Science Quiz / Immunology Review

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HintAnswer
Dz: anti-histone antibodies
Edema, necrosis, complement activation from local antibody reaction to intradermal injection of antigen
Dz: c-ANCA
Interleukin chemotactic factor for neutrophils
Supports growth and differentiation of bone marrow stem cells
20-30yo with lymphoma and sinus/lung infections
Cell type expressing MHCII
Type II hypersensitivity to blood transfusion RBCs, hemolytic
Rx: interferes with nucleic acid synthesis
Secretes IL-2, IFNγ; regulates cell-mediated response
Lymphocyte in innate immune system
Rx: binds FK-binding protein
Common infecting species in complement deficiency
Tissue damage from membrane deposition of immune complexes to foreign proteins
Dz: anti-dsDNA, anti-Smith antibodies
Cause of Howell-Jolly bodies, target cells, thrombocytosis
Recurrent infxns, no thymic shadow, no germinal centers, no B cells
Rx: inhibits mTOR
MHC whose antigen is loaded in endosome following invariant chain release
Cell type stimulated by MHCII
Promotes B cell differentiation, eosinophil growth, class switching to IgA
Microbe surface molecule mediated complement pathway
Rx: inhibits calcineurin
Leukocyte with CD14, CD40
Causes fever, production of acute-phase proteins
Mediates septic shock, causes leukocyte recruitment and vascular leak
MHC whose antigen is loaded in RER
Given after exposure to tetanus, botulinum, HBV, rabies
Coarse facies, noninflamed staph abcesses, high IgE, eczema, retained baby teeth
HintAnswer
Graft from identical twin/clone
Boy with thrombocytopenic purpura, infxns, eczema
Vasculitis of graft vessels, dense interstitial lymphocytic infiltrate weeks after transplant
Dz: anti-GBM antibodies
Delayed umbilical cord separation, no pus, recurrent bacterial infxns
Psoriasis, Ankylosing spondylitis, IBS, Reiter's syndrome
Ig produced in primary response to antigen
Vaccine inducing a primarily humoral response
Dz: anti-Ro, anti-La antibodies
Cytotoxic, antibody-mediated hypersensitivity
Encoded by HLA-DR, HLA-DP, HLA-DQ
Leukocyte with CD19, CD20, CD21, CD40
Cross-link TCR to MHCII
Immune complex hypersensitivity
Maculopapular rash, jaundice, hepatosplenomegaly, diarrhea after transplant
Vaccine inducing a primarily cellular response
NK cell marker
Directly stimulate macrophages by binding CD14
Produce IL-10, TGF-β; suppress CD4/CD8 effector function
Inhibits activated T cells, Th1; activates Th2
Process by which self-reactive T cells w/o costimulatory molecule become nonreactive
Induces Th2 differentiation, class switching to IgG/E
Recurrent viral/fungal infxns, tetany, heart/vessel defects
Recurrent catalase positive infections
Ichemia, necrosis of graft within minutes
Recurrent febrile staph/strep infxns, partial albinism, peripheral neuropathy
Function of C3a and C5a
Severe febrile infections early in life
Induces differentiation of T cells into Th1 cells, activates NK cells
HintAnswer
Secretes IL-4, IL-5, IL-6, IL-10; regulates humoral response
IgG or IgM mediated complement pathway
Function of C5b-C9
Fibrosis of graft tissue and vessels years after transplant
Encoded by HLA-A, HLA-B, HLA-C
Activates macrophages, Th1; suppresses Th2; antitumor and antiviral
Type II hypersensitivity to blood transfusion HLA and leukocytes, nonhemolytic
Complement component important in opsonization
Activated by MHCI and IL-2
Primary place you find T cells in spleen
Rx: anti-IL-2 receptor antibody
SCID treatment
Boy >6mo with recurrent bacterial infections
Leukocyte with CD3, CD28
Costimulatory signal (signal 2) for T helper
Delayed, cell-mediated hypersensitivity
B cell EBV receptor
Rx: anti-CD3 antibody
Ig that crosses placenta
Ig released in allergy, parasitic infxn
Dz: anti-desmoglein antibodies
Causes fever, acute inflammation, chemokine secretion, leukocyte recruitment
Triad of ataxia, spider angiomas, IgA deficiency
Milk allergies, diarrhea, sinus/lung infections
Stimulates growth of Th and CD8 cells
Anaphylactic and atopic hypersensitivity
Dz: anti-Scl-70 antibodies

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Created Dec 4, 2012ReportNominate
Tags:Buzzword, immunology, review

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