Science Quiz / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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InfoAnswerdetails
Regulates nuclear transcription (not VHL)
Lung colon, breast carcinomas
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Wilms' tumor
Familial polyposis
Gene product inhibits going from G1-S (not TGF beta or p53)
Breast, ovary carcinomas
InfoAnswerdetails
Regulates nuclear transcription (not WT1)
Pancreatic and colorectal carcinomas
Li Fraumeni
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Gene product regulates DNA repair
Gene product inhibits going from G1-S (not Rb or p53)
OSTEOSARCOMA, breast carcinoma, retinoblastoma
activated by p53 product to promote apoptosis

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