Warwick 2018-19 Block 4 Drugs

Can you name the Warwick 2018-19 Block 4 Drugs?

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Drug ClassDrug
Biological Agents (monoclonal antibodies; Anti-TNF, RA, Chrons)
Osteoporosis Management (Vit D Precursor; converted into Calcidiol (liver), then Calcitriol (kidneys). Acts to ↑Ca2+ by ↑absorption, reabsorption and bone resorption)
Hypercalcaemia Imm. Management
Fluoroquinolone Antibiotic (bacteriostatic, targeting DNA structure/function; Gram -ve infections / MRSA)
Biological Agents (monoclonal antibodies; Anti-CD20 RA, SLE)
Beta-Lactam Antibiotic (Penicillin; bactericidal, targeting cell wall; tonsillitis)
Anti-Proliferative Agents (DMARDs; acts against purine synthesis; RA)
Hypocalcaemia Management (↑ serum Ca2+ to reduce NM symptoms)
Anti-Proliferative Agents (DMARDs; acts against folate activity; RA)
Osteoporosis Management (inhibits RANK-L which prevents osteoclast activation, thus ↓ bone resorption)
Beta-Lactam Antibiotic (Penicillin; bactericidal, targeting cell wall; LRTI)
Tetracycline Antibiotic (bactericidal, targeting RNA & protein synthesis; atypical bacteria that lack cell wall e.g. Chlamydia)
Beta-Lactam Antibiotic (Cephalosporin; bactericidal, targeting cell wall; sepsis/bacterial meningitis - broad spec)
Beta-Lactam Antibiotic (Carbapenem; bactericidal, targeting cell wall; infections in ITU - most broad spec/powerful)
Aminosalicylates (DMARDs; suppress immune-mediated inflammatory response in RA, Mechanism unclear)
SERM (bone-specific oestrogen-R agonist; osteoporosis)
Drug ClassDrug
Aminosalicylates (DMARDs; suppress immune-mediated inflammatory response in RA, Mechanism unclear)
Beta-Lactam Antibiotic (Penicillin; bactericidal, targeting cell wall; mixed infections)
Loop Diuretic (for hypercalcaemia)
Vitamin D Deficiency (Vit D Precursor; converted into Calcidiol (liver), then Calcitriol (kidneys). Acts to ↑Ca2+ by ↑absorption, reabsorption and bone resorption)
Thyroid Hormone (opposes PTH to ↓ serum Ca2+ by ↓bone resorption & ↓reabsorption; hypercalcaemia)
Vitamin D Deficiency (active form of Vit D; CKD)
Osteoporosis Management (intermittent dose can ↑osteoblast activity and may ↑BMD)
Lincosamide Antibiotic (bacteriostatic, targeting RNA & protein synthesis; SSTI)
Bisphosphonate (disrupt osteoclast function to ↓rate of bone remodelling; first-line for osteoporosis)
Hypocalcaemia Management (Vit D Precursor; converted into Calcidiol (liver), then Calcitriol (kidneys). Acts to ↑Ca2+ by ↑absorption, reabsorption and bone resorption)
Nitroimidazole Antibiotic (bacteriostatic, targeting DNA structure/function; anaerobic infections e.g. abscess)
Tetracycline Antibiotic (bactericidal, targeting RNA & protein synthesis; atypical bacteria that lack cell wall e.g. Chlamydia)
Bisphosphonate (disrupt osteoclast function to ↓rate of bone remodelling; hypercalcaemia)
Macrolide Antibiotic (Bacteriostatic – inhibition of bacterial protein synthesis)
Beta-Lactam Antibiotic (Penicillin; bactericidal, targeting cell wall; SSTI)

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