Science Quiz / Goljan 4 of X: Glomerular Disease

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Can you name the Goljan 4 of X: Glomerular Disease

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HintAnswer
Nodular masses in the mesangial matrix + hyaline arteriolosclerosis
MCC1 GN in heroin abuse
MCC1 chronic glomerulonephritis
 
MCC1 renal failure in the US
Initial manifestation of diabetic kidney Dz
Increased serum IgA + focal proliferative GN
Sclerosis = build up of...
Coarse granular sub-epithelial deposits of IgG and C3
Focal proliferative GN with mesangial Ig deposits and granular IF
Fibrosis = build up of...
Nose bleeds + hematuria + glomerulonephritis
Titer seen in PSGN
Glomerular capillaries damaged by buildup of...
'Rim pattern' of serum ANA
Treatment for FSGS
Treatment for minimal change disease
Sub-endothelial ICs with granular IF + nephrotic syndrome
JGA found in what structure?
Diffuse intra-membranous deposits with tram-tracking
Episodic hematuria + premature HTN + s/p upper respiratory infection
Linear IF without electron dense deposits
Foam cells in glomerulus
Fatty casts with maltese crosses
Minimum proteinuria for nephrotic syndrome
Secondary cause of minimal change disease
Antigen associated with MGN
Diffuse proliferative GN + sub-epithelial ICs
HBV + nephrotic syndrome
Crescentic proliferation is an expansion of what cells?
Anti-GBM antibodies against T4C
Cryoglobulinemia + nephrotic syndrome
'Spike and dome' on silver stain beneath VECs
Maximum proteinuria for nephritic syndrome
LM shows nodular glomerulosclerosis with mesangial expansion and nodular thickening
Dense deposit disease
HintAnswer
Begins with hemoptysis, rapid progression to renal failure
Sub-endothelial ICs, granular IF, tram-tracking
Sorbitol is formed by what enzyme
Crescent of fibrin and c3b with linear IF
Sub-endothelial IC despots with granular IF
Diffuse proliferative GN + sub-endothelial ICs
RPGN + c-ANCA
Associated with C3 nephritic factor
Infection in nephrotic syndrome
MCC1 normotensive nephrotic syndrome
Deposits of this cause linear pattern on IF
Anatomic area of the kidney susceptible to ischemia
Inheritance of benign familial hematuria
Non-enzymatic glycosylation of the GBM
Glomerular basement membrane produced by...
RBC casts are pathognomonic for
Afferent arteriole flow controlled by...
JGA produces...
Cause of hyper coagulability in nephrotic syndrome
RPGN + p-ANCA
'Lumpy bumpy' glomeruli on LM with sub-epithelial humps and granular IF + nephritic proteinuria
Diffuse capillary-GBM thickening with spike and dome sub-epithelial ICs
Sub-epithelial IC deposits with granular IF + Nephritic
Efferent arteriole flow controlled by...
Hyaline arteriolosclerosis prefers this structure
Congo red stain
'Wire-looping' of capillaries with hyaline thrombi
Diffuse thickening of membranes with sub-epithelial ICs
Negative IF with podocyte fusion on EM
Sub-endothelial DNA-anti-DNA ICs
Mutated in Alport syndrome
Term meaning thickened GBM w/o proliferation
MCC2 nephrotic syndrome in adults
MCC1 nephrotic syndrome in adults
Extremely low C3 levels
MCC1 GN in young black males
HintAnswer
Associated with Ab against C3-convertase
Most common form of MPGN
Sub-epithelial ICs + granular IF + nephrotic
Tram-tracking on EM
MCC1 GN in HIV+ status
Most common inheritance of Alport syndrome
MCC2 chronic glomerulonephritis
GBM made of what type of collagen
Diffuse proliferative GN with neutrophil infiltration
Hematuria 2-3 days after URI
Purpuric lesions of skin + abdominal pain + hematuria
T-cell cytokine destruction of GBM
Apple-green birefringence
Nerve dz + ocular dz + deafness
Mesangial Ig deposits with granular IF
Term meaning parietal epithelial cell proliferation
EM shows splitting of GBM by ingrowing mesangium
Positive anti-cationic proteinase with low C3
HCV + nephrotic syndrome
PLA2R IgG4 antibodies
MGN appears similar to what nephritic syndrome on EM/IF
Minimum proteinuria for nephritic syndrome
Gold therapy predisposes to...
Rheumatoid arthritis + nephrotic syndrome
Negative IF with focal damage of visceral epithelial cells
MCC1 nephrotic syndrome in children
Hematuria 2-3 weeks after URI
Term meaning thickened GBM w/ hyper cellular glomeruli
Lipid accumulation in visceral epithelial cells
Deposits of this cause granular pattern on IF
Multiple myeloma + nephrotic syndrome
What structure retains albumin in the glomerulus?
MCC1 post-infectious GN
MCC1 death in SLE
Hypercellular nuclei and (+)ASO

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