Science Quiz / Anticancer I-III (Antimetabolites & Alkylating agents)

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Can you name the Anticancer?

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HintAnswer
Unique side effect of MTX
Side effects: Neutropenia,thrombocytopenia, anemia, alopecia, GI and gonad disruption
Activates p53 to treat colon cancer
What type of alkylating agent depurinates cancer cells by adduct formation
At what phase to antimetabolites stop the cell cycle
It's efficacy is improved by folinic acid
A mutant drug derived from alkylating agents and antimetabolites
6-MP & 6-thioguanine (purine antagonists) block what enzyme for purine recycling
What drugs activate organic isocyanates to maintain DNA repair and avoid brain cancer (lipophilic)
What drug blocks Xanthine Oxidase and can induce bone marrow suppresion via 6-MP toxicicty
What antimetabolite inhibits ribonucleotide reductase to treat sickle cell anemia
Hydration and what drug PREVENT acrolein build up?
At what phase do Vinca alkaloids, Podophyllotoxins '-posides', anthracyclines '-rubicins'
Are Cytarabine and 5-FU dose dependent or schedule dependent?
Inhibits proteosome to treat myeloma
HintAnswer
What kind of complexes do Cisplatin, Carbopatin, and Oxaliplatin make when attached to DNA
Chloracetaldehyde, a neurotoxin, is a byproduct of ifosamide is treated by what
What type of genetic polymorphism also leads to an overproduction of 6-MP?
MAOI disinhibits teramines
At what phase does L-Asparaginase work?
Cytarabine and Gemcitabine block what enzyme?
Blocks thymidylate synthase
Standard treatment for MTX
At what phase do alkylating agents stop cancer
Which is the more liphophilic of these triazenes darbazine or temozolamide
Is a prodrug for 5-fluorouracil
What class of alkylating agent methylates DNA?
Blocks dihydrofolate reductase
Prodrug mustards that yield acroleins, a bladder toxin?
What structure stabalizes mustards

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Created Nov 19, 2016ReportNominate
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