Science Quiz / Immunology Review

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Can you name the immunology buzzword?

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HintAnswer
Tissue damage from membrane deposition of immune complexes to foreign proteins
NK cell marker
IgG or IgM mediated complement pathway
Coarse facies, noninflamed staph abcesses, high IgE, eczema, retained baby teeth
Rx: anti-CD3 antibody
Type II hypersensitivity to blood transfusion HLA and leukocytes, nonhemolytic
Encoded by HLA-DR, HLA-DP, HLA-DQ
Ig that crosses placenta
B cell EBV receptor
Cause of Howell-Jolly bodies, target cells, thrombocytosis
Dz: anti-GBM antibodies
Dz: anti-histone antibodies
Rx: inhibits calcineurin
20-30yo with lymphoma and sinus/lung infections
Ig produced in primary response to antigen
Boy >6mo with recurrent bacterial infections
Cell type expressing MHCII
Interleukin chemotactic factor for neutrophils
Triad of ataxia, spider angiomas, IgA deficiency
Immune complex hypersensitivity
Encoded by HLA-A, HLA-B, HLA-C
Cytotoxic, antibody-mediated hypersensitivity
Dz: c-ANCA
Common infecting species in complement deficiency
Type II hypersensitivity to blood transfusion RBCs, hemolytic
Delayed, cell-mediated hypersensitivity
Costimulatory signal (signal 2) for T helper
Dz: anti-desmoglein antibodies
Activates macrophages, Th1; suppresses Th2; antitumor and antiviral
HintAnswer
MHC whose antigen is loaded in endosome following invariant chain release
Graft from identical twin/clone
Rx: binds FK-binding protein
Vaccine inducing a primarily humoral response
Function of C3a and C5a
Primary place you find T cells in spleen
Dz: anti-dsDNA, anti-Smith antibodies
Activated by MHCI and IL-2
Ichemia, necrosis of graft within minutes
Rx: inhibits mTOR
Dz: anti-Ro, anti-La antibodies
Promotes B cell differentiation, eosinophil growth, class switching to IgA
SCID treatment
Stimulates growth of Th and CD8 cells
Cross-link TCR to MHCII
Recurrent febrile staph/strep infxns, partial albinism, peripheral neuropathy
Dz: anti-Scl-70 antibodies
Microbe surface molecule mediated complement pathway
Produce IL-10, TGF-β; suppress CD4/CD8 effector function
Leukocyte with CD14, CD40
Given after exposure to tetanus, botulinum, HBV, rabies
Delayed umbilical cord separation, no pus, recurrent bacterial infxns
Causes fever, acute inflammation, chemokine secretion, leukocyte recruitment
Edema, necrosis, complement activation from local antibody reaction to intradermal injection of antigen
Complement component important in opsonization
Psoriasis, Ankylosing spondylitis, IBS, Reiter's syndrome
Recurrent viral/fungal infxns, tetany, heart/vessel defects
Lymphocyte in innate immune system
Boy with thrombocytopenic purpura, infxns, eczema
HintAnswer
Fibrosis of graft tissue and vessels years after transplant
MHC whose antigen is loaded in RER
Induces differentiation of T cells into Th1 cells, activates NK cells
Milk allergies, diarrhea, sinus/lung infections
Process by which self-reactive T cells w/o costimulatory molecule become nonreactive
Supports growth and differentiation of bone marrow stem cells
Secretes IL-4, IL-5, IL-6, IL-10; regulates humoral response
Ig released in allergy, parasitic infxn
Inhibits activated T cells, Th1; activates Th2
Induces Th2 differentiation, class switching to IgG/E
Function of C5b-C9
Rx: interferes with nucleic acid synthesis
Secretes IL-2, IFNγ; regulates cell-mediated response
Severe febrile infections early in life
Recurrent catalase positive infections
Vaccine inducing a primarily cellular response
Leukocyte with CD3, CD28
Anaphylactic and atopic hypersensitivity
Mediates septic shock, causes leukocyte recruitment and vascular leak
Directly stimulate macrophages by binding CD14
Cell type stimulated by MHCII
Rx: anti-IL-2 receptor antibody
Vasculitis of graft vessels, dense interstitial lymphocytic infiltrate weeks after transplant
Maculopapular rash, jaundice, hepatosplenomegaly, diarrhea after transplant
Leukocyte with CD19, CD20, CD21, CD40
Recurrent infxns, no thymic shadow, no germinal centers, no B cells
Causes fever, production of acute-phase proteins

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