Miscellaneous Quiz / Anti-arrhythmia drugs

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Can you name the Anti-arrhythmia drugs?

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Need to monitor PFTs, LFTs, and TFTs
Class II drug used in surgery and acute arrhythmias
Class IB drugs
Amiodarone
Preferential for ectopic arryhythmias and ventricular arrhythmias d/t increased automaticity and reentry
Class IA drug that also blocks N-R
Used to maintain SR after cardioversion of A fib and A flutter
Class III IV only
Class II Drugs
SE: arrythmias, N/V, diarrhea, cinchonism, displaces digoxin from tissue binding site, thrombocytopenia, hepatitis, angioneurotic edema
Used in rate control for supraventricular arrythmias including A fib, A flutter
Procainamide is excrexted by the....
MOA: beta-1 selective beta blockade
Class IA drug that also blocks alpha-R
SE pulmonary fibrosis, liver tox, hypothyroid, photosensitivty, corneal discoloration, blue skin
Dofetilide
SE: profound anti-muscarinic effects, dry mouth, urinary retention, blurred vision, constipation, confusion, convulsions, etc.
MOA: non-selective beta blockade
Class IB drug with pulmonary fibrosis as a side effect
IV only class 1B drug with a wide therapeutic window
Ibutilide
DOC for paroxsymal supraventricular tachycardia and V tach
Class IC drug with weak beta blocking activity
MOA: high affinity for blockade of open Na channels and also K channels -->decrease phase 0 depolarizing slope, prolong AP, decrease phase 4 spontaneous depolarization
Blocks K channels
Class III drugs with high affinity for inactive channels
SE: more pronounced SA and AV block, lupus erythmatosus like syndrome, ganglion blockade
HintAnswer
Disopyramide is excreted by the....
SE: safe, flushing, SOB, hypotension, transient asystole
Contraindicated in WPW
MOA: decrease phase 4 spontaneous depolarization, slows conduction in cells dependent on Ca current. Also vasodilates
Class IC drugs
Decreases sudden death MI for sustained ventricular tachycardia
Used in refractory ventricular arrythmias and some SVT -- oral with long half life
Used in supraventricular and ventricular tachy-arrhythmias, paroxsymal A fib
MOA: blockade of open and inactivated sodium channels -> no effect on AP duration, slows phase 0 depolarization, decreases conduction velocity
Na channel blocker
Bretylium
Used in life threatening ventricular arrhythmias when lidocaine and cardioconversion have failed
Class IA Drugs
Other: Used in digitalis associated arrhythmias, torsades de pointes, and acute MI
MOA: blockade of open and inactivated sodium channels -> shortened AP, decreased slope of repolarization, and shortened phase 3 repolarization
SE: least toxic for cardiac arrhythmias, CNS, drowsiness, slurred speech, paresthesia, agitation, convulsions
Caution in CHF, asthmas, COPD, MAOI, eldery, depressed, PVD
Sotolol
Other: Used in SV arrhythmias, Afib, Aflutter, controls ventricular response rate
MOA: partial beta agonist
Class IV drugs
SE: torsades de pointes
Used in conversion in a fib and a flutter
Other antiarrhythmias
DOC for ventricular arrhythmias, esp. post-MI and cardioversion
Quidine is metabolized by the .....

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