| Hint | Answer |
|---|
| Blocks K channels | |
| Used in refractory ventricular arrythmias and some SVT -- oral with long half life | |
| Class IC drugs | |
| Dofetilide | |
| DOC for paroxsymal supraventricular tachycardia and V tach | |
| DOC for ventricular arrhythmias, esp. post-MI and cardioversion | |
| SE: torsades de pointes | |
| MOA: high affinity for blockade of open Na channels and also K channels -->decrease phase 0 depolarizing slope, prolong AP, decrease phase 4 spontaneous depolarization | |
| SE: least toxic for cardiac arrhythmias, CNS, drowsiness, slurred speech, paresthesia, agitation, convulsions | |
| Class IC drug with weak beta blocking activity | |
| Used in conversion in a fib and a flutter | |
| Quidine is metabolized by the ..... | |
| MOA: beta-1 selective beta blockade | |
| Decreases sudden death MI for sustained ventricular tachycardia | |
| IV only class 1B drug with a wide therapeutic window | |
| Amiodarone | |
| Class IB drugs | |
| Class IV drugs | |
| Caution in CHF, asthmas, COPD, MAOI, eldery, depressed, PVD | |
| Sotolol | |
| Used in rate control for supraventricular arrythmias including A fib, A flutter | |
| Other: Used in digitalis associated arrhythmias, torsades de pointes, and acute MI | |
| MOA: decrease phase 4 spontaneous depolarization, slows conduction in cells dependent on Ca current. Also vasodilates | |
| Ibutilide | |
| Procainamide is excrexted by the.... | |
| Class IB drug with pulmonary fibrosis as a side effect | |
| Contraindicated in WPW | |
| | Hint | Answer |
|---|
| MOA: non-selective beta blockade | |
| Disopyramide is excreted by the.... | |
| SE: safe, flushing, SOB, hypotension, transient asystole | |
| Class II Drugs | |
| SE: arrythmias, N/V, diarrhea, cinchonism, displaces digoxin from tissue binding site, thrombocytopenia, hepatitis, angioneurotic edema | |
| MOA: blockade of open and inactivated sodium channels -> no effect on AP duration, slows phase 0 depolarization, decreases conduction velocity | |
| Class II drug used in surgery and acute arrhythmias | |
| Need to monitor PFTs, LFTs, and TFTs | |
| Na channel blocker | |
| Used in supraventricular and ventricular tachy-arrhythmias, paroxsymal A fib | |
| Class III drugs with high affinity for inactive channels | |
| Class IA Drugs | |
| Preferential for ectopic arryhythmias and ventricular arrhythmias d/t increased automaticity and reentry | |
| SE: more pronounced SA and AV block, lupus erythmatosus like syndrome, ganglion blockade | |
| Class IA drug that also blocks alpha-R | |
| Other antiarrhythmias | |
| MOA: partial beta agonist | |
| SE: profound anti-muscarinic effects, dry mouth, urinary retention, blurred vision, constipation, confusion, convulsions, etc. | |
| Used to maintain SR after cardioversion of A fib and A flutter | |
| Other: Used in SV arrhythmias, Afib, Aflutter, controls ventricular response rate | |
| Class IA drug that also blocks N-R | |
| MOA: blockade of open and inactivated sodium channels -> shortened AP, decreased slope of repolarization, and shortened phase 3 repolarization | |
| Bretylium | |
| Used in life threatening ventricular arrhythmias when lidocaine and cardioconversion have failed | |
| Class III IV only | |
| SE pulmonary fibrosis, liver tox, hypothyroid, photosensitivty, corneal discoloration, blue skin | |
|
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