Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Contraindicated in kidney, liver, and biliary dz
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Synergistic with statins
Simvastatin
Ezetimibe
Fenofibrate
Colesevelam
Fluvastatin
Lovastatin
Colestipol
Anion exchange resin prevents bile acid binding
Inhibits NPC1L1 transport in the gut
Cholestyramine
Decreases CRP
Decreases FFA to liver
Contraindicated in pregnancy and liver dz
Downregulates apo CIII
Take this drug to decrease flushing with Niacin
QuestionAnswer
Atorvastatin
Decreases VLDL and TG, increases LPL activity
Niacin/Nicotinic acid/Vit B3
Upregulates LPL, apo AI, AII
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Gemfibrozil
Decreases LDL and TG
Single agent to treat familial dysbetalipidemia
Competitively inhibits HMG-CoA reductase
Rosuvastatin
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Decreases LDL
Must monitor creatine kinase
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Pravastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Decreases VLDL, LDL, Lp(a) and increases HDL
Contraindicated in DM, peptic ulcers, chronic liver dz, gout

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