| Hint | Answer |
|---|
| Slow onset Ca channel blocker | |
| Classes of drugs used in vasospastic angina | |
| MOA to block open Ca channels on smooth muscle cells -> calcium mediated excitation contraction coupling ->decreased myocardial O2 consumption | |
| Amyl Nitrate | |
| Nitroglycerin | |
| Fast onset Ca channel blocker | |
| Non-dihydrodipine used in stable and vasopastic angina and arrhythmia | |
| Medium onset Ca channel blocker | |
| Class to use with caution in conjunction with Sildenafil, tadalafil, vardenafil | |
| Isosorbide mononitrate | |
| SE: fatigue, impotence, ED, inability to exercise | |
| MOA to donate NO ->cGMP -> SM relaxation via inactivation of MLCK -> Vasodilation of large veins and arteries -> decreased myocardial O2 consumptions | |
| Dihydropiridine used in HTN, Raynaud's, CHF | |
| CCB contraindications | |
| Subclass of Ca channel blocker with more cardiac effects | |
| Fast medium onset Ca channel blocker | |
| Dihydropiridine used in SAH, migrainge prophylaxis | |
| Dihydropiridine used in HTN, stable and vasospastic angina | |
| | Hint | Answer |
|---|
| Dihydropiridine used in HTN | |
| Immediate relief drug from stable angina | |
| Also called Prinzmetal's angina | |
| Can be given sublingual, transdermal, IV | |
| Very long half life Ca channel blocker | |
| SE: increased K, edema, heart block, hypotension, bradycardia, nausea, constipation, liver dysfunction, increased MI risk d/t sympathetic response to sudden drop in BP | |
| CCB: compelling indication | |
| Isosorbide dinitrate | |
| BB used in stable and unstable angina BUT not vasospastic angina | |
| Non-dihydrodipine used in stable and vasospastic angina, HTN, arrhythmia, migraine | |
| Subclass of Ca channel blocker with more vascular effects | |
| Gas, inhaled nitrate/nitrite | |
| Dihydropiridine used in stable and vasospastic angina, HTN, CHF | |
| Dihydropiridine used in stable and vasopastic angina, HTN, migraine, cardiomyopathy, Raynaud's | |
| Class contraindicated in increased ICP | |
| Non-dihydrodipine used in stable and vasospastic angina, HTN, arrhythmia, and Raynaud's | |
| Slowest onset Ca channel blocker | |
| BB contraindications | |
|
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