Miscellaneous Quiz / anti-viral agents

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Can you name the anti-viral agents?

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Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
SE: bronchospasm and psychological effects
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
Conditions increasing hospitalization rates by 4-5X
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated
Most common cause of bronchiolitis and PNA in children < 1 y.o.
________ + peg IFN alpha-2A = standard tx for HCV
100% resistance with seasonal H3N2 and 2009 pandemic flu
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
Hospitalizes 2-3% of infants in the first 12 months of life
Active against BOTH Influenza A and B
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy
AVOID in asthma and COPD
Used in children with severe RSV to minimize bronchiolitis or PNA.
HintAnswer
Neuroaminidase Inhibitors
RSV agent used only for prophylaxis
Negative sense, single-stranded RNA virus
Agents used in RSV infections
SE: GI symptoms and psychological effects
Anti-influenza agent classes
SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
Oral bioavailability is increased with high fat meal and decreased with antacid
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
Blocks ___ ion channels and INHIBITS UNCOATING
MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
M2 Inhibitors
Active against Influenza A only
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz

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