Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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Cystic brain tumor with granular eosinophilic bodies
BCR-ABL fusion gene
t(8;21)
Anti-U1 RNP antibodies
CALLA is a positive indicator in...
Anti-giladin IgA
HPV viral protein E7 target
Anti-Jo-1 antibodies
Homer-wright rosettes
Cause of liver angiosarcoma
Anti-DNA topoisomerase 1 antibodies
Auto-antiobdy seen in rheumatoid arthritis
Anti-thyroglobulin antibodies
Missing enzyme to degrade C3 and C4 convertase on RBCs
Gene is involved in t(11;14)
Anti-proteinase 3 antibodies
BRAF V600E
High urinary HVA/VMA + N-Myc
t(8;14)
Auto-antibody seen in microscopic polyangiitis
Cancer of CyclinD dysregulation
Anti-histone antibodies
CD10 is a positive indicator in...
Anti-TSH receptor antibodies
What is translocation of mantle cell lymphoma?
DPC mutation
Inheritance of hereditary angioedema
AFP tumor marker
t(14;18)
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Gene involved in t(14;18)
Anti-MPO antibodies
CEA tumor marker
Anti-tissue transglutiminase IgA
Receptor targeted by tratuzumab
t(11;22)
C-kit
Elevated bombesin
Anti-SCL 70 antibodies
HintAnswer
Anti-Yo, Anti-P|Q, Anti-Hu
Deficiency of C1 esterase inhibitor
Anti-endomysial IgA
NSE, Chromogranin, Synaptophysin, S100 (+)
Anti-ribonucleoprotein antibodies
AD mutation in APC gene
Anti-parietal cell antibodies
Cells that stain (+) for synaptophysin
Anti-SS-A (Ro) antibodies
Defect in decay accelerating factor (DAF)
Tumor marker for neuroblastoma
t(11;14)
Gene mutated in NF2
DCC mutation
AD mutation of NF1
Anti-IgG antibodies
Inversion c.16
ERB-B2 gene
AD mutation in p53 gene
Anti-GBM antibodies
Growth factor affected by osteosarcoma
Anti-glutamate decarboxylase antibodies
Auto-antiobdy seen in CREST syndrome
Anti-thyroperoxidase antibodies
HPV viral protein E6 target
HVA in urine
Anti-voltage-gated Ca2+ channel antibodies
Anti-dsDNA antibodies
Auto-antiobdy seen in seen in PBC
Anti-SS-B (La) antibodies
Pleomorphic astrocytes with brisk activity and necrosis
Anti-nuclear antibodies
N-MYC implicated in what cancer
Elevated tartrate-resistant acid phosphatase
t(8;14) affects what gene
Anti-mitochondrial antibodies
Anti-centormere antibodies
Auto-antiobdy seen in mixed connective tissue disease
Hypocretin-1
HintAnswer
14-3-3
C-MYC implicated in what cancer
MCC1 complement deficiency
Auto-antibody seen in Wegener's granulomatosis
Anti-desmoglein antibodies
Anti-intrinsic factor antibodies
Gene mutated in MEN 2a/2b
Auto-antiobdy seen in Grave's disease
Anti-ACh receptor antibodies
Anti-islet cell antibodies
Thorotrast, arsenic, polyvinyl chloride
Auto-antiobdy seen in drug-induced lupus
CA 125 tumor marker
Mutated in familial adenomatous polyposis
Anti-insulin antibodies
S-100 tumor marker
AD mutation in MLH1/MSH2
PML/RARa gene created by
Spindle cells with hair-like glial processes
Rosenthal fibers
Auto-antiobdy seen in Churg-Strauss syndrome
Auto-antiobdy seen in Goodpasture syndrome
LDH tumor marker
Auto-antiobdy seen in polymyositis
t(9;22)
CA 19-9 tumor marker
Anti-smooth muscle antibodies
CA 15-3 tumor marker
Auto-antiobdy seen in autoimmune hepatitis
Pseudorosettes with GFAP positive processes
Analine dyes
Anti-LKM antibodies
t(15;17)
Mutated in Li-Fraumani syndrome
Ki67 fraction >99%
Causes centrilobular necrosis and fatty change of the liver
Anti-Sm antibodies
c-Myc activating cancer leads to EWSFL1 over-production
Anti-microsomal antibodies

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Created Jan 15, 2014ReportNominate
Tags:disease, gene, marker

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