Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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HPV viral protein E6 target
Anti-tissue transglutiminase IgA
Anti-histone antibodies
Defect in decay accelerating factor (DAF)
Auto-antiobdy seen in autoimmune hepatitis
DCC mutation
t(11;14)
Elevated bombesin
Anti-U1 RNP antibodies
Anti-SCL 70 antibodies
CD10 is a positive indicator in...
Spindle cells with hair-like glial processes
Anti-microsomal antibodies
Auto-antiobdy seen in rheumatoid arthritis
What is translocation of mantle cell lymphoma?
Auto-antiobdy seen in mixed connective tissue disease
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
HVA in urine
ERB-B2 gene
t(15;17)
Hypocretin-1
t(14;18)
t(8;14)
Anti-thyroglobulin antibodies
S-100 tumor marker
AFP tumor marker
BCR-ABL fusion gene
Anti-parietal cell antibodies
Anti-proteinase 3 antibodies
Anti-GBM antibodies
Anti-intrinsic factor antibodies
c-Myc activating cancer leads to EWSFL1 over-production
Cancer of CyclinD dysregulation
Mutated in Li-Fraumani syndrome
Anti-giladin IgA
CALLA is a positive indicator in...
Anti-voltage-gated Ca2+ channel antibodies
Cells that stain (+) for synaptophysin
BRAF V600E
HintAnswer
Anti-thyroperoxidase antibodies
Inheritance of hereditary angioedema
Auto-antiobdy seen in Grave's disease
Anti-insulin antibodies
Ki67 fraction >99%
t(8;21)
C-kit
LDH tumor marker
Homer-wright rosettes
Cystic brain tumor with granular eosinophilic bodies
Anti-MPO antibodies
Inversion c.16
Auto-antiobdy seen in CREST syndrome
Anti-ribonucleoprotein antibodies
Mutated in familial adenomatous polyposis
Anti-DNA topoisomerase 1 antibodies
Anti-centormere antibodies
AD mutation in MLH1/MSH2
t(9;22)
Anti-endomysial IgA
14-3-3
Thorotrast, arsenic, polyvinyl chloride
C-MYC implicated in what cancer
Anti-mitochondrial antibodies
Gene mutated in MEN 2a/2b
Anti-Jo-1 antibodies
Anti-glutamate decarboxylase antibodies
Auto-antibody seen in Wegener's granulomatosis
CEA tumor marker
AD mutation in p53 gene
Anti-SS-A (Ro) antibodies
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-dsDNA antibodies
High urinary HVA/VMA + N-Myc
Anti-Sm antibodies
Elevated tartrate-resistant acid phosphatase
NSE, Chromogranin, Synaptophysin, S100 (+)
Anti-LKM antibodies
HPV viral protein E7 target
HintAnswer
Anti-islet cell antibodies
CA 19-9 tumor marker
PML/RARa gene created by
AD mutation in APC gene
Anti-TSH receptor antibodies
Anti-desmoglein antibodies
CA 15-3 tumor marker
Auto-antiobdy seen in drug-induced lupus
t(11;22)
Gene mutated in NF2
Anti-nuclear antibodies
Pseudorosettes with GFAP positive processes
Anti-ACh receptor antibodies
Auto-antiobdy seen in polymyositis
Cause of liver angiosarcoma
N-MYC implicated in what cancer
Gene is involved in t(11;14)
Missing enzyme to degrade C3 and C4 convertase on RBCs
AD mutation of NF1
Anti-smooth muscle antibodies
Auto-antiobdy seen in Churg-Strauss syndrome
Deficiency of C1 esterase inhibitor
Receptor targeted by tratuzumab
Auto-antiobdy seen in seen in PBC
Analine dyes
Rosenthal fibers
Pleomorphic astrocytes with brisk activity and necrosis
t(8;14) affects what gene
Tumor marker for neuroblastoma
Auto-antibody seen in microscopic polyangiitis
DPC mutation
MCC1 complement deficiency
CA 125 tumor marker
Growth factor affected by osteosarcoma
Gene involved in t(14;18)
Causes centrilobular necrosis and fatty change of the liver
Auto-antiobdy seen in Goodpasture syndrome
Anti-SS-B (La) antibodies
Anti-IgG antibodies

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