Science Quiz / Immunology Review

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Can you name the immunology buzzword?

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HintAnswer
Induces Th2 differentiation, class switching to IgG/E
Stimulates growth of Th and CD8 cells
Produce IL-10, TGF-β; suppress CD4/CD8 effector function
Rx: anti-CD3 antibody
Rx: anti-IL-2 receptor antibody
Costimulatory signal (signal 2) for T helper
Lymphocyte in innate immune system
Severe febrile infections early in life
Psoriasis, Ankylosing spondylitis, IBS, Reiter's syndrome
Rx: inhibits calcineurin
SCID treatment
Cause of Howell-Jolly bodies, target cells, thrombocytosis
Mediates septic shock, causes leukocyte recruitment and vascular leak
Microbe surface molecule mediated complement pathway
Edema, necrosis, complement activation from local antibody reaction to intradermal injection of antigen
Dz: c-ANCA
Milk allergies, diarrhea, sinus/lung infections
Directly stimulate macrophages by binding CD14
Common infecting species in complement deficiency
Leukocyte with CD19, CD20, CD21, CD40
Cell type expressing MHCII
Triad of ataxia, spider angiomas, IgA deficiency
Coarse facies, noninflamed staph abcesses, high IgE, eczema, retained baby teeth
Type II hypersensitivity to blood transfusion RBCs, hemolytic
Dz: anti-Ro, anti-La antibodies
Vaccine inducing a primarily humoral response
Causes fever, production of acute-phase proteins
Type II hypersensitivity to blood transfusion HLA and leukocytes, nonhemolytic
Recurrent catalase positive infections
HintAnswer
Secretes IL-2, IFNγ; regulates cell-mediated response
Rx: interferes with nucleic acid synthesis
Recurrent viral/fungal infxns, tetany, heart/vessel defects
Activates macrophages, Th1; suppresses Th2; antitumor and antiviral
Ichemia, necrosis of graft within minutes
Given after exposure to tetanus, botulinum, HBV, rabies
Tissue damage from membrane deposition of immune complexes to foreign proteins
Ig that crosses placenta
Induces differentiation of T cells into Th1 cells, activates NK cells
Anaphylactic and atopic hypersensitivity
MHC whose antigen is loaded in RER
Dz: anti-dsDNA, anti-Smith antibodies
Rx: binds FK-binding protein
Delayed umbilical cord separation, no pus, recurrent bacterial infxns
Interleukin chemotactic factor for neutrophils
Boy with thrombocytopenic purpura, infxns, eczema
Function of C3a and C5a
Cell type stimulated by MHCII
Immune complex hypersensitivity
Cytotoxic, antibody-mediated hypersensitivity
Dz: anti-GBM antibodies
Dz: anti-Scl-70 antibodies
Vaccine inducing a primarily cellular response
NK cell marker
Ig produced in primary response to antigen
Recurrent infxns, no thymic shadow, no germinal centers, no B cells
Supports growth and differentiation of bone marrow stem cells
Encoded by HLA-A, HLA-B, HLA-C
Function of C5b-C9
HintAnswer
Causes fever, acute inflammation, chemokine secretion, leukocyte recruitment
Complement component important in opsonization
Fibrosis of graft tissue and vessels years after transplant
B cell EBV receptor
20-30yo with lymphoma and sinus/lung infections
Cross-link TCR to MHCII
Secretes IL-4, IL-5, IL-6, IL-10; regulates humoral response
Inhibits activated T cells, Th1; activates Th2
Delayed, cell-mediated hypersensitivity
Dz: anti-desmoglein antibodies
Leukocyte with CD3, CD28
Ig released in allergy, parasitic infxn
Rx: inhibits mTOR
Graft from identical twin/clone
IgG or IgM mediated complement pathway
Dz: anti-histone antibodies
Vasculitis of graft vessels, dense interstitial lymphocytic infiltrate weeks after transplant
Activated by MHCI and IL-2
Process by which self-reactive T cells w/o costimulatory molecule become nonreactive
Leukocyte with CD14, CD40
Boy >6mo with recurrent bacterial infections
Encoded by HLA-DR, HLA-DP, HLA-DQ
Recurrent febrile staph/strep infxns, partial albinism, peripheral neuropathy
Primary place you find T cells in spleen
Promotes B cell differentiation, eosinophil growth, class switching to IgA
MHC whose antigen is loaded in endosome following invariant chain release
Maculopapular rash, jaundice, hepatosplenomegaly, diarrhea after transplant

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