Miscellaneous Quiz / anti-mycotic / anti-leprosy drugs

Random Miscellaneous Quiz

Can you name the anti-mycotic / anti-leprosy drugs?

Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
Score 0/59 Timer 15:00
HintAnswer
Used in place of rifampin for tx of TB in HIV-infected pts who are receiving concurrent anti-retroviral tx
Tx of PB leprosy
MOA: Inhibits mycolic acid synthesis by targeting InhA; penetrates into macrophages; needs activation; most active drug
Tx of M. kansaii
Contraindicated with certain meds (warfarin, digoxin, quinidine, cyclosporine, ketoconazole, phenytoin, anti-HIV agents, oral contraceptives) d/t strong inducer of P450
Accumulates in RF. SE: dose-related retrobulbar neuritis (loss of visual acuity and red-green color blindness)
MOA: phenazine dye that can be used as an alternative to dapsone. Inhibits bacterial DNA synthesis
Rifapentine class
Rifampin class
MOA: Cell wall synthesis inhibitor taken with pyridoxine. SE: peripheral neuropathy, CNS dysfunction - monitor serum concentration
MOA: macrolide that binds to and inhibits 50S ribosomes
MOA: rifamycin derivative - bacterial RNA polymerase inhibitor; inhibits P450 enzymes
Ethionamide class
Tx of M. avium complex (MAC)
Ethambutol class
Resistance via point mutations of rpoB gene --> decreases binding of __________ to RNA polymerase
M. leprae tx
Tx of MB leprosy
SE: GI intolerance, dry skin, and discoloration
Levofloxacin class
Inhibits P450 enzymes; SE increased serum aminotransferase --> hepatotoxicity; peripheral neuropathy d/t pyridoxine deficiency; seizures (d/t decreased GABA)
Used as a combo with rifampin and clofazimine recommended to prevent resistance
MOA: Fluroquinolone - DNA synthesis inhibitor active against M. tuberculosis and atypical mycobacteria
Azithromycin class
MOA: similar to INH, mycolic acid synthesis inhibitor. SE: GI upset, hepatitis, hemolysis
Isoniazid class
M. tuberculosis complex tx
Contraindicated in HIV pts d/t high relapse rate with rifampin resistant strains
Resistance via mutations in the InhA gene and/or mutation or deletion of katG gene
Resistance via overexpression of the arabinosyl transferase
HintAnswer
MOA: inhibits bacterial folate synthesis by inhibiting dihydropteroate synthase
MOA: Inhibits mycobacterial arabinosyl transferase; bacteriostatic
Clofazimine class
SE: neprotoxicity and ototoxicity
p-Aminosalicyclic Acid class
Capeomycin class
Strains of TB also resistant to the best 2nd line meds (fluoroquinolone and at least one of the three IV drugs - amikacin, kanamycin, or capreomycin)
Rifabutin class
Amikacin class
Strains of TB resistant to at least 2 of the main 1st line drugs (INH and RIF)
MOA: Aminoglycoside injectable drug which causes irreversible inhibition of 30S ribosome
MOA: Inhibits bacterial RNA synthesis by binding to the b subunit of bacterial RNA polymerase; used against active TB and as an anti-leprosy agent
Pyrazinamide class
SE: concentration and time dependent - ototoxicity and nephrotoxicity. Resistance via ribosomal binding site
Contraindicated in _____ allergy, hepatotoxicity, and acute liver dz. Also inhibits P450 mediated drug metabolism (caution for increased concentration of phenytoin, carbamazepine,
Used for sulfone resistant leprosy or when pts are intolerant to sulfones. Useful for the tx of erythema nodosum leprosum
SE: hemolysis (esp in G6PD deficiency), erythema nodosum leprosum
MOA: similar to PABA - folate synthesis inhibitor
SE: hepatotoxicity, n/v, fever, hyperuricemia, polyarthralgia
Dapsone class
MOA: Injectable protein synthesis inhibitor for tx of drug-resistant TB
Streptomycin class
Cycloserine class
Resistance via mutations in pncA gene which encodes ___________
Excreted mainly through the liver/bile. SE: reddish color in urine, sweat, tears, and contact lenses; rashes; renal failure (nephritis); thrombocytopenia; cholestatic jaundice; hep
MOA: Unknown; Active against mycobacteria in the acidic lysosomes; structurally related to nicotinamide
Ciprofloxacin class
MOA: aminoglycoside - inhibits protein synthesis used in the tx of streptomycin-resistant TB
Clarithromycin class

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Join for Free
OR
Log In

You Might Also Like...

Show Comments

Extras

Created Apr 25, 2011ReportNominate
Tags:drug

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.

Report this User

Report this user for behavior that violates our Community Guidelines.

Details: