Miscellaneous Quiz / Doctoring Test Pharm

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Can you name the Doctoring Test Pharm?

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HintAnswer
SE: Photosensitivity
Class: better for positive symptoms
Anti-cholinergics that tx EPS
SE typical of high dose/low potency drugs
Aripiprazole (Abilify) class
Fluphenazine (Prolixin) class
Chlorpromazine (Thorazine) class
Seroquel (Quetiapine) class
Standard drug used to compare doses
Low dose/high potency drugs
MOA: D4, D1, and 5HT2 (Serotonergic blockade)
Dose related increase in prolactin
Phenothiazines with > D2 affinity, increased EPS, requiring lower dose than other typicals
Haloperidol (Haldol) class
MOA: blocks cholinergic receptors
Class: better for negative symptoms
Antihistamines to tx EPS
SE: elevated temp, high CPK, rhabdomyolosis, muscle rigidity, delirium
Trifluoperazine (Stelazine) class
No effect on prolactin
HintAnswer
SE: high anticholinergic effects (constipation), antihistamine (--> sedation), seizure, low BP, agranulocytosis, metabolic syndrome
Slight increase in prolactin with high dose
Ziprasidone (Geodon) class
MOA: weak D2 antagonist. 10x > D4 affinty than D2 affinity
Drug NOT to exceed 800 mg - irreversible retinal pigmentation
Risperidal (Risperidone) class
Decreases prolactin secretion
When to avoid antipsychotics during pregnancy
Drugs with depot preparations available
Thiothixene (Navane) class
Behavior SE of antipsychotics
Motor SE of antipsychotics
Endocrine SE of antipsychotics
MOA: Low D2-R potency, highly sedative, causes decreased BP
SE: increased QT or PR interval
Test for Tardive Dyskinesia
Olanzapine (Zyprexa) class
Thioridazine (Mellaril) class
Clozapine class
Paliperidone (Invega) class

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