Miscellaneous Quiz / Doctoring Test Pharm

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QUIZ: Can you name the Doctoring Test Pharm?

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Paliperidone (Invega) class
Fluphenazine (Prolixin) class
Clozapine class
Thiothixene (Navane) class
Thioridazine (Mellaril) class
Ziprasidone (Geodon) class
When to avoid antipsychotics during pregnancy
Trifluoperazine (Stelazine) class
MOA: Low D2-R potency, highly sedative, causes decreased BP
SE: elevated temp, high CPK, rhabdomyolosis, muscle rigidity, delirium
MOA: blocks cholinergic receptors
Drug NOT to exceed 800 mg - irreversible retinal pigmentation
Standard drug used to compare doses
Antihistamines to tx EPS
SE: increased QT or PR interval
Chlorpromazine (Thorazine) class
Drugs with depot preparations available
Dose related increase in prolactin
SE: Photosensitivity
Olanzapine (Zyprexa) class
Endocrine SE of antipsychotics
MOA: D4, D1, and 5HT2 (Serotonergic blockade)
Motor SE of antipsychotics
Class: better for positive symptoms
Decreases prolactin secretion
Behavior SE of antipsychotics
Anti-cholinergics that tx EPS
Class: better for negative symptoms
No effect on prolactin
Seroquel (Quetiapine) class
Haloperidol (Haldol) class
Phenothiazines with > D2 affinity, increased EPS, requiring lower dose than other typicals
SE typical of high dose/low potency drugs
SE: high anticholinergic effects (constipation), antihistamine (--> sedation), seizure, low BP, agranulocytosis, metabolic syndrome
Low dose/high potency drugs
Slight increase in prolactin with high dose
Risperidal (Risperidone) class
Aripiprazole (Abilify) class
Test for Tardive Dyskinesia
MOA: weak D2 antagonist. 10x > D4 affinty than D2 affinity

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