Miscellaneous Quiz / Anti-arrhythmia drugs

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Can you name the Anti-arrhythmia drugs?

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Blocks K channels
Used in refractory ventricular arrythmias and some SVT -- oral with long half life
Class IC drugs
Dofetilide
DOC for paroxsymal supraventricular tachycardia and V tach
DOC for ventricular arrhythmias, esp. post-MI and cardioversion
SE: torsades de pointes
MOA: high affinity for blockade of open Na channels and also K channels -->decrease phase 0 depolarizing slope, prolong AP, decrease phase 4 spontaneous depolarization
SE: least toxic for cardiac arrhythmias, CNS, drowsiness, slurred speech, paresthesia, agitation, convulsions
Class IC drug with weak beta blocking activity
Used in conversion in a fib and a flutter
Quidine is metabolized by the .....
MOA: beta-1 selective beta blockade
Decreases sudden death MI for sustained ventricular tachycardia
IV only class 1B drug with a wide therapeutic window
Amiodarone
Class IB drugs
Class IV drugs
Caution in CHF, asthmas, COPD, MAOI, eldery, depressed, PVD
Sotolol
Used in rate control for supraventricular arrythmias including A fib, A flutter
Other: Used in digitalis associated arrhythmias, torsades de pointes, and acute MI
MOA: decrease phase 4 spontaneous depolarization, slows conduction in cells dependent on Ca current. Also vasodilates
Ibutilide
Procainamide is excrexted by the....
Class IB drug with pulmonary fibrosis as a side effect
Contraindicated in WPW
HintAnswer
MOA: non-selective beta blockade
Disopyramide is excreted by the....
SE: safe, flushing, SOB, hypotension, transient asystole
Class II Drugs
SE: arrythmias, N/V, diarrhea, cinchonism, displaces digoxin from tissue binding site, thrombocytopenia, hepatitis, angioneurotic edema
MOA: blockade of open and inactivated sodium channels -> no effect on AP duration, slows phase 0 depolarization, decreases conduction velocity
Class II drug used in surgery and acute arrhythmias
Need to monitor PFTs, LFTs, and TFTs
Na channel blocker
Used in supraventricular and ventricular tachy-arrhythmias, paroxsymal A fib
Class III drugs with high affinity for inactive channels
Class IA Drugs
Preferential for ectopic arryhythmias and ventricular arrhythmias d/t increased automaticity and reentry
SE: more pronounced SA and AV block, lupus erythmatosus like syndrome, ganglion blockade
Class IA drug that also blocks alpha-R
Other antiarrhythmias
MOA: partial beta agonist
SE: profound anti-muscarinic effects, dry mouth, urinary retention, blurred vision, constipation, confusion, convulsions, etc.
Used to maintain SR after cardioversion of A fib and A flutter
Other: Used in SV arrhythmias, Afib, Aflutter, controls ventricular response rate
Class IA drug that also blocks N-R
MOA: blockade of open and inactivated sodium channels -> shortened AP, decreased slope of repolarization, and shortened phase 3 repolarization
Bretylium
Used in life threatening ventricular arrhythmias when lidocaine and cardioconversion have failed
Class III IV only
SE pulmonary fibrosis, liver tox, hypothyroid, photosensitivty, corneal discoloration, blue skin

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Created Mar 15, 2011ReportNominate
Tags:Drug

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