Science Quiz / Endocrine drugs

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Can you name the Endocrinology histology?

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Score 0/39 Timer 10:00
IndicationDrugContraindications, side effects and note
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Obesity (against appetite)Depression, anxiety, nausea
Obesity (against fat absorption)Steatorrhea
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Paget's diseaseA cytotoxic antibiotic
HyperthyroidismDelayed hypothyroidism
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
IndicationDrugContraindications, side effects and note
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T1DM and T2DMWeight gain, hypoglycemia
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Osteoporosis (for increasing bone mass)Very expensive
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
PCOS (hirsutism)Hyperkalemia
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Cortisol suppression tests, psoriasis, eczemaThinning skin
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
Kidney stones, idiopathic hypercalciuriaHypercalcemia

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