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Anticancer IV-V (Miscellaneous, Hormone, and Targeted) Stats
Can you name the Anticancer (Miscellaneous, Hormone, and Targeted)?
By
okayiranga
18m
30 Questions
6 Plays
6 Plays
6 Plays
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Avg Score
59%
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Score
0/30
Timer
18:00
0
Plays Today
Hint
Answer
% Correct
Block Mitosis by inhibiting MT polymerization
Vinca alkaloids
83.3%
Drug-
drug interactions with vinca alkyloids can lead to?
Neurotoxicity
83.3%
ER antagonist in breasts, but partial agonist everywhere else
Tamoxifen
83.3%
An iron chelator that treats anthracycline side effects but my also disinhibit tumors
Dexrazoxane
66.7%
Side effects: ROS, Cardiac Toxicity, damage to host TOP2B
Anthracyclines
66.7%
Binds to GC rich DNA using iron
Bleomycin
66.7%
Side effects:ROS, Skin and Lung toxicity
Bleomycin
66.7%
Similar MOA to anthracyclines produces NO2 instead of ROS
Anthracenediones
66.7%
Side effects: Early and delayed onset diarrhea
Irinotecan
66.7%
Camptothecin that acts as reversible AchE inhibitor
Irinotecan
66.7%
Block Mitosis by inhibiting MT depolymerization
Taxanes
66.7%
TKIs are substrates for what clearance enzyme
CYP3A4
66.7%
Blocks HER2/
neu in breast cancer
Trastuzumab
66.7%
B cell suppressor that also stop reacting to vaccines
Rituximab
66.7%
Makes tumors more immunogenic or alters there reactions with other cells by acting on the co-
repressor receptor RAR-
alpha
All-trans retinoic acid
66.7%
Hint
Answer
% Correct
Class of drug that intercalates in DNA chain and blocs Topoisomerase II
Anthracyclines
50%
Topoisomerase II poison
Podophyllotoxins
50%
Topoisomerase I poison
Camptothecins
50%
Irinotecan is induced/
inhibited by what hepatic clearance phase
phase I & II
50%
G1 enzyme that Asparagine which is essential in some tumors but not in humans
L-Asparaginase
50%
Treatment for chronic myelogenous leukemia (CML)
Imatinib
50%
Treatment for Non-
hodgkin lymphoma
Rituximab
50%
'-
nibs'
Tyrosine Kinase inhibitors
50%
An adverse affect brought on by a mechanism of action intended to treat
Off-target effects
50%
What enzyme does Azacitidine and Cecitabine inhibit for 3/
4 replication cycles
DNA methyltransferase
50%
Who will have the most benefit from Tamoxifen and Aromatase Inhibitors
postmenopausal women
50%
What type of agonist is used to treat Prostate cancer but causes an initial LH/
FSH
GnRH
50%
Side effects:Gynecomastia, breast pain
Androgen deprivation therapy
50%
TKI that can cause pleural or pericardial edema
dasatinib
50%
Side effects:GI toxicity & myelosupression
Podophyllotoxins
33.3%
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Last Updated: Feb 16, 2017
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