Science Quiz / Anticancer IV-V (Miscellaneous, Hormone, and Targeted)

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Can you name the Anticancer (Miscellaneous, Hormone, and Targeted)?

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'-nibs'
TKI that can cause pleural or pericardial edema
G1 enzyme that Asparagine which is essential in some tumors but not in humans
Side effects:Gynecomastia, breast pain
Topoisomerase I poison
Block Mitosis by inhibiting MT polymerization
What enzyme does Azacitidine and Cecitabine inhibit for 3/4 replication cycles
Side effects:ROS, Skin and Lung toxicity
An iron chelator that treats anthracycline side effects but my also disinhibit tumors
Makes tumors more immunogenic or alters there reactions with other cells by acting on the co-repressor receptor RAR-alpha
B cell suppressor that also stop reacting to vaccines
TKIs are substrates for what clearance enzyme
Topoisomerase II poison
Side effects: ROS, Cardiac Toxicity, damage to host TOP2B
Treatment for Non-hodgkin lymphoma
HintAnswer
Blocks HER2/neu in breast cancer
Block Mitosis by inhibiting MT depolymerization
Side effects:GI toxicity & myelosupression
An adverse affect brought on by a mechanism of action intended to treat
Drug-drug interactions with vinca alkyloids can lead to?
Side effects: Early and delayed onset diarrhea
What type of agonist is used to treat Prostate cancer but causes an initial LH/FSH
Treatment for chronic myelogenous leukemia (CML)
Camptothecin that acts as reversible AchE inhibitor
Class of drug that intercalates in DNA chain and blocs Topoisomerase II
ER antagonist in breasts, but partial agonist everywhere else
Binds to GC rich DNA using iron
Irinotecan is induced/inhibited by what hepatic clearance phase
Similar MOA to anthracyclines produces NO2 instead of ROS
Who will have the most benefit from Tamoxifen and Aromatase Inhibitors

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Created Nov 19, 2016ReportNominate
Tags:hormone, Targeted

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