Miscellaneous Quiz / Rheumatology Meds

Random Miscellaneous Quiz

Can you name the Rheumatology Meds?

Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
Score 0/76 Timer 20:00
HintAnswer
SE: Long term -->: osteoporosis
Reduces serum Ca and phos, reduces osteoclastic bone resorption, decreases renal resorption of Ca & phos. Increases bone mass & reduces spine fx.
Use: Prevent dental caries. Not yet approved for osteoporosis
Use: Tx hyper-Ca assoc w/ malignancy & granulomatous dz. Useful in Vit. D intoxication
Cinacalcet class
MOA: NET RESULT = REDUCED RENAL EXCRETION OF CA
Drugs that induce osteoporosis
SE: Long term use is assoc w/ breast cancer.
Class MOA: Promotes bone formation. Inihibits PTH secretion. Promotes immunosuppression, phagocytosis, & anti-tumor activity
Use: Hypercalcemia of malignancy
MOA: Binds to hydroxyapatite & retards formation & dissolution of hydroxyapatite crystals (slow down resorption) --> decreased resorption by osteoclasts & modest increase in BMD.
Tiludronate class
24,25 Dihydroxyvitamin D3 name
25-Hydroxyvitamin D3 name
P-kinetics: Poor GI absorption. 50% of the absorbed drug is taken up by bones. Eliminated in urine (unaltered). Absorbed drugs accumulate in bone for months.
Route for Ca gluconate
SE: Has the most significant effects. Risk of femoral fx (atypical subtrochanteric & diaphyseal breaks)
PTH (or its analog recombinate Teriparatide 1-34) class
Glucocorticoids class
1,25-Dihydroxyvitamin D3 name
Drug MOA: Made in the lab by radiating fungus; not naturally occuring in the body
MOA: Reduces bone resorption
Class MOA: Binds to receptors thru-out body. Regulates Ca & phos serum levels; promotes absorption in the GI; promote renal reabsorption of Ca.
Use: Tx hypocalcemia & helps to tx hyperphosphatemia.
MOA: Activated form made from calcidiol in the kidneys & tissues; the most potent steroid hormone in the body
MOA: Increases PTH effect on renal Ca resorption & reduced Ca excretion by blocking Na resorption in the proximal tubules.
HintAnswer
MOA: Analogues of pyrophosphate (PPI - inhibits calcification in plasma but easily degraded by alk phos) -- P-C-P core is less degradable.
SE: Major SE: gastritis, esophagitis (caused by GERD) -- to minimize: take w/ H2O and remain upright for 30 min.
Alternative to estrogen tx. Prevents the increased risk of breast/uterus CA. Protects spine fxs (not hip).
Vitamin D3 name
MOA: ____ bisphosphonate (___-BPs = more potent) (except etidronate & tiludronate)
Use: Topical tx for psoriasis
PTH Use
Riserdronate class
Drug MOA: Naturally occuring form made by the skin upon sun exposure; found in food & most supplements
MOA: A sex hormone. Reduces PTH's effect on bone resorption (via OPG). NET RESULT = BLOCKS BONE LOSS
Use: Tx hyperparathyroidism 2nd to chronic renal dz as well as parathyroid CA. In trials for primary hyperparathyroidism
Calciprotriene name (analog)
Rx interactions: P450 inducers (phenytoin & phenobarbital) increase liver metabolism to inactivate product.
Use: Tx hypophosphatemia & hypercalcemia
Use: serum Vit D concentration testing
MOA: RESULT = REDUCED PTH RELEASE FROM PARATHYROID GLAND
Use: Tx hypercalcemia assoc w/ malignancy, Paget's dz, & postemenopausal osteoporosis
MOA: NET RESULT = INCREASED SERUM CA AND DECREASED SERUM PHOSPHATE.
Calcitonin class
SE: Hypercalcemia
NET RESULT = REDUCED SERUM CALCIUM
Alendronate class
MOA: Accumulated by bone & teeth. Stabilizes the hydroxyapatite crystal. Prevents dental caries & vertebral compression fx.
19-nor-1,25-Dihydroxyvitamin D2
SE: Overdose -> dental fluorosis (yellow teeth)
Vitamin D2 name
HintAnswer
SE: The least potent drug & has less side effects
Zolendronate class
Use: Tx postmenopausal osteoporosis. Long term use discouraged d/t SE on breast, uterus, & CVS
MOA: Enhance absorption of Ca from the GI (stim production of active Vit. D in the kidney). Supress of Ca loss in urine (stim reabsorption of Ca). Stim loss of phos in urine.
Use: Hypercalciuria, prevent stone formation in idiopathic hypercalciuria (by decreasing oxalate excretion & increasing urine Mg and Zn)
Use: tx of hypoparathyroidism, refractory rickets, & familal hypophosphatemia
Class MOA: Stimulates new bone formation
Rx interactions: lipophilic-intestinal absorption reduced by statins & cholestyramine (take the drugs a few hrs apart). CS blocks GI vit D absorption.
Use: Hypocalcemia & ancillary tx for osteoporosis
MOA: Act on Ca sensing receptor (CaR) and LOWER its sensitivity --> block of PTH secretion.
Use: Tx hypercalcemia, Paget's disease, osteoporosis
MOA: Blocks farnesyl pyrophosphate synthase in the HMG-CoA reductase pathway (mevolante pathway) --> osteoclast apoptosis. Increase bone density; reduce fx in hips, spines, etc.
Estrogens class
MOA: Secreted by the parafollicular cells of the thyroid; stimu by hyper-Ca.
Ibandronate class
Use: Tx secondary hyperparathyroidism in renal failure pts
MOA: Prehormone made directly from cholecalciferol in the liver; low biologic activity, major form circulating in the blood
MOA: Stimulate renal Ca excretion. Blocks bone formation. Increases osteoclast differentiation.
1-alpha hydroxyvitamin D2 name
MOA: Regulates Ca & Phos conc in ECF. Mobilizes Ca from bone (stim osteoclast diff via RANKL).
Etidronate class
Pamidronate class
MOA: Produced by adrenal gland. Antagonizes Vit D's effect on intestinal Ca absorption.
SE: GI symptoms, nausea, flush

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.