Miscellaneous Quiz / anti-asthmatic agents

Random Miscellaneous Quiz

Can you name the anti-asthmatic agents?

Quiz not verified by Sporcle

Forced Order
Also try: 'M' Blitz
Challenge
Share
Tweet
Embed
Score 0/67 Timer 20:00
HintAnswer
Added to inhaled corticosteroid for increased symptomatic relief in moderate to severe asthma. >12 hrs
SE: dose dependent tox (monitor plasma levels), low anorexia, N/V, abd discomfort, HA, anxiety. May cause nervousness and insomnia. High level of seizures and arrhythmias.
Albuterol class
Advantage = inexpensive and oral; Disadvantage = needs plasma monitoring, insomnia, serious toxicity of OD
Used as 1st line therapy for COPD or in combo with b2/steroid for moderate asthma for relief of acute bronchospasm. Added to SABA or given if SABA not tolerated
Methylprednisolone
Drug(s) which in older adults may be associated with dose-dependent reduction in bone mineral content. Needs to be given with Ca supplements and Vit D.
Clearance by liver, rate varies widely -- fastest in children, slowest in neonates and infants, dose corrected needed in liver dz.
Limit to 5-10 days. Many SE: change in glucose metabolism, increased appetite, wt gain, fluid retention, mood changes, peptic ulcer, HTN, adrenal suppression (cushings), candiasis
Caffiene class
Theophylline class
SE: B1 effects: tachycardia, arrhythmia, angina pectoris
Zileuton class
Plasma concentration of methylxanthine 5-20 mg/ml
MOA: alters chloride channel function reducing mast cell degranulation and nerve conduction in lungs mediating cough
Budesonide class
Used if beta-2-glucocorticoid combo is not effective. Not preferred, used as an alternative
Mometasone furoate class
Montelukast class
Tiotropium class
Pirbuterol class
SE: occasional liver toxicity
MOA: decreases vascular permeability and potentiates B-agonist effects on airway obstruction. Inhaled are more effective in the long term
HintAnswer
Nedocromil class
MOA: increases release of norepinephrine used as a second-line asthma therapy
Always given in combo with anti-inflammatory. Used long-term mgmt of moderate and severe persistent asthma. Not for acute symptoms or exacerbation.
MOA: b2 receptor agonist -> increased intracellular cAMP and smooth muscle relaxation -> relaxed airway smooth muscle -- somewhat resistant to receptor downregulation and desensiti
Salmetrol class
Used systemically: very severe persistent asthma uncontrolled by ICS and LABA or for emergent severe asthma or exacerbation of symptoms
MOA: LTD4 receptor antagonist (prevents leukotriene-induced bronchoconstriction)
SE: well tolerated, occasional N/V, bitter taste, sore throat, HA, cough, rhinitis
Ipratropium class
MOA: muscarinic receptor antagonist --> blocks parasympathetic bronchoconstriction and mucus release
Used as an inhaled agent. Most potent and effective. Mild persistent or exercise induced asthma, and moderate to severe asthma
L-albuterol class
MOA: inhibits late phase of airway inflamm & hyperreactivity via inhibition of transcription of pro-inflamm mediators & enzymes. Inactivates phospholipase A2 preventing prod of pro
Theobromine class
Low risk for adverse SE at recommended dose. Reduce SE with spacer and rinsing mouth; use lowest dose; use in combo w/ LABA. Monitor growth in kids - poorly controlled asthma may d
MOA 2: Inhibits function of immune cells - inhibit cell growth, prevent release of inflammatory mediators and cytokines, susceptible to receptor down regulation and desensitization
MOA: lowers IgE to undetectable levels: inhibit the binding of IgE to mast cells. Inhibits early and late responses to antigen challenge
Formoterol class
SE: increased mortality with monotherapy -- systemic effects are reduced by inhalation application
MOA: phosphodiesterase inhibitor --> increased cAMP and cGMP AND adenosine receptor antagonist --> smooth muscle relaxation. Mild to moderate bronchodilator
Cromolyn class
Possible contraindications or caution needed with sympathomimetics, SABAs, and LABAs for:
Used in long-term prevention of symptoms, PROPHYLACTIC use only. Use if nonresponder to steroid, want to reduce steroid dose when used in combo or when inciting stimulus is known
HintAnswer
Plasma concentration of methylxanthine > 20 mg/ml
SE: inhaled (low), tachycardia, cardiac arrhythmias, tremulousness, muscle cramps, metabolic disturbances
Used in adjunctive therapy only for patients > 12 yrs who have allergies and moderate to severe persistent asthma inadequately controlled with ICS. Given SC q 2-4 weeks
Metaproterenol class
Beclomethasone class
Zafirlukast class
Not appropriate for monotherapy
Sympathomimetic drugs
Triamcinolone class
More than one canister/month suggests inadequate asthma control. Regularly scheduled use is not recommended.
Most effective bronchodilator is theophylline. Given as different salts, good PO absorption.
MOA: 5-lipooxygenase inhibitor --> decreased leukotriene production
Drug(s) which may cause older adults to experience confusion, agitation, and changes in glucose metabolism
Used for long-term control in mild persistent asthma (secondary to corticoids) In combo ICS, allergic rhinitis. Improves lung function, reduces need for SABA, prevents exacerbation
Terbutaline class
Prednisone class
Most effective med for symptomatic relief of acute bronchospasm. Used in mild to moderate asthma alone or in combo for severe asthma.
Plasma concentration of methylxanthine > 40 mg/ml
SE: comparable to placebo, rash, GI upset, bleeding, viral infections, may increase potential for malignant neoplasms
Omalizumab class
Flunisolide class

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras


Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.