Miscellaneous Quiz / Anti-arrhythmia drugs

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Can you name the Anti-arrhythmia drugs?

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HintAnswer
Contraindicated in WPW
Dofetilide
Other: Used in SV arrhythmias, Afib, Aflutter, controls ventricular response rate
SE: profound anti-muscarinic effects, dry mouth, urinary retention, blurred vision, constipation, confusion, convulsions, etc.
MOA: decrease phase 4 spontaneous depolarization, slows conduction in cells dependent on Ca current. Also vasodilates
Ibutilide
Class II Drugs
Quidine is metabolized by the .....
Class IC drug with weak beta blocking activity
Disopyramide is excreted by the....
Used in conversion in a fib and a flutter
DOC for paroxsymal supraventricular tachycardia and V tach
IV only class 1B drug with a wide therapeutic window
Need to monitor PFTs, LFTs, and TFTs
SE: more pronounced SA and AV block, lupus erythmatosus like syndrome, ganglion blockade
Decreases sudden death MI for sustained ventricular tachycardia
MOA: partial beta agonist
MOA: blockade of open and inactivated sodium channels -> no effect on AP duration, slows phase 0 depolarization, decreases conduction velocity
Na channel blocker
Caution in CHF, asthmas, COPD, MAOI, eldery, depressed, PVD
DOC for ventricular arrhythmias, esp. post-MI and cardioversion
SE: torsades de pointes
SE: least toxic for cardiac arrhythmias, CNS, drowsiness, slurred speech, paresthesia, agitation, convulsions
Class IA drug that also blocks N-R
Class IA drug that also blocks alpha-R
SE: arrythmias, N/V, diarrhea, cinchonism, displaces digoxin from tissue binding site, thrombocytopenia, hepatitis, angioneurotic edema
Amiodarone
HintAnswer
Used in rate control for supraventricular arrythmias including A fib, A flutter
Other: Used in digitalis associated arrhythmias, torsades de pointes, and acute MI
SE: safe, flushing, SOB, hypotension, transient asystole
Other antiarrhythmias
Class III IV only
Class IC drugs
Class IB drugs
Procainamide is excrexted by the....
Class IB drug with pulmonary fibrosis as a side effect
Sotolol
MOA: non-selective beta blockade
MOA: high affinity for blockade of open Na channels and also K channels -->decrease phase 0 depolarizing slope, prolong AP, decrease phase 4 spontaneous depolarization
Used in supraventricular and ventricular tachy-arrhythmias, paroxsymal A fib
Class IA Drugs
Used in refractory ventricular arrythmias and some SVT -- oral with long half life
Used to maintain SR after cardioversion of A fib and A flutter
Preferential for ectopic arryhythmias and ventricular arrhythmias d/t increased automaticity and reentry
Class III drugs with high affinity for inactive channels
Class II drug used in surgery and acute arrhythmias
MOA: beta-1 selective beta blockade
SE pulmonary fibrosis, liver tox, hypothyroid, photosensitivty, corneal discoloration, blue skin
MOA: blockade of open and inactivated sodium channels -> shortened AP, decreased slope of repolarization, and shortened phase 3 repolarization
Class IV drugs
Blocks K channels
Bretylium
Used in life threatening ventricular arrhythmias when lidocaine and cardioconversion have failed

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