Miscellaneous Quiz / Doctoring Test Pharm

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Can you name the Doctoring Test Pharm?

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SE: elevated temp, high CPK, rhabdomyolosis, muscle rigidity, delirium
Motor SE of antipsychotics
SE: increased QT or PR interval
Low dose/high potency drugs
MOA: D4, D1, and 5HT2 (Serotonergic blockade)
Test for Tardive Dyskinesia
Trifluoperazine (Stelazine) class
When to avoid antipsychotics during pregnancy
Behavior SE of antipsychotics
Ziprasidone (Geodon) class
Anti-cholinergics that tx EPS
Chlorpromazine (Thorazine) class
Class: better for positive symptoms
Olanzapine (Zyprexa) class
Thioridazine (Mellaril) class
Standard drug used to compare doses
Aripiprazole (Abilify) class
Drugs with depot preparations available
Class: better for negative symptoms
Paliperidone (Invega) class
MOA: Low D2-R potency, highly sedative, causes decreased BP
MOA: weak D2 antagonist. 10x > D4 affinty than D2 affinity
SE typical of high dose/low potency drugs
Clozapine class
SE: Photosensitivity
Risperidal (Risperidone) class
Slight increase in prolactin with high dose
Dose related increase in prolactin
MOA: blocks cholinergic receptors
Haloperidol (Haldol) class
Decreases prolactin secretion
Antihistamines to tx EPS
No effect on prolactin
Fluphenazine (Prolixin) class
Endocrine SE of antipsychotics
Seroquel (Quetiapine) class
Phenothiazines with > D2 affinity, increased EPS, requiring lower dose than other typicals
Drug NOT to exceed 800 mg - irreversible retinal pigmentation
SE: high anticholinergic effects (constipation), antihistamine (--> sedation), seizure, low BP, agranulocytosis, metabolic syndrome
Thiothixene (Navane) class

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