Science Quiz / Anticancer I-III (Antimetabolites & Alkylating agents)

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Can you name the Anticancer?

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What antimetabolite inhibits ribonucleotide reductase to treat sickle cell anemia
What type of genetic polymorphism also leads to an overproduction of 6-MP?
At what phase to antimetabolites stop the cell cycle
What class of alkylating agent methylates DNA?
MAOI disinhibits teramines
At what phase do alkylating agents stop cancer
It's efficacy is improved by folinic acid
Unique side effect of MTX
What type of alkylating agent depurinates cancer cells by adduct formation
Prodrug mustards that yield acroleins, a bladder toxin?
Is a prodrug for 5-fluorouracil
At what phase does L-Asparaginase work?
6-MP & 6-thioguanine (purine antagonists) block what enzyme for purine recycling
Blocks thymidylate synthase
At what phase do Vinca alkaloids, Podophyllotoxins '-posides', anthracyclines '-rubicins'
Are Cytarabine and 5-FU dose dependent or schedule dependent?
Inhibits proteosome to treat myeloma
Cytarabine and Gemcitabine block what enzyme?
Activates p53 to treat colon cancer
Blocks dihydrofolate reductase
Which is the more liphophilic of these triazenes darbazine or temozolamide
Standard treatment for MTX
Chloracetaldehyde, a neurotoxin, is a byproduct of ifosamide is treated by what
Hydration and what drug PREVENT acrolein build up?
What drugs activate organic isocyanates to maintain DNA repair and avoid brain cancer (lipophilic)
A mutant drug derived from alkylating agents and antimetabolites
What kind of complexes do Cisplatin, Carbopatin, and Oxaliplatin make when attached to DNA
Side effects: Neutropenia,thrombocytopenia, anemia, alopecia, GI and gonad disruption
What drug blocks Xanthine Oxidase and can induce bone marrow suppresion via 6-MP toxicicty
What structure stabalizes mustards

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Created Nov 19, 2016ReportNominate

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