Science Quiz / Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
PCOS (hirsutism)Hyperkalemia
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
IndicationDrugContraindications, side effects and note
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Obesity (against appetite)Depression, anxiety, nausea
Paget's diseaseA cytotoxic antibiotic
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
T1DM and T2DMWeight gain, hypoglycemia
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Cortisol suppression tests, psoriasis, eczemaThinning skin
Kidney stones, idiopathic hypercalciuriaHypercalcemia
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Obesity (against fat absorption)Steatorrhea
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
Osteoporosis (for increasing bone mass)Very expensive
HyperthyroidismDelayed hypothyroidism

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