Miscellaneous Quiz / anti-viral agents

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Can you name the anti-viral agents?

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100% resistance with seasonal H3N2 and 2009 pandemic flu
Anti-influenza agent classes
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
M2 Inhibitors
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
________ + peg IFN alpha-2A = standard tx for HCV
Blocks ___ ion channels and INHIBITS UNCOATING
SE: bronchospasm and psychological effects
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
Conditions increasing hospitalization rates by 4-5X
Used in children with severe RSV to minimize bronchiolitis or PNA.
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz
HintAnswer
Negative sense, single-stranded RNA virus
Active against Influenza A only
Active against BOTH Influenza A and B
Agents used in RSV infections
RSV agent used only for prophylaxis
Oral bioavailability is increased with high fat meal and decreased with antacid
AVOID in asthma and COPD
Most common cause of bronchiolitis and PNA in children < 1 y.o.
Neuroaminidase Inhibitors
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated
MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
SE: GI symptoms and psychological effects
Hospitalizes 2-3% of infants in the first 12 months of life
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy

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