Science Quiz / Tumor Supressor Genes (Goljan Table 8-4)

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QUIZ: Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Regulates nuclear transcription (not WT1)
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Li Fraumeni
Familial polyposis
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Gene product inhibits going from G1-S (not Rb or p53)
Breast, ovary carcinomas
Wilms' tumor
Gene product inhibits going from G1-S (not TGF beta or p53)
Gene product regulates DNA repair
Pancreatic and colorectal carcinomas
Lung colon, breast carcinomas
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Regulates nuclear transcription (not VHL)
activated by p53 product to promote apoptosis

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