Anticancer I-III (Antimetabolites & Alkylating agents)

Can you name the Anticancer?

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HintAnswer
Activates p53 to treat colon cancer
What type of genetic polymorphism also leads to an overproduction of 6-MP?
Is a prodrug for 5-fluorouracil
Side effects: Neutropenia,thrombocytopenia, anemia, alopecia, GI and gonad disruption
Hydration and what drug PREVENT acrolein build up?
6-MP & 6-thioguanine (purine antagonists) block what enzyme for purine recycling
What kind of complexes do Cisplatin, Carbopatin, and Oxaliplatin make when attached to DNA
At what phase do Vinca alkaloids, Podophyllotoxins '-posides', anthracyclines '-rubicins'
Inhibits proteosome to treat myeloma
A mutant drug derived from alkylating agents and antimetabolites
What drug blocks Xanthine Oxidase and can induce bone marrow suppresion via 6-MP toxicicty
What class of alkylating agent methylates DNA?
What antimetabolite inhibits ribonucleotide reductase to treat sickle cell anemia
At what phase do alkylating agents stop cancer
Prodrug mustards that yield acroleins, a bladder toxin?
HintAnswer
MAOI disinhibits teramines
Cytarabine and Gemcitabine block what enzyme?
At what phase does L-Asparaginase work?
Which is the more liphophilic of these triazenes darbazine or temozolamide
Blocks dihydrofolate reductase
Are Cytarabine and 5-FU dose dependent or schedule dependent?
Unique side effect of MTX
Blocks thymidylate synthase
Standard treatment for MTX
It's efficacy is improved by folinic acid
What structure stabalizes mustards
Chloracetaldehyde, a neurotoxin, is a byproduct of ifosamide is treated by what
What type of alkylating agent depurinates cancer cells by adduct formation
What drugs activate organic isocyanates to maintain DNA repair and avoid brain cancer (lipophilic)
At what phase to antimetabolites stop the cell cycle

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