Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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AD mutation in p53 gene
AD mutation of NF1
Anti-insulin antibodies
Anti-parietal cell antibodies
Anti-ACh receptor antibodies
Elevated tartrate-resistant acid phosphatase
Auto-antiobdy seen in drug-induced lupus
Auto-antiobdy seen in Goodpasture syndrome
Hypocretin-1
Anti-Sm antibodies
Anti-voltage-gated Ca2+ channel antibodies
Anti-SCL 70 antibodies
Deficiency of C1 esterase inhibitor
ERB-B2 gene
What is translocation of mantle cell lymphoma?
Homer-wright rosettes
HPV viral protein E7 target
Auto-antiobdy seen in seen in PBC
Tumor marker for neuroblastoma
Rosenthal fibers
Anti-microsomal antibodies
Causes centrilobular necrosis and fatty change of the liver
Auto-antibody seen in Wegener's granulomatosis
Anti-desmoglein antibodies
Elevated bombesin
Auto-antiobdy seen in polymyositis
Inheritance of hereditary angioedema
BCR-ABL fusion gene
Auto-antiobdy seen in Churg-Strauss syndrome
c-Myc activating cancer leads to EWSFL1 over-production
Anti-ribonucleoprotein antibodies
S-100 tumor marker
Cystic brain tumor with granular eosinophilic bodies
MCC1 complement deficiency
Pleomorphic astrocytes with brisk activity and necrosis
Anti-proteinase 3 antibodies
Anti-DNA topoisomerase 1 antibodies
DPC mutation
t(11;22)
HintAnswer
Anti-giladin IgA
Auto-antiobdy seen in CREST syndrome
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-GBM antibodies
Anti-dsDNA antibodies
Anti-thyroglobulin antibodies
Auto-antiobdy seen in autoimmune hepatitis
CA 125 tumor marker
Anti-SS-B (La) antibodies
Anti-thyroperoxidase antibodies
Gene mutated in MEN 2a/2b
Gene mutated in NF2
Gene involved in t(14;18)
t(8;21)
Anti-tissue transglutiminase IgA
Anti-LKM antibodies
Inversion c.16
HPV viral protein E6 target
PML/RARa gene created by
Growth factor affected by osteosarcoma
t(9;22)
Anti-SS-A (Ro) antibodies
BRAF V600E
Auto-antiobdy seen in rheumatoid arthritis
Anti-TSH receptor antibodies
Spindle cells with hair-like glial processes
t(8;14)
N-MYC implicated in what cancer
Auto-antiobdy seen in mixed connective tissue disease
Anti-mitochondrial antibodies
AD mutation in APC gene
Anti-histone antibodies
Anti-Jo-1 antibodies
HVA in urine
AFP tumor marker
DCC mutation
Anti-endomysial IgA
Anti-glutamate decarboxylase antibodies
14-3-3
HintAnswer
CA 15-3 tumor marker
CA 19-9 tumor marker
Cells that stain (+) for synaptophysin
Cancer of CyclinD dysregulation
Anti-MPO antibodies
t(8;14) affects what gene
Anti-smooth muscle antibodies
t(14;18)
Anti-U1 RNP antibodies
t(11;14)
Anti-nuclear antibodies
Thorotrast, arsenic, polyvinyl chloride
Auto-antibody seen in microscopic polyangiitis
NSE, Chromogranin, Synaptophysin, S100 (+)
Analine dyes
CALLA is a positive indicator in...
Mutated in Li-Fraumani syndrome
Mutated in familial adenomatous polyposis
Ki67 fraction >99%
Cause of liver angiosarcoma
Defect in decay accelerating factor (DAF)
Pseudorosettes with GFAP positive processes
Anti-islet cell antibodies
Anti-centormere antibodies
AD mutation in MLH1/MSH2
Receptor targeted by tratuzumab
t(15;17)
LDH tumor marker
Anti-intrinsic factor antibodies
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
High urinary HVA/VMA + N-Myc
CD10 is a positive indicator in...
Gene is involved in t(11;14)
CEA tumor marker
C-MYC implicated in what cancer
Anti-IgG antibodies
Auto-antiobdy seen in Grave's disease
Missing enzyme to degrade C3 and C4 convertase on RBCs
C-kit

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