Science Quiz / Goljan 4 of X: Glomerular Disease

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Can you name the Goljan 4 of X: Glomerular Disease

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Crescentic proliferation is an expansion of what cells?
Sub-epithelial IC deposits with granular IF + Nephritic
Minimum proteinuria for nephritic syndrome
MCC1 chronic glomerulonephritis
Infection in nephrotic syndrome
Antigen associated with MGN
Nodular masses in the mesangial matrix + hyaline arteriolosclerosis
Hyaline arteriolosclerosis prefers this structure
MCC1 death in SLE
Diffuse proliferative GN + sub-endothelial ICs
Sclerosis = build up of...
Term meaning thickened GBM w/ hyper cellular glomeruli
Hematuria 2-3 weeks after URI
Term meaning thickened GBM w/o proliferation
MCC1 GN in HIV+ status
Nose bleeds + hematuria + glomerulonephritis
Episodic hematuria + premature HTN + s/p upper respiratory infection
Extremely low C3 levels
'Spike and dome' on silver stain beneath VECs
Term meaning parietal epithelial cell proliferation
MCC1 GN in young black males
'Lumpy bumpy' glomeruli on LM with sub-epithelial humps and granular IF + nephritic proteinuria
MCC1 GN in heroin abuse
'Wire-looping' of capillaries with hyaline thrombi
Negative IF with podocyte fusion on EM
Inheritance of benign familial hematuria
Associated with C3 nephritic factor
MCC1 nephrotic syndrome in adults
GBM made of what type of collagen
Non-enzymatic glycosylation of the GBM
MCC2 chronic glomerulonephritis
Mesangial Ig deposits with granular IF
Positive anti-cationic proteinase with low C3
Lipid accumulation in visceral epithelial cells
Glomerular capillaries damaged by buildup of...
Hypercellular nuclei and (+)ASO
Negative IF with focal damage of visceral epithelial cells
Sub-endothelial ICs with granular IF + nephrotic syndrome
Treatment for FSGS
HBV + nephrotic syndrome
Focal proliferative GN with mesangial Ig deposits and granular IF
Cryoglobulinemia + nephrotic syndrome
Diffuse proliferative GN with neutrophil infiltration
Purpuric lesions of skin + abdominal pain + hematuria
Treatment for minimal change disease
LM shows nodular glomerulosclerosis with mesangial expansion and nodular thickening
Deposits of this cause granular pattern on IF
Foam cells in glomerulus
'Rim pattern' of serum ANA
MCC1 renal failure in the US
Sub-endothelial DNA-anti-DNA ICs
Congo red stain
MCC2 nephrotic syndrome in adults
Diffuse intra-membranous deposits with tram-tracking
Sorbitol is formed by what enzyme
Diffuse thickening of membranes with sub-epithelial ICs
Cause of hyper coagulability in nephrotic syndrome
Dense deposit disease
Tram-tracking on EM
Minimum proteinuria for nephrotic syndrome
MCC1 nephrotic syndrome in children
Fatty casts with maltese crosses
Afferent arteriole flow controlled by...
Anatomic area of the kidney susceptible to ischemia
Titer seen in PSGN
Sub-endothelial IC despots with granular IF
Nerve dz + ocular dz + deafness
Maximum proteinuria for nephritic syndrome
Mutated in Alport syndrome
Fibrosis = build up of...
RBC casts are pathognomonic for
Hematuria 2-3 days after URI
Linear IF without electron dense deposits
Multiple myeloma + nephrotic syndrome
Secondary cause of minimal change disease
MCC1 post-infectious GN
PLA2R IgG4 antibodies
Crescent of fibrin and c3b with linear IF
JGA found in what structure?
Apple-green birefringence
T-cell cytokine destruction of GBM
JGA produces...
Initial manifestation of diabetic kidney Dz
Begins with hemoptysis, rapid progression to renal failure
HCV + nephrotic syndrome
Most common inheritance of Alport syndrome
Glomerular basement membrane produced by...
Most common form of MPGN
Coarse granular sub-epithelial deposits of IgG and C3
MCC1 normotensive nephrotic syndrome
Sub-epithelial ICs + granular IF + nephrotic
Rheumatoid arthritis + nephrotic syndrome
Gold therapy predisposes to...
Associated with Ab against C3-convertase
MGN appears similar to what nephritic syndrome on EM/IF
Deposits of this cause linear pattern on IF
Diffuse proliferative GN + sub-epithelial ICs
Sub-endothelial ICs, granular IF, tram-tracking
Efferent arteriole flow controlled by...
EM shows splitting of GBM by ingrowing mesangium
Anti-GBM antibodies against T4C
Diffuse capillary-GBM thickening with spike and dome sub-epithelial ICs
Increased serum IgA + focal proliferative GN
What structure retains albumin in the glomerulus?

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