Anti-hypertensive drugs

Can you name the Anti-hypertensive drugs?

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BB used in IV hypertensive emergency and HTN caused by pheochromocytomas
Contraindicated in pregnant and renovascular disease
BB used in IV hypertensive emergency with MI or unstable angina
Short half life but prolonged effects
Compelling indication for alpha adrenergic receptor blocker
SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs
Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism
Alpha 1 adrenergic blocker
Similar SE to ACEI with no cough or angioedema
ACEI
Used in severe HTN, preeclampsia
SE: increased risk of HF
Spironalactone
Mixed alpha and beta blocking
SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision
CNS acting drug used for HTN in pregnant pts
Inhibits NaCl transport in DCT preventing Na reabsorption
Direct vasodilator of venules and arterioles
Partial beta agonist
Main use of venule/arteriolar dilators
SE: inhibits pancreatic insulin release
Hydrochlorothiazide
Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery
MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR
Blocks release of NE - replaces NE as a false transmitter - used in severe HTN
CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist
HintAnswer
SE: same as methyldopa, dry mouth common
Vasodilator with lupus erythematosus SE
Inhibits aldosterone receptor
ARB - blocks angiotensin type 1 (AT1) receptor
Diuretic used in hypertensive emergencies with acute left ventricular failure
Mecamylamine
Long acting ACEI
Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake
Compelling indication for diuretic therapy
SE: accumulation of cyanide, metabolic acidosis
Beta 1 specific blocker
Hydralazine
D1 agonist
Adrenergic nerve blockers
More pronounced blockade but no effects on bradykinin
Furosemide
Minoxidil
BB may be better in pts with depressed cardiac function or lung disease
SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects
Vasodilator wtih MOA NO release and cGMP activation
Inhibits Na-K-Cl exhanger in TAL
Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis
Needs multiple daily dosing or TD patch
SE: increased TG, decreased HDL, decreased recovery from hypoglycemia
CNS acting alpha receptor agonist

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