Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Fluvastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Anion exchange resin prevents bile acid binding
Must monitor creatine kinase
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Synergistic with statins
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Downregulates apo CIII
Ezetimibe
Inhibits NPC1L1 transport in the gut
Gemfibrozil
Take this drug to decrease flushing with Niacin
Niacin/Nicotinic acid/Vit B3
Competitively inhibits HMG-CoA reductase
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Single agent to treat familial dysbetalipidemia
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Pravastatin
Decreases CRP
QuestionAnswer
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Colesevelam
Contraindicated in kidney, liver, and biliary dz
Cholestyramine
Decreases FFA to liver
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Fenofibrate
Decreases VLDL, LDL, Lp(a) and increases HDL
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Atorvastatin
Decreases LDL and TG
Decreases VLDL and TG, increases LPL activity
Lovastatin
Upregulates LPL, apo AI, AII
Contraindicated in pregnancy and liver dz
Simvastatin
Rosuvastatin
Decreases LDL
Colestipol

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