Hint | Answer |
Inhibit DNA synthesis/maintenance (bacteria) | |
Side effects: Arthralgia, myalgia, hyberbilluribinemia, thrombocytopenia | |
Interferes with cell wall and protein synthesis only locally (UTI) | |
Side effects: N/V/D, abdominal pain, cholestatic hepatitis, prolonged QT interval, maculopapular rash | |
Nalidixic Acid | |
Tetracycline | |
Reversible 30S inhibitor and tRNA binding inhibitor/ oral administration | |
Side effects: N/V/D, photosensitivity, teeth and bone issues, liver toxicity | |
Side effects:Thrombocytopenia, Neutropenia, 5HT syndrome | |
Nitro group that disrupts Nucleic Acid synth., disulfaram Rx, DOC for C. difficile | |
Side effects: Orange body fluid (gatorade), rash, thrombocytopenia, nephritis, jaundice | |
Influx/efflux active transport pump mutation | |
Tobramycin | |
Irreversible 30S inhibitor of gram(-) aerobics/ Topical and Intravenous administration | |
Cinoxacin | |
Demeclocycline | |
Chelates with Calcium (dairy products) to cause Bone and Teeth malformation | |
Ciprofloxacin | |
Amikacin | |
| Hint | Answer |
Side effects: N/V/D, fever, rash, itching, B9 deficiency, prehepatic jaundice => kernicterus | |
Minocycline | |
Side effects: NMJ blockade, Ototoxicity, Pregnancy concerns, and nephrotoxicity | |
Side effects:Photosensitivity, Tendon rupture, QT prolongation, Cartilage growth damage, avoid during pregnancy, headache, dizziness | |
Binds to beta subunit of bacterial RNAP, all cocci, enterica | |
Side effects: Don't use w/ severe renal insufficiency, N/V, neuropathy and hemolytic anemia for G6PDD | |
Tetracycline for resistant strains but inadequate for blood infections | |
Norfloxacin | |
Gentamycin | |
Ribosome binding site mutation | |
Bactericidal macrolide that is reserved for C. difficile | |
Used for gram + resistant strains, prevents peptide chain elongation inhibits cyp450 | |
Doxycycline | |
Linezolid | |
Clindamycin | |
Erythromycin | |
The aminoglycoside that can be used during pregnancy | |
Used for gram + resistant strains, prevents peptide chain formation, inhibits Cyp450 | |
Reversible 50s inhibitors that attack atypical bacteria and poor CNS enterance | |
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