Science Quiz / Goljan 3 of X: Vitamins

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QUIZ: Can you name the Vitamins

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HintAnswer
Hemolytic anemia + peripheral neuropathy
MCC1 thiamine deficiency in the US
Impaired night vision
Used to treat measles
Required for homocysteine conversion to cystathionine
Bear liver consumption
Cofactor for dopamine b-hydroxylase
Neutralizes free radicals, also renews Vitamin E
Deficiency caused by phenytoin, valproate, Sulfas, MTX...
Prevents LDL oxidation
Reduces tetrahydrofolate
Cofactor for formation of methylmalonyl CoA
Seen in pernicious anemia or chron's
Needed to convert dopamine to NE
Needed for transaminase reactions
What are the active forms of vitamin B3
Supplementation needed after gastrojejunostomy
Subacute combined degeneration of the spinal cord
Deficiency causes microcytic anemia + aortic dissection + poor healing
Deficiency causes muscle weakness and dilated cardiomyopathy
Vitamin K function
Cofactor for pyruvate dehydrogenase
Deficiency = megaloblastic anemia + neurologic Sx
 
Deficient in Hartnup disease
Cofactor for pyruvate carboxylase
Needed to convert pyruvate to Acetyl CoA
Cofactor for transketolase
Primary source is intestinal flora
Rachitic rosary
Required for metabolism of a-ketoglutarate
Papilledema + seizures 2/2 ICP
Increases Ca++ and PO4- resorption
MCC1 cobalamin deficiency?
Cofactor for ALA synthetase
Lemon-colored elderly white woman with dementia
Bow legs ┬▒ craniotabes
Assists in clearance of free radicals from cytosol
Pseudotumor cerebri
HintAnswer
Protects cell membranes from lipid peroxidation
Deficiency causes spinocerebellar ataxia + pigmented retinopathy
Supplementation required in pregnancy
Required for transamination to derive glucose from alanine
In excess, synergistic with warfarin (blocks Vit K factor synthesis)
Deficiency in CF or abetalipoproteinemia
Deficiency causes decreased proprioception and hyporeflexia
Bitot's spot
Deficiency caused by Hartnup disease
Loss of sebaceous glands
Cofactor for AcCoA to malonyl CoA conversion
MCC1 vitamin D deficiency
Binds osteoblasts to mineralize bone and cartilage
Required for homocysteine conversion to methionine
Cofactor for methylmalonyl-CoA mutase
Lip scaling + fissures at the corners
Cofactor for the production of ATP
Component of glutathione peroxidase
Increased in sarcoidosis
Congestive cardiomyopathy with biV failure
Storage form of vitamin A
Required for conversion of NE to Epi
Essential component of Coenzyme A
Found in outer layer of grain/seed
Periosteal proliferation causing bone pain
Present only in animal products
Deficiency caused by eating raw eggs
Deficiency caused by isoniazid
Corneal neovascularization + glossitis + cheilosis + stomatitis
Deficiency causes RBC fragility and weakness
Tetany
Riboflavin important in what process
Osteomalacia
Deficiency causes dysgeusia + anosmia + perioral rash with poor healing
Diarrhea + dermatitis + dementia
Deficiency causes sideroblastic anemia + peripheral neuropathy
Reaction type that requires biotin
Active forms = FAD and FMN
Deficiency often caused by broad spectrum Abx
HintAnswer
Cofactor in carboxylase reactions
Perifollicular hemorrhages + corkscrew hairs + bleeding gums
Needed to convert pyruvate to oxaloacetate
Microcytic hypochromic anemia + osteoprosis + skin depigmentation
y-carboxylates glutamate residues
Location of formation of 1,25-OH Vitamin D
Deficiency causes decreased adult hair + predisposition to EtOH cirrhosis
Supplementation needed after gastric bypass
Prolonged PT and PTT
Peripheral neuropathy 2/2 demyelination
Schilling's test concerns...
Squamus metaplasia of corneal epithelium
Scurvy = deficiency of...
Follicular hyperkeratosis
Deficiency causes microcytic anemia 2/2 loss of Fe3+ reduction to Fe2+
Uric acid calculi 2/2 excess of...
MCC1 vitamin deficiency in the US
Deficiency damages medial dorsal nucleus of the thalamus and mammillary bodies
Diphyllobothrium latum
Niacin is synthesized from...
Required for DNA synthesis + odd-chain fatty acid metabolism
Irregular keratin deposits in the cornea
MCC1 deficiency WW = non-enriched grain
Assists in clearance of free radicals from membranes
Corn-based diet causes this vitamin deficiency
Excess causes flushing
Important in immune Fn + mucus secreting epithelium + growth
Hydroxylates lysine and proline
Cofactor for homocysteine methyltransferase
Deficiency causes impaired glucose tolerance + neuropathy
Homocystinuria treated with...
CNS bleeding + ecchymosis in a newborn
Toxic levels cause hypercalcemia
Tea and toast diet causes deficiency in...
Deficiency caused by strict vegan diet
Cancer that causes niacin deficiency
Needed for final step of incorporating odd-chain FAs into TCA
Active forms of vitamin B2
Location of formation of 25-OH Vitamin D

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