Science Quiz / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Gene product inhibits going from G1-S (not Rb or p53)
Gene product inhibits going from G1-S (not TGF beta or p53)
Regulates nuclear transcription (not WT1)
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Gene product regulates DNA repair
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Breast, ovary carcinomas
activated by p53 product to promote apoptosis
Wilms' tumor
Pancreatic and colorectal carcinomas
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Familial polyposis
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Li Fraumeni
Lung colon, breast carcinomas
Regulates nuclear transcription (not VHL)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia

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