Miscellaneous Quiz / Anti-hypertensive drugs

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Can you name the Anti-hypertensive drugs?

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BB used in IV hypertensive emergency with MI or unstable angina
Direct vasodilator of venules and arterioles
Diuretic used in hypertensive emergencies with acute left ventricular failure
Inhibits aldosterone receptor
Mixed alpha and beta blocking
Long acting ACEI
Main use of venule/arteriolar dilators
Causes irreversible block of amine uptake into synaptic vesicles -> depletion of NT = blocks catecholamine uptake
Needs multiple daily dosing or TD patch
SE: CNS, sedation, mental lassitude, nightmares, mental depression, vertigo, extrpyramidal effects
CNS acting drug that is converted to active products in nerves producing alpha 2 receptor agonist
SE: sympathoplegia = orthostatic hypotension, sexual dysfunction and parasympathoplegia = constipation, urinary retention, dry mouth, blurred vision
Minoxidil
Used in severe HTN, preeclampsia
More pronounced blockade but no effects on bradykinin
MOA: unk, may increase K conductance preventing SM contraction -> arteriolar dilation -> decreased PVR
Alpha 1 adrenergic blocker
Vasodilator with lupus erythematosus SE
SE: inhibits pancreatic insulin release
CNS acting drug used for HTN in pregnant pts
BB may be better in pts with depressed cardiac function or lung disease
Short half life but prolonged effects
SE: same as methyldopa, dry mouth common
Hydrochlorothiazide
Hydralazine
Blocks release of NE - replaces NE as a false transmitter - used in severe HTN
HintAnswer
Compelling indication - angina, post-MI, essential tremor, SVT, hyperthyroidism
SE: increased TG, decreased HDL, decreased recovery from hypoglycemia
Beta 1 specific blocker
Adrenergic nerve blockers
Contraindicated in pregnant and renovascular disease
Vasodilator wtih MOA NO release and cGMP activation
Similar SE to ACEI with no cough or angioedema
SE: accumulation of cyanide, metabolic acidosis
D1 agonist
CNS acting alpha receptor agonist
Partial beta agonist
Compelling indication for diuretic therapy
ACEI
SE: initial dose severe low BP, renal failure, dry cough, angioedema, hyperkalemia in RF or DM. Affected by NSAIDs
Inhibits NaCl transport in DCT preventing Na reabsorption
BB used in IV hypertensive emergency and HTN caused by pheochromocytomas
SE: increased risk of HF
Spironalactone
Compelling indication for alpha adrenergic receptor blocker
ARB - blocks angiotensin type 1 (AT1) receptor
Inhibits Na-K-Cl exhanger in TAL
Mecamylamine
Ganglion blocker used IV to manage hypertensive crisis, acute aortic dissection, and BP control for neurosurgery
Furosemide
Non selective alpha 1 and 2 blocker used in hypertensive emergencies with adrenergic crisis

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