Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Colestipol
Synergistic with statins
Downregulates apo CIII
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Cholestyramine
Niacin/Nicotinic acid/Vit B3
Fenofibrate
Contraindicated in kidney, liver, and biliary dz
Gemfibrozil
Anion exchange resin prevents bile acid binding
Pravastatin
Colesevelam
Decreases VLDL and TG, increases LPL activity
Fluvastatin
Simvastatin
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Lovastatin
QuestionAnswer
Contraindicated in pregnancy and liver dz
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Competitively inhibits HMG-CoA reductase
Decreases LDL and TG
Decreases CRP
Decreases LDL
Atorvastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Rosuvastatin
Take this drug to decrease flushing with Niacin
Upregulates LPL, apo AI, AII
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Inhibits NPC1L1 transport in the gut
Decreases FFA to liver
Single agent to treat familial dysbetalipidemia
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Must monitor creatine kinase
Decreases VLDL, LDL, Lp(a) and increases HDL
Ezetimibe

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Created Mar 14, 2011ReportNominate
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