Miscellaneous Quiz / Glaucoma Drugs

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Can you name the Glaucoma Drugs?

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Carteolol class
P-kinetics: Topical drops or gel, plastic film slow-release insert
Metipranolol class
MOA: Increased outflow via the uveo scleral system (vasoconstriction)
P-kinetics: Topical Drops
MOA: Increases outflow of aqueous humor
MOA: M-receptor activation leads to ciliary muscle contraction, opening of trabecular meshwork & increased outflow
SE: Ocular allergic-like reactions. Upper lid elevation, blepharitis, conjunctivitis, abnormal or blurred vision, xerophthalmia, photophobia, corneal staining
Apraclonidine class
Contraindicated: in pts w/ bradycardia, heart block, HF, asthma, & COPD.
Use: closed angle glaucoma
Methazolamide class
Physostigmine class
SE: keratitis, conjunctival blanching, mydriasis, xerostomia (10%), dysgeusia (3%), & nasal dryness (2%)
SE: Myopia, blurred vision, & night blindness are fairly common w/ topical application. Ciliary spasm may cause HA. Long term cataracts & lens adhesions
P-kinetics: topical or oral
P-kinetics: topical
CA Inhibitor given orally
Mannitol class
Pilocarpine class
Brinzolamide class
SE: Blurred vision, conjunctival hyperemia, foreign body sensation, irital discoloration, ocular irritation (itching, burning, stinging), & punctate corneal keratopathy
Use: 2nd most common, often used in combo
Acetazolamide class
Carbachol class
P-kinetics: systemic administration
SE: Hyperemia (6.5%) & burning or stinging (6%). Mydriasis occurs within 30 min & may persist for several hours -> transient blurred vision
Travoprost class
Use: Open and closed angle glaucoma
Lantoprost class
Echothiophate class
MOA: Decrease B-1 mediated aqueous humor production. Decreases aqueous secretion from ciliary epithelium
Epinephrine class
MOA: Decrease the release of endogenous NE via a-2-R agonism -> Gi activation -> decrease of the activation of B-1 receptors
SE: Hyperemia (6.5%) & burning or stinging (6%). Mydriasis occurs within 30 mins & may persist for several hrs -> transient blurred vision
Dipivefrin class
Brimonidine class
Timolol class
Dorzolamide class
Levobunolol class
Demarcarium class
SE: Ocular pruitus, ocular pain, photophobia (2%). Caution: in pts w/ cerebral or coronary insufficiency, Raynauds, postural hypotension, hepatic & renal impairment
Betaxolol class
MOA: Directly decrease the production of acqueous humor. Decreased secretion due to lack of HCO3-
Unoprostone class
MOA: Osmotic diuretic. Reduces intraocular pressure via diuresis
Use: Common initial therapy
Bimatoprost class

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