Miscellaneous Quiz / Anti-hepatitis Agents

Random Miscellaneous Quiz

Can you name the Anti-hepatitis Agents?

 Plays Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
Score 0/50 Timer 20:00
HintAnswer
Group MOA cont. (2) Ribonuclease L (activated by 2'5' oligo A): degrades mRNA.
P-kinetics: Natural. SC or IM
P-kinetics: Oral (TID). P450 substrates (potential rx interactions)
IFN α-2b Class
SE: HA, fatigue, nausea. Potential mitochondrial toxicity (lactic acidosis & hepatic steatosis)
SE: Anemia, neutropenia, dysgeusia, skin rash (esp. telaprevir), increased QT intervals (telaprevir)
Use: HBV treatment adults only
MOA: A prodrug (a guanosine nucleoside analogue). Phosphorylated by host cell enzymes; inhibits viral RNA-dependent polymerases.
MOA: A cytosine analogue
MOA: An adenosine analogue. Structurally similar to adefovir.
P-kinetics: Synthetic (consensus). SC
Boceprevir Class
SE: Flu-like symptoms (fever, chills, myalgias, malaise). Neurotoxicity, myelosuppression, fatigue (chronic use). Transient hepatic enzyme elevation.
Group MOA cont. (3) Protein kinase (activated by dsRNA): phosphorylates/inhibits eIF-2, therefore blocking PRO synthesis
P-kinetics: Oral bioavailability increased with high-fat meal, decreased with antacid.
Drug MOA: PEG = polyethylene glycol
Group MOA cont: Associated with mitochondrial DNA toxicity (by inhibiting DNA polymerase gamma)
Contraindications: Hepatic decompensation, autoimmune dz, cardiac arrhythmia, pregnancy
Contraindications: Pts w/ uncorrected anemia, ESRD, preggo. Teratogenic: avoid pregnancy for > 6 mos thereafter
PEG-IFN α-2a Class
P-kinetics: Clinical resistance is rare. Oral bioavailability decreased by food (taken w/ empty stomach). Renal elimination (serum concentration increased w/ altered kidney activit
Adefovir dipivoxil (Hepsera) Class
Group P-kinetics: Pills once a day for a year or longer
Lamivudine (3TC, Heptovir) Class
Telbivudine (Tyzeka) Class
HintAnswer
P-kinetics:Oral bioavailability not affected by food. Emergence of resistance in long term use.
Use: Effective suppression of HBV DNA, normalization of ALT & reducing HBeAg. Adults only
PEG-IFN α-2a/2b class
Use: HBV: Safer for pts w/ decompensated liver dz. For both adults & peds
IFN α-2a/2b class
P-kinetics: Slower clearance (less frequent dosing). Dosage adjustment is needed in renal dysfunction
SE: Dose-dependent hemolytic anemia. Depression, fatigue, irritability, nausea, insomnia.
Group MOA: 3 major enzymes are activated by IFN-JNK/STAT signaling pathway: (1) 2',5' oligo A synthase: produces 2'5' oligo A.
Tenofovir Class
Group MOA: Competively inhibit HBV DNA polymerase +/- incorporate into viral DNA causing chain termination. Phosphorylated to active forms intracellularly by cellular kinases.
Telaprevir Class
MOA: A thymidine analog
IFN alfacon-1 class
MOA: A prodrug of adefovir (adenosine analogue). Slows suppression of HBV DNA; least seroconversion
MOA: A guanisine analog. Inhibits all 3 functions of HBV RNA-dependent DNA polymerase (base priming, reverse transcription of the -strand, synthesis of the + strand of HBV DNA.
Use: The most potent anti-HBV agent. Adults only
P-kinetics: Lipophilic (pivoxil) moiety enhances oral bioavailability.
P-kinetics: Prolonged intracellular half-life in HBV (than in HIV). Rapid oral absorption; eliminated unchanged. Used at lower doses for hepatitis than for AIDS.
SE: Increased pancreatitis in HIV/HBV pts. Emergence of resistance (mutations of DNA polymerase)
Entecavir (Baraclude) Class
MOA: Serine protease inhibitors. Bind to inhibit HCV non-structural protein NS3
Use: Improve therapeutic response in pts (>18 yo) w/ HCV genotype 1 when combined w/ IFN/ribavirin
Use: Lamivudine-resistant HBV. Adults only
SE: Nephrotoxicity (at high doses). Potential mitochondrial DNA toxicity
P-kinetics: Higher rate of complete response & less resistance vs. adefovir

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Join for Free
OR
Log In

You Might Also Like...

Show Comments

Extras

Created Feb 10, 2012ReportNominate
Tags:agent

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.

Report this User

Report this user for behavior that violates our Community Guidelines.

Details: