Science Quiz / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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InfoAnswerdetails
Li Fraumeni
Pancreatic and colorectal carcinomas
Regulates nuclear transcription (not VHL)
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Regulates nuclear transcription (not WT1)
Wilms' tumor
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Familial polyposis
InfoAnswerdetails
Gene product inhibits going from G1-S (not TGF beta or p53)
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Gene product inhibits going from G1-S (not Rb or p53)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
activated by p53 product to promote apoptosis
Gene product regulates DNA repair
Lung colon, breast carcinomas
Breast, ovary carcinomas

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