Question | Answer |
Colestipol | |
Synergistic with statins | |
Downregulates apo CIII | |
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200 | |
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias | |
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants | |
Cholestyramine | |
Niacin/Nicotinic acid/Vit B3 | |
Fenofibrate | |
Contraindicated in kidney, liver, and biliary dz | |
Gemfibrozil | |
Anion exchange resin prevents bile acid binding | |
Pravastatin | |
Colesevelam | |
Decreases VLDL and TG, increases LPL activity | |
Fluvastatin | |
Simvastatin | |
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins | |
Lovastatin | |
| Question | Answer |
Contraindicated in pregnancy and liver dz | |
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa) | |
Competitively inhibits HMG-CoA reductase | |
Decreases LDL and TG | |
Decreases CRP | |
Decreases LDL | |
Atorvastatin | |
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia | |
Rosuvastatin | |
Take this drug to decrease flushing with Niacin | |
Upregulates LPL, apo AI, AII | |
Contraindicated in DM, peptic ulcers, chronic liver dz, gout | |
Inhibits NPC1L1 transport in the gut | |
Decreases FFA to liver | |
Single agent to treat familial dysbetalipidemia | |
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV) | |
Must monitor creatine kinase | |
Decreases VLDL, LDL, Lp(a) and increases HDL | |
Ezetimibe | |
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