| Question | Answer |
|---|
| Synergistic with statins | |
| Decreases VLDL and TG, increases LPL activity | |
| Upregulates LPL, apo AI, AII | |
| Atorvastatin | |
| SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias | |
| Fluvastatin | |
| Decreases VLDL, LDL, Lp(a) and increases HDL | |
| Lovastatin | |
| Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa) | |
| Colestipol | |
| Cholestyramine | |
| Downregulates apo CIII | |
| Single agent to treat familial dysbetalipidemia | |
| Contraindicated in DM, peptic ulcers, chronic liver dz, gout | |
| Anion exchange resin prevents bile acid binding | |
| Decreases CRP | |
| Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia | |
| Colesevelam | |
| Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV) | |
| | Question | Answer |
|---|
| Pravastatin | |
| Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200 | |
| SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants | |
| Decreases LDL | |
| Take this drug to decrease flushing with Niacin | |
| Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins | |
| Fenofibrate | |
| Gemfibrozil | |
| Decreases LDL and TG | |
| Rosuvastatin | |
| Decreases FFA to liver | |
| Niacin/Nicotinic acid/Vit B3 | |
| Ezetimibe | |
| Contraindicated in pregnancy and liver dz | |
| Simvastatin | |
| Competitively inhibits HMG-CoA reductase | |
| Contraindicated in kidney, liver, and biliary dz | |
| Inhibits NPC1L1 transport in the gut | |
| Must monitor creatine kinase | |
|
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