Miscellaneous Quiz / Doctoring Test Pharm

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Can you name the Doctoring Test Pharm?

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Standard drug used to compare doses
Clozapine class
Low dose/high potency drugs
SE: increased QT or PR interval
Thiothixene (Navane) class
Class: better for negative symptoms
MOA: blocks cholinergic receptors
MOA: weak D2 antagonist. 10x > D4 affinty than D2 affinity
Trifluoperazine (Stelazine) class
Ziprasidone (Geodon) class
SE: Photosensitivity
Test for Tardive Dyskinesia
Behavior SE of antipsychotics
Aripiprazole (Abilify) class
Endocrine SE of antipsychotics
Fluphenazine (Prolixin) class
Chlorpromazine (Thorazine) class
Paliperidone (Invega) class
Dose related increase in prolactin
Drug NOT to exceed 800 mg - irreversible retinal pigmentation
Drugs with depot preparations available
Thioridazine (Mellaril) class
Slight increase in prolactin with high dose
Haloperidol (Haldol) class
Decreases prolactin secretion
SE: high anticholinergic effects (constipation), antihistamine (--> sedation), seizure, low BP, agranulocytosis, metabolic syndrome
Anti-cholinergics that tx EPS
Phenothiazines with > D2 affinity, increased EPS, requiring lower dose than other typicals
Antihistamines to tx EPS
When to avoid antipsychotics during pregnancy
Olanzapine (Zyprexa) class
MOA: Low D2-R potency, highly sedative, causes decreased BP
Class: better for positive symptoms
SE: elevated temp, high CPK, rhabdomyolosis, muscle rigidity, delirium
Risperidal (Risperidone) class
SE typical of high dose/low potency drugs
Motor SE of antipsychotics
No effect on prolactin
Seroquel (Quetiapine) class
MOA: D4, D1, and 5HT2 (Serotonergic blockade)

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Created Dec 14, 2011ReportFavoriteNominate

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