Miscellaneous Quiz / anti-histamines

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Can you name the anti-histamines?

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Agents with local anesthetic effect via sodium channel blockage in nerves
Promethazine class
Physiologic antagonist for anaphylaxis
Kinetics: less CNS penetration (dose related sedation), CYP3A4 metabolism (drug interactions). Active metabolites (hydroxyzine -> cetirizine; terfen
Drug interactions: metabolized in the liver, DOA 4-6 hours, caution w/ drug sedative drug combos and antimuscarinic drugs. Lethal ventricular arrhythmias --> prolonged QT.
Anti-cholinergic + / Sedation +
Meclizine class
Other action: sleep aid
SE: flushing hypotension, tachycardia, HA, wheal and flare reactions, bronchoconstriction, GI upset
Anti-cholinergic +++ / Sedation ++
Other action: anti-motion sickness
Drug interactions: metabolized by CYP, inhibitors, and inducers effect therapy and toxicity
Other action: OTC 'sleep aid'
Anti-cholinergic +++ / Sedation +++
Other action: OTC 'cold' med
Anti-cholinergic - / Sedation +++
Release inhibitors used in asthma and AR
SE: serotonin-receptor blockade (increased appetite). Sedation, drowsiness, memory impairment, dystonia, dyskinesia, hallucinations, mydriasis, dry eye, weight gain.
Contraindicated in glaucoma and BPH
Brompheniramine class
Not very useful except for inducing bronchial hyperreactivity to check pulmonary function
Cetirizine class
Fexofenadine class
SE: high dose sedation
SE: muscarinic receptor blockage: dry mouth, urinary retention, constipation, ED, blurred vision, ST; alpha receptor blockade: orthostatic hypotension, reflex tachycardia;
Tripelennamine class
May inhibit absorption of other drugs through active transport mechanism and CYP metabolism
Anti-cholinergic + / Sedation ++
Loratodine class
Little CNS penetration
Anti-cholinergic - / Sedation +/-
SE: > placebo = viral infection, N/V, dysmenorrhea, drowsiness, dyspepsia, and fatigue
Cyproheptadine class
Other action: Anti-serotonin action and weight gain
Cyclizine class
Anti-cholinergic - / Sedation +
Pyrilamine class
Class with anti-parkinsonian effects
Diphenhydramine class
Carbinoxamine class
Hydroxyzine class
Containdications for histamine agonist
Doxylamine class
Chloropheniramine class
Other action: Anti-emetic

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Created Apr 29, 2011ReportNominate
Tags:Nintendo Quiz

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