Science Quiz / Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Obesity (against appetite)Depression, anxiety, nausea
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Cortisol suppression tests, psoriasis, eczemaThinning skin
Paget's diseaseA cytotoxic antibiotic
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
HyperthyroidismDelayed hypothyroidism
Osteoporosis (for increasing bone mass)Very expensive
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
IndicationDrugContraindications, side effects and note
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Obesity (against fat absorption)Steatorrhea
PCOS (hirsutism)Hyperkalemia
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
T1DM and T2DMWeight gain, hypoglycemia
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
Kidney stones, idiopathic hypercalciuriaHypercalcemia

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