Science Quiz / Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T1DM and T2DMWeight gain, hypoglycemia
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Paget's diseaseA cytotoxic antibiotic
HyperthyroidismDelayed hypothyroidism
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
PCOS (hirsutism)Hyperkalemia
Osteoporosis (for increasing bone mass)Very expensive
IndicationDrugContraindications, side effects and note
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Kidney stones, idiopathic hypercalciuriaHypercalcemia
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Obesity (against appetite)Depression, anxiety, nausea
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Obesity (against fat absorption)Steatorrhea
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Cortisol suppression tests, psoriasis, eczemaThinning skin
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer

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Created Nov 7, 2011ReportNominate
Tags:drug, effect, endocrine, indication, note, side

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