Miscellaneous Quiz / Angina Drugs

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Can you name the Angina Drugs?

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Dihydropiridine used in HTN
Dihydropiridine used in HTN, stable and vasospastic angina
Dihydropiridine used in HTN, Raynaud's, CHF
MOA to block open Ca channels on smooth muscle cells -> calcium mediated excitation contraction coupling ->decreased myocardial O2 consumption
Dihydropiridine used in stable and vasospastic angina, HTN, CHF
Can be given sublingual, transdermal, IV
Non-dihydrodipine used in stable and vasospastic angina, HTN, arrhythmia, and Raynaud's
MOA to donate NO ->cGMP -> SM relaxation via inactivation of MLCK -> Vasodilation of large veins and arteries -> decreased myocardial O2 consumptions
Gas, inhaled nitrate/nitrite
Classes of drugs used in vasospastic angina
CCB: compelling indication
Isosorbide dinitrate
Isosorbide mononitrate
CCB contraindications
Slowest onset Ca channel blocker
Very long half life Ca channel blocker
Class contraindicated in increased ICP
SE: fatigue, impotence, ED, inability to exercise
HintAnswer
Also called Prinzmetal's angina
Nitroglycerin
Fast onset Ca channel blocker
Fast medium onset Ca channel blocker
Non-dihydrodipine used in stable and vasospastic angina, HTN, arrhythmia, migraine
Amyl Nitrate
Medium onset Ca channel blocker
Subclass of Ca channel blocker with more vascular effects
Class to use with caution in conjunction with Sildenafil, tadalafil, vardenafil
BB contraindications
Subclass of Ca channel blocker with more cardiac effects
Dihydropiridine used in SAH, migrainge prophylaxis
Slow onset Ca channel blocker
SE: increased K, edema, heart block, hypotension, bradycardia, nausea, constipation, liver dysfunction, increased MI risk d/t sympathetic response to sudden drop in BP
BB used in stable and unstable angina BUT not vasospastic angina
Non-dihydrodipine used in stable and vasopastic angina and arrhythmia
Immediate relief drug from stable angina
Dihydropiridine used in stable and vasopastic angina, HTN, migraine, cardiomyopathy, Raynaud's

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