Science Quiz / Immunology Vocabulary

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Can you name the terms that match the following immunological definitions?

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DefinitionTerm
A lymphoepithelial organ in the upper part of the middle of the chest; site of T cell development
Process occuring in the thymus during T cell development that selects immature T cells with receptors recognizing peptide antigens presented by self MHC molecules
Rejection of organ grafts that occurs years after transplantation and is characterized by degeneration and occlusion of the blood vessels in the graft, caused by an antibody respon
Phagocytic, granulocytic white blood cell that enters infected tissues in large numbers and engulfs and kills extracellular pathogens
Diseases caused by abnormal and invasive cell proliferation
Mature T cell that has left the thymus but not yet encountered its specific antigen
Thick yellow-white fluid formed in infected wounds; composed mainly of dead and dying leukocytes, dead microorganisms, and tissue debris
Cell-surface glycoprotein that distinguishes a subset of T cells that recognize antigens presented by MHC class I
Common inflammatory disease of the joints that is due to an autoimmune response
Mechanism of cell death in which the cells to be killed are induced to degrade themselves tidily from within
The toxic effects of infection of the bloodstream
Immunity to a given pathogen that has been acquired by injection of preformed antibodies, antiserum, or T cells
Hypothesis advanced to explain the increasing incidence over the past 50 years of hypersensitivity and autoimmune diseases in developed countries; basically, we're too clean for ou
Cellular internalization of particulate matter, such as bacteria, by means of endocytosis
The class of immunoglobulin involved in allergic reactions
polypeptide that associates with MHC class II molecules in the endoplasmic reticulum to prevent them from binding peptides there
Inflammatory hypersensitivity disease of the gut mucosa caused by an immune response to the gluten proteins present in some cereals
The increase in addinty of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response
Rejection of an allogeneic tissue gradt as a result of preformed antibodies that react against ABO blood group antigens or HLA class I antigens on the gradt
Component of the surface of Gram-negative bacteria that activates Toll receptors on macrophages and other leukocytes as part of the innate immune response
Any molecule or molecular fragment that can be bound by an MHC molecule and presented to a T cell receptor
Professional antigen-presenting cells with a branched morphology; the most potent stimulators of T cell responses
The larger of the two types of polypeptide in an immunoglobulin molecule, consisting of one variable domain and a number of constant domains
tissue graft made between genetically non-identical members of the same species
DefinitionTerm
Adaptive immunity specific for an antigenic component of the individual's body
The mechanism by which B cells can change the heavy-chain isotype of the immunoglobulin they make
Large granular cytotoxic lymphocyte that is important to innate immunity against intracellular pathogens
Molecules that induce fever, including some cytokines and bacterial products
One of the two main classes of lymphocytes; dedicated to the production of immunoglobulins and antibodies
Large mononuclear phagocytic cell resident in most tissues; derived from blood monocytes; serves as antigen-presenting cells
Metabolic change accompanied by a transient increase in oxygen consumption that occurs in phagocytes that have taken up opsonized particles; generates toxic oxygen species
The intracellular degradation of proteins into peptides that bind to MHC molecules for presentation to T cells
Any adaptive immune response in which antigen-specific T cells dominate
Organism, most commonly a microorganism, that can cause disease
One of the two main classes of lymphocyte; develop in the thymus; responsible for cell-mediated immunity
The coating of the surface of a pathogen or other particular with any molecule that makes it more readily ingested by phagocytes
Cell-surface glycoprotein that distinguishes a subset of T cells that recognize antigens presented by MHC class II
Large multisubunit protease present in the cytosol of all cells that degrades cytoplasmic proteins, thus produced peptides presented by MHC class I
Process in the thymus whereby developing T cells that recognize self antigens are induced to die by apoptosis
The host defense mechanisms that act from the start of an infection and do not adapt to a particular pathogen
Substances used in experimental immunology and in vaccines to enhance the adaptive immune response to an antigen
Rejection of transplanted cells, tissues, or organs due to a T cell response stimulated by the transplant
State of hypersensitivity to a normally innocuous environmental antigen
Proteins made by cells that affect the behavior of other cells; subsets produced by lymphocytes include lymphokines and interleukins
Mature B cell that has left the bone marrow but has not yet encountered its specific antigen
Area in secondary lymphoid tissue that is a site of intense B cell proliferation, selection, maturation, and death
Immunity that is mediated by antibodies
A process in self-reactive developing B cells, whereby further light chain rearrangement occurs to replace the self-reactive light chain
DefinitionTerm
The tissues, cells, and molecules involved in the defense of the body against infectious diseases
Large group of small proteins involved in guiding white blood cells to sites where they are needed
The smaller of the two types of polypeptide chain in an immunoglobulin molecule, consisting of one variable domain and one constant domain; comes in two classes: lambda and kappa
Bacterial invasion of the blood
Cytokines that help cells resist viral infections
Disease caused by infection with human immunodeficiency virus, involving a gradual destruction of CD4 T cells and increased susceptibility to infection
The portion of an antigenic molecule that is bound by an antibody or gives rise to the MHC-binding peptide that is recognized by a T cell receptor
The class of immunoglobulin that is most abundant in plasma
Set of plasma proteins, many of which are serine proteases, that act in a cascade of reactions to attack extracellular forms of pathogens
The complex of terminal complement components that forms a pore in the membrane of the target cell
Terminally differentiated B cell that secretes antibody
State of nonresponsiveness to an antigen; one mechanism of tolerance, whereby B and T cells no longer respond to their specific antigens
Mutation that occurs at high frequency in the rearranged variable-region DNA of immunoglobulin genes in activated B cells, resulting in the production of variant antibodies, some o
Ther response of antigen-specific B and T lymphocytes to antigen, including the development of immunological memory
The class of immunoglobulin that is present as a dimer in mucosal secretions but as a monomer in the blood
The immunoglobulin whose function is still poorly understood
Process whereby antigen of extracellular origin can be presented by MHC class I
The secreted form of an immunoglobulin made by a B cell
The grafting of organs or tissues from one organisms to another
The elimination of immature lymphocytes that bind to self antigens
The first class of immunglobulin to be secreted in an immune response; secreted as a pentamer
Specialized type of intestinal cell through which antigens and pathogens enter gut-associated lymphoid tissue from the intestines
Molecules that stimulate polyclonal T cell activation by binding nonspecifically to MHC class II molecules

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