Science Quiz / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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InfoAnswerdetails
Pancreatic and colorectal carcinomas
Gene product inhibits going from G1-S (not TGF beta or p53)
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
activated by p53 product to promote apoptosis
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Gene product regulates DNA repair
Regulates nuclear transcription (not WT1)
Breast, ovary carcinomas
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
InfoAnswerdetails
Familial polyposis
Wilms' tumor
Regulates nuclear transcription (not VHL)
Lung colon, breast carcinomas
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Gene product inhibits going from G1-S (not Rb or p53)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Li Fraumeni

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