Science Quiz / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Lung colon, breast carcinomas
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Breast, ovary carcinomas
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Wilms' tumor
activated by p53 product to promote apoptosis
Gene product regulates DNA repair
Gene product inhibits going from G1-S (not Rb or p53)
Cerebellar hemang, retinal angioma, bilat RCC and PCC
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Regulates nuclear transcription (not WT1)
Pancreatic and colorectal carcinomas
Regulates nuclear transcription (not VHL)
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Familial polyposis
Li Fraumeni
Gene product inhibits going from G1-S (not TGF beta or p53)

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