Science Quiz / Goljan 4 of X: Glomerular Disease

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Can you name the Goljan 4 of X: Glomerular Disease

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HintAnswer
Afferent arteriole flow controlled by...
Maximum proteinuria for nephritic syndrome
Most common form of MPGN
GBM made of what type of collagen
T-cell cytokine destruction of GBM
MCC1 GN in HIV+ status
MCC1 nephrotic syndrome in children
Purpuric lesions of skin + abdominal pain + hematuria
Mutated in Alport syndrome
Foam cells in glomerulus
RPGN + c-ANCA
EM shows splitting of GBM by ingrowing mesangium
Positive anti-cationic proteinase with low C3
Diffuse thickening of membranes with sub-epithelial ICs
Crescent of fibrin and c3b with linear IF
Sub-endothelial DNA-anti-DNA ICs
Sub-epithelial IC deposits with granular IF + Nephritic
HCV + nephrotic syndrome
Hematuria 2-3 days after URI
JGA found in what structure?
Hyaline arteriolosclerosis prefers this structure
Gold therapy predisposes to...
Sub-epithelial ICs + granular IF + nephrotic
Lipid accumulation in visceral epithelial cells
Initial manifestation of diabetic kidney Dz
Sub-endothelial IC despots with granular IF
Diffuse proliferative GN + sub-epithelial ICs
MCC1 chronic glomerulonephritis
Negative IF with podocyte fusion on EM
MCC1 post-infectious GN
Congo red stain
Glomerular capillaries damaged by buildup of...
Term meaning thickened GBM w/o proliferation
Hypercellular nuclei and (+)ASO
Rheumatoid arthritis + nephrotic syndrome
Treatment for minimal change disease
HintAnswer
Cause of hyper coagulability in nephrotic syndrome
MCC1 normotensive nephrotic syndrome
Coarse granular sub-epithelial deposits of IgG and C3
Most common inheritance of Alport syndrome
Deposits of this cause granular pattern on IF
MCC1 renal failure in the US
Cryoglobulinemia + nephrotic syndrome
Crescentic proliferation is an expansion of what cells?
Associated with Ab against C3-convertase
Episodic hematuria + premature HTN + s/p upper respiratory infection
Negative IF with focal damage of visceral epithelial cells
What structure retains albumin in the glomerulus?
'Wire-looping' of capillaries with hyaline thrombi
Minimum proteinuria for nephritic syndrome
MCC1 GN in young black males
Nerve dz + ocular dz + deafness
Antigen associated with MGN
Extremely low C3 levels
Sorbitol is formed by what enzyme
Term meaning parietal epithelial cell proliferation
LM shows nodular glomerulosclerosis with mesangial expansion and nodular thickening
Minimum proteinuria for nephrotic syndrome
MCC1 nephrotic syndrome in adults
Multiple myeloma + nephrotic syndrome
'Rim pattern' of serum ANA
Nodular masses in the mesangial matrix + hyaline arteriolosclerosis
'Spike and dome' on silver stain beneath VECs
Fibrosis = build up of...
Tram-tracking on EM
Sub-endothelial ICs, granular IF, tram-tracking
Deposits of this cause linear pattern on IF
MCC2 chronic glomerulonephritis
Sub-endothelial ICs with granular IF + nephrotic syndrome
 
Treatment for FSGS
Term meaning thickened GBM w/ hyper cellular glomeruli
HintAnswer
Hematuria 2-3 weeks after URI
Titer seen in PSGN
Associated with C3 nephritic factor
Anti-GBM antibodies against T4C
Diffuse intra-membranous deposits with tram-tracking
Anatomic area of the kidney susceptible to ischemia
Increased serum IgA + focal proliferative GN
Secondary cause of minimal change disease
HBV + nephrotic syndrome
MGN appears similar to what nephritic syndrome on EM/IF
RPGN + p-ANCA
PLA2R IgG4 antibodies
MCC2 nephrotic syndrome in adults
JGA produces...
Linear IF without electron dense deposits
Apple-green birefringence
RBC casts are pathognomonic for
Nose bleeds + hematuria + glomerulonephritis
Infection in nephrotic syndrome
MCC1 death in SLE
Diffuse capillary-GBM thickening with spike and dome sub-epithelial ICs
Sclerosis = build up of...
Begins with hemoptysis, rapid progression to renal failure
Mesangial Ig deposits with granular IF
Efferent arteriole flow controlled by...
Inheritance of benign familial hematuria
Glomerular basement membrane produced by...
Non-enzymatic glycosylation of the GBM
Dense deposit disease
Fatty casts with maltese crosses
Diffuse proliferative GN + sub-endothelial ICs
Focal proliferative GN with mesangial Ig deposits and granular IF
MCC1 GN in heroin abuse
'Lumpy bumpy' glomeruli on LM with sub-epithelial humps and granular IF + nephritic proteinuria
Diffuse proliferative GN with neutrophil infiltration

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