Science Quiz / Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Osteoporosis (for increasing bone mass)Very expensive
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Paget's diseaseA cytotoxic antibiotic
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Obesity (against fat absorption)Steatorrhea
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
HyperthyroidismDelayed hypothyroidism
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
IndicationDrugContraindications, side effects and note
T1DM and T2DMWeight gain, hypoglycemia
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
Obesity (against appetite)Depression, anxiety, nausea
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (hirsutism)Hyperkalemia
Cortisol suppression tests, psoriasis, eczemaThinning skin
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)

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