Science Quiz / Anticancer I-III (Antimetabolites & Alkylating agents)

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Can you name the Anticancer?

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HintAnswer
Hydration and what drug PREVENT acrolein build up?
Which is the more liphophilic of these triazenes darbazine or temozolamide
What type of genetic polymorphism also leads to an overproduction of 6-MP?
Is a prodrug for 5-fluorouracil
At what phase do alkylating agents stop cancer
What drug blocks Xanthine Oxidase and can induce bone marrow suppresion via 6-MP toxicicty
Blocks dihydrofolate reductase
At what phase do Vinca alkaloids, Podophyllotoxins '-posides', anthracyclines '-rubicins'
What antimetabolite inhibits ribonucleotide reductase to treat sickle cell anemia
Cytarabine and Gemcitabine block what enzyme?
Activates p53 to treat colon cancer
Prodrug mustards that yield acroleins, a bladder toxin?
Standard treatment for MTX
Are Cytarabine and 5-FU dose dependent or schedule dependent?
At what phase does L-Asparaginase work?
HintAnswer
Inhibits proteosome to treat myeloma
What type of alkylating agent depurinates cancer cells by adduct formation
MAOI disinhibits teramines
Blocks thymidylate synthase
A mutant drug derived from alkylating agents and antimetabolites
What kind of complexes do Cisplatin, Carbopatin, and Oxaliplatin make when attached to DNA
Chloracetaldehyde, a neurotoxin, is a byproduct of ifosamide is treated by what
What structure stabalizes mustards
What drugs activate organic isocyanates to maintain DNA repair and avoid brain cancer (lipophilic)
Side effects: Neutropenia,thrombocytopenia, anemia, alopecia, GI and gonad disruption
What class of alkylating agent methylates DNA?
6-MP & 6-thioguanine (purine antagonists) block what enzyme for purine recycling
At what phase to antimetabolites stop the cell cycle
It's efficacy is improved by folinic acid
Unique side effect of MTX

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