Miscellaneous Quiz / Muscle Relaxants and Anti-Spasmotics

Random Miscellaneous Quiz

Can you name the Muscle Relaxants and Anti-Spasmotics?

Quiz not verified by Sporcle

Forced Order
Also try: High and Low
Challenge
Share
Tweet
Embed
Score 0/72 Timer 20:00
HintAnswer
MOA: Congener of clonidine - central effects not fully known. Spasmolytic effect d/t reinforcement of both presynaptic & postsynaptic inhibition of the motor neuron in the cord
Tizanidine class
SE: rhabdomyolysis (poss w/ myoglobinuria), prolonged paralysis in pts w/ cholinesterase def, increased intragastric pressure (emesis), assoc w/ acute onset of malignant hypothermi
P-kinetics: Hepatic: faster elimination (20-35 mins). Eliminated 70-90% via biliary excretion. Metabolic accumulation w/ extended use
MOA: Competitive antagonist of Ach (low doses) -> surmountable blockade by tetanic stimulation and cholinesterase inhibitors. High doses block poorly.
Dizaepam class
Baclofen class
SE: Drowsiness, hypotension
MOA: Decrease excitation-contraction coupling -> reduced skeletal muscle strength. Binds to the 'ryanodine' Ca channel in the SR, inhibits the release of (activator) Ca from the SR
Vecuronium class
Use: As effective spasmolytics as diazepam - no sedation. Does not reduce muscle strength like dantrolene
P-kinetics: Onset 1-2 mins (fastest on non-depolarizing)
MOA: Inhibition of glutaminergic transmission in the CNS
Cistatracurium class
Riluzole class
Use: Cause paralysis during sx & ICU. Used for control of ventilat (elim. chest wall resistance) & tx of convulstions & seizures (no central effect).
P-kinetics: Long duration - 60 mins
Reversal: Cholinesterase inhibitors - antagonizing ACh-esterase -> increased ACh at NMJ
Metaxalone class
Pancuronium class
SE: Drowsiness (transient), seizure in epileptics
MOA: Increase (inhibitory) internuncial interneuron activity
Atracurium class
Methocarbamol class
HintAnswer
MOA: Prevents release of ACh from vesicles
SE: Arrhythmias (w/ halothane); brady (alleviated w/ co-admin of Atropine); histamine release, increased IOP, transient dilation of choroidal vessels or myofibrils contraction
Use: ALS-induced spasm
P-kinetics: Fastest onset - 1 min. Shortest DOA: 5-10 mins. Very rapid hydrolysis by plasma cholinesterase; prolonged in pts w/ abnormal ACh. Two Phases
Metocurine class
Succinylcholine class
Phase I cont.. unresponsive to subsequent stimulus; augmented (NOT reversed) by ACh inhibitors.
Chlorphenesin class
Botulinum Toxin A (Botox) class
SE: jaw rigidity, hyperkalemia (burn pts, nerve damage, head injury pts... denervation -> upregulation of extrajunctional receptors... poss -> cardiac arrest), myalgia
Gabapentin class
Phase II cont. Late in phase II becomes similar to blockade w/ nondepolarizing drugs, reversible by ACh inhibitors. Use w/ caution in kids
Pipecuronium class
Use: Malignant hyperthermia, triggered by gen anesthesia, NM blockers in pts w/ hered defects in Ca sequesteration -> sudden & prolonged release of Ca -> massive muscle contraction
P-kinetics: All must be given IV. Quaternary amine- no access to CNS. Once injected rapid distrib. Vol of distrib similar to blood volume. Highly charged prevents membrane crossing
P-kinetics: After IV admin during anesthesia --> skeletal muscle weakness --> flaccid --> inexcitable to stimulus. Sensitivity of muscles: Facial, foot, and hand >>> abd, trunk, di
Phase I - depolarizing: same effects as Ach but last longer. Generalized disorganized contraction of motor units (muscle fasciculation) over chest, abd; weakened by gen anesthesia
Use: Opthalmic use & local muscle spasm. Also for more generalized spastic disorders d/t neuro injury (e.g. one limb post stroke) & cosmetic applications
Dantrolene class
Phase I cont. -> paralysis of arm, neck, leg muscles -> facial & pharyngeal muscles -> resp muscles. More slowly metabolized than ACh -> membrane remains depolarized, no 'repriming
Rocuronium class
Use: May be useful in spasm of MS pt
Interactions: Low dose nondepolarizing NM blockers antagonize succs-induced fasciculations & post-op pain.
SE: Muscle weakness and sedation
HintAnswer
Mivacurium class
MOA: Decrease Ia fiber activity. GABA-B agonist. Metabotropic receptor activation, increase gK+ -> hyperpolarization -> decrease in excitatory NT release in stretch reflex arc.
SE: Less histamine release so less CV effects
Use: Comparable in efficacy to diazepam, baclofen, dantrolene in several types of spasticity
SE: Sedation, antimusc effects (dry mouth), fatigue, asthenia, nausea, constipation, dyspepsia, taste changes, blurred vision, HA, nervousness, confusion, transient visual hallucin
Interactions: NM block is enhanced by gen anesthetics, local anesthetics, antiarrhythmic drugs, some antibiotics (aminoglycosides).
P-kinetics: Plasma cholinesterase: rapid inactivation (10-20 min). Note less PC in pts w/ renal failure
Carisoprodol class
Botulinum Toxin B (Myobloc) class
Phase II: desensitizing: endplate depolarization decreases; membrane repolarizes, but cannot produce generalized depolarization
Use: Sensitivity to NM blockers is increased in myasthenia gravis & older age AND is decreased in burn pts.
P-kinetics: Single injection works for weeks to months
P-kinetics: Renal: slow elimination: long (60 mins) duration.
Use: Prototype for acute, temporary muscle spasm caused by trauma or strain. Ineffective in cerebral palsy & SC injury.
P-kinetics: Short duration - 15 mins
P-kinetics: Spontaneous breakdown - Hoffman elim: 20-35 min. Breakdown product, laudanosine, crosses BBB -> seizure w/ pronlonged use. Isomer w/ advantagous properties: cis-atracur
Turbocurarine class
MOA: Agonist of nicotinic receptor (relatively resistant to degradation) -> excessive channel opening & muscle fatigue. Essentially blockade from excess stimulation
P-kinetics: PO - rapidly absorbed, t1/2 = 4 hrs, BID. Intrathecal for severe spasticity & muscle pain
Orphenadrine class
Doxacurium class
SE: Bronchospasm & hypotension (attenuated by premedication w/ antihistamine). Histamine release
MOA: Related to TCAs. Interferes w/ polysynaptic reflexes in the brainstem that maintain skeletal muscle tone.
SE: Vagolytic - tachycardia (may be useful in kids who tend to be bradycardic). No histamine release

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.