Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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Auto-antiobdy seen in rheumatoid arthritis
Hypocretin-1
Anti-glutamate decarboxylase antibodies
Anti-islet cell antibodies
Anti-voltage-gated Ca2+ channel antibodies
Auto-antibody seen in microscopic polyangiitis
Inheritance of hereditary angioedema
t(8;21)
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-ribonucleoprotein antibodies
Thorotrast, arsenic, polyvinyl chloride
Anti-dsDNA antibodies
S-100 tumor marker
Anti-thyroglobulin antibodies
Gene involved in t(14;18)
t(8;14)
Anti-Jo-1 antibodies
Anti-IgG antibodies
Homer-wright rosettes
Anti-Sm antibodies
t(8;14) affects what gene
Elevated bombesin
Anti-LKM antibodies
Cells that stain (+) for synaptophysin
t(11;14)
t(9;22)
Analine dyes
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Anti-parietal cell antibodies
High urinary HVA/VMA + N-Myc
Inversion c.16
Anti-microsomal antibodies
N-MYC implicated in what cancer
Defect in decay accelerating factor (DAF)
MCC1 complement deficiency
Causes centrilobular necrosis and fatty change of the liver
Anti-insulin antibodies
Anti-SS-A (Ro) antibodies
Tumor marker for neuroblastoma
HintAnswer
Anti-tissue transglutiminase IgA
Pleomorphic astrocytes with brisk activity and necrosis
Elevated tartrate-resistant acid phosphatase
DPC mutation
HVA in urine
Auto-antiobdy seen in autoimmune hepatitis
Auto-antibody seen in Wegener's granulomatosis
Anti-endomysial IgA
Auto-antiobdy seen in CREST syndrome
C-kit
Anti-proteinase 3 antibodies
Anti-U1 RNP antibodies
Spindle cells with hair-like glial processes
Anti-nuclear antibodies
Anti-intrinsic factor antibodies
Auto-antiobdy seen in mixed connective tissue disease
Pseudorosettes with GFAP positive processes
HPV viral protein E6 target
Anti-ACh receptor antibodies
Anti-TSH receptor antibodies
CALLA is a positive indicator in...
Gene mutated in NF2
C-MYC implicated in what cancer
Cancer of CyclinD dysregulation
Anti-thyroperoxidase antibodies
Deficiency of C1 esterase inhibitor
NSE, Chromogranin, Synaptophysin, S100 (+)
Mutated in familial adenomatous polyposis
Cause of liver angiosarcoma
Auto-antiobdy seen in polymyositis
AD mutation of NF1
AD mutation in p53 gene
Auto-antiobdy seen in seen in PBC
CA 15-3 tumor marker
Gene is involved in t(11;14)
LDH tumor marker
Growth factor affected by osteosarcoma
DCC mutation
AD mutation in APC gene
HintAnswer
Anti-mitochondrial antibodies
BCR-ABL fusion gene
Anti-centormere antibodies
Rosenthal fibers
Auto-antiobdy seen in Churg-Strauss syndrome
t(15;17)
AD mutation in MLH1/MSH2
HPV viral protein E7 target
Cystic brain tumor with granular eosinophilic bodies
Auto-antiobdy seen in Goodpasture syndrome
Anti-SCL 70 antibodies
What is translocation of mantle cell lymphoma?
Auto-antiobdy seen in Grave's disease
Anti-DNA topoisomerase 1 antibodies
Receptor targeted by tratuzumab
Anti-SS-B (La) antibodies
Ki67 fraction >99%
c-Myc activating cancer leads to EWSFL1 over-production
AFP tumor marker
CA 125 tumor marker
14-3-3
Anti-histone antibodies
Anti-giladin IgA
PML/RARa gene created by
Mutated in Li-Fraumani syndrome
CD10 is a positive indicator in...
Anti-GBM antibodies
Auto-antiobdy seen in drug-induced lupus
CA 19-9 tumor marker
Anti-MPO antibodies
Gene mutated in MEN 2a/2b
t(14;18)
Anti-smooth muscle antibodies
BRAF V600E
t(11;22)
CEA tumor marker
ERB-B2 gene
Anti-desmoglein antibodies
Missing enzyme to degrade C3 and C4 convertase on RBCs

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