Miscellaneous Quiz / Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Fluvastatin
Synergistic with statins
Rosuvastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Anion exchange resin prevents bile acid binding
Decreases LDL
Lovastatin
Decreases LDL and TG
Upregulates LPL, apo AI, AII
Single agent to treat familial dysbetalipidemia
Decreases VLDL, LDL, Lp(a) and increases HDL
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Niacin/Nicotinic acid/Vit B3
Contraindicated in kidney, liver, and biliary dz
Inhibits NPC1L1 transport in the gut
Fenofibrate
Atorvastatin
Must monitor creatine kinase
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
QuestionAnswer
Competitively inhibits HMG-CoA reductase
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Cholestyramine
Ezetimibe
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Pravastatin
Take this drug to decrease flushing with Niacin
Decreases VLDL and TG, increases LPL activity
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Decreases CRP
Colesevelam
Simvastatin
Contraindicated in pregnancy and liver dz
Decreases FFA to liver
Downregulates apo CIII
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Colestipol
Gemfibrozil
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias

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