Science Quiz / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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AD mutation in MLH1/MSH2
Anti-thyroglobulin antibodies
Anti-IgG antibodies
Cells that stain (+) for synaptophysin
Cause of liver angiosarcoma
Elevated tartrate-resistant acid phosphatase
t(9;22)
Auto-antiobdy seen in Goodpasture syndrome
Mutated in Li-Fraumani syndrome
AD mutation in p53 gene
Mutated in familial adenomatous polyposis
Anti-smooth muscle antibodies
Elevated bombesin
Auto-antiobdy seen in autoimmune hepatitis
Spindle cells with hair-like glial processes
Anti-giladin IgA
CA 125 tumor marker
Auto-antiobdy seen in polymyositis
AD mutation in APC gene
Anti-MPO antibodies
Gene is involved in t(11;14)
Anti-insulin antibodies
Causes centrilobular necrosis and fatty change of the liver
Anti-intrinsic factor antibodies
Receptor targeted by tratuzumab
NSE, Chromogranin, Synaptophysin, S100 (+)
Anti-mitochondrial antibodies
Analine dyes
CALLA is a positive indicator in...
Anti-LKM antibodies
Anti-histone antibodies
MCC1 complement deficiency
Hypocretin-1
Anti-proteinase 3 antibodies
High urinary HVA/VMA + N-Myc
HPV viral protein E7 target
Auto-antibody seen in Wegener's granulomatosis
Anti-TSH receptor antibodies
Auto-antiobdy seen in rheumatoid arthritis
HintAnswer
Gene mutated in MEN 2a/2b
Tumor marker for neuroblastoma
Anti-DNA topoisomerase 1 antibodies
C-kit
Anti-thyroperoxidase antibodies
Auto-antiobdy seen in seen in PBC
BRAF V600E
HPV viral protein E6 target
t(8;14) affects what gene
Cystic brain tumor with granular eosinophilic bodies
t(15;17)
Pseudorosettes with GFAP positive processes
Anti-Jo-1 antibodies
Anti-U1 RNP antibodies
Homer-wright rosettes
t(11;22)
Anti-GBM antibodies
PML/RARa gene created by
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Anti-glutamate decarboxylase antibodies
Thorotrast, arsenic, polyvinyl chloride
Anti-centormere antibodies
S-100 tumor marker
DPC mutation
Growth factor affected by osteosarcoma
CA 19-9 tumor marker
Anti-microsomal antibodies
Auto-antiobdy seen in drug-induced lupus
Cancer of CyclinD dysregulation
t(8;14)
Anti-dsDNA antibodies
Anti-SS-B (La) antibodies
Anti-endomysial IgA
Defect in decay accelerating factor (DAF)
Inheritance of hereditary angioedema
DCC mutation
ERB-B2 gene
t(11;14)
Anti-voltage-gated Ca2+ channel antibodies
HintAnswer
Inversion c.16
Auto-antiobdy seen in Churg-Strauss syndrome
Missing enzyme to degrade C3 and C4 convertase on RBCs
Anti-nuclear antibodies
Gene mutated in NF2
Deficiency of C1 esterase inhibitor
Anti-ACh receptor antibodies
AFP tumor marker
Auto-antiobdy seen in mixed connective tissue disease
CEA tumor marker
N-MYC implicated in what cancer
c-Myc activating cancer leads to EWSFL1 over-production
Auto-antiobdy seen in CREST syndrome
CA 15-3 tumor marker
CD10 is a positive indicator in...
Anti-SS-A (Ro) antibodies
HVA in urine
LDH tumor marker
Anti-desmoglein antibodies
Anti-ribonucleoprotein antibodies
Ki67 fraction >99%
What is translocation of mantle cell lymphoma?
t(8;21)
BCR-ABL fusion gene
Anti-tissue transglutiminase IgA
Gene involved in t(14;18)
Auto-antiobdy seen in Grave's disease
Auto-antibody seen in microscopic polyangiitis
C-MYC implicated in what cancer
t(14;18)
14-3-3
Rosenthal fibers
AD mutation of NF1
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-SCL 70 antibodies
Pleomorphic astrocytes with brisk activity and necrosis
Anti-parietal cell antibodies
Anti-Sm antibodies
Anti-islet cell antibodies

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Created Jan 15, 2014ReportNominate
Tags:disease, gene, marker

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