Miscellaneous Quiz / Anti-hypertensive drugs

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Can you name the Anti-hypertensive drugs?

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Hydralazine
Mecamylamine
Contraindicated in pregnant and renovascular disease
SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision
Beta 1 specific blocker
Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake
Mixed alpha and beta blocking
Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism
Main use of venule/arteriolar dilators
Inhibits Na-K-Cl exhanger in TAL
CNS acting alpha receptor agonist
Partial beta agonist
SE: increased TG, decreased HDL, decreased recovery from hypoglycemia
Vasodilator with lupus erythematosus SE
Blocks release of NE - replaces NE as a false transmitter - used in severe HTN
BB may be better in pts with depressed cardiac function or lung disease
D1 agonist
Inhibits NaCl transport in DCT preventing Na reabsorption
Spironalactone
CNS acting drug used for HTN in pregnant pts
SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs
SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects
Adrenergic nerve blockers
Similar SE to ACEI with no cough or angioedema
Diuretic used in hypertensive emergencies with acute left ventricular failure
SE: accumulation of cyanide, metabolic acidosis
HintAnswer
BB used in IV hypertensive emergency with MI or unstable angina
ACEI
SE: increased risk of HF
Long acting ACEI
MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR
Furosemide
SE: inhibits pancreatic insulin release
Needs multiple daily dosing or TD patch
ARB - blocks angiotensin type 1 (AT1) receptor
Compelling indication for alpha adrenergic receptor blocker
SE: same as methyldopa, dry mouth common
More pronounced blockade but no effects on bradykinin
Alpha 1 adrenergic blocker
Compelling indication for diuretic therapy
Hydrochlorothiazide
Vasodilator wtih MOA NO release and cGMP activation
Short half life but prolonged effects
CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist
Used in severe HTN, preeclampsia
BB used in IV hypertensive emergency and HTN caused by pheochromocytomas
Direct vasodilator of venules and arterioles
Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis
Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery
Minoxidil
Inhibits aldosterone receptor

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Created Mar 15, 2011ReportNominate
Tags:Drug

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