Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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QUIZ: Can you name the Goljan 5 of X: Disease markers and genes

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HintAnswer
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-DNA topoisomerase 1 antibodies
Homer-wright rosettes
Anti-histone antibodies
Anti-mitochondrial antibodies
Anti-tissue transglutiminase IgA
BRAF V600E
ERB-B2 gene
t(8;14) affects what gene
Anti-dsDNA antibodies
Auto-antiobdy seen in Goodpasture syndrome
What is translocation of mantle cell lymphoma?
AD mutation of NF1
Growth factor affected by osteosarcoma
Auto-antiobdy seen in rheumatoid arthritis
Cystic brain tumor with granular eosinophilic bodies
t(8;14)
HPV viral protein E6 target
Anti-thyroglobulin antibodies
C-MYC implicated in what cancer
Anti-Sm antibodies
Auto-antiobdy seen in polymyositis
AD mutation in MLH1/MSH2
Anti-nuclear antibodies
Missing enzyme to degrade C3 and C4 convertase on RBCs
PML/RARa gene created by
Auto-antiobdy seen in autoimmune hepatitis
Anti-intrinsic factor antibodies
Tumor marker for neuroblastoma
HPV viral protein E7 target
Anti-SCL 70 antibodies
Mutated in familial adenomatous polyposis
Anti-parietal cell antibodies
Anti-desmoglein antibodies
S-100 tumor marker
Ki67 fraction >99%
Inheritance of hereditary angioedema
Mutated in Li-Fraumani syndrome
t(9;22)
HintAnswer
Anti-IgG antibodies
Anti-smooth muscle antibodies
Anti-MPO antibodies
Auto-antiobdy seen in drug-induced lupus
Anti-SS-B (La) antibodies
Elevated bombesin
Auto-antibody seen in microscopic polyangiitis
Auto-antiobdy seen in Grave's disease
Auto-antiobdy seen in CREST syndrome
CA 15-3 tumor marker
HVA in urine
AFP tumor marker
Auto-antiobdy seen in seen in PBC
Anti-SS-A (Ro) antibodies
C-kit
Pseudorosettes with GFAP positive processes
N-MYC implicated in what cancer
Anti-giladin IgA
14-3-3
Anti-thyroperoxidase antibodies
t(8;21)
Anti-centormere antibodies
Anti-ACh receptor antibodies
Hypocretin-1
High urinary HVA/VMA + N-Myc
Anti-endomysial IgA
Anti-proteinase 3 antibodies
Analine dyes
Anti-microsomal antibodies
AD mutation in p53 gene
Causes centrilobular necrosis and fatty change of the liver
Thorotrast, arsenic, polyvinyl chloride
Elevated tartrate-resistant acid phosphatase
t(14;18)
Anti-islet cell antibodies
Anti-U1 RNP antibodies
Cause of liver angiosarcoma
Anti-LKM antibodies
NSE, Chromogranin, Synaptophysin, S100 (+)
HintAnswer
Cancer of CyclinD dysregulation
DPC mutation
Deficiency of C1 esterase inhibitor
Inversion c.16
t(11;22)
Gene mutated in MEN 2a/2b
Gene mutated in NF2
Anti-TSH receptor antibodies
CA 125 tumor marker
Anti-GBM antibodies
Defect in decay accelerating factor (DAF)
Anti-voltage-gated Ca2+ channel antibodies
MCC1 complement deficiency
AD mutation in APC gene
Spindle cells with hair-like glial processes
Anti-ribonucleoprotein antibodies
Rosenthal fibers
CALLA is a positive indicator in...
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
CA 19-9 tumor marker
Auto-antiobdy seen in mixed connective tissue disease
CD10 is a positive indicator in...
Auto-antiobdy seen in Churg-Strauss syndrome
t(15;17)
Anti-insulin antibodies
Anti-glutamate decarboxylase antibodies
Gene involved in t(14;18)
Auto-antibody seen in Wegener's granulomatosis
c-Myc activating cancer leads to EWSFL1 over-production
Receptor targeted by tratuzumab
BCR-ABL fusion gene
Gene is involved in t(11;14)
LDH tumor marker
t(11;14)
Anti-Jo-1 antibodies
Cells that stain (+) for synaptophysin
Pleomorphic astrocytes with brisk activity and necrosis
DCC mutation
CEA tumor marker

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