Science Quiz / Anticancer I-III (Antimetabolites & Alkylating agents)

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Can you name the Anticancer?

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What kind of complexes do Cisplatin, Carbopatin, and Oxaliplatin make when attached to DNA
Cytarabine and Gemcitabine block what enzyme?
Prodrug mustards that yield acroleins, a bladder toxin?
What class of alkylating agent methylates DNA?
A mutant drug derived from alkylating agents and antimetabolites
Chloracetaldehyde, a neurotoxin, is a byproduct of ifosamide is treated by what
Inhibits proteosome to treat myeloma
What type of alkylating agent depurinates cancer cells by adduct formation
Side effects: Neutropenia,thrombocytopenia, anemia, alopecia, GI and gonad disruption
Activates p53 to treat colon cancer
Are Cytarabine and 5-FU dose dependent or schedule dependent?
6-MP & 6-thioguanine (purine antagonists) block what enzyme for purine recycling
Standard treatment for MTX
Blocks dihydrofolate reductase
What type of genetic polymorphism also leads to an overproduction of 6-MP?
HintAnswer
What antimetabolite inhibits ribonucleotide reductase to treat sickle cell anemia
What drugs activate organic isocyanates to maintain DNA repair and avoid brain cancer (lipophilic)
It's efficacy is improved by folinic acid
At what phase does L-Asparaginase work?
At what phase do Vinca alkaloids, Podophyllotoxins '-posides', anthracyclines '-rubicins'
Which is the more liphophilic of these triazenes darbazine or temozolamide
Is a prodrug for 5-fluorouracil
At what phase do alkylating agents stop cancer
MAOI disinhibits teramines
At what phase to antimetabolites stop the cell cycle
What drug blocks Xanthine Oxidase and can induce bone marrow suppresion via 6-MP toxicicty
Unique side effect of MTX
What structure stabalizes mustards
Blocks thymidylate synthase
Hydration and what drug PREVENT acrolein build up?

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Created Nov 19, 2016ReportFavoriteNominate
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