Miscellaneous Quiz / Anti-arrhythmia drugs

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Can you name the Anti-arrhythmia drugs?

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Used in conversion in a fib and a flutter
Used in supraventricular and ventricular tachy-arrhythmias, paroxsymal A fib
Class IA drug that also blocks N-R
Disopyramide is excreted by the....
Class III drugs with high affinity for inactive channels
DOC for paroxsymal supraventricular tachycardia and V tach
SE: more pronounced SA and AV block, lupus erythmatosus like syndrome, ganglion blockade
MOA: blockade of open and inactivated sodium channels -> no effect on AP duration, slows phase 0 depolarization, decreases conduction velocity
Ibutilide
SE pulmonary fibrosis, liver tox, hypothyroid, photosensitivty, corneal discoloration, blue skin
MOA: decrease phase 4 spontaneous depolarization, slows conduction in cells dependent on Ca current. Also vasodilates
Other: Used in digitalis associated arrhythmias, torsades de pointes, and acute MI
SE: torsades de pointes
Sotolol
Contraindicated in WPW
MOA: high affinity for blockade of open Na channels and also K channels -->decrease phase 0 depolarizing slope, prolong AP, decrease phase 4 spontaneous depolarization
Used in rate control for supraventricular arrythmias including A fib, A flutter
DOC for ventricular arrhythmias, esp. post-MI and cardioversion
Class IC drug with weak beta blocking activity
MOA: non-selective beta blockade
MOA: beta-1 selective beta blockade
Class II Drugs
Class IB drugs
SE: least toxic for cardiac arrhythmias, CNS, drowsiness, slurred speech, paresthesia, agitation, convulsions
Used in life threatening ventricular arrhythmias when lidocaine and cardioconversion have failed
Used to maintain SR after cardioversion of A fib and A flutter
Bretylium
HintAnswer
Preferential for ectopic arryhythmias and ventricular arrhythmias d/t increased automaticity and reentry
SE: profound anti-muscarinic effects, dry mouth, urinary retention, blurred vision, constipation, confusion, convulsions, etc.
Class IA drug that also blocks alpha-R
Quidine is metabolized by the .....
Na channel blocker
Decreases sudden death MI for sustained ventricular tachycardia
Class IA Drugs
SE: arrythmias, N/V, diarrhea, cinchonism, displaces digoxin from tissue binding site, thrombocytopenia, hepatitis, angioneurotic edema
Class IB drug with pulmonary fibrosis as a side effect
SE: safe, flushing, SOB, hypotension, transient asystole
Used in refractory ventricular arrythmias and some SVT -- oral with long half life
Dofetilide
Blocks K channels
Other antiarrhythmias
Caution in CHF, asthmas, COPD, MAOI, eldery, depressed, PVD
Amiodarone
Class IV drugs
Procainamide is excrexted by the....
MOA: partial beta agonist
IV only class 1B drug with a wide therapeutic window
Class III IV only
MOA: blockade of open and inactivated sodium channels -> shortened AP, decreased slope of repolarization, and shortened phase 3 repolarization
Need to monitor PFTs, LFTs, and TFTs
Class IC drugs
Other: Used in SV arrhythmias, Afib, Aflutter, controls ventricular response rate
Class II drug used in surgery and acute arrhythmias

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Created Mar 15, 2011ReportNominate
Tags:drug

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