Drug Category | Drug |
Dopaminergic (DA synthetic agonist that can cross BBB to replace lost DA; Parkinson's) | |
Antibiotic (CNS infection e.g. bacterial meningitis) | |
AED (blocks VGSC in inactivated state to ↓neuronal excitability; neuropathic pain) | |
General Anaesthetic (IH; invasive procedures) | |
Barbiturate (GABA-A receptor (b-subunit) co-agonist; epilepsy) | |
Strong Opioid (acts on opioid-R to close Ca2+ channels & ↑K+ outflow to ↓transmission; analgesic) | |
Anticholinesterase (inhibits ACh breakdown to ↑ACh in the cleft; mild-to-mod dementia) | |
Barbiturate (GABA-A receptor (b-subunit) co-agonist; epilepsy) | |
NeuroMuscular Blocker (non-depolarising; competitive with ACh in cleft to prevent depolarisation; pre-surgery) | |
MAO-B Inhibitor (prevents CNS breakdown of levodopa by MonoAmine Oxidase-B; Parkinson's) | |
Dopa-decarboxylase Inhibitor (prevents peripheral breakdown of levodopa by dopa-decarboxylase; Parkinson's) | |
Weak Opioid (acts on opioid-R to close Ca2+ channels & ↑K+ outflow to ↓transmission; analgesic) | |
NeuroMuscular Blocker (depolarising; non-competitive but prevent depolarisation by overloading cleft with ACh; pre-surgery) | |
Atypical Antidepressant (SNRI; ↑5HT & NA in cleft by inhibiting reuptake pump) | |
Muscle Relaxant (b-Blocker) | |
COX2-specific NSAID (inhibit COX-2 enzymes to ↓AA breakdown into PGs, which is req. for VGSC activation, therefore ↓pain transmission; analgesic) | |
Strong Opioid (acts on opioid-R to close Ca2+ channels & ↑K+ outflow to ↓transmission; analgesic) | |
COX2-specific NSAID (inhibit COX-2 enzymes to ↓AA breakdown into PGs, which is req. for VGSC activation, therefore ↓pain transmission; analgesic) | |
AED (for neuropathic pain; GABA mimetic, acts on Ca2+ channels; increases GABA transport) | |
Dopa-decarboxylase Inhibitor (prevents peripheral breakdown of levodopa by dopa-decarboxylase; Parkinson's) | |
Partial / Mixed Agonist Opioid (analgesic) | |
Local Anaesthetic (blocks VGSC to prevent depolarisation) | |
1st Generation Antipsychotic (inhibit D2-R to ↓DA in mesolimbic pathways; schizophrenia) | |
Dopaminergic (DA synthetic agonist that can cross BBB to replace lost DA; Parkinson's) | |
NSAID (inhibit COX enzymes to ↓AA breakdown into PGs, which is req. for VGSC activation, therefore ↓pain transmission; analgesic) | |
AED (blocks VGSC in inactivated state to ↓neuronal excitability; focal seizures) | |
Anticholinergic (dopaminergic effect by re-balancing dopamine with ACh; Parkinson's) | |
Weak Analgesic / Antipyretic (analgesic) | |
Used to reverse NMB block | |
Atypical Antidepressant (NDRI; ↑NA & DA in cleft by inhibiting reuptake pump) | |
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