Miscellaneous Quiz / Angina Drugs

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Can you name the Angina Drugs?

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HintAnswer
Very long half life Ca channel blocker
Fast onset Ca channel blocker
SE: increased K, edema, heart block, hypotension, bradycardia, nausea, constipation, liver dysfunction, increased MI risk d/t sympathetic response to sudden drop in BP
MOA to block open Ca channels on smooth muscle cells -> calcium mediated excitation contraction coupling ->decreased myocardial O2 consumption
Nitroglycerin
Slow onset Ca channel blocker
Immediate relief drug from stable angina
Dihydropiridine used in stable and vasospastic angina, HTN, CHF
Isosorbide mononitrate
Non-dihydrodipine used in stable and vasospastic angina, HTN, arrhythmia, migraine
Dihydropiridine used in HTN, Raynaud's, CHF
Dihydropiridine used in HTN
MOA to donate NO ->cGMP -> SM relaxation via inactivation of MLCK -> Vasodilation of large veins and arteries -> decreased myocardial O2 consumptions
Dihydropiridine used in SAH, migrainge prophylaxis
Can be given sublingual, transdermal, IV
Amyl Nitrate
Gas, inhaled nitrate/nitrite
Classes of drugs used in vasospastic angina
HintAnswer
Non-dihydrodipine used in stable and vasopastic angina and arrhythmia
Also called Prinzmetal's angina
Dihydropiridine used in stable and vasopastic angina, HTN, migraine, cardiomyopathy, Raynaud's
Class contraindicated in increased ICP
Subclass of Ca channel blocker with more vascular effects
BB used in stable and unstable angina BUT not vasospastic angina
Medium onset Ca channel blocker
CCB contraindications
Non-dihydrodipine used in stable and vasospastic angina, HTN, arrhythmia, and Raynaud's
Class to use with caution in conjunction with Sildenafil, tadalafil, vardenafil
Subclass of Ca channel blocker with more cardiac effects
Slowest onset Ca channel blocker
Fast medium onset Ca channel blocker
Isosorbide dinitrate
CCB: compelling indication
BB contraindications
SE: fatigue, impotence, ED, inability to exercise
Dihydropiridine used in HTN, stable and vasospastic angina

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