Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Decreases VLDL, LDL, Lp(a) and increases HDL
Fenofibrate
Contraindicated in pregnancy and liver dz
Contraindicated in kidney, liver, and biliary dz
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Ezetimibe
Cholestyramine
Decreases VLDL and TG, increases LPL activity
Decreases LDL
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Gemfibrozil
Anion exchange resin prevents bile acid binding
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Rosuvastatin
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Must monitor creatine kinase
Synergistic with statins
Competitively inhibits HMG-CoA reductase
Pravastatin
QuestionAnswer
Inhibits NPC1L1 transport in the gut
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Colesevelam
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Downregulates apo CIII
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Lovastatin
Simvastatin
Upregulates LPL, apo AI, AII
Take this drug to decrease flushing with Niacin
Atorvastatin
Fluvastatin
Niacin/Nicotinic acid/Vit B3
Single agent to treat familial dysbetalipidemia
Colestipol
Decreases CRP
Decreases LDL and TG
Decreases FFA to liver
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)

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Created Mar 14, 2011ReportNominate
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