Drug Class | Drug |
Osmotic Diuretic (↑filtrate osmolality in PCT/d.LoH; raised IOP/ICP) | |
Faecal Softener (↓oil-water tension so ↑water/fat into stool; act slowly; constipation, fissures/piles) | |
Osmotic Laxative (poorly absorbed solute retaining ↑water in GIT; chronic constipation, negating opioids) | |
Osmotic Laxative (poorly absorbed solutes, retaining ↑water in GIT; chronic constipation) | |
Bulk Laxative (non-digestable polysaccharide that retains ↑water in GIT; 1st choice for constipation, IBS) | |
H2 Receptor Antagonist (prevents histamine action on parietal cells, ↓HCl secretion) | |
Potassium Sparing Diuretic (aldosterone antagonist; binds to mineralocorticoid-R in principal cells of L.DCT to ↓ENaC & Na+K+ ATPase synthesis; CHF, ascites) | |
Thiazide Diuretic (↓Na+Cl- co-transporter in e.DCT; peripheral oedema (CHF), hypertension) | |
Opioid Anti-Motility Agent (acts on myenteric plexus to ↓mass movements / contract sphincters; acute diarrhoea in adults) | |
Stimulant Purgative (stim. rectal mucosa to cause mass movement contractions; ST use to negate opioids) | |
Carbonic Anhydrase Inhibitor Diuretic (↓HCO3- reabsorption in PCT, so also ↓Na+ and water reabsorption; raised IOP) | |
ACE Inhibitor (RAAS blockade: ↓conversion of angiotensin I to angiotensin II to ↓BP) | |
Proton Pump Inhibitor (irreversibly inactivates H+K+ ATP-ase pump, ↓HCl secretion from parietal cells; reflux oesophagitis, H.Pylori) | |
Thiazide Diuretic (↓Na+Cl- co-transporter in e.DCT; peripheral oedema (CHF), hypertension) | |
Thyroid Hormone (Synthetic T4 - commonly prescribed for hypothyroidism) | |
a-Adrenergic Blocker (Relaxes sphincters/smooth muscle to treat urinary retention) | |
Thyroid Hormone (Synthetic T3 - too rapid) | |
Renin Inhibitor (RAAS blockade: ↓conversion of angiotensinogen to angiotensin I to ↓BP) | |
Potassium Sparing Diuretic (ENaC antagonist; ↓ENaC's in principal cells of L.DCT to ↓K+ secretion in exchange; in combo with LD/TD to ↓K+ loss) | |
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