Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Decreases LDL
Must monitor creatine kinase
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Pravastatin
Simvastatin
Take this drug to decrease flushing with Niacin
Ezetimibe
Gemfibrozil
Decreases CRP
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Niacin/Nicotinic acid/Vit B3
Single agent to treat familial dysbetalipidemia
Fenofibrate
Decreases LDL and TG
Downregulates apo CIII
Colestipol
Rosuvastatin
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
QuestionAnswer
Anion exchange resin prevents bile acid binding
Competitively inhibits HMG-CoA reductase
Atorvastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Inhibits NPC1L1 transport in the gut
Cholestyramine
Contraindicated in kidney, liver, and biliary dz
Decreases FFA to liver
Decreases VLDL, LDL, Lp(a) and increases HDL
Lovastatin
Contraindicated in pregnancy and liver dz
Synergistic with statins
Decreases VLDL and TG, increases LPL activity
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Colesevelam
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Upregulates LPL, apo AI, AII
Fluvastatin

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