Science Quiz / Pharm CNS

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Can you name the Pharm CNS

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besides sz's, gabapentin and carbamazepine treat what
class of abortive drugs for migraines
period prior to development of epilepsy where changes can be picked up on EEG
stimulate hypothalamic gray matter to treat what headache
side effects include aplastic anemia and severe hepatitis
first line drug for generalized seizures
add-on for regractory partial/generalize sx's, Lennon-Gastaut as well; can lessen effectiveness of BCP
only AED which known actions on K channels
most common lobe involved in partial seizure
rectal administration what benzo drug
what type of migraine increases chance of stroke
most AEDs are metabolized in
lamotrigine is metabolized by
1st line of seizure medication in children
blocks use dependant sodium channels (P,C)
PR, subQ, and nasal spray triptan
what drug increases phenytoin and valproate levels but decreases carbamazapine levels
alcohol, barbs, and benzos use what receptor
increase GABA, block Na channels, augments K/Ca channels
GABA analog that closes Ca channels, and increases GABA in cleft
FHM2 related to gene __ and affects ___ pump
1st line of tx for status epilepticus
AED contraindicated in pregnancy due to causing neural tube defects
seizure commonly seen in kids that last less than a minute and patients are unaware of incident
phenytoin, carbamazapine, pimidone, and PB are metabolized and stimulate the production of
gabapentin is used to treat sz's and
seizure with focal abnormal discharge and normal consciousness
AED that blocks sodium channels, increases freq of GABA Cl- channels, deal with AMPA/kainate
blocks Na channels, interferes with glutamate release, inhibits Ca channels
1st line drugs for partial seizures
side effects include agranulocytosis and aplastic anemia or transient leukopenia
what AED loses its effect in 6 months
what part of brain can atrophy with epilepsy
what drug is converted to PB or PEMA in the body
SSADH is inhibited with
migraine headache needs 2 of what symptoms
most common type of epilepsy
blocks GABA reuptake
AED that blocks Na channels adn modulates NMDA receptors
side effects include EFGH
if abscence sz in kid becomes tonic/clonic, give what
what AED binds to synaptic vesicle protein SV2A, regulated NT release
side effects include GI distress but fewer CNS effects (absences sz's)
partial onset sz with secondary generalization: use carb or phenytoin, then? (v,p,p)
headaches cause what lesions
absence seizures are caused by oscillations between __ and cortex
lamotrigine and carbamazepine can also be used for
migraine needs to last how long for diagnosis
drug similar to carbamasepine that is less toxic
1st line drug for trigeminal neuralgia
percent of patients that can become seizure free with therapy
monotherapy for infantile spasms; can cause opthalmologic problems
ionotropic channel for glutamate that is both ligand gated and voltage gated
what drug blocks Na channels and also affects K channels
FHM3 related to gene ___ and affects __ channel
percent of patients with refractive seizures
short acting treatment of status epilepticus
blocks Na channels and T-type Ca channels
recent AED used for refractory partial sz's, Lennox syndrome, new epilepsy, generalized seizure
what AED inhibits P450
what drug stimulates GAD
what 2 drugs can exacerbate absence and myoclonic sz's
best triptan
side effects include hirsutism, SJS, gum hyperplasia, drug induced lupus
GABA-B is a presynaptic autoreceptor that open up what channels
most common cause of epilepsy
MRM occurs when what hormone levels are high
seizure with local onset causing impaired consciousness
FHM1 related to gene ___ and affects __ channels
what drugs prolongs GABA-A chloride channel openings
AED with long half life with tolerance and physical dependence possible
pediatric condition with recurrent seizures of various types and severity, accompanied with developmental delay
50% of patients with head trauma will develop a
glutamate ionotropic receptor that opens up calcium channels
AED with saturable absorption, short half life, and renal excretion that is effective along in newly diagnosed sz's
longer acting tx of status epilepticus
side effect of lamotrigine
valproate inhibits GABA-T which converts __ to __, which eventually forms ___
what irreversibly blocks GABA-T and increases GABA levels
what drug class increases frequency of GABA-A chloride channels
seizure with 3Hz spikes
side effects of this AED include CNS depression, anorexia, n/v, hair loss, elevated LFTs
postsynaptic GABA receptor is linked to what channel
GAD converts __ to __
fast-melt triptans
what drug blocks transient Ca currents

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