Miscellaneous Quiz / Anti-hypertensive drugs

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Can you name the Anti-hypertensive drugs?

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SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision
MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR
Hydrochlorothiazide
BB used in IV hypertensive emergency and HTN caused by pheochromocytomas
Contraindicated in pregnant and renovascular disease
Compelling indication for diuretic therapy
Alpha 1 adrenergic blocker
Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism
Mecamylamine
Vasodilator wtih MOA NO release and cGMP activation
Main use of venule/arteriolar dilators
SE: inhibits pancreatic insulin release
SE: same as methyldopa, dry mouth common
D1 agonist
SE: increased risk of HF
Minoxidil
SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs
SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects
Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery
Direct vasodilator of venules and arterioles
Beta 1 specific blocker
Partial beta agonist
CNS acting drug used for HTN in pregnant pts
Long acting ACEI
Mixed alpha and beta blocking
Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake
HintAnswer
Adrenergic nerve blockers
Compelling indication for alpha adrenergic receptor blocker
Diuretic used in hypertensive emergencies with acute left ventricular failure
Needs multiple daily dosing or TD patch
Inhibits NaCl transport in DCT preventing Na reabsorption
SE: increased TG, decreased HDL, decreased recovery from hypoglycemia
CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist
More pronounced blockade but no effects on bradykinin
SE: accumulation of cyanide, metabolic acidosis
BB used in IV hypertensive emergency with MI or unstable angina
Spironalactone
ACEI
Vasodilator with lupus erythematosus SE
Furosemide
Hydralazine
BB may be better in pts with depressed cardiac function or lung disease
Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis
Short half life but prolonged effects
Inhibits aldosterone receptor
Inhibits Na-K-Cl exhanger in TAL
ARB - blocks angiotensin type 1 (AT1) receptor
CNS acting alpha receptor agonist
Blocks release of NE - replaces NE as a false transmitter - used in severe HTN
Similar SE to ACEI with no cough or angioedema
Used in severe HTN, preeclampsia

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