Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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HintAnswer
Auto-antiobdy seen in Grave's disease
Anti-nuclear antibodies
Anti-Yo, Anti-P|Q, Anti-Hu
Auto-antiobdy seen in drug-induced lupus
t(11;14)
Elevated bombesin
Auto-antiobdy seen in mixed connective tissue disease
t(11;22)
t(8;21)
Auto-antiobdy seen in autoimmune hepatitis
N-MYC implicated in what cancer
C-kit
Defect in decay accelerating factor (DAF)
C-MYC implicated in what cancer
Anti-thyroglobulin antibodies
Anti-SS-A (Ro) antibodies
Anti-LKM antibodies
Auto-antiobdy seen in CREST syndrome
DPC mutation
Gene mutated in NF2
ERB-B2 gene
CEA tumor marker
HPV viral protein E7 target
Elevated tartrate-resistant acid phosphatase
BRAF V600E
Anti-histone antibodies
Anti-GBM antibodies
Anti-Jo-1 antibodies
Cystic brain tumor with granular eosinophilic bodies
c-Myc activating cancer leads to EWSFL1 over-production
Anti-SS-B (La) antibodies
Hypocretin-1
Pleomorphic astrocytes with brisk activity and necrosis
CA 19-9 tumor marker
Pseudorosettes with GFAP positive processes
AD mutation in p53 gene
Rosenthal fibers
Auto-antiobdy seen in Churg-Strauss syndrome
BCR-ABL fusion gene
HintAnswer
Anti-smooth muscle antibodies
t(8;14) affects what gene
Auto-antiobdy seen in rheumatoid arthritis
Anti-proteinase 3 antibodies
Auto-antibody seen in microscopic polyangiitis
Homer-wright rosettes
Anti-U1 RNP antibodies
Thorotrast, arsenic, polyvinyl chloride
NSE, Chromogranin, Synaptophysin, S100 (+)
AD mutation in APC gene
t(8;14)
AFP tumor marker
HVA in urine
Missing enzyme to degrade C3 and C4 convertase on RBCs
Mutated in familial adenomatous polyposis
Cause of liver angiosarcoma
Anti-dsDNA antibodies
Mutated in Li-Fraumani syndrome
Anti-TSH receptor antibodies
Anti-mitochondrial antibodies
Anti-tissue transglutiminase IgA
Anti-DNA topoisomerase 1 antibodies
AD mutation of NF1
Anti-giladin IgA
14-3-3
Anti-parietal cell antibodies
Cells that stain (+) for synaptophysin
Tumor marker for neuroblastoma
Anti-microsomal antibodies
Anti-ribonucleoprotein antibodies
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Anti-IgG antibodies
HPV viral protein E6 target
t(14;18)
Cancer of CyclinD dysregulation
Anti-glutamate decarboxylase antibodies
Anti-thyroperoxidase antibodies
Anti-intrinsic factor antibodies
Anti-endomysial IgA
HintAnswer
S-100 tumor marker
Anti-centormere antibodies
What is translocation of mantle cell lymphoma?
MCC1 complement deficiency
Anti-desmoglein antibodies
Spindle cells with hair-like glial processes
Anti-ACh receptor antibodies
Growth factor affected by osteosarcoma
Anti-Sm antibodies
Ki67 fraction >99%
Gene is involved in t(11;14)
Gene involved in t(14;18)
DCC mutation
Inversion c.16
Anti-MPO antibodies
Anti-insulin antibodies
Anti-SCL 70 antibodies
Analine dyes
Receptor targeted by tratuzumab
Causes centrilobular necrosis and fatty change of the liver
LDH tumor marker
Auto-antiobdy seen in polymyositis
CALLA is a positive indicator in...
AD mutation in MLH1/MSH2
Anti-voltage-gated Ca2+ channel antibodies
High urinary HVA/VMA + N-Myc
Gene mutated in MEN 2a/2b
Auto-antiobdy seen in seen in PBC
Deficiency of C1 esterase inhibitor
Anti-islet cell antibodies
CA 15-3 tumor marker
Auto-antiobdy seen in Goodpasture syndrome
CA 125 tumor marker
PML/RARa gene created by
t(15;17)
t(9;22)
Inheritance of hereditary angioedema
Auto-antibody seen in Wegener's granulomatosis
CD10 is a positive indicator in...

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