Science Quiz / Pharm CNS

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Can you name the Pharm CNS

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HintAnswer
percent of patients with refractive seizures
FHM2 related to gene __ and affects ___ pump
longer acting tx of status epilepticus
blocks Na channels, interferes with glutamate release, inhibits Ca channels
postsynaptic GABA receptor is linked to what channel
what part of brain can atrophy with epilepsy
what 2 drugs can exacerbate absence and myoclonic sz's
add-on for regractory partial/generalize sx's, Lennon-Gastaut as well; can lessen effectiveness of BCP
pediatric condition with recurrent seizures of various types and severity, accompanied with developmental delay
PR, subQ, and nasal spray triptan
gabapentin is used to treat sz's and
1st line of seizure medication in children
side effects include EFGH
what AED loses its effect in 6 months
monotherapy for infantile spasms; can cause opthalmologic problems
GABA analog that closes Ca channels, and increases GABA in cleft
seizure with focal abnormal discharge and normal consciousness
most common type of epilepsy
what drugs prolongs GABA-A chloride channel openings
phenytoin, carbamazapine, pimidone, and PB are metabolized and stimulate the production of
only AED which known actions on K channels
AED that blocks Na channels adn modulates NMDA receptors
fast-melt triptans
50% of patients with head trauma will develop a
side effects include aplastic anemia and severe hepatitis
most AEDs are metabolized in
what drug blocks Na channels and also affects K channels
AED with saturable absorption, short half life, and renal excretion that is effective along in newly diagnosed sz's
ionotropic channel for glutamate that is both ligand gated and voltage gated
HintAnswer
side effects include GI distress but fewer CNS effects (absences sz's)
if abscence sz in kid becomes tonic/clonic, give what
GAD converts __ to __
what irreversibly blocks GABA-T and increases GABA levels
FHM3 related to gene ___ and affects __ channel
what AED inhibits P450
rectal administration what benzo drug
most common cause of epilepsy
side effects of this AED include CNS depression, anorexia, n/v, hair loss, elevated LFTs
what drug blocks transient Ca currents
stimulate hypothalamic gray matter to treat what headache
GABA-B is a presynaptic autoreceptor that open up what channels
glutamate ionotropic receptor that opens up calcium channels
1st line drug for trigeminal neuralgia
what drug class increases frequency of GABA-A chloride channels
AED with long half life with tolerance and physical dependence possible
lamotrigine and carbamazepine can also be used for
migraine needs to last how long for diagnosis
AED contraindicated in pregnancy due to causing neural tube defects
best triptan
lamotrigine is metabolized by
blocks Na channels and T-type Ca channels
first line drug for generalized seizures
FHM1 related to gene ___ and affects __ channels
side effects include agranulocytosis and aplastic anemia or transient leukopenia
blocks GABA reuptake
valproate inhibits GABA-T which converts __ to __, which eventually forms ___
AED that blocks sodium channels, increases freq of GABA Cl- channels, deal with AMPA/kainate
partial onset sz with secondary generalization: use carb or phenytoin, then? (v,p,p)
HintAnswer
increase GABA, block Na channels, augments K/Ca channels
side effects include hirsutism, SJS, gum hyperplasia, drug induced lupus
most common lobe involved in partial seizure
absence seizures are caused by oscillations between __ and cortex
what type of migraine increases chance of stroke
what drug stimulates GAD
1st line of tx for status epilepticus
migraine headache needs 2 of what symptoms
drug similar to carbamasepine that is less toxic
percent of patients that can become seizure free with therapy
seizure commonly seen in kids that last less than a minute and patients are unaware of incident
what drug is converted to PB or PEMA in the body
what drug increases phenytoin and valproate levels but decreases carbamazapine levels
MRM occurs when what hormone levels are high
1st line drugs for partial seizures
seizure with local onset causing impaired consciousness
alcohol, barbs, and benzos use what receptor
side effect of lamotrigine
short acting treatment of status epilepticus
what AED binds to synaptic vesicle protein SV2A, regulated NT release
period prior to development of epilepsy where changes can be picked up on EEG
blocks use dependant sodium channels (P,C)
besides sz's, gabapentin and carbamazepine treat what
SSADH is inhibited with
class of abortive drugs for migraines
headaches cause what lesions
recent AED used for refractory partial sz's, Lennox syndrome, new epilepsy, generalized seizure
seizure with 3Hz spikes

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