Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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HintAnswer
Cystic brain tumor with granular eosinophilic bodies
Anti-LKM antibodies
c-Myc activating cancer leads to EWSFL1 over-production
DCC mutation
Inversion c.16
Anti-nuclear antibodies
Auto-antibody seen in microscopic polyangiitis
Anti-endomysial IgA
Homer-wright rosettes
t(8;14)
Defect in decay accelerating factor (DAF)
S-100 tumor marker
Receptor targeted by tratuzumab
Tumor marker for neuroblastoma
Gene involved in t(14;18)
Auto-antibody seen in Wegener's granulomatosis
PML/RARa gene created by
Anti-SS-A (Ro) antibodies
t(11;14)
t(11;22)
Pleomorphic astrocytes with brisk activity and necrosis
Auto-antiobdy seen in CREST syndrome
Anti-SS-B (La) antibodies
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-tissue transglutiminase IgA
Auto-antiobdy seen in mixed connective tissue disease
Cancer of CyclinD dysregulation
Anti-desmoglein antibodies
Anti-parietal cell antibodies
Thorotrast, arsenic, polyvinyl chloride
Cause of liver angiosarcoma
C-MYC implicated in what cancer
Auto-antiobdy seen in Goodpasture syndrome
Anti-thyroglobulin antibodies
C-kit
DPC mutation
N-MYC implicated in what cancer
Auto-antiobdy seen in seen in PBC
Causes centrilobular necrosis and fatty change of the liver
HintAnswer
Gene mutated in MEN 2a/2b
Rosenthal fibers
AFP tumor marker
BRAF V600E
MCC1 complement deficiency
Anti-islet cell antibodies
HPV viral protein E6 target
Growth factor affected by osteosarcoma
Anti-glutamate decarboxylase antibodies
ERB-B2 gene
Anti-giladin IgA
Auto-antiobdy seen in autoimmune hepatitis
AD mutation in MLH1/MSH2
CEA tumor marker
LDH tumor marker
Anti-Jo-1 antibodies
Auto-antiobdy seen in Churg-Strauss syndrome
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Auto-antiobdy seen in Grave's disease
Anti-MPO antibodies
Inheritance of hereditary angioedema
Anti-ACh receptor antibodies
Ki67 fraction >99%
CALLA is a positive indicator in...
Gene is involved in t(11;14)
BCR-ABL fusion gene
Auto-antiobdy seen in polymyositis
Anti-U1 RNP antibodies
Mutated in familial adenomatous polyposis
CA 125 tumor marker
CD10 is a positive indicator in...
t(9;22)
Anti-smooth muscle antibodies
AD mutation in APC gene
Deficiency of C1 esterase inhibitor
Anti-IgG antibodies
Auto-antiobdy seen in rheumatoid arthritis
Mutated in Li-Fraumani syndrome
Anti-TSH receptor antibodies
HintAnswer
Pseudorosettes with GFAP positive processes
t(15;17)
HVA in urine
t(14;18)
Anti-dsDNA antibodies
Anti-mitochondrial antibodies
Hypocretin-1
AD mutation of NF1
Anti-thyroperoxidase antibodies
NSE, Chromogranin, Synaptophysin, S100 (+)
t(8;21)
High urinary HVA/VMA + N-Myc
What is translocation of mantle cell lymphoma?
Gene mutated in NF2
Auto-antiobdy seen in drug-induced lupus
Anti-ribonucleoprotein antibodies
CA 15-3 tumor marker
Anti-microsomal antibodies
Spindle cells with hair-like glial processes
Cells that stain (+) for synaptophysin
Elevated bombesin
Anti-voltage-gated Ca2+ channel antibodies
HPV viral protein E7 target
Anti-proteinase 3 antibodies
Anti-Sm antibodies
Anti-SCL 70 antibodies
Elevated tartrate-resistant acid phosphatase
Anti-histone antibodies
CA 19-9 tumor marker
Analine dyes
Anti-GBM antibodies
Anti-DNA topoisomerase 1 antibodies
t(8;14) affects what gene
Anti-insulin antibodies
Anti-centormere antibodies
AD mutation in p53 gene
14-3-3
Missing enzyme to degrade C3 and C4 convertase on RBCs
Anti-intrinsic factor antibodies

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