglycerides in small intestine
Apolipoprotein that mediates remnant uptake
Formed in degradation of VLDL. Delivers TGs and cholesterol to liver
Delivers dietary TGs to peripheral tissues; delivers cholesterol to liver in form of remnants (most depleted of their TGs). Secreted by intestinal epithelial cells
Dyslipidemia with defective ApoE
Vitamin used in tx of abetalipoproteinemia?
Delivers hepatic cholesterol to peripheral tissues. Formed by HL modification of IDL in liver and peripheral tissue
Presents with creamy layer in supernatant
Presents with acute pancreatitis
Degradation of TGs stored in adipocytes
Taken up by target cells via receptor-mediated endocytosis
Degradation of TGs remaining in IDL
Apolipoprotein that mediates chylomicron secretion into lymphatics
Dyslipidemia with lipoprotein lipase or apolipoprotein C-II deficiency

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