Science Quiz / Pharm CNS

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Can you name the Pharm CNS

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pediatric condition with recurrent seizures of various types and severity, accompanied with developmental delay
what drug class increases frequency of GABA-A chloride channels
AED that blocks Na channels adn modulates NMDA receptors
what drug blocks Na channels and also affects K channels
what AED binds to synaptic vesicle protein SV2A, regulated NT release
longer acting tx of status epilepticus
AED that blocks sodium channels, increases freq of GABA Cl- channels, deal with AMPA/kainate
FHM1 related to gene ___ and affects __ channels
seizure with 3Hz spikes
side effects include aplastic anemia and severe hepatitis
percent of patients that can become seizure free with therapy
glutamate ionotropic receptor that opens up calcium channels
absence seizures are caused by oscillations between __ and cortex
AED with saturable absorption, short half life, and renal excretion that is effective along in newly diagnosed sz's
headaches cause what lesions
1st line of tx for status epilepticus
lamotrigine is metabolized by
blocks Na channels and T-type Ca channels
stimulate hypothalamic gray matter to treat what headache
lamotrigine and carbamazepine can also be used for
besides sz's, gabapentin and carbamazepine treat what
most common lobe involved in partial seizure
fast-melt triptans
seizure with focal abnormal discharge and normal consciousness
what drugs prolongs GABA-A chloride channel openings
1st line drugs for partial seizures
what type of migraine increases chance of stroke
seizure commonly seen in kids that last less than a minute and patients are unaware of incident
AED with long half life with tolerance and physical dependence possible
recent AED used for refractory partial sz's, Lennox syndrome, new epilepsy, generalized seizure
GABA analog that closes Ca channels, and increases GABA in cleft
most common cause of epilepsy
percent of patients with refractive seizures
side effects include hirsutism, SJS, gum hyperplasia, drug induced lupus
most common type of epilepsy
side effects include GI distress but fewer CNS effects (absences sz's)
add-on for regractory partial/generalize sx's, Lennon-Gastaut as well; can lessen effectiveness of BCP
alcohol, barbs, and benzos use what receptor
rectal administration what benzo drug
gabapentin is used to treat sz's and
blocks Na channels, interferes with glutamate release, inhibits Ca channels
what drug blocks transient Ca currents
best triptan
50% of patients with head trauma will develop a
monotherapy for infantile spasms; can cause opthalmologic problems
most AEDs are metabolized in
blocks GABA reuptake
SSADH is inhibited with
side effect of lamotrigine
if abscence sz in kid becomes tonic/clonic, give what
partial onset sz with secondary generalization: use carb or phenytoin, then? (v,p,p)
only AED which known actions on K channels
short acting treatment of status epilepticus
GAD converts __ to __
what drug is converted to PB or PEMA in the body
blocks use dependant sodium channels (P,C)
1st line of seizure medication in children
class of abortive drugs for migraines
GABA-B is a presynaptic autoreceptor that open up what channels
first line drug for generalized seizures
drug similar to carbamasepine that is less toxic
what drug increases phenytoin and valproate levels but decreases carbamazapine levels
migraine needs to last how long for diagnosis
ionotropic channel for glutamate that is both ligand gated and voltage gated
migraine headache needs 2 of what symptoms
FHM3 related to gene ___ and affects __ channel
valproate inhibits GABA-T which converts __ to __, which eventually forms ___
phenytoin, carbamazapine, pimidone, and PB are metabolized and stimulate the production of
seizure with local onset causing impaired consciousness
side effects include EFGH
MRM occurs when what hormone levels are high
what part of brain can atrophy with epilepsy
side effects include agranulocytosis and aplastic anemia or transient leukopenia
what AED loses its effect in 6 months
AED contraindicated in pregnancy due to causing neural tube defects
increase GABA, block Na channels, augments K/Ca channels
what irreversibly blocks GABA-T and increases GABA levels
1st line drug for trigeminal neuralgia
what drug stimulates GAD
FHM2 related to gene __ and affects ___ pump
side effects of this AED include CNS depression, anorexia, n/v, hair loss, elevated LFTs
what 2 drugs can exacerbate absence and myoclonic sz's
period prior to development of epilepsy where changes can be picked up on EEG
what AED inhibits P450
PR, subQ, and nasal spray triptan
postsynaptic GABA receptor is linked to what channel

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