Science Quiz / Pharmocology Adrenergics and Cholinergics

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Can you name the Pharm Drugs Fundamentals Exam 2?

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DescriptionDrug (Generic)Uses
Adrenergic Antagonistscompetitive antagonists of both β1 and β2 receptors, decreases HR, contractility, and peripheral vascular resistance
Adrenergic Antagonistsselective for α1 antagonism and inhibition of cyclic phosphodiesterase (PDE)- direct vasodilatory effect (no α1 vasoconstriction); decreased peripheral resistance due to PDE inhi
Adrenergic Agoniststransient HTN, then prolonged hypotensive effects; acts at brainstem to decrease sympathetic ouflow and lower BP
Adrenergic Agonistsinotropic- raises HR and contractility, looks like dopamine but acts like NE except more β1 action, also acts on β2 & α1
Neuromuscular Blockerimmediate duration, no renal or hepatic metabolism; non-depolarizing agents: Competitive antagonists at Nm/ occupy the nicotinic R on skeletal muscle and prevent ACh from depolarizing it (competitive antagonists and can be overcome
Muscarinic AgonistsPredominantly M1 action, preferred drug to treat Glaucoma
Neuro Adrenergic Agentsinhibits tyrosine hydroxylase to stop synthesis of catecholamines
Neuromuscular Blockerrapid onset, short duration- use in surgical procedures w/anesthesia, endotracheal intubation/ Metabolized by pseudo-ChE, not AChE; depolarizing agent that binds muscular nicotinic R, initially activating, then desensitizing to ACh
AchE InhibitorLonger acting treatment for Alzheimer's disease (one of 4)
Neuromuscular Blockershort duration, rapidly degraded, hydrolized by pseudocholinesterase, outpatient surgery; non-depolarizing agents: Competitive antagonists at Nm/ occupy the nicotinic R on skeletal muscle and prevent ACh from depolarizing it (competitive antagonists and can be overcome
AchE Inhibitorlike neostigmine but also inhibits AChE in CNS
Muscarinic AntagonistsOveractive Bladder, Selective for M3 receptor agonists (one of 4)
AchE Inhibitorprevents ACh degradation, potentiates its action and neurotransmission
Neuro Adrenergic Agentscreates false NE- mimics DOPA and is incorporated during NE synthesis
Other Skeletal Muscle Blockersspasticity from SC lesions- MS or trauma, CN V, IX neuralgias; acts in CNS- mimics GABA and produces same inhibitory effects)
Neuromuscular Blockerleast potent, rapid onset; non-depolarizing agents: Competitive antagonists at Nm/ occupy the nicotinic R on skeletal muscle and prevent ACh from depolarizing it (competitive antagonists and can be overcome
Neuro Adrenergic Agentsirreversible inhibition of dopamine and NE uptake into storage vesicles which blocks NE storage and synthesis but not NE release like guanethidine
Muscarinic Antagonistsblocks postgang cholinergic receptors of smooth muscle, glands, and CNS sites
Muscarinic AntagonistsPeptic Ulcers, selective for M1 receptors in autonomic ganglia
Muscarinic AntagonistsCOPD/More bronchioselective/ Less affinity for M2 receptors, Similar to ipratropium
Adrenergic Agonistsno β effects, not metabolized by COMT or MAO
Adrenergic Antagonistsirreversible block, especially α1 which has more effect on smooth muscle
Muscarinic AntagonistsMotion sickness, obstetrics, Similar to atropine, Produces depression and amnesia
DescriptionDrug (Generic)Uses
Adrenergic Agonistsexerts effects similar to that of NE- stimulates β1 and α receptors and is a CNS stimulant b/c it can cross the BBB unlike NE
Adrenergic Agonistsselective β-agonist, doesn't affect the heart because it doesn't act on β1 receptors
Neuromuscular Blockerlonger acting/ more selective; non-depolarizing agents: Competitive antagonists at Nm/ occupy the nicotinic R on skeletal muscle and prevent ACh from depolarizing it (competitive antagonists and can be overcome
It's a Hell of a druginhibition of uptake 1 causes NE accumulation in synaptic cleft and overstimulation of postsynaptic receptor
Other Skeletal Muscle BlockersCosmetic Use, reduces wrinkles; prevents ACh release from presynaptic neuron
Adrenergic Agonistsweak β effects too- dilates bronchioles,similar in structure to NE but not a substrate for COMT so longer 1/2 life
Adrenergic Antagonistsnon-selective, competitive α1 &2 antagonist (more reversible antagonism)
Neuro Adrenergic Agentsdepletes NE from presynaptic neuron and inhibits its release; does not cross BBB
Other Skeletal Muscle BlockersSpasticity from SC lesions, MS or trauma, Malignant hyperthermia; acts directly on skeletal muscle- reduces its contraction by decreasing amt of Ca released from SR (esp fast reflex fibers)
Adrenergic Antagonistscompetitive antagonists of β1 receptor, decreases HR, contractility, and peripheral vascular resistance
AchE InhibitorInhibits Ach destruction
Neuromuscular Blockerpartial block of autonomic ganglia; non-depolarizing agents: Competitive antagonists at Nm/ occupy the nicotinic R on skeletal muscle and prevent ACh from depolarizing it (competitive antagonists and can be overcome
Adrenergic Agonistsdirect: stimulates α1 receptors, weak β indirect: a false NT that replaces NE in storage graules
Muscarinic AntagonistsIsopropyl-atropine / antagonizes Ach action on M3R of bronchial smooth muscle in lungs causing bronchodilation (inhaled form)
Muscarinic Agonistsboth muscarinic and nicotinic actions (mostly muscarinic); not a substrate for AChE
Ganglionic BlockerGanglionic Nn receptor blocker/ Competitive blockade at Nn receptor
Other Skeletal Muscle BlockersJoint disease pain, muscle spasm, anti-anxiety; acts in CNS- enhances GABA binding to R to facilitate inhibition
AchE InhibitorSimilar to Neostigmine, but longer lasting
Adrenergic Agonistsdirect: stimulates α & β receptors indirect: induces NE release like amphetamines and stimulate CNS
Muscarinic AgonistsDiagnosis of Bronchial airway hyperactivity, Similar to Ach
Muscarinic Agonistsstimulates PNS to restore GI and GU motility, increase glandular secretions
Nictonic AgonistAids in smoking cessation - comes in different forms, Activates Nn and Nm receptors / reduces nicotine withdrawal symptoms by providing nicotine levels lower than those assoc with smoking
Nictonic AgonistPartial agonist in CNS for nAchR; Aids in smoking cessation

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