Miscellaneous Quiz / anti-mycotic / anti-leprosy drugs

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Can you name the anti-mycotic / anti-leprosy drugs?

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Tx of M. avium complex (MAC)
SE: neprotoxicity and ototoxicity
Used for sulfone resistant leprosy or when pts are intolerant to sulfones. Useful for the tx of erythema nodosum leprosum
Tx of PB leprosy
MOA: aminoglycoside - inhibits protein synthesis used in the tx of streptomycin-resistant TB
MOA: Injectable protein synthesis inhibitor for tx of drug-resistant TB
Rifabutin class
SE: hepatotoxicity, n/v, fever, hyperuricemia, polyarthralgia
Resistance via mutations in pncA gene which encodes ___________
Tx of MB leprosy
MOA: similar to INH, mycolic acid synthesis inhibitor. SE: GI upset, hepatitis, hemolysis
Ethambutol class
Isoniazid class
MOA: Cell wall synthesis inhibitor taken with pyridoxine. SE: peripheral neuropathy, CNS dysfunction - monitor serum concentration
Levofloxacin class
Azithromycin class
Resistance via mutations in the InhA gene and/or mutation or deletion of katG gene
M. tuberculosis complex tx
Clofazimine class
MOA: Inhibits mycobacterial arabinosyl transferase; bacteriostatic
Rifapentine class
MOA: macrolide that binds to and inhibits 50S ribosomes
MOA: Unknown; Active against mycobacteria in the acidic lysosomes; structurally related to nicotinamide
MOA: rifamycin derivative - bacterial RNA polymerase inhibitor; inhibits P450 enzymes
SE: GI intolerance, dry skin, and discoloration
Contraindicated with certain meds (warfarin, digoxin, quinidine, cyclosporine, ketoconazole, phenytoin, anti-HIV agents, oral contraceptives) d/t strong inducer of P450
MOA: similar to PABA - folate synthesis inhibitor
MOA: Inhibits mycolic acid synthesis by targeting InhA; penetrates into macrophages; needs activation; most active drug
Contraindicated in _____ allergy, hepatotoxicity, and acute liver dz. Also inhibits P450 mediated drug metabolism (caution for increased concentration of phenytoin, carbamazepine,
SE: hemolysis (esp in G6PD deficiency), erythema nodosum leprosum
Accumulates in RF. SE: dose-related retrobulbar neuritis (loss of visual acuity and red-green color blindness)
Contraindicated in HIV pts d/t high relapse rate with rifampin resistant strains
M. leprae tx
Used in place of rifampin for tx of TB in HIV-infected pts who are receiving concurrent anti-retroviral tx
SE: concentration and time dependent - ototoxicity and nephrotoxicity. Resistance via ribosomal binding site
Strains of TB also resistant to the best 2nd line meds (fluoroquinolone and at least one of the three IV drugs - amikacin, kanamycin, or capreomycin)
Pyrazinamide class
Ciprofloxacin class
p-Aminosalicyclic Acid class
Tx of M. kansaii
MOA: Inhibits bacterial RNA synthesis by binding to the b subunit of bacterial RNA polymerase; used against active TB and as an anti-leprosy agent
Cycloserine class
MOA: Fluroquinolone - DNA synthesis inhibitor active against M. tuberculosis and atypical mycobacteria
Amikacin class
Resistance via overexpression of the arabinosyl transferase
MOA: Aminoglycoside injectable drug which causes irreversible inhibition of 30S ribosome
Streptomycin class
Inhibits P450 enzymes; SE increased serum aminotransferase --> hepatotoxicity; peripheral neuropathy d/t pyridoxine deficiency; seizures (d/t decreased GABA)
Excreted mainly through the liver/bile. SE: reddish color in urine, sweat, tears, and contact lenses; rashes; renal failure (nephritis); thrombocytopenia; cholestatic jaundice; hep
MOA: phenazine dye that can be used as an alternative to dapsone. Inhibits bacterial DNA synthesis
Resistance via point mutations of rpoB gene --> decreases binding of __________ to RNA polymerase
Dapsone class
Rifampin class
Ethionamide class
Used as a combo with rifampin and clofazimine recommended to prevent resistance
Strains of TB resistant to at least 2 of the main 1st line drugs (INH and RIF)
MOA: inhibits bacterial folate synthesis by inhibiting dihydropteroate synthase
Clarithromycin class
Capeomycin class

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Created Apr 25, 2011ReportNominate

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