Science Quiz / Goljan 3 of X: Vitamins

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Can you name the Vitamins

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Vitamin K function
Bear liver consumption
Cofactor for pyruvate carboxylase
y-carboxylates glutamate residues
Cofactor for methylmalonyl-CoA mutase
Bow legs ± craniotabes
Uric acid calculi 2/2 excess of...
Active forms of vitamin B2
Reaction type that requires biotin
Bitot's spot
Deficiency causes microcytic anemia 2/2 loss of Fe3+ reduction to Fe2+
Hemolytic anemia + peripheral neuropathy
Excess causes flushing
Deficiency causes decreased adult hair + predisposition to EtOH cirrhosis
Deficiency caused by eating raw eggs
Location of formation of 25-OH Vitamin D
Supplementation required in pregnancy
Component of glutathione peroxidase
Deficiency causes dysgeusia + anosmia + perioral rash with poor healing
Required for DNA synthesis + odd-chain fatty acid metabolism
What are the active forms of vitamin B3
Required for conversion of NE to Epi
Squamus metaplasia of corneal epithelium
Microcytic hypochromic anemia + osteoprosis + skin depigmentation
Deficiency causes decreased proprioception and hyporeflexia
Niacin is synthesized from...
Congestive cardiomyopathy with biV failure
CNS bleeding + ecchymosis in a newborn
Cofactor for ALA synthetase
Diphyllobothrium latum
Required for metabolism of a-ketoglutarate
Storage form of vitamin A
Deficiency damages medial dorsal nucleus of the thalamus and mammillary bodies
Deficiency causes spinocerebellar ataxia + pigmented retinopathy
Rachitic rosary
Essential component of Coenzyme A
Deficiency caused by Hartnup disease
Required for homocysteine conversion to methionine
Follicular hyperkeratosis
Riboflavin important in what process
Toxic levels cause hypercalcemia
Cofactor for formation of methylmalonyl CoA
Location of formation of 1,25-OH Vitamin D
Deficiency = megaloblastic anemia + neurologic Sx
Loss of sebaceous glands
Prevents LDL oxidation
Used to treat measles
MCC1 cobalamin deficiency?
Cofactor for AcCoA to malonyl CoA conversion
Lip scaling + fissures at the corners
Cofactor for the production of ATP
Needed for transaminase reactions
Deficiency causes impaired glucose tolerance + neuropathy
Perifollicular hemorrhages + corkscrew hairs + bleeding gums
Deficiency causes sideroblastic anemia + peripheral neuropathy
Prolonged PT and PTT
Supplementation needed after gastrojejunostomy
Reduces tetrahydrofolate
Primary source is intestinal flora
MCC1 thiamine deficiency in the US
Papilledema + seizures 2/2 ICP
Cancer that causes niacin deficiency
Needed to convert pyruvate to oxaloacetate
Lemon-colored elderly white woman with dementia
Protects cell membranes from lipid peroxidation
Deficiency in CF or abetalipoproteinemia
Increases Ca++ and PO4- resorption
MCC1 vitamin D deficiency
Deficiency caused by isoniazid
Deficiency caused by strict vegan diet
Present only in animal products
Increased in sarcoidosis
Found in outer layer of grain/seed
Peripheral neuropathy 2/2 demyelination
Tea and toast diet causes deficiency in...
Cofactor for homocysteine methyltransferase
Cofactor for transketolase
Subacute combined degeneration of the spinal cord
Cofactor for pyruvate dehydrogenase
Required for homocysteine conversion to cystathionine
Deficiency causes microcytic anemia + aortic dissection + poor healing
Needed for final step of incorporating odd-chain FAs into TCA
Periosteal proliferation causing bone pain
Homocystinuria treated with...
Required for transamination to derive glucose from alanine
Cofactor for dopamine b-hydroxylase
Needed to convert pyruvate to Acetyl CoA
Deficient in Hartnup disease
Cofactor in carboxylase reactions
Assists in clearance of free radicals from membranes
Corneal neovascularization + glossitis + cheilosis + stomatitis
In excess, synergistic with warfarin (blocks Vit K factor synthesis)
Active forms = FAD and FMN
Seen in pernicious anemia or chron's
Needed to convert dopamine to NE
Important in immune Fn + mucus secreting epithelium + growth
Deficiency causes muscle weakness and dilated cardiomyopathy
Hydroxylates lysine and proline
Scurvy = deficiency of...
Schilling's test concerns...
Deficiency often caused by broad spectrum Abx
Irregular keratin deposits in the cornea
Binds osteoblasts to mineralize bone and cartilage
MCC1 deficiency WW = non-enriched grain
Diarrhea + dermatitis + dementia
Impaired night vision
Deficiency caused by phenytoin, valproate, Sulfas, MTX...
Neutralizes free radicals, also renews Vitamin E
MCC1 vitamin deficiency in the US
Pseudotumor cerebri
Assists in clearance of free radicals from cytosol
Supplementation needed after gastric bypass
Deficiency causes RBC fragility and weakness
Corn-based diet causes this vitamin deficiency

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