Miscellaneous Quiz / anti-mycotic / anti-leprosy drugs

Random Miscellaneous Quiz

Can you name the anti-mycotic / anti-leprosy drugs?

Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
Score 0/59 Timer 15:00
HintAnswer
Ethambutol class
Dapsone class
Used as a combo with rifampin and clofazimine recommended to prevent resistance
Levofloxacin class
Strains of TB also resistant to the best 2nd line meds (fluoroquinolone and at least one of the three IV drugs - amikacin, kanamycin, or capreomycin)
Strains of TB resistant to at least 2 of the main 1st line drugs (INH and RIF)
MOA: Fluroquinolone - DNA synthesis inhibitor active against M. tuberculosis and atypical mycobacteria
Resistance via mutations in the InhA gene and/or mutation or deletion of katG gene
Azithromycin class
Resistance via mutations in pncA gene which encodes ___________
SE: GI intolerance, dry skin, and discoloration
MOA: Unknown; Active against mycobacteria in the acidic lysosomes; structurally related to nicotinamide
Ciprofloxacin class
M. leprae tx
MOA: similar to INH, mycolic acid synthesis inhibitor. SE: GI upset, hepatitis, hemolysis
MOA: aminoglycoside - inhibits protein synthesis used in the tx of streptomycin-resistant TB
MOA: macrolide that binds to and inhibits 50S ribosomes
Excreted mainly through the liver/bile. SE: reddish color in urine, sweat, tears, and contact lenses; rashes; renal failure (nephritis); thrombocytopenia; cholestatic jaundice; hep
p-Aminosalicyclic Acid class
MOA: Aminoglycoside injectable drug which causes irreversible inhibition of 30S ribosome
Contraindicated in HIV pts d/t high relapse rate with rifampin resistant strains
MOA: rifamycin derivative - bacterial RNA polymerase inhibitor; inhibits P450 enzymes
Contraindicated in _____ allergy, hepatotoxicity, and acute liver dz. Also inhibits P450 mediated drug metabolism (caution for increased concentration of phenytoin, carbamazepine,
MOA: Inhibits bacterial RNA synthesis by binding to the b subunit of bacterial RNA polymerase; used against active TB and as an anti-leprosy agent
Pyrazinamide class
MOA: Cell wall synthesis inhibitor taken with pyridoxine. SE: peripheral neuropathy, CNS dysfunction - monitor serum concentration
SE: hepatotoxicity, n/v, fever, hyperuricemia, polyarthralgia
M. tuberculosis complex tx
Cycloserine class
MOA: Injectable protein synthesis inhibitor for tx of drug-resistant TB
HintAnswer
SE: concentration and time dependent - ototoxicity and nephrotoxicity. Resistance via ribosomal binding site
Capeomycin class
Rifapentine class
Tx of MB leprosy
MOA: Inhibits mycobacterial arabinosyl transferase; bacteriostatic
Resistance via overexpression of the arabinosyl transferase
MOA: inhibits bacterial folate synthesis by inhibiting dihydropteroate synthase
Tx of M. avium complex (MAC)
Inhibits P450 enzymes; SE increased serum aminotransferase --> hepatotoxicity; peripheral neuropathy d/t pyridoxine deficiency; seizures (d/t decreased GABA)
Resistance via point mutations of rpoB gene --> decreases binding of __________ to RNA polymerase
Streptomycin class
Rifampin class
MOA: Inhibits mycolic acid synthesis by targeting InhA; penetrates into macrophages; needs activation; most active drug
MOA: similar to PABA - folate synthesis inhibitor
Contraindicated with certain meds (warfarin, digoxin, quinidine, cyclosporine, ketoconazole, phenytoin, anti-HIV agents, oral contraceptives) d/t strong inducer of P450
Accumulates in RF. SE: dose-related retrobulbar neuritis (loss of visual acuity and red-green color blindness)
Used in place of rifampin for tx of TB in HIV-infected pts who are receiving concurrent anti-retroviral tx
Ethionamide class
Rifabutin class
Clofazimine class
Tx of M. kansaii
Amikacin class
Clarithromycin class
Tx of PB leprosy
SE: neprotoxicity and ototoxicity
SE: hemolysis (esp in G6PD deficiency), erythema nodosum leprosum
MOA: phenazine dye that can be used as an alternative to dapsone. Inhibits bacterial DNA synthesis
Isoniazid class
Used for sulfone resistant leprosy or when pts are intolerant to sulfones. Useful for the tx of erythema nodosum leprosum

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.