Science Quiz / Pharm CNS

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Can you name the Pharm CNS

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what part of brain can atrophy with epilepsy
side effects include EFGH
blocks Na channels and T-type Ca channels
postsynaptic GABA receptor is linked to what channel
what drug is converted to PB or PEMA in the body
seizure with 3Hz spikes
most common type of epilepsy
blocks use dependant sodium channels (P,C)
seizure with local onset causing impaired consciousness
side effects include aplastic anemia and severe hepatitis
increase GABA, block Na channels, augments K/Ca channels
phenytoin, carbamazapine, pimidone, and PB are metabolized and stimulate the production of
class of abortive drugs for migraines
side effects include hirsutism, SJS, gum hyperplasia, drug induced lupus
first line drug for generalized seizures
most common cause of epilepsy
GAD converts __ to __
1st line of seizure medication in children
blocks GABA reuptake
lamotrigine and carbamazepine can also be used for
FHM1 related to gene ___ and affects __ channels
AED contraindicated in pregnancy due to causing neural tube defects
FHM3 related to gene ___ and affects __ channel
recent AED used for refractory partial sz's, Lennox syndrome, new epilepsy, generalized seizure
AED that blocks sodium channels, increases freq of GABA Cl- channels, deal with AMPA/kainate
GABA-B is a presynaptic autoreceptor that open up what channels
only AED which known actions on K channels
best triptan
what AED inhibits P450
migraine headache needs 2 of what symptoms
what drugs prolongs GABA-A chloride channel openings
rectal administration what benzo drug
GABA analog that closes Ca channels, and increases GABA in cleft
what irreversibly blocks GABA-T and increases GABA levels
drug similar to carbamasepine that is less toxic
percent of patients that can become seizure free with therapy
valproate inhibits GABA-T which converts __ to __, which eventually forms ___
fast-melt triptans
percent of patients with refractive seizures
SSADH is inhibited with
what AED loses its effect in 6 months
what drug stimulates GAD
short acting treatment of status epilepticus
absence seizures are caused by oscillations between __ and cortex
AED with saturable absorption, short half life, and renal excretion that is effective along in newly diagnosed sz's
alcohol, barbs, and benzos use what receptor
blocks Na channels, interferes with glutamate release, inhibits Ca channels
what drug class increases frequency of GABA-A chloride channels
longer acting tx of status epilepticus
PR, subQ, and nasal spray triptan
1st line of tx for status epilepticus
what 2 drugs can exacerbate absence and myoclonic sz's
what AED binds to synaptic vesicle protein SV2A, regulated NT release
FHM2 related to gene __ and affects ___ pump
side effects of this AED include CNS depression, anorexia, n/v, hair loss, elevated LFTs
what type of migraine increases chance of stroke
besides sz's, gabapentin and carbamazepine treat what
AED with long half life with tolerance and physical dependence possible
MRM occurs when what hormone levels are high
monotherapy for infantile spasms; can cause opthalmologic problems
what drug blocks transient Ca currents
glutamate ionotropic receptor that opens up calcium channels
stimulate hypothalamic gray matter to treat what headache
partial onset sz with secondary generalization: use carb or phenytoin, then? (v,p,p)
side effects include GI distress but fewer CNS effects (absences sz's)
ionotropic channel for glutamate that is both ligand gated and voltage gated
period prior to development of epilepsy where changes can be picked up on EEG
lamotrigine is metabolized by
seizure commonly seen in kids that last less than a minute and patients are unaware of incident
gabapentin is used to treat sz's and
1st line drug for trigeminal neuralgia
side effect of lamotrigine
if abscence sz in kid becomes tonic/clonic, give what
what drug blocks Na channels and also affects K channels
most AEDs are metabolized in
pediatric condition with recurrent seizures of various types and severity, accompanied with developmental delay
most common lobe involved in partial seizure
AED that blocks Na channels adn modulates NMDA receptors
add-on for regractory partial/generalize sx's, Lennon-Gastaut as well; can lessen effectiveness of BCP
what drug increases phenytoin and valproate levels but decreases carbamazapine levels
1st line drugs for partial seizures
migraine needs to last how long for diagnosis
headaches cause what lesions
50% of patients with head trauma will develop a
side effects include agranulocytosis and aplastic anemia or transient leukopenia
seizure with focal abnormal discharge and normal consciousness

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Created Sep 17, 2013ReportNominate

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