Anticancer IV-V (Miscellaneous, Hormone, and Targeted)

Can you name the Anticancer (Miscellaneous, Hormone, and Targeted)?

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ER antagonist in breasts, but partial agonist everywhere else
Drug-drug interactions with vinca alkyloids can lead to?
Topoisomerase I poison
Side effects: Early and delayed onset diarrhea
Blocks HER2/neu in breast cancer
Class of drug that intercalates in DNA chain and blocs Topoisomerase II
What enzyme does Azacitidine and Cecitabine inhibit for 3/4 replication cycles
Side effects:Gynecomastia, breast pain
Irinotecan is induced/inhibited by what hepatic clearance phase
Camptothecin that acts as reversible AchE inhibitor
Makes tumors more immunogenic or alters there reactions with other cells by acting on the co-repressor receptor RAR-alpha
Who will have the most benefit from Tamoxifen and Aromatase Inhibitors
Block Mitosis by inhibiting MT polymerization
Block Mitosis by inhibiting MT depolymerization
TKIs are substrates for what clearance enzyme
HintAnswer
'-nibs'
G1 enzyme that Asparagine which is essential in some tumors but not in humans
Side effects:GI toxicity & myelosupression
Side effects: ROS, Cardiac Toxicity, damage to host TOP2B
Treatment for Non-hodgkin lymphoma
Binds to GC rich DNA using iron
An adverse affect brought on by a mechanism of action intended to treat
Treatment for chronic myelogenous leukemia (CML)
What type of agonist is used to treat Prostate cancer but causes an initial LH/FSH
Similar MOA to anthracyclines produces NO2 instead of ROS
Topoisomerase II poison
B cell suppressor that also stop reacting to vaccines
An iron chelator that treats anthracycline side effects but my also disinhibit tumors
TKI that can cause pleural or pericardial edema
Side effects:ROS, Skin and Lung toxicity

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