Miscellaneous Quiz / anti-histamines

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Can you name the anti-histamines?

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Forced Order
Also try: Oddly Shaped Foods
Score 0/45 Timer 15:00
Hydroxyzine class
Anti-cholinergic +++ / Sedation +++
Other action: Anti-emetic
Little CNS penetration
Class with anti-parkinsonian effects
Anti-cholinergic + / Sedation +
Other action: OTC 'cold' med
Brompheniramine class
Other action: sleep aid
Anti-cholinergic +++ / Sedation ++
Cetirizine class
SE: high dose sedation
Other action: anti-motion sickness
Drug interactions: metabolized in the liver, DOA 4-6 hours, caution w/ drug sedative drug combos and antimuscarinic drugs. Lethal ventricular arrhythmias --> prolonged QT.
Pyrilamine class
Other action: OTC 'sleep aid'
Kinetics: less CNS penetration (dose related sedation), CYP3A4 metabolism (drug interactions). Active metabolites (hydroxyzine -> cetirizine; terfen
Fexofenadine class
Contraindicated in glaucoma and BPH
Tripelennamine class
Loratodine class
Cyclizine class
Chloropheniramine class
Doxylamine class
Not very useful except for inducing bronchial hyperreactivity to check pulmonary function
Drug interactions: metabolized by CYP, inhibitors, and inducers effect therapy and toxicity
Meclizine class
Agents with local anesthetic effect via sodium channel blockage in nerves
Containdications for histamine agonist
Anti-cholinergic - / Sedation +
SE: > placebo = viral infection, N/V, dysmenorrhea, drowsiness, dyspepsia, and fatigue
SE: flushing hypotension, tachycardia, HA, wheal and flare reactions, bronchoconstriction, GI upset
Other action: Anti-serotonin action and weight gain
Anti-cholinergic - / Sedation +++
Cyproheptadine class
Carbinoxamine class
Physiologic antagonist for anaphylaxis
SE: muscarinic receptor blockage: dry mouth, urinary retention, constipation, ED, blurred vision, ST; alpha receptor blockade: orthostatic hypotension, reflex tachycardia;
Release inhibitors used in asthma and AR
Promethazine class
May inhibit absorption of other drugs through active transport mechanism and CYP metabolism
Diphenhydramine class
SE: serotonin-receptor blockade (increased appetite). Sedation, drowsiness, memory impairment, dystonia, dyskinesia, hallucinations, mydriasis, dry eye, weight gain.
Anti-cholinergic - / Sedation +/-
Anti-cholinergic + / Sedation ++

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