Science Quiz / Immunology Review

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Can you name the immunology buzzword?

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Maculopapular rash, jaundice, hepatosplenomegaly, diarrhea after transplant
Secretes IL-4, IL-5, IL-6, IL-10; regulates humoral response
Function of C3a and C5a
Delayed, cell-mediated hypersensitivity
Lymphocyte in innate immune system
20-30yo with lymphoma and sinus/lung infections
Vaccine inducing a primarily humoral response
Primary place you find T cells in spleen
Encoded by HLA-DR, HLA-DP, HLA-DQ
Ig that crosses placenta
Edema, necrosis, complement activation from local antibody reaction to intradermal injection of antigen
Encoded by HLA-A, HLA-B, HLA-C
Boy with thrombocytopenic purpura, infxns, eczema
Activated by MHCI and IL-2
Fibrosis of graft tissue and vessels years after transplant
Boy >6mo with recurrent bacterial infections
Common infecting species in complement deficiency
MHC whose antigen is loaded in endosome following invariant chain release
Activates macrophages, Th1; suppresses Th2; antitumor and antiviral
Graft from identical twin/clone
Rx: interferes with nucleic acid synthesis
Function of C5b-C9
Dz: anti-Ro, anti-La antibodies
Inhibits activated T cells, Th1; activates Th2
MHC whose antigen is loaded in RER
Cell type stimulated by MHCII
Stimulates growth of Th and CD8 cells
Rx: anti-CD3 antibody
Recurrent infxns, no thymic shadow, no germinal centers, no B cells
HintAnswer
Cause of Howell-Jolly bodies, target cells, thrombocytosis
Induces differentiation of T cells into Th1 cells, activates NK cells
Ig produced in primary response to antigen
Directly stimulate macrophages by binding CD14
Dz: anti-GBM antibodies
Given after exposure to tetanus, botulinum, HBV, rabies
Milk allergies, diarrhea, sinus/lung infections
Anaphylactic and atopic hypersensitivity
Produce IL-10, TGF-β; suppress CD4/CD8 effector function
Psoriasis, Ankylosing spondylitis, IBS, Reiter's syndrome
NK cell marker
Microbe surface molecule mediated complement pathway
Dz: anti-desmoglein antibodies
Dz: c-ANCA
Dz: anti-histone antibodies
Severe febrile infections early in life
Causes fever, acute inflammation, chemokine secretion, leukocyte recruitment
Process by which self-reactive T cells w/o costimulatory molecule become nonreactive
Leukocyte with CD3, CD28
Recurrent febrile staph/strep infxns, partial albinism, peripheral neuropathy
Delayed umbilical cord separation, no pus, recurrent bacterial infxns
Secretes IL-2, IFNγ; regulates cell-mediated response
Cytotoxic, antibody-mediated hypersensitivity
Induces Th2 differentiation, class switching to IgG/E
Type II hypersensitivity to blood transfusion HLA and leukocytes, nonhemolytic
Leukocyte with CD19, CD20, CD21, CD40
Vasculitis of graft vessels, dense interstitial lymphocytic infiltrate weeks after transplant
Rx: inhibits mTOR
Coarse facies, noninflamed staph abcesses, high IgE, eczema, retained baby teeth
HintAnswer
Rx: binds FK-binding protein
Interleukin chemotactic factor for neutrophils
Promotes B cell differentiation, eosinophil growth, class switching to IgA
Dz: anti-dsDNA, anti-Smith antibodies
Cell type expressing MHCII
Triad of ataxia, spider angiomas, IgA deficiency
Causes fever, production of acute-phase proteins
Vaccine inducing a primarily cellular response
Costimulatory signal (signal 2) for T helper
Tissue damage from membrane deposition of immune complexes to foreign proteins
SCID treatment
Mediates septic shock, causes leukocyte recruitment and vascular leak
Rx: inhibits calcineurin
Immune complex hypersensitivity
Rx: anti-IL-2 receptor antibody
Ig released in allergy, parasitic infxn
Recurrent catalase positive infections
Complement component important in opsonization
Type II hypersensitivity to blood transfusion RBCs, hemolytic
B cell EBV receptor
Leukocyte with CD14, CD40
Ichemia, necrosis of graft within minutes
Recurrent viral/fungal infxns, tetany, heart/vessel defects
Supports growth and differentiation of bone marrow stem cells
IgG or IgM mediated complement pathway
Dz: anti-Scl-70 antibodies
Cross-link TCR to MHCII

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