Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Simvastatin
Single agent to treat familial dysbetalipidemia
Rosuvastatin
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Must monitor creatine kinase
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Fluvastatin
Pravastatin
Fenofibrate
Lovastatin
Contraindicated in pregnancy and liver dz
Decreases LDL
Synergistic with statins
Niacin/Nicotinic acid/Vit B3
Colestipol
Decreases VLDL and TG, increases LPL activity
Colesevelam
Upregulates LPL, apo AI, AII
Decreases CRP
QuestionAnswer
Inhibits NPC1L1 transport in the gut
Decreases LDL and TG
Decreases FFA to liver
Atorvastatin
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Contraindicated in kidney, liver, and biliary dz
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Gemfibrozil
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Anion exchange resin prevents bile acid binding
Cholestyramine
Take this drug to decrease flushing with Niacin
Downregulates apo CIII
Competitively inhibits HMG-CoA reductase
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Decreases VLDL, LDL, Lp(a) and increases HDL
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Ezetimibe

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Created Mar 14, 2011ReportNominate
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