Hint | Answer |
BB used in IV hypertensive emergency and HTN caused by pheochromocytomas | |
Contraindicated in pregnant and renovascular disease | |
BB used in IV hypertensive emergency with MI or unstable angina | |
Short half life but prolonged effects | |
Compelling indication for alpha adrenergic receptor blocker | |
SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs | |
Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism | |
Alpha 1 adrenergic blocker | |
Similar SE to ACEI with no cough or angioedema | |
ACEI | |
Used in severe HTN, preeclampsia | |
SE: increased risk of HF | |
Spironalactone | |
Mixed alpha and beta blocking | |
SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision | |
CNS acting drug used for HTN in pregnant pts | |
Inhibits NaCl transport in DCT preventing Na reabsorption | |
Direct vasodilator of venules and arterioles | |
Partial beta agonist | |
Main use of venule/arteriolar dilators | |
SE: inhibits pancreatic insulin release | |
Hydrochlorothiazide | |
Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery | |
MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR | |
Blocks release of NE - replaces NE as a false transmitter - used in severe HTN | |
CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist | |
| Hint | Answer |
SE: same as methyldopa, dry mouth common | |
Vasodilator with lupus erythematosus SE | |
Inhibits aldosterone receptor | |
ARB - blocks angiotensin type 1 (AT1) receptor | |
Diuretic used in hypertensive emergencies with acute left ventricular failure | |
Mecamylamine | |
Long acting ACEI | |
Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake | |
Compelling indication for diuretic therapy | |
SE: accumulation of cyanide, metabolic acidosis | |
Beta 1 specific blocker | |
Hydralazine | |
D1 agonist | |
Adrenergic nerve blockers | |
More pronounced blockade but no effects on bradykinin | |
Furosemide | |
Minoxidil | |
BB may be better in pts with depressed cardiac function or lung disease | |
SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects | |
Vasodilator wtih MOA NO release and cGMP activation | |
Inhibits Na-K-Cl exhanger in TAL | |
Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis | |
Needs multiple daily dosing or TD patch | |
SE: increased TG, decreased HDL, decreased recovery from hypoglycemia | |
CNS acting alpha receptor agonist | |
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