| Hint | Answer |
|---|
| SE: same as methyldopa, dry mouth common | |
| Hydrochlorothiazide | |
| SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects | |
| CNS acting drug used for HTN in pregnant pts | |
| SE: accumulation of cyanide, metabolic acidosis | |
| CNS acting alpha receptor agonist | |
| Minoxidil | |
| Furosemide | |
| Direct vasodilator of venules and arterioles | |
| Mixed alpha and beta blocking | |
| Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism | |
| More pronounced blockade but no effects on bradykinin | |
| ARB - blocks angiotensin type 1 (AT1) receptor | |
| Spironalactone | |
| MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR | |
| BB used in IV hypertensive emergency with MI or unstable angina | |
| BB used in IV hypertensive emergency and HTN caused by pheochromocytomas | |
| Hydralazine | |
| Adrenergic nerve blockers | |
| Used in severe HTN, preeclampsia | |
| Beta 1 specific blocker | |
| Blocks release of NE - replaces NE as a false transmitter - used in severe HTN | |
| Main use of venule/arteriolar dilators | |
| Diuretic used in hypertensive emergencies with acute left ventricular failure | |
| Mecamylamine | |
| Vasodilator wtih MOA NO release and cGMP activation | |
| | Hint | Answer |
|---|
| Long acting ACEI | |
| Inhibits Na-K-Cl exhanger in TAL | |
| D1 agonist | |
| SE: inhibits pancreatic insulin release | |
| ACEI | |
| Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery | |
| CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist | |
| Partial beta agonist | |
| SE: increased risk of HF | |
| Compelling indication for alpha adrenergic receptor blocker | |
| Compelling indication for diuretic therapy | |
| SE: increased TG, decreased HDL, decreased recovery from hypoglycemia | |
| BB may be better in pts with depressed cardiac function or lung disease | |
| Needs multiple daily dosing or TD patch | |
| Short half life but prolonged effects | |
| SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision | |
| Similar SE to ACEI with no cough or angioedema | |
| Vasodilator with lupus erythematosus SE | |
| Contraindicated in pregnant and renovascular disease | |
| Inhibits NaCl transport in DCT preventing Na reabsorption | |
| Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis | |
| Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake | |
| SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs | |
| Inhibits aldosterone receptor | |
| Alpha 1 adrenergic blocker | |
|
ltakehana
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