Miscellaneous Quiz / Anti-hypertensive drugs

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Can you name the Anti-hypertensive drugs?

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SE: same as methyldopa, dry mouth common
Hydrochlorothiazide
SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects
CNS acting drug used for HTN in pregnant pts
SE: accumulation of cyanide, metabolic acidosis
CNS acting alpha receptor agonist
Minoxidil
Furosemide
Direct vasodilator of venules and arterioles
Mixed alpha and beta blocking
Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism
More pronounced blockade but no effects on bradykinin
ARB - blocks angiotensin type 1 (AT1) receptor
Spironalactone
MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR
BB used in IV hypertensive emergency with MI or unstable angina
BB used in IV hypertensive emergency and HTN caused by pheochromocytomas
Hydralazine
Adrenergic nerve blockers
Used in severe HTN, preeclampsia
Beta 1 specific blocker
Blocks release of NE - replaces NE as a false transmitter - used in severe HTN
Main use of venule/arteriolar dilators
Diuretic used in hypertensive emergencies with acute left ventricular failure
Mecamylamine
Vasodilator wtih MOA NO release and cGMP activation
HintAnswer
Long acting ACEI
Inhibits Na-K-Cl exhanger in TAL
D1 agonist
SE: inhibits pancreatic insulin release
ACEI
Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery
CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist
Partial beta agonist
SE: increased risk of HF
Compelling indication for alpha adrenergic receptor blocker
Compelling indication for diuretic therapy
SE: increased TG, decreased HDL, decreased recovery from hypoglycemia
BB may be better in pts with depressed cardiac function or lung disease
Needs multiple daily dosing or TD patch
Short half life but prolonged effects
SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision
Similar SE to ACEI with no cough or angioedema
Vasodilator with lupus erythematosus SE
Contraindicated in pregnant and renovascular disease
Inhibits NaCl transport in DCT preventing Na reabsorption
Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis
Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake
SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs
Inhibits aldosterone receptor
Alpha 1 adrenergic blocker

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