Miscellaneous Quiz / Adrenal Drugs

Random Miscellaneous Quiz

Can you name the Adrenal Drugs?

Quiz not verified by Sporcle

Forced Order
Also try: Groups of Five
Challenge
Share
Tweet
Embed
Score 0/89 Timer 20:00
HintAnswer
SE: Salt & fluid retention, hirsutism, dizziness, GI upset
Mitotane class
Anti-inflammatory: 0; Topical 0, Na Retaining: 20
DOC Acetate (DOCA)
Eplerenone class
MOA: Blocks 11β-hydroxylase in steroid synthesis
P-kinetics: Keep the dose low. Tx should not be decreased or stopped abruptly.
Anti-inflammatory: 5; Topical 4, Na Retaining: 0.3; Equivalent oral dose: 5 mg
Use: Decrease steroid production in pts w/ Cushing's d/t adrenocortical CA (w/ metyrapone or ketoconazole)
Anti-inflammatory: 5; Topical 5; Na Retaining: 0; Equivalent oral dose: 4 mg
SE: IV -Severe tachycardia, arrythmias, myocardial ischemia. Oral - tachycardia, nasal congestion, HA
SE: Postural hypotension, tachycardia, nasal stuffiness, inhibition of ejaculation, fatigue, sedation, nausea
Deoxycorticosterone class
Trilostane class
Use: Tx of non-adrenal disorders -Suppress inflammatory & immune responses (e.g. arthritis, lupus, UC, asthma, SJS) - Use medium- to intermediate-acting glucocorticoids.
Phenoxybenzamine class
Paramethasone class
Anti-inflammatory: 4; Topical 0, Na Retaining: 0.3; Equivalent oral dose: 5 mg
P-kinetics: High plasma PRO binding activity (albumin and glycoprotein but not CBG). T1/2 ~ 20 hours
Aminoglutethimide class
Mifepristone class
Spironolactone class
SE: Abd pain, uterine cramping, bleeding. Causes glucocorticoid resistance
Anti-inflammatory: 30; Topical 10; Na Retaining: 0; Equivalent oral dose: 0.75 mg
Use: Tx hirsutism. May decrease PMDD. A progestin oral contraceptive (Yasmin)
Route: Injectable, pellets
Special precautions: pts should be monitored for: hyperglycemia, glycosuria, edema or HTN, hypokalemia, peptic ulcers, osteoporosis.
MOA: A potent competitive α-antagonist (α1 = α2). Minor inhibitory effect on serotonin-R. Agonistic effects on MR & H1/H2-R. Decreased PVR, increased cardiac stim (reflex)
MOA: A more selective receptor antagonist
Prenisolone class
HintAnswer
Use: Stimulation of fetal lung maturation - used in pregnant women to prevent RDS in preterm infants
SE: impaired wound healing, hyperglycemia, hyperlipidemia, anxiety, insomnia, depression, steroid psychosis, infections,
Anti-inflammatory: 15; Topical 7, Na Retaining: 0; Equivalent oral dose: 1.5 mg
SE: Hyperkalemia
SE: Hepatotoxicity. Interferes w/ the metabolism of sex steroid hormones, warfarin, phenytoin, etc.
Use: For inoperable pts w/ adrenal CA who failed to respond to other txs. Abortificant (< 2mos). Emergency contraceptive (prevent ovulation).
Cortisone class
Use: Pheochromocytomoa (esp intra-op) & ED
Phentolamine class
Use: Tx of disturbed adrenal function - (1) Adrenocortical insufficiency [Chronic = Addison's dz or Acute]
Use: Tx pregnant women w/ Cushing's. Dx of adrenal insufficiency (measure blood levels of 11-deoxycortisol & urinary 17-hydroxysteroid)
Anti-inflammatory: 0.8; Topical 0, Na Retaining: 0.8; Equivalent oral dose: 25 mg
Drospirenone class
Use: Cushing's syndrome, fungal infections
Route: Oral
Route: Oral, injected, topical
P-kinetics:Shorter t1/2 (5-7 hrs) than phenoxybenzamine
Anti-inflammatory: 25-40; Topical 10, Na Retaining: 0; Equivalent oral dose: 0.6 mg
Hydrocortisone (Cortisol) class
Aldosterone class
Dexamethasone class
Contraindications: peptic ulcer, heart disease, HTN w/ heart failure, infectious diseases, psychosis, DM, osteoporosis, glaucoma
SE: Lethary, dizziness, and skin rashs (at high doses)
MOA: Glucocorticoid receptor antagonist. Also blocks progesterone receptor (antiprogestin activity: a contraceptive-contragestive agent).
Triamcinolone class
Route: Oral, injected
Topical 5, Na Retaining: 0; Equivalent oral dose: 4 mg
MOA: Irreversible long-duration (14-48 hrs) blockade of α-receptor (α1 > α2). Also blocks H1-R, Ach-R, serotonin-R. Vasodilates & increases CO. Oral
Use: Decrease estrogen production in breast CA pts (used in w/ dexamethasone or hydrocortisone).
Meprednisone class
HintAnswer
Ketoconazole class
SE: Serious SE unusual for short-term tx (< 2 weeks). Major SE(> 2 weeks of treatment): Iatrogenic Cushing's syndrome, adrenal suppression, acute pancreatitis (high dose tx; rare).
SE: Osteoporosis, severe myopathy, cataracts, glaucoma, peptic ulcers, hypokalemia, edema, HTN
Anti-inflammatory: 1; Topical 1, Na Retaining: 1; Equivalent oral dose: 20 mg
Anti-inflammatory: 5; Na Retaining: 0; Equivalent oral dose: 4 mg
Use: Primary aldosteronism (Conn's syndrome). Used as a diuretic in CHF. Tx hirsutism
Methylprednisone class
Use: Pheochromocytoma (esp. pre-op)
Fludrocortisone class
MOA: Blocks progesterone receptors & androgen receptors -> Na loss & K retention
SE: Hyperkalemia, cardiac arrhythmia, gynecomastia, mentrual abnormalities, GI disturbances, skin rashes
Fluprenisolone class
Use: Tx of disturbed adrenal function: (2) Adrenocortical hypo- or hyperfunction [congenital adrenal hyperplasia; glucocorticoid remediable aldosteronism (GRA)]
Anti-inflammatory: 10; Topical 0, Na Retaining: 250; Equivalent oral dose: 2 mg
MOA: Blocks synthesis of pregnenolone -> Decreased mineralocortioids, glucocorticoids & androgens/estrogens
Anti-inflammatory: 10; Na Retaining: 0; Equivalent oral dose: 2 mg
Use: Prevention of chemo-induced emesis (e.g. dexamethasone prevents cisplatin-induced emesis)
Prednisone class
Use: HTN
MOA: Act on mineralocorticoid receptors. Activation of the aldosterone receptor -> increased expression of Na/K/ATPase. Increase reabsorption of Na & excretion of K.
Use: Dx purposes - dexamethasone suppression test - for Cushing's - measures response of the adrenal glands to ACTH
Use: Tx adrenal insufficiency associed w/ mineralocorticoid deficiency (i.e. Addison's dz)
MOA: Inhibits cholesterol side chain cleavage (p450scc) & other p450 enzymes required for steroid synthesis
MOA: An analogue of spironolactone. Has anti-mineralocortioid & anti-androgenic activities.
Betamethasone class
Metyrapone class
SE: Oversecretion or overdosing may result in hypokalemia, metabolic alkalosis, HTN.
Has both glucocorticoid and mineralocorticoid activity
Use: Tx of tpx rejection- reduces antigen expression from grafted tissue; delays revascularization; interferes w/ sensitization of cytotoxic Tcells & generation of Ab-forming cells

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.