Miscellaneous Quiz / Anti-arrhythmia drugs

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QUIZ: Can you name the Anti-arrhythmia drugs?

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Used in refractory ventricular arrythmias and some SVT -- oral with long half life
Preferential for ectopic arryhythmias and ventricular arrhythmias d/t increased automaticity and reentry
MOA: partial beta agonist
SE: least toxic for cardiac arrhythmias, CNS, drowsiness, slurred speech, paresthesia, agitation, convulsions
DOC for ventricular arrhythmias, esp. post-MI and cardioversion
Class III drugs with high affinity for inactive channels
Class IC drug with weak beta blocking activity
MOA: decrease phase 4 spontaneous depolarization, slows conduction in cells dependent on Ca current. Also vasodilates
Used to maintain SR after cardioversion of A fib and A flutter
MOA: blockade of open and inactivated sodium channels -> no effect on AP duration, slows phase 0 depolarization, decreases conduction velocity
Used in conversion in a fib and a flutter
Procainamide is excrexted by the....
Class II drug used in surgery and acute arrhythmias
SE: safe, flushing, SOB, hypotension, transient asystole
SE: arrythmias, N/V, diarrhea, cinchonism, displaces digoxin from tissue binding site, thrombocytopenia, hepatitis, angioneurotic edema
Class IC drugs
Class IA drug that also blocks N-R
Class IV drugs
MOA: high affinity for blockade of open Na channels and also K channels -->decrease phase 0 depolarizing slope, prolong AP, decrease phase 4 spontaneous depolarization
Used in supraventricular and ventricular tachy-arrhythmias, paroxsymal A fib
Na channel blocker
MOA: non-selective beta blockade
IV only class 1B drug with a wide therapeutic window
Blocks K channels
Class II Drugs
Used in life threatening ventricular arrhythmias when lidocaine and cardioconversion have failed
Class IB drugs
SE: profound anti-muscarinic effects, dry mouth, urinary retention, blurred vision, constipation, confusion, convulsions, etc.
DOC for paroxsymal supraventricular tachycardia and V tach
Class IA drug that also blocks alpha-R
Class III IV only
Other: Used in digitalis associated arrhythmias, torsades de pointes, and acute MI
SE pulmonary fibrosis, liver tox, hypothyroid, photosensitivty, corneal discoloration, blue skin
Class IB drug with pulmonary fibrosis as a side effect
SE: torsades de pointes
Need to monitor PFTs, LFTs, and TFTs
Caution in CHF, asthmas, COPD, MAOI, eldery, depressed, PVD
Other antiarrhythmias
Used in rate control for supraventricular arrythmias including A fib, A flutter
MOA: beta-1 selective beta blockade
SE: more pronounced SA and AV block, lupus erythmatosus like syndrome, ganglion blockade
MOA: blockade of open and inactivated sodium channels -> shortened AP, decreased slope of repolarization, and shortened phase 3 repolarization
Decreases sudden death MI for sustained ventricular tachycardia
Other: Used in SV arrhythmias, Afib, Aflutter, controls ventricular response rate
Contraindicated in WPW
Disopyramide is excreted by the....
Quidine is metabolized by the .....
Class IA Drugs

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